CN101417142A - Preparation method of external natural diatomite emergency life-saving hemostat - Google Patents
Preparation method of external natural diatomite emergency life-saving hemostat Download PDFInfo
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- CN101417142A CN101417142A CNA200810122047XA CN200810122047A CN101417142A CN 101417142 A CN101417142 A CN 101417142A CN A200810122047X A CNA200810122047X A CN A200810122047XA CN 200810122047 A CN200810122047 A CN 200810122047A CN 101417142 A CN101417142 A CN 101417142A
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- diatomaceous earth
- hemostat
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 title claims abstract description 58
- 239000002874 hemostatic agent Substances 0.000 title claims abstract description 15
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000003814 drug Substances 0.000 claims abstract description 6
- 239000005909 Kieselgur Substances 0.000 claims description 31
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 9
- 229910052814 silicon oxide Inorganic materials 0.000 claims description 5
- 238000010298 pulverizing process Methods 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 3
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 claims description 3
- 239000000292 calcium oxide Substances 0.000 claims description 3
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims description 3
- 239000000395 magnesium oxide Substances 0.000 claims description 3
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims description 3
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- CHWRSCGUEQEHOH-UHFFFAOYSA-N potassium oxide Chemical compound [O-2].[K+].[K+] CHWRSCGUEQEHOH-UHFFFAOYSA-N 0.000 claims description 3
- 229910001950 potassium oxide Inorganic materials 0.000 claims description 3
- KKCBUQHMOMHUOY-UHFFFAOYSA-N sodium oxide Chemical compound [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 claims description 3
- 229910001948 sodium oxide Inorganic materials 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 2
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 239000000463 material Substances 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 9
- 238000000034 method Methods 0.000 abstract description 3
- 230000000699 topical effect Effects 0.000 abstract 3
- 208000032843 Hemorrhage Diseases 0.000 description 14
- 230000000025 haemostatic effect Effects 0.000 description 12
- 208000027418 Wounds and injury Diseases 0.000 description 9
- 239000008280 blood Substances 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 229940030225 antihemorrhagics Drugs 0.000 description 7
- 230000023597 hemostasis Effects 0.000 description 7
- 206010052428 Wound Diseases 0.000 description 6
- 230000023555 blood coagulation Effects 0.000 description 6
- 230000002439 hemostatic effect Effects 0.000 description 6
- 206010053567 Coagulopathies Diseases 0.000 description 4
- 230000035602 clotting Effects 0.000 description 4
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 208000034158 bleeding Diseases 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 230000034994 death Effects 0.000 description 3
- 231100000517 death Toxicity 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- 108090000190 Thrombin Proteins 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000015271 coagulation Effects 0.000 description 2
- 238000005345 coagulation Methods 0.000 description 2
- 239000011162 core material Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 229960004072 thrombin Drugs 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 210000000709 aorta Anatomy 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 239000012779 reinforcing material Substances 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000009306 yunnan baiyao Substances 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
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Abstract
The invention discloses a preparing method for a topical natural diatomite emergency hemostat. The natural diatomite is used as a material; the content of monox in the material is more than 60 percent; the layer distance is between 1.0 and 2.0nm; and the specific surface is 30 to 1000m<2>/g. The preparation method comprises the following steps: the natural diatomite is cracked into grains of different sizes by a Chinese medicine cracker; the diameters of the grains are between 1micron to 1mm; the cracked natural diatomite is heated and treated for 1 to 24 hours directly at the temperature between 60 and 900 DEG C to obtain the topical natural diatomite emergency hemostat. The preparation method is simple; the material is abundant, cheap and easy to be obtained; and the topical natural diatomite emergency hemostat is convenient for being applied and has a good stanching effect.
Description
Technical field
The present invention relates to a kind of natural externally applied diatomite emergency life-saving hemostat and preparation method thereof, particularly a kind of hemorrhage natural diatomaceous earth hemorrhage and preparation technology thereof of the uncontrollable mortality trunk of conventional hemostasis measure that be used for the treatment of.
Background technology
Emergency haemostatic is an emerging research field in the world.Emergency haemostatic is primarily aimed at the outer damaging the spleen and stomach emergency that The blood streamed down and develops.(3 minutes) just can control the emergency as aorta is bled in a short period of time, for further medical treatment tries to gain time precious to one.
Ministry of Public Health statistics according to 2007, annual all kinds of injuries take place about 200,000,000 person-times, because of about 700,000-750,000 people of injury death toll such as war, vehicle accident, major natural disasters, severe loss of blood is the biggest factor that causes died of wounds, and about 67% people dies from uncontrollable losing blood.If hinder several Yuans after wound 1～3 hour obtaining treatment, hemorrhage being effectively controlled, dead people will reduce greatly, rescue the wounded and divide six First aid procedures, be respectively hemostasis, will fix, wrapping, ventilation, carrying and basic life support.Wherein hemostasis is a step at first, is the key of rescuing life.
So far, domesticly be used for, the emergency haemostatic product of severe bleeding is few, hemorrhage commonly used has tourniquet, gauze and YUNNAN BAIYAO, they in, the quick-acting haemostatic powder effect of severe bleeding is limited.Therefore research is used for the quick hemostasis agent of urgent rescue, in can saving, severe bleeding patient life.Quick hemostasis agent is used for army, police, fire fighter, first-aid personnel, medical personnel and domestic hemostasis first aid, and rescue of battlefield etc., also can play a role at vital emergent event such as earthquake, blast mine accident etc.Caused 51151 people's death as the 8.0 grades of violent earthquakes in Wenchuan, Sichuan on the 12nd in May in this year by 10 o'clock on the 22nd May, 288431 people are injured.And in the earthquake relief work, a lot of local hemorrhages are in an emergency, so the blood demand is big especially, and many wounded are lost valuable life because can not in time transfuse blood.The hemorrhage that the present invention developed helps to reduce the injures and deaths situation of spectrum of war, geological disaster.
Studies show that inorganic matter Quikclot haemostatic effect is outstanding, the U.S. has all used Quikclot in Afghanistan and Irak military operation, and it is very satisfied that effect is made us.The more important thing is that effect is much better than traditional hemostasia products because easy to use, Quikclot is entering average family, and its market prospect is very bright.
But there is the significantly side effect of suction heat release in Quikclot.The maximum temperature of zeolite haemostatic Quikclot suction heat release can reach about 100 ℃, zoopery shows laboratory animal wound surrounding skin, muscle, nerve, blood vessel and fatty tissue is caused obvious hot injury, thereby further treatment is very inconvenient to the back of stopping blooding.
Because natural diatomaceous earth is the same with Quikclot, chance blood can absorb rapidly, swelling, not only can accomplish only to absorb moisture and do not absorb thrombin through effects such as physics, chemistry, biologies, reach the enrichment latter's purpose, thereby promote the thrombin activation and adhere to platelet, natural diatomaceous earth its surface in blood also has negative charge simultaneously, thereby excited the intrinsic coagulation passage, thereby the acceleration coagulation process promotes thrombosis, reaches the purpose of quick-acting haemostatic powder.Simultaneously have more superior character in some aspects, can become the research of novel hemostatic material to guarantee it.The natural diatomaceous earth thermal discharge is few, nature content abundant because compare with Quikclot; The price of Quikclot is 150 yuan/bag (100 gram), and valency is gone down the hill less than 0.02 yuan/100 grams in natural diatomaceous earth ore deposit, Zhejiang, and tangible price advantage is arranged.And porosity height, the specific surface of natural diatomaceous earth are big, unit weight is little, adsorptivity is strong, utilize the blood coagulation performance that these characteristics can reinforcing material.
Studies show that natural diatomaceous earth has hemostatic function efficiently, has better market prospect.So far, do not see to have natural diatomaceous earth is applied to blood coagulation material, treatment of wounds and creates reparation outward and natural diatomaceous earth and multi-form combinations such as medical bandage, medical adhesive, be used for the domestic and international patent document report that outer wound is repaired.
Summary of the invention
The objective of the invention is to propose extremely preparation technology of a kind of novel natural diatomite emergency life-saving hemostatic material.
The present invention proposes a kind of is the feedstock production emergency haemostatic with the natural diatomaceous earth, after the kieselguhr source is the remains accumulation of unicellular rudimentary plant diatom in ancient times for kieselguhr, through preliminary diagenesis and the porous biological silicalite that form, has the porosity height, specific surface is big, unit weight is little, adsorptivity is strong, good characteristic such as wear-resisting, acidproof.Be that natural diatomaceous earth is ground into certain particle diameter by Chinese medicine grinder among the present invention, obtained having the diatomite material of efficient hemostatic function, and can be used for different medical applications hemostasis, with other medical materials, medical apparatus and instruments combination, can be made into adhesive bandage, infusion patch, sticking dressing, tablet and capsule core material, operation bag, first-aid kit etc., utilize adsorbable antibiotics of porous characteristics and analgesic to equal wherein simultaneously, can also carry as medicine transmission, thereby obtain better therapeutic.
Natural diatomite emergency life-saving hemostat preparation method provided by the invention, be to be raw material with the natural diatomaceous earth, the main component of natural diatomaceous earth is: silicon oxide, aluminium oxide, ferrum oxide, magnesium oxide, calcium oxide, sodium oxide and potassium oxide, wherein the content of silicon oxide surpasses 60%, and preparation process is as follows:
1) block natural diatomaceous earth is ground into particle diameter at 1 micron～1 millimeter granule by Chinese medicine grinder;
2) will pulverize the back natural diatomaceous earth and under 60～900 ℃ of temperature, handle 1～24 hour, and then in 100 ℃ of baking ovens dry 1h, obtain natural diatomite emergency life-saving hemostat.
The treatment temperature of natural diatomaceous earth is 100～700 ℃ among the present invention, and the processing time is 4 hours.
The present invention has following advantage:
1, operation is simple, and abundant raw material is cheap and easy to get, and it is convenient to use, and haemostatic effect is good, and thermal discharge is few.
2, the distinctive porous of natural diatomaceous earth, more adsorbable antibiotics or analgesic etc. help the treatment of wound.This material can mix use with multiple hemostatic material, if you would take off soil, Gypsum Fibrosum, Ophicalcitum etc.And can reduce the heat that the suction reaction produces to a certain extent, reduce clotting time simultaneously.This material can also be used for the hemostasis of different medical applications, with other medical materials, medical apparatus and instruments combination, can be made into adhesive bandage, infusion patch, sticking dressing, tablet and capsule core material, operation bag first-aid kit etc.; This material can also play slow release and controlled-release function as the additive of multiple medicinal tablet, powder.
Description of drawings:
Fig. 1 is the XRD figure spectrum of natural diatomaceous earth Ore related among the present invention.
Fig. 2 is the mineral original appearance figure of natural diatomaceous earth Ore related among the present invention.
Fig. 3 is the external blood coagulation design sketch that obtains the natural diatomaceous earth hemorrhage under the different disposal temperature, and its empty group is the nature blood coagulation, and matched group is for using the haemostatic effect figure of commercialization hemorrhage Quikclot, (error line is ± 0.08min).
Fig. 4 is the external hemostasis heat effect figure of natural diatomaceous earth hemorrhage related among the present invention, and wherein matched group is commercialization hemorrhage Quikclot (error line is for ± 0.5 ℃).
The specific embodiment
The invention is further illustrated by the following examples.
Selecting Shengxian County, Zhejiang Province natural diatomaceous earth is raw material, and main component is: silicon oxide, aluminium oxide, ferrum oxide, magnesium oxide, calcium oxide, sodium oxide and potassium oxide, and wherein the content of silicon oxide surpasses 60%, and its XRD figure spectrum is seen accompanying drawing 1, and Ore original appearance figure sees accompanying drawing 2..
A certain amount of Zhejiang Province Shengxian County natural diatomaceous earth is put into Chinese medicine grinder, the pulverizing time is about 5min, grain diameter after the pulverizing with the dry 1h in 100 ℃ of baking ovens of the natural diatomaceous earth after the above-mentioned pulverizing, obtains natural diatomite emergency life-saving hemostat between 1 micron～1 millimeter.Its haemostatic effect and Quikclot are close, on quiet blender, carrying out of external blood coagulation experiment, get the stable blood of a certain amount of adding sodium citrate, add an amount of calcium chloride and determine the nature clotting time, under natural clotting time situation, carry out the external blood coagulation experiment of hemostatic material then, the record clotting time.See accompanying drawing 3.
Natural diatomaceous earth was handled respectively under 300 ℃, 500 ℃, 700 ℃ 4 hours in Muffle furnace, and then in 100 ℃ of baking ovens dry 1h, obtain heat treated natural diatomite emergency life-saving hemostat.Its haemostatic effect and Quikclot are close, see accompanying drawing 3.
Get 1g natural diatomaceous earth hemorrhage, 1g Quikclot respectively in test tube, add 1ml water then, measure variations in temperature with infrared sensitometer, reflect its heat effect by variations in temperature, its heat effect is seen accompanying drawing 4.
Claims (2)
1, a kind of preparation method of external natural diatomite emergency life-saving hemostat, it is characterized in that utilizing natural diatomaceous earth to be raw material, natural diatomaceous earth consists of silicon oxide, aluminium oxide, ferrum oxide, magnesium oxide, calcium oxide, sodium oxide and potassium oxide, wherein silica content surpasses 60%, and preparation process is as follows:
1) block natural diatomaceous earth is ground into particle diameter at 1 micron～1 millimeter granule by Chinese medicine grinder;
2) will pulverize the back natural diatomaceous earth and under 60～900 ℃ of temperature, handle 1～24 hour, and then in 100 ℃ of baking ovens dry 1h, obtain natural diatomite emergency life-saving hemostat.
2, the preparation method of natural diatomite emergency life-saving hemostat according to claim 1 is characterized in that pulverizing the back natural diatomaceous earth and handled 4 hours under 100～700 ℃ of temperature.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200810122047XA CN101417142A (en) | 2008-10-30 | 2008-10-30 | Preparation method of external natural diatomite emergency life-saving hemostat |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200810122047XA CN101417142A (en) | 2008-10-30 | 2008-10-30 | Preparation method of external natural diatomite emergency life-saving hemostat |
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| CN101417142A true CN101417142A (en) | 2009-04-29 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104189000A (en) * | 2014-09-12 | 2014-12-10 | 朴荣范 | Traumatism liquid medicine and preparation method thereof |
| CN106178091A (en) * | 2016-08-08 | 2016-12-07 | 桂林市晟博科技服务有限公司 | A kind of hemostatic material and preparation method thereof |
| CN109453424A (en) * | 2018-12-06 | 2019-03-12 | 安徽省科晟生物科技有限公司 | A kind of trauma care dressing and preparation method thereof |
| CN110433319A (en) * | 2019-09-07 | 2019-11-12 | 江西百伊宠物用品有限公司 | A kind of paper urine pad with deodorization functions |
| CN112972752A (en) * | 2021-02-04 | 2021-06-18 | 中国海洋大学 | Method for stopping bleeding by mixing frustules with different structural characteristics |
-
2008
- 2008-10-30 CN CNA200810122047XA patent/CN101417142A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104189000A (en) * | 2014-09-12 | 2014-12-10 | 朴荣范 | Traumatism liquid medicine and preparation method thereof |
| CN106178091A (en) * | 2016-08-08 | 2016-12-07 | 桂林市晟博科技服务有限公司 | A kind of hemostatic material and preparation method thereof |
| CN109453424A (en) * | 2018-12-06 | 2019-03-12 | 安徽省科晟生物科技有限公司 | A kind of trauma care dressing and preparation method thereof |
| CN109453424B (en) * | 2018-12-06 | 2021-06-08 | 安徽省科晟生物科技有限公司 | Wound treatment dressing and preparation method thereof |
| CN110433319A (en) * | 2019-09-07 | 2019-11-12 | 江西百伊宠物用品有限公司 | A kind of paper urine pad with deodorization functions |
| CN112972752A (en) * | 2021-02-04 | 2021-06-18 | 中国海洋大学 | Method for stopping bleeding by mixing frustules with different structural characteristics |
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Application publication date: 20090429 |