CN101670013A - 苦豆豆足部抑菌喷剂的生产方法 - Google Patents
苦豆豆足部抑菌喷剂的生产方法 Download PDFInfo
- Publication number
- CN101670013A CN101670013A CN200910175655A CN200910175655A CN101670013A CN 101670013 A CN101670013 A CN 101670013A CN 200910175655 A CN200910175655 A CN 200910175655A CN 200910175655 A CN200910175655 A CN 200910175655A CN 101670013 A CN101670013 A CN 101670013A
- Authority
- CN
- China
- Prior art keywords
- liquor
- liquid
- weight
- volatile oil
- medicinal liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007921 spray Substances 0.000 title claims abstract description 15
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 12
- 230000003385 bacteriostatic effect Effects 0.000 title claims abstract description 11
- 244000250129 Trigonella foenum graecum Species 0.000 title claims abstract description 10
- 235000001484 Trigonella foenum graecum Nutrition 0.000 title claims abstract description 10
- 235000001019 trigonella foenum-graecum Nutrition 0.000 title claims abstract description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 33
- 239000000341 volatile oil Substances 0.000 claims abstract description 15
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract description 11
- 229920000053 polysorbate 80 Polymers 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000012153 distilled water Substances 0.000 claims abstract description 10
- 238000001914 filtration Methods 0.000 claims abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 8
- 238000000605 extraction Methods 0.000 claims abstract description 8
- 238000003756 stirring Methods 0.000 claims abstract description 7
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 4
- 239000007788 liquid Substances 0.000 claims description 29
- 241000628997 Flos Species 0.000 claims description 8
- 229930013930 alkaloid Natural products 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 6
- 239000000047 product Substances 0.000 claims description 6
- 238000003809 water extraction Methods 0.000 claims description 5
- 239000012567 medical material Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 238000004140 cleaning Methods 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 7
- 241000222122 Candida albicans Species 0.000 abstract description 4
- 241000196324 Embryophyta Species 0.000 abstract description 4
- 241000588724 Escherichia coli Species 0.000 abstract description 4
- 241000191967 Staphylococcus aureus Species 0.000 abstract description 4
- 229940095731 candida albicans Drugs 0.000 abstract description 4
- 239000000284 extract Substances 0.000 abstract description 4
- 230000002147 killing effect Effects 0.000 abstract description 4
- 241000894006 Bacteria Species 0.000 abstract description 3
- 241000607479 Yersinia pestis Species 0.000 abstract description 3
- 244000052616 bacterial pathogen Species 0.000 abstract description 3
- 238000000034 method Methods 0.000 abstract description 3
- 208000024891 symptom Diseases 0.000 abstract description 3
- 244000005700 microbiome Species 0.000 abstract description 2
- 230000008569 process Effects 0.000 abstract description 2
- 230000000638 stimulation Effects 0.000 abstract description 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 244000020518 Carthamus tinctorius Species 0.000 abstract 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 abstract 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 abstract 1
- 241000218691 Cupressaceae Species 0.000 abstract 1
- 244000234609 Portulaca oleracea Species 0.000 abstract 1
- 235000001855 Portulaca oleracea Nutrition 0.000 abstract 1
- 240000001341 Reynoutria japonica Species 0.000 abstract 1
- 235000018167 Reynoutria japonica Nutrition 0.000 abstract 1
- 244000223014 Syzygium aromaticum Species 0.000 abstract 1
- 235000016639 Syzygium aromaticum Nutrition 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- 235000017803 cinnamon Nutrition 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- 239000003995 emulsifying agent Substances 0.000 abstract 1
- 210000002683 foot Anatomy 0.000 description 13
- 244000046052 Phaseolus vulgaris Species 0.000 description 5
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 241000233866 Fungi Species 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 241000219784 Sophora Species 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 230000001408 fungistatic effect Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 201000004647 tinea pedis Diseases 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 208000008454 Hyperhidrosis Diseases 0.000 description 1
- 241001300479 Macroptilium Species 0.000 description 1
- 206010025421 Macule Diseases 0.000 description 1
- 241000893976 Nannizzia gypsea Species 0.000 description 1
- 241000588652 Neisseria gonorrhoeae Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 206010037888 Rash pustular Diseases 0.000 description 1
- 241000223238 Trichophyton Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000037315 hyperhidrosis Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000000749 insecticidal effect Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019476 oil-water mixture Nutrition 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 230000000590 parasiticidal effect Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 235000021251 pulses Nutrition 0.000 description 1
- 208000029561 pustule Diseases 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
Images
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种苦豆豆足部抑菌喷剂的生产方法，主要工艺过程是公丁香、当归、青川椒用蒸馏水提取挥发油，再用吐温80和甘油包含；五倍子、草红花、肉桂、马齿苋、虎杖、黄柏用蒸馏水混合提取，得药液A；加入苦参总碱浸膏到药液A中，搅拌、过滤，得药液B；冰片用乙醇溶解，加入药液B中得药液C，把挥发油加入到药液C中，搅拌过滤，滤液即为成品。本生产方法优选中药配方，采用先进提取工艺分离精制而成。本品为纯天然植物提取的有效抑菌产品，对皮肤无任何刺激且有燥湿、杀虫作用，适用于金黄色葡萄球菌、大肠杆菌、白色念珠菌等致病菌、细菌、有害微生物引起的皮肤症状。
Description
技术领域
本发明涉及一种抑菌喷剂的生产方法，特别指一种以苦豆豆为主要原料的足部抑菌喷剂的生产方法。
背景技术
足癣是一种的常见皮肤病，系指趾、跖面皮肤的浅部真菌感染，以脚丫白斑湿烂或足跖、趾间起水疱为特征，主要致病菌是红色毛癣菌、絮状表皮癣菌和石膏样毛癣菌。此病好发于成年人，南方较多见，尤以穿胶鞋、球鞋、塑料鞋足部多汗者易患此病。临床表现为趾间浸渍糜烂、散发臭味、瘙痒难忍、足癣合并细菌感染还可出现脓包、红肿热痛等症状。此病病程缓慢，常经年累月发作。中医认为此病系外受风毒，湿热虫毒郁结而至，久之血虚肌肤失养。而现代医学认为，细菌、病毒是造成此病症的主要原因。
槐属豆科植物苦豆豆的药用功能在临床已得到了证明。苦参总碱对金黄色葡萄球菌、真菌、白色念珠菌、大肠杆菌有较强的杀灭作用。以苦参总碱为主要有效成分，佐以其它具有清热燥湿、解毒杀虫的中药材，制备出有效杀灭有害细菌的同时，还具有清毒、燥湿、杀虫抑菌的喷剂对足部卫生是大有好处的。
发明内容
本发明要解决的技术问题是提供一种苦豆豆足部抑菌喷剂的生产方法，这种生产方法优选中药配方，采用现代生物技术，从多种植物中萃取精华，采用先进提取工艺分离精制成对足部具有杀虫抑菌功效的喷剂。
本发明要解决的技术问题由如下方案来实现：苦豆豆足部抑菌喷剂的生产方法，其特征是：将公丁香、当归、青川椒的粗粉分别加入到挥发油提取器中，三种药材的重量比为1∶1-2∶1-2，各加入6-10倍重量的蒸馏水提取，提取8-9小时，混合三种挥发油，再用吐温80和甘油包含，留取待用，其中吐温80和甘油与混合后挥发油的重量比分别为1∶1-2和2-3∶1，将净选后的五倍子、草红花、肉桂、马齿苋、虎杖、黄柏六种药材粗粉混合后放入提取罐中，六种药材的重量比为1∶1∶1-2∶2∶2∶2，加入8-10倍重量的蒸馏水提取二次，每次提取时间为1-2小时，合并两次提取液，再水浴浓缩、过滤得药液A，留取待用，将苦参总碱液水浴浓缩成浸膏，按药液A重量的5％加入到药液A中，搅拌均匀放置后过滤，得到药液B待用，将冰片用6-10倍重量的浓度为75％乙醇溶解，再将其按药液B重量的10％-16％加入到药液B中成为药液C，放置12小时后过滤，再把用吐温80和甘油包含后的挥发油加入到药液C中，吐温80和甘油包含后的挥发油与药液C的重量比为1∶20-40，搅拌均匀后过滤，滤液即为成品。
本发明的优点是：本生产方法工艺科学合理，它采用现代生物技术，优选中药配方，以苦豆豆为主要原料，从苦豆豆、马齿苋、虎杖等中药中萃取精华，并辅以当归、公丁香、青川椒等燥湿除虫、清热解毒、杀菌止痒功效的中草药，采用先进提取工艺分离精制而成。实验表明苦豆豆足部抑菌喷剂对细菌、真菌等多种致病菌具有较好的抑制作用。其中，苦豆豆属于豆科槐属，多年生草本植物，耐旱防风固沙作用强，其有效成分苦参总碱作为抗菌消炎药已载入国家药品标准。有研究显示，苦参总碱对金黄色葡萄球菌、白色念珠菌、大肠杆菌和淋病奈瑟菌等多种致病菌均具有较强的抑制作用，而且抑菌效果稳定，对皮肤和粘膜无刺激性，属于无毒级，在皮肤粘膜消毒方面具有很好的应用前景。其它辅助中药材如公丁香、青川椒等对苦参总碱的抗菌具有协同作用，能够显著增强配方抑菌效果。苦豆豆足部抑菌喷剂为纯天然植物提取的有效抑菌产品，由纯植物药物精制而成，对皮肤无任何刺激且有燥湿、杀虫作用，适用于金黄色葡萄球菌、大肠杆菌、白色念珠菌等致病菌、细菌、有害微生物引起的皮肤症状。本成品使用方法为用清水洗净患处，喷出少量本品涂上，并按摩片刻至完全吸收，每天两次至三次。
附图说明
图1为苦豆豆足部抑菌喷剂生产工艺流程图
具体实施方式
下面详述实施例：将公丁香9kg、当归12kg、青川椒12kg(分别单提)粗粉加入到挥发油提取罐中，各加入8倍重量的蒸馏水回流提取8小时，回收后混合挥发油共得10kg(油水混合物比例为1∶10)。再用10kg吐温80和5kg甘油包含，留取待用。将净选后的五倍子9kg、草红花9kg、肉桂15kg、马齿苋18kg、虎杖18kg、黄柏18kg粗粉混合后放入提取灌中，加入蒸馏水提取二次，第一次加入10倍重量的蒸馏水870kg，提取2小时，第二次加入8倍重量的蒸馏水700kg，提取1.5小时，合并两次的提取液，再水浴浓缩至300kg，过滤得到药液A，留取待用。将苦参总碱液水浴浓缩成浸膏取15kg加入到药液A中，搅拌均匀放置后过滤，得到315kg药液B待用，将冰片6kg用42kg的浓度为75％的乙醇溶解后加入到药液B中，得363kg药液C，放置12小时后过滤，再把用吐温80和甘油包含后的挥发油加入到药液C中，搅拌均匀后再过滤，滤液即为成品。
Claims (1)
1、苦豆豆足部抑菌喷剂的生产方法，其特征是：将公丁香、当归、青川椒的粗粉分别加入到挥发油提取器中，三种药材的重量比为1∶1-2∶1-2，各加入6-10倍重量的蒸馏水提取，提取8-9小时，混合三种挥发油，再用吐温80和甘油包含，留取待用，其中吐温80和甘油与混合后挥发油的重量比分别为1∶1-2和2-3∶1，将净选后的五倍子、草红花、肉桂、马齿苋、虎杖、黄柏六种药材粗粉混合后放入提取罐中，六种药材的重量比为1∶1∶1-2∶2∶2∶2，加入8-10倍重量的蒸馏水提取二次，每次提取时间为1-2小时，合并两次提取液，再水浴浓缩、过滤得药液A，留取待用，将苦参总碱液水浴浓缩成浸膏，按药液A重量的5％加入到药液A中，搅拌均匀放置后过滤，得到药液B待用，将冰片用6-10倍重量的浓度为75％乙醇溶解，再将其按药液B重量的10％-16％加入到药液B中成为药液C，放置12小时后过滤，再把用吐温80和甘油包含后的挥发油加入到药液C中，吐温80和甘油包含后的挥发油与药液C的重量比为1∶20-40，搅拌均匀后过滤，滤液即为成品。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101756551A CN101670013B (zh) | 2009-09-19 | 2009-09-19 | 苦豆豆足部抑菌喷剂的生产方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101756551A CN101670013B (zh) | 2009-09-19 | 2009-09-19 | 苦豆豆足部抑菌喷剂的生产方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101670013A true CN101670013A (zh) | 2010-03-17 |
| CN101670013B CN101670013B (zh) | 2011-09-07 |
Family
ID=42017569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009101756551A Active CN101670013B (zh) | 2009-09-19 | 2009-09-19 | 苦豆豆足部抑菌喷剂的生产方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101670013B (zh) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104274536A (zh) * | 2014-05-25 | 2015-01-14 | 许春晖 | 一种足用杀菌除味喷剂 |
| US10184033B1 (en) | 2018-04-19 | 2019-01-22 | King Saud University | Synthesis of silver-PMMA nanocomposite film |
| CN115245539A (zh) * | 2021-09-26 | 2022-10-28 | 上海江笙生物科技有限公司 | 一种抑菌止痒保健足部喷剂及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100418578C (zh) * | 2004-12-30 | 2008-09-17 | 中国人民武装警察部队医学院 | 用于阴道炎的植物雌激素类药物组合物 |
| CN101336958B (zh) * | 2008-02-15 | 2013-01-16 | 上海海天医药科技开发有限公司 | 苦参中提取的生物碱在治疗支原体、衣原体和真菌引起的疾病中的药物用途 |
| CN101361790A (zh) * | 2008-09-12 | 2009-02-11 | 中国人民武装警察部队医学院 | 治疗皮炎湿疹、蚊虫叮咬所致瘙痒药物及用途 |
-
2009
- 2009-09-19 CN CN2009101756551A patent/CN101670013B/zh active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104274536A (zh) * | 2014-05-25 | 2015-01-14 | 许春晖 | 一种足用杀菌除味喷剂 |
| US10184033B1 (en) | 2018-04-19 | 2019-01-22 | King Saud University | Synthesis of silver-PMMA nanocomposite film |
| CN115245539A (zh) * | 2021-09-26 | 2022-10-28 | 上海江笙生物科技有限公司 | 一种抑菌止痒保健足部喷剂及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101670013B (zh) | 2011-09-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101467598B (zh) | 用蜜蜂采集的天然中药蜂蜜及其制备方法 | |
| CN104208245B (zh) | 手足癣中药药浴及制备方法 | |
| CN105663245A (zh) | 一种含绞股蓝的复方中药组合物及其制备方法 | |
| CN103039876B (zh) | 一种清肝补肺的马蹄粉及制备方法 | |
| CN103520381B (zh) | 一种去脚气足浴粉及其制备方法 | |
| CN101664482B (zh) | 治疗脚气和皮肤瘙痒的外用药及其制备方法 | |
| CN101670013B (zh) | 苦豆豆足部抑菌喷剂的生产方法 | |
| CN105535196A (zh) | 一种用于治疗鼻炎的药物组合物及其制备方法 | |
| CN101297899B (zh) | 治疗奶牛急性乳房炎的中药制剂及其制备方法 | |
| CN101264240A (zh) | 一种治疗脚癣的外用药物 | |
| CN101507743A (zh) | 艾蒿提取物及其制备方法 | |
| KR20190062833A (ko) | 새싹보리의 풋내와 누에가루 및 꾸지뽕의 불쾌취를 제거한 항산화 또는 혈당강하 활성성분 함량이 증가된 새싹보리, 누에가루 및 꾸지뽕잎 혼합차 제조방법 | |
| CN105327262A (zh) | 一种治疗小儿便秘的中药配方及其制备方法 | |
| CN114931214B (zh) | 一种改善听力损伤的中草药组合物及其制备方法与应用 | |
| CN104784534B (zh) | 一种预防手足口病用洗手液 | |
| CN108815235A (zh) | 一种外用植物源止痒消炎膏及其制备方法 | |
| CN102641483B (zh) | 一种治疗便秘的中药组合物 | |
| CN103705556B (zh) | 一种治疗破伤风的中药组合物 | |
| CN102716419A (zh) | 复方益智补肾口服液 | |
| CN101112546A (zh) | 用于防治禽病毒性疾病的中药物组合物及其制备方法 | |
| CN101002854A (zh) | 治疗痤疮的含克林霉素药物 | |
| CN104547198A (zh) | 一种多功能中药制剂 | |
| CN101444568B (zh) | 苦豆子肌肤抑菌喷剂的生产方法 | |
| CN103816400A (zh) | 一种治疗儿童原发性肺结核的胶囊及其制备方法 | |
| CN109692278A (zh) | 一种治疗肺热病的医药制剂 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| PP01 | Preservation of patent right |
Effective date of registration: 20160907 Granted publication date: 20110907 |
|
| RINS | Preservation of patent right or utility model and its discharge | ||
| DD01 | Delivery of document by public notice |
Addressee: INNER MONGOLIA YONGYE BIO-TECHNOLOGY CO.,LTD. Document name: Notification to Pay the Fees |
|
| PD01 | Discharge of preservation of patent | ||
| PD01 | Discharge of preservation of patent |
Date of cancellation: 20170307 Granted publication date: 20110907 |
|
| PP01 | Preservation of patent right |
Effective date of registration: 20170307 Granted publication date: 20110907 |
|
| PP01 | Preservation of patent right | ||
| DD01 | Delivery of document by public notice |
Addressee: INNER MONGOLIA YONGYE BIO-TECHNOLOGY CO.,LTD. Document name: Notice of preservation procedure Addressee: INNER MONGOLIA YONGYE BIO-TECHNOLOGY CO.,LTD. Document name: Notification of Termination of Procedure |
|
| DD01 | Delivery of document by public notice | ||
| PD01 | Discharge of preservation of patent | ||
| PD01 | Discharge of preservation of patent |
Date of cancellation: 20170907 Granted publication date: 20110907 |
|
| PP01 | Preservation of patent right |
Effective date of registration: 20170907 Granted publication date: 20110907 |
|
| PP01 | Preservation of patent right | ||
| DD01 | Delivery of document by public notice | ||
| DD01 | Delivery of document by public notice |
Addressee: INNER MONGOLIA YONGYE BIO-TECHNOLOGY CO.,LTD. Document name: Notice of preservation procedure Addressee: INNER MONGOLIA YONGYE BIO-TECHNOLOGY CO.,LTD. Document name: Notification of Termination of Procedure |
|
| PD01 | Discharge of preservation of patent | ||
| PD01 | Discharge of preservation of patent |
Date of cancellation: 20200907 Granted publication date: 20110907 |
|
| PP01 | Preservation of patent right | ||
| PP01 | Preservation of patent right |
Effective date of registration: 20200907 Granted publication date: 20110907 |
|
| PD01 | Discharge of preservation of patent |
Date of cancellation: 20230907 Granted publication date: 20110907 |
|
| PD01 | Discharge of preservation of patent | ||
| PP01 | Preservation of patent right | ||
| PP01 | Preservation of patent right |
Effective date of registration: 20230907 Granted publication date: 20110907 |