CN101441223A - Precision trace sampling apparatus with mixing function - Google Patents
Precision trace sampling apparatus with mixing function Download PDFInfo
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- CN101441223A CN101441223A CNA2008101876281A CN200810187628A CN101441223A CN 101441223 A CN101441223 A CN 101441223A CN A2008101876281 A CNA2008101876281 A CN A2008101876281A CN 200810187628 A CN200810187628 A CN 200810187628A CN 101441223 A CN101441223 A CN 101441223A
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Abstract
The invention relates to an automatic sampling device for biochemical analysis apparatus, in particular to a precise trace sampling device with mixing function, which integrates sampling and mixing of the sample and the agent into a whole. The sampling device comprises a sealed cylinder, a sampling needle tube arranged on the bottom of the cylinder and communicated with the cavity of the cylinder, and a linear motor, wherein, the cavity of the sealed cylinder is a stepped cavity with necking at the lower portion, and the cavity is internally provided with a mixing piston with a cavity and a sampling plunger rod; the linear motor drives the sampling plunger rod and the mixing piston to move to and fro, so as to realize the precise sampling of the trace sample and the mixing of the sample and the agent. The invention overcomes the defects that the independent arrangement of the sampling device and the mixing device in prior biochemical analysis apparatus results in the complicated structure and thus it is difficult to the integrate and miniaturize the fully-automatic biochemical analysis apparatus.
Description
Technical field
The present invention relates to be used for automatic sampling and the sample and the reagent mix device of biochemical analyzer, specifically a kind of to collect sampling and sample and reagent mix function be the precision trace sampling apparatus of one.
Background technology
In automatic clinical chemistry analyzer, in order to improve precision of test result, sampler and mixing arrangement all are essential.It is to draw and release sample or reagent that sampler mainly acts on; It is that sample or reagent to being discharged in the reaction cup mixes that mixing arrangement mainly acts on, to guarantee reaction uniformity and precision of test result.
At present, realize in the existing automatic clinical chemistry analyzer that sampling is similar substantially to mixed method, that is: sampler is what to separate with mixing arrangement, adopts two to overlap independently system, and course of action is controlled respectively, mutually noninterfere.Sampler and mixing arrangement are installed in respectively on the automatic clinical chemistry analyzer, are sample disc, reagent dish and reaction tray all around, and sampler drives the sampling probe cantilever under the drive of motor, successively sample and reagent are placed in the reaction tray.Afterwards, mixing arrangement drives the mixing needle cantilever under the drive of motor, mixing needle is stirred in reaction cup.
Because sampler is what to separate with mixing arrangement, so automatic clinical chemistry analyzer is succinct inadequately on layout, especially for large-scale relatively Biochemical Analyzer, part is many more, cost is also just high more, and the probability that breaks down is also just big more.
Summary of the invention
The purpose of this invention is to provide a kind of precision trace sampling apparatus with mixed function, sampler causes automatic clinical chemistry analyzer layout complexity with mixing arrangement because of separating in the existing Biochemical Analyzer to solve, structure is loaded down with trivial details, is unfavorable for the defectives such as integrated and miniaturization of Biochemical Analyzer.
The present invention has the precision trace sampling apparatus of mixed function, comprises a sealed cylinder block and is arranged on sample introduction needle tubing, the linear electric motors that this cylinder body bottom is connected with inner chamber of cylinder block; The inner chamber of described sealed cylinder block is the staged cavity that the bottom has necking down, the bottom necking down cavity sliding fit of one cylinder and sealed cylinder block is set in the sealed cylinder block inner chamber, its upper end has the mixing piston of boss, mix piston and also have and the homoaxial inner chamber of sealed cylinder block, and in this inner chamber, be provided with sampling column stopper rod with its sliding fit; Be installed with sleeve in the upper end of mixing piston;
Axially in the inner chamber of sealed cylinder block and sleeve, its lower end is connected with described sampling column stopper rod the axostylus axostyle that one lower end has a flange, and its upper end is connected with the output shaft of described linear electric motors; Linear electric motors are connected on the gland of described sealed cylinder block upper end by electric machine support;
On the lower surface of sealed cylinder block upper end gland, be provided with permanent magnet, on the upper surface of sleeve, be provided with permanent magnet down.
On described electric machine support, also be provided with a photoelectric sensor, on described axostylus axostyle, be provided with position indicator pointer corresponding, to realize accurate quantitative sampling with it.
When the present invention works in two kinds of situation, the one, during sample introduction, the linear electric motors output shaft drives the sampling column stopper rod by axostylus axostyle and moves upward, to mix piston simultaneously and take the extreme higher position to, two block permanent magnets are inhaled mutually, the sampling column stopper rod can move down, and is held and maintains static by the magnet of its upper end and mix piston, so can accurately take a sample in certain range ability; The 2nd, when mixing, linear electric motors can drive the mixing piston by axostylus axostyle and move within the specific limits, can inhale the reagent of telling large volume and mix.
The present invention has the precision trace sampling apparatus of mixed function, sampling device and mixing arrangement are designed to one, make the automatic clinical chemistry analyzer designs simplification, simple to operation, quantitatively accurately, satisfied the high precision and the miniaturization demand of full-automatic biochemical analytic system.
Description of drawings
Fig. 1 is the structural representation of apparatus of the present invention;
Fig. 2 is the working state schematic representation of apparatus of the present invention.
Embodiment
The embodiment that provides below in conjunction with accompanying drawing describes in further detail apparatus of the present invention.
With reference to Fig. 1, have the precision trace sampling apparatus of mixed function, comprise a sealed cylinder block 11 and be arranged on sample introduction needle tubing 13, the linear electric motors 1 that this cylinder body bottom is connected with inner chamber of cylinder block; The inner chamber of described sealed cylinder block 11 is staged cavitys that the bottom has necking down, the bottom necking down cavity sliding fit of one cylinder and sealed cylinder block 11 is set in sealed cylinder block 11 inner chambers, its upper end has the mixing piston 10 of boss, mix piston 10 and also have and sealed cylinder block 11 homoaxial inner chambers, and in this inner chamber, be provided with sampling column stopper rod 16 with its sliding fit; Be installed with sleeve 8 in the upper end of mixing piston 10;
Axially in the inner chamber of sealed cylinder block 11 and sleeve 8, its lower end is connected with described sampling column stopper rod 16 axostylus axostyle 18 that one lower end has a flange, is connected with the output shaft 20 of described linear electric motors 1 on it; Linear electric motors 1 are connected on the gland 5 of described sealed cylinder block 11 upper ends by electric machine support 2;
Be provided with permanent magnet 6 on the lower surface of sealed cylinder block 11 upper end glands 5, on the upper surface of sleeve 8, be provided with permanent magnet 7 down.
On described electric machine support 2, also be provided with a photoelectric sensor 19, on described axostylus axostyle 18, be provided with position indicator pointer 3 corresponding, to realize accurate quantitative sampling with it.
The upper end of described mixing piston 10 is connected with described sleeve 8 by sealed briquette 9.
Described sample introduction needle tubing 13 is packed on the bottom of sealed cylinder block 11 by sample introduction needle seal of tube piece 12.
Be equipped with teflon coating on the surfaces externally and internally of described sample introduction needle tubing 13.
The course of work of apparatus of the present invention is as follows: accurately during microsampling, the output shaft 20 of linear electric motors 1 drives sampling column stopper rod 16 by axostylus axostyle 18 and moves up, after moving a segment distance, axostylus axostyle 18 drives mixing piston 10 by sleeve 8 again to be continued to move up, after arriving uppermost position in fig-ure, last permanent magnet 6 is inhaled mutually with following permanent magnet 7, and mix piston 10 and maintain static this moment, linear electric motors 1 counter-rotating then, make sampling column stopper rod 16 declines one segment distance, at this moment, can quantitatively draw micro-example, arrive and to tell liquid level when putting, the motor counter-rotating, axostylus axostyle 18 promotes to mix pistons 10 and overcomes magnet suction and descend, and have sizable evacuation volume this moment, can make that to tell liquid cleaner.During mixing, linear electric motors 1 drive mixing piston 10 by axostylus axostyle 18 and move within the specific limits, can inhale the reagent of telling suitable volume and mix.Linear electric motors 1 are step-by-step linear electric motor, adopt special-purpose controllor for step-by-step motor to control its rotating.
Claims (5)
1. precision trace sampling apparatus with mixed function, comprise a sealed cylinder block (11) and be arranged on the sample introduction needle tubing (13) that this cylinder body bottom is connected with inner chamber of cylinder block, linear electric motors (1), it is characterized in that: the inner chamber of described sealed cylinder block (11) is the staged cavity that the bottom has necking down, the bottom necking down cavity sliding fit of one cylinder and sealed cylinder block (11) is set in sealed cylinder block (11) inner chamber, its upper end has the mixing piston (10) of boss, mix piston (10) and also have and the homoaxial inner chamber of sealed cylinder block (11), and in this inner chamber, be provided with sampling column stopper rod (16) with its sliding fit; Be installed with sleeve (8) in the upper end of mixing piston (10);
Axially in the inner chamber of sealed cylinder block (11) and sleeve (8), its lower end is connected with described sampling column stopper rod (16) axostylus axostyle (18) that one lower end has a flange, and its upper end is connected with the output shaft (20) of described linear electric motors (1); Linear electric motors (1) are connected on the gland (5) of described sealed cylinder block (11) upper end by electric machine support (2);
On the lower surface of sealed cylinder block (11) upper end gland (5), be provided with permanent magnet (6), on the upper surface of sleeve (8), be provided with permanent magnet (7) down.
2. the precision trace sampling apparatus with mixed function according to claim 1 is characterized in that, is provided with a photoelectric sensor (19) on described electric machine support (2), is provided with position indicator pointer corresponding with it (3) on described axostylus axostyle (18).
3. the precision trace sampling apparatus with mixed function according to claim 1 is characterized in that, the upper end of described mixing piston (10) is connected with described sleeve (8) by sealed briquette (9).
4. the precision trace sampling apparatus with mixed function according to claim 1 is characterized in that, described sample introduction needle tubing (13) is packed on the bottom of sealed cylinder block (11) by sample introduction needle seal of tube piece (12).
5. the precision trace sampling apparatus with mixed function according to claim 1 is characterized in that, is equipped with teflon coating on the surfaces externally and internally of described sample introduction needle tubing (13).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101876281A CN101441223B (en) | 2008-12-29 | 2008-12-29 | Precision trace sampling apparatus with mixing function |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101876281A CN101441223B (en) | 2008-12-29 | 2008-12-29 | Precision trace sampling apparatus with mixing function |
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| Publication Number | Publication Date |
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| CN101441223A true CN101441223A (en) | 2009-05-27 |
| CN101441223B CN101441223B (en) | 2012-06-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2008101876281A Expired - Fee Related CN101441223B (en) | 2008-12-29 | 2008-12-29 | Precision trace sampling apparatus with mixing function |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101581729B (en) * | 2009-06-05 | 2012-06-27 | 何峰 | Liquid sample processing device |
| CN108854868A (en) * | 2017-05-08 | 2018-11-23 | 神华集团有限责任公司 | Fluidized-bed reactor and its application |
| CN109856398A (en) * | 2019-01-31 | 2019-06-07 | 京东方科技集团股份有限公司 | Vaccine detection device and its detection method |
| CN111893036A (en) * | 2019-12-12 | 2020-11-06 | 山东鑫科生物科技股份有限公司 | Bacterium counting assembly with bubble mixing mechanism |
| CN113588352A (en) * | 2021-09-28 | 2021-11-02 | 山东柏源技术有限公司 | Petroleum detection sampling device |
| CN114894984A (en) * | 2022-05-12 | 2022-08-12 | 蔡辉逢 | Detection device and detection method for camellia oil refined by ancient method |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2801108B1 (en) * | 1999-11-16 | 2002-03-01 | Maxmat S A | CHEMICAL OR BIOCHEMICAL ANALYZER WITH REACTIONAL TEMPERATURE REGULATION |
| US7976793B2 (en) * | 2003-11-27 | 2011-07-12 | Gilson S.A.S. | Electronic pipette |
| CN2704843Y (en) * | 2004-03-03 | 2005-06-15 | 上海求精生化试剂仪器有限公司 | Miniature liquid transferring devices |
| CN1687789A (en) * | 2005-05-09 | 2005-10-26 | 宋雪冬 | Common suction nozzle adjustable continuous liquid trasfer device |
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2008
- 2008-12-29 CN CN2008101876281A patent/CN101441223B/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101581729B (en) * | 2009-06-05 | 2012-06-27 | 何峰 | Liquid sample processing device |
| CN108854868A (en) * | 2017-05-08 | 2018-11-23 | 神华集团有限责任公司 | Fluidized-bed reactor and its application |
| CN108854868B (en) * | 2017-05-08 | 2020-11-24 | 神华集团有限责任公司 | Fluidized bed reactor and application thereof |
| CN109856398A (en) * | 2019-01-31 | 2019-06-07 | 京东方科技集团股份有限公司 | Vaccine detection device and its detection method |
| CN109856398B (en) * | 2019-01-31 | 2022-04-29 | 京东方科技集团股份有限公司 | Vaccine detection device and detection method thereof |
| CN111893036A (en) * | 2019-12-12 | 2020-11-06 | 山东鑫科生物科技股份有限公司 | Bacterium counting assembly with bubble mixing mechanism |
| CN113588352A (en) * | 2021-09-28 | 2021-11-02 | 山东柏源技术有限公司 | Petroleum detection sampling device |
| CN113588352B (en) * | 2021-09-28 | 2021-12-07 | 山东柏源技术有限公司 | Petroleum detection sampling device |
| CN114894984A (en) * | 2022-05-12 | 2022-08-12 | 蔡辉逢 | Detection device and detection method for camellia oil refined by ancient method |
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| Publication number | Publication date |
|---|---|
| CN101441223B (en) | 2012-06-13 |
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