CN101444568B - 苦豆子肌肤抑菌喷剂的生产方法 - Google Patents
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Abstract
本发明公开了一种苦豆子肌肤抑菌喷剂的生产方法，主要工艺过程是将当归、土槿皮、川芎、黄柏、青川椒、鱼腥草六种药材混合粉碎成粗粉，用乙醇加热回流二次，得到中药液A；将苦豆子总碱液用水浴加热浓缩成浸膏，加入到中药液A中，搅拌均匀，静置过滤得药液B；将丁香粉碎成粗粉，加水加热回流，提取挥发油用吐温80、甘油包含，得药液C；用乙醇溶解薄荷、冰片，待溶解后和药液B加入到药液C中，搅拌均匀后即得苦豆子肌肤抑菌喷剂成品。本生产方法从苦豆子、丁香、黄柏、川芎等多种植物药中萃取精华。生产的成品为纯天然植物提取的有效抑菌制剂，清凉舒爽，易于吸收，对皮肤无任何刺激且有护肤作用。
Description
技术领域
本发明涉及肌肤抑菌剂的生产方法，特别指一种苦豆子肌肤抑菌喷剂的生产方法。
背景技术
瘙痒是许多皮肤病常见的自觉症状。对瘙痒的形成，现代医学认为：痒觉的发生和痛觉一样，是真皮交界处的游离神经末稍网络受到刺激的结果，当机械、温度或电刺激以点状方式作用于皮肤的痒点时，即可诱导出瘙痒，引起瘙痒的确切机制至今尚未明了；中医学按审症求因，归纳有十种病因：即风痒、湿痒、虫痒、热痒、燥痒、毒痒、食痒、瘀痒、酒痒和虚痒，皮肤病瘙痒之病因病机主要是风、湿、热、虫之邪客于皮肤肌表，引起皮肉间气血不利而成，或由于血虚风燥，阻于皮肤间，皮肤失濡养而成。临床上常见的皮炎、湿疹、癣等都有瘙痒症状，在治疗方面审症求因，常用活血祛风、消炎杀菌的药物达到止痒目的。目前临床上治疗瘙痒病的外用药物以镇静止痒、滋润皮肤为原则，常选用糖皮质激素如盐酸地塞米松、氯氟舒松等，长期搽用会使皮肤萎缩，毛细血管扩张，并产生依赖性，所以要求用药适量或间断性用药。选用中药对皮肤瘙痒可避免上述西药的不良反应，取得了较好的治疗效果。
发明内容
本发明要解决的技术问题是提供一种苦豆子肌肤抑菌喷剂的生产方法，这种生产方法优选中药配方，采用现代生物技术，从多种植物中萃取精华，采用先进提取工艺，分离精制而成。
本发明要解决的技术问题由如下方案实现：苦豆子肌肤抑菌喷剂的生产方法，其特征是：将净选后的药材当归、土槿皮、川芎、黄柏、青川椒、鱼腥草按1∶1∶1.2-1.6∶1.3-1.8∶1.3-1.8∶3-4的重量比混合粉碎成粗粉，用浓度80％的乙醇加热回流二次，第一次加入药材总重量6倍的乙醇，提取1-2小时，第二次加入药材总重量4倍的乙醇提取1-2小时，合并两次提取液，得到中药液A；将苦豆子总碱液用水浴加热浓缩成浸膏，加入到中药液A中，搅拌均匀，静置48小时后过滤得药液B；将丁香粉碎成粗粉，加10倍重的水加热回流，用挥发油提取器提取挥发油，将所有挥发油用吐温80、甘油包含，得药液C；取少量浓度95％的乙醇溶解薄荷冰、冰片，待完全溶解后和药液B缓慢加入到药液C中，边加边搅拌，搅拌均匀后即得苦豆豆肌肤抑菌喷剂成品，成品中中药液A、苦豆子总碱浸膏、吐温80、甘油、薄荷冰、冰片、丁香挥发油各占重量百分比为85-90％、4-5％、2-4％、2-4％、0.5-1％、0.5-1％、0.2-0.5％。
本发明的优点是：本生产方法优选中药配方，采用现代生物技术，以苦豆子为主要原料，从苦豆子、丁香、黄柏、川芎等多种植物药中萃取精华，并辅以黄柏、鱼腥草、丁香等燥湿除痒、清热解毒、杀菌止痒功效的中草药，采用先进提取工艺，分离精制而成。实验表明对细菌、真菌和蚊虫叮咬引起的皮肤瘙痒具有较好的抑制作用。其中，苦豆子属豆科槐属，多年生草本植物，耐旱防风固沙作用强，其有效成分苦豆子总碱作为抗菌消炎药已载入国家药品标准，有研究显示，苦豆子总碱对金黄色葡萄球菌、白色念珠菌、大肠杆菌和淋病奈瑟菌等均具有较强的抑制作用而且抑菌效果稳定，对皮肤和粘膜无刺激性，属于无毒级，在皮肤粘膜消毒方面具有很好的应用前景；鱼腥草属三白草科蕺菜属，野生草本植物，其有效成份鱼腥草素对金黄色葡萄球菌、大肠杆菌及酵母菌具有较强的抑制作用，而黄柏中的小檗碱，丁香中的挥发油对上述菌类均有抑制作用。这些辅助中药材对苦豆子总碱的抗菌具有协同作用，能够显著增强配方抑菌效果。另外，配方中含有滋润皮肤的成分可改善皮肤干燥程度，进一步缓解瘙痒症状。苦豆子肌肤抑菌喷剂成品为纯天然植物提取的有效抑菌制剂，清凉舒爽，纯植物药物合成，易于吸收，对皮肤无任何刺激且有护肤作用。适用于金黄色葡萄球菌、大肠杆菌、白色念珠菌等致病菌、细菌、有害微生物引起的皮肤痛痒、刺痒、奇痒，以及皮肤过敏、蚊虫叮咬等不适。本成品使用方法为将药液直接喷于患处，隔时段连续喷涂数次。
附图说明
附图为苦豆子肌肤抑菌喷剂生产工艺流程图
具体实施方式
下面详述一实施例：将净选后的药材当归、土槿皮、川芎、黄柏、青川椒、鱼腥草按1∶1∶1.5∶1.8∶1.8∶3的重量比混合粉碎成粗粉，用浓度80％的乙醇加热回流二次，第一次加入总重量6倍的乙醇，提取1.5小时，第二次加入总重量4倍的乙醇提取1小时，合并两次提取液，得到中药液A；将苦豆子总碱液用水浴加热浓缩成浸膏，加入到中药液A中，搅拌均匀，静置48小时后过滤得药液B；将丁香粉碎成粗粉，加10倍重的水加热回流，用挥发油提取器提取挥发油，将所有挥发油用吐温80、甘油包含，得药液C；取少量浓度95％的乙醇溶解薄荷、冰片，待完全溶解后和药液B缓慢加入到药液C中，边加边搅拌，搅拌均匀后即得苦豆子肌肤抑菌喷剂成品，成品中中药液A89.35kg、苦豆子总碱浸膏4.1kg、吐温803kg、甘油2kg、薄荷冰0.6kg、冰片0.6kg、丁香0.35kg挥发油。
Claims (1)
1.苦豆子肌肤抑菌喷剂的生产方法，其特征是：将净选后的药材当归、土槿皮、川芎、黄柏、青川椒、鱼腥草按1∶1∶1.2-1.6∶1.3-1.8∶1.3-1.8∶3-4的重量比混合粉碎成粗粉，用浓度80％的乙醇加热回流二次，第一次加入药材总重量6倍的乙醇，提取1-2小时，第二次加入药材总重量4倍的乙醇提取1-2小时，合并两次提取液，得到中药液A；将苦豆子总碱液用水浴加热浓缩成浸膏，加入到中药液A中，搅拌均匀，静置48小时后过滤得药液B；将丁香粉碎成粗粉，加10倍重的水加热回流，用挥发油提取器提取挥发油，将所有挥发油用吐温80、甘油包含，得药液C；取少量浓度95％的乙醇溶解薄荷冰、冰片，待完全溶解后和药液B缓慢加入到药液C中，边加边搅拌，搅拌均匀后即得苦豆子肌肤抑菌喷剂成品，成品中中药液A、苦豆子总碱浸膏、吐温80、甘油、薄荷冰、冰片、丁香挥发油各占重量百分比为85-90％、4-5％、2-4％、2-4％、0.5-1％、0.5-1％、0.2-0.5％。
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| CN1177478A (zh) * | 1996-09-26 | 1998-04-01 | 内蒙古苦参生化集团有限责任公司 | 一种含有苦豆子总生物碱的洗浴液 |
| CN1280775A (zh) * | 2000-08-15 | 2001-01-24 | 西北农业大学无公害农药研究服务中心 | 苦豆子杀菌剂及其制法 |
| CN1596660A (zh) * | 2003-09-19 | 2005-03-23 | 武长安 | 天然植物源杀菌剂及其制法 |
| CN1736207A (zh) * | 2005-09-07 | 2006-02-22 | 刘继东 | 中药植物杀菌制剂 |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1177478A (zh) * | 1996-09-26 | 1998-04-01 | 内蒙古苦参生化集团有限责任公司 | 一种含有苦豆子总生物碱的洗浴液 |
| CN1280775A (zh) * | 2000-08-15 | 2001-01-24 | 西北农业大学无公害农药研究服务中心 | 苦豆子杀菌剂及其制法 |
| CN1596660A (zh) * | 2003-09-19 | 2005-03-23 | 武长安 | 天然植物源杀菌剂及其制法 |
| CN1736207A (zh) * | 2005-09-07 | 2006-02-22 | 刘继东 | 中药植物杀菌制剂 |
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