CN101433660A - Pure Chinese medicine for treating ulcer bleeding - Google Patents

Abstract

The invention relates to a pure traditional Chinese medicine for treating ulcerous bleeding. According to the theory of the traditional Chinese medicine prescription and the medicine compatibility logic of assistant and guide, and by scientific research and careful medicine selection, the pure traditional Chinese medicine for treating various bleedings such as mucous membranes, muscles, blood vessels, tendons and bones, tissue erosion, ulceration, necrosis, blood stasis, swelling, pain, festering, trauma infection and the like can be prepared; the medicine has three characteristics of quick hemostasis, tissue rehabilitating and strong infection resisting capability; and the medicine has the bi-directional effect of not only preventing and curing bleeding but also absorbing clots and promoting tissue regeneration. The medicine is mainly prepared from 13 types of unique traditional Chinese medicines such as root of pseudo-ginseng, pearl, sea snake, root of Japanese thistle, cuttlebone, tuber of hyacinth bletilla, Endothelium Corneum Gigeriae Galli, seadragon and the like. The medicine has the advantages as follows: 1. the medicine can speed up the improvement of ulcerous, necrotic and rotten tissues, and has the effects of absorbing clots and promoting tissue regeneration and rehabilitate damaged tissues; 2. the medicine has the bi-directional effect of not only quickly stopping bleeding, but also activating blood circulation to dissipate blood stasis, smoothening blood stream and enforcing the regeneration of rehabilitated tissues; and 3. the medicine has the efficacies of removing toxins and promoting the subsidence of swelling, eliminating source of infection, improving immunity and strongly resisting infection.

Description

The pure Chinese medicine of treatment ulcerative hemorrhage

One, technical field

The present invention relates to the pure Chinese medicine of the treatment ulcerative hemorrhage that a kind of pure Chinese medicine makes.

Two, background technology

Though existing treatment ulcer, infection, hemorrhage medicine are many, do not have specific medicament, even effective, also be both advantageous and disadvantageous, or cure the symptoms, not the disease.One, at the medicine for the treatment of hemorrhage, except that the Chinese medicine YUNNAN BAIYAO, " reptilase " of the U.S., though hemostasis can cause increasing the weight of of cardiovascular and cerebrovascular disease rapidly, these existing a large amount of clinical datas prove, also be well-known, its drawback is very big, and the very big mistake of " Trostin M it " is arranged.YUNNAN BAIYAO, bleeding stopping period is long, also has only and the not drawback of tissue regeneration promoting.The hemostasis injection also exists weak point.Present all hemorrhages remove no specially good effect, blood stasis all can occur and not change, and influence blood circulation, and tissue is newborn, even downright bad.Though two, the medicine of existing treatment ulcerate disease is many, repair tissue impels cell new life's medicine also not have the medicine of specific short.As: gastric ulcer, oral ulcer, colonic ulcer, vitro tissue ulcer, though many Drug therapys are arranged, touching difficulty is more.The 3rd, the medicine of treatment venereal infection is many, is difficult to rapid control infection, though some effect of a large amount of antibiotics, for easy infection ulcer person, also difficulty obtains effect.Decubital ulcer, post-operative infection, trauma infection contamination, the infection of internal organs chronic inflammatory disease, chronic pharyngitis, superficial gastritis and erosions etc. as everyone knows, many difficulties are produced effects, and touchingly do not heal.

Three, summary of the invention

The purpose of this invention is to provide the pure Chinese medicine for the treatment of ulcerative hemorrhage.One the present invention can impel chronic ulcer tissue, slough, the tissue that rots, and accelerates to improve, and acquisition is newborn, and having is saprophytic new, impels the effect of repair of damaged tissues.Its two the present invention has and can stop blooding rapidly, again can blood circulation promoting and blood stasis dispelling, and it is unimpeded to improve blood flow, promotes the two-way effect of repair tissue tissue regeneration promoting.Its three the present invention energy removing toxic substances and promoting subsidence of swelling can be eliminated the source of infection, improves immune function, has the very strong effect of resistance infection.

Task of the present invention is finished like this, and it is the medicament of being made by following raw materials by weight proportions:

Radix Notoginseng 10～50 Radix Trichosanthis 15～45 Endoconcha Sepiaes 10～25 Margaritas 5～15

Cortex Moutan 15～35 Colla cornus cervis 10～30 Solenognathus 5～20 Endothelium Corneum Gigeriae Galli 10～30

Flat shellfish 10～25 Radix Cirsii Japonicis 30～60 sea snakes 10～30 osseocolla 10～30

Olibanum 6～20

The preferred prescription of preparation medicine of the present invention scope by weight ratio is:

Radix Notoginseng 15～40 Radix Trichosanthis 15～35 Endoconcha Sepiaes 10～20 Margaritas 5～10

Cortex Moutan 15～30 Colla cornus cervis 10～25 Solenognathus 5～15 Endothelium Corneum Gigeriae Galli 10～25

Flat shellfish 10～20 Radix Cirsii Japonicis 30～50 sea snakes 10～25 osseocolla 15～30

Olibanum 10～20

The best prescription of preparation medicine of the present invention scope by weight ratio is:

Radix Notoginseng 10～35 Radix Trichosanthis 15～30 Endoconcha Sepiaes 10～15 Margaritas 8～10

Cortex Moutan 15～25 Colla cornus cervis 10～20 Solenognathus 10～15 Endothelium Corneum Gigeriae Galli 10～20

Flat shellfish 10～15 Radix Cirsii Japonicis 35～50 sea snakes 10～20 osseocolla 15～25

Olibanum 10～15g

The optimum formula of preparation medicine of the present invention is:

Radix Notoginseng 20 Radix Trichosanthis 30 Endoconcha Sepiaes 15 Margaritas 10 Cortex Moutans 20 Colla cornus cervis 10

Solenognathus 10 Endothelium Corneum Gigeriae Galli 15 flat shellfish 10 Radix Cirsii Japonicis 50 sea snakes 15 osseocolla 15

Olibanum 15

Above-mentioned each component is made the preparation method of medicine of the present invention:

(1), with Radix Notoginseng, sea snake, Solenognathus, Colla cornus cervi, select, clean, after by the process of preparing Chinese medicine of traditional Chinese medical science allusion quotation process of preparing Chinese medicine method, develop impalpable powder respectively.

(2), Margarita (water is carried powder), osseocolla, Colla cornus cervi development smalls is mixed prior to a small amount of medicamental pulverata, be incorporated in its even stirring, fully mix homogeneously.

(3), medicine coarse powder such as Cortex Moutan, Radix Cirsii Japonici, Radix Trichosanthis, flat shellfish, Endothelium Corneum Gigeriae Galli, sea snake, through decoction and alcohol sedimentation technique, extract its effective ingredient.

(4), with the abundant mix homogeneously of all medicines, get final product.

The present invention is the compatibility logic according to traditional Chinese medical science monarch, and a kind of special pure Chinese medicine preparation is provided, in the side with part medicine fine powder with extract the medicamental pulverata mix preparation.Selecting Radix Cirsii Japonici among this side for use is monarch, tool blood-cleaning detoxifying, cooling blood for hemostasis, active promoting blood circulation, " only not coagulating ", the special-effect of " alive and broken ".Can stop blooding, but disperse blood stasis and dredge collateral again, the tissue regeneration promoting that purifies the blood, anti-hemostasis-coagulation can stop blooding and not stay the stasis of blood, the effect of the local vascular of contraction is arranged, shortening clotting time, enhancing VAR; Radix Notoginseng, Cortex Moutan, Margarita, Radix Trichosanthis, flat Bei Weichen; Cooling blood for hemostasis, astringing to arrest bleeding, blood-cleaning detoxifying, dissolving blood stasis and detoxication helps the effect of monarch drug hemostasis, active, removing the necrotic tissue, blood stasis dispelling, tissue regeneration promoting; Olibanum, Endothelium Corneum Gigeriae Galli, Endoconcha Sepiae help the monarch drug promoting flow of QI and blood for assistant, and mass dissipating and swelling eliminating restores menstrual flow and invigorates blood circulation, the effect of blood-activating analgetic.Colla cornus cervi, sea snake, Solenognathus, osseocolla etc. have invigorating the liver and kidney, bone and muscle strengthening, and beneficial marrow, continuous muscle arteries and veins, QI invigorating and blood producing, the toxin expelling granulation promoting, putrefaction removing and tissue regeneration promoting, promotion yard grass are repaired.The interior internal organs that can be in harmonious proportion, external enwergy is nourished the muscles and bones skin, improves immune function.Its comprehensive effect has benefiting QI and nourishing blood, heat-clearing and toxic substances removing, cooling blood for hemostasis, blood circulation promoting and blood stasis dispelling, removes the rotten and lets fresh grow, effects such as reducing swelling and alleviating pain, mediation internal organs, the continuous muscle of long bone.

The pure Chinese medicine of treatment ulcerative hemorrhage provided by the invention, through clinical observation, to various ulcer (comprising internal organs) and body surface organization's damage, or the ulcer necrosis; Wound causes skin to hinder meat wound, fracture, tendon breaking; The infection of swelling and ache that the different reasons in inside and outside cause; And various hemorrhages, have the good curing effect, than treatment ulcer medicine commonly used, anti-infective, the hemorrhage instant effect is had every advantage and not a single disadvantage, and behind the Orally taken and externally, can accelerate tissue repair, promotion ulcer healing; Heat-clearing and toxic substances removing, mass dissipating and swelling eliminating, resistance infection are strong; The stasis of blood rapidly and is not stayed in hemostasis, can not cause blood coagulation, can not form thrombosis, infraction.It is the ideal medicament of a kind of comparatively desirable infection, repair tissue, hemostasis rapidly, blood circulation promoting and blood stasis dispelling, dissolving blood stasis and detoxication, active tissue regeneration promoting.

Through clinical observation: the present invention is to 1. atrophic gastritis, gastroenteritis, gastrointestinal functional failure, myocarditis, pneumonia, tracheitis, hepatitis, nephritis, appendicitis, and wound soft tissue, osteomyelitis, bone tuberculosis, aseptic necrosis of bone, fracture, soft tissue injury infect disease.2. various ulcerate diseases such as gastric and duodenal ulcers, colonic ulcer, pharyngitis erosion, redness, oral ulcer, cervical erosion, scald ulcer, decubital ulcer, infective ulcer.3. upper gastrointestinal hemorrhage, lung qi pipe spitting of blood, infectivity is hemorrhage, hemorrhagic fever is hemorrhage, traumatic hemorrhage, postpartum hemorrhage, dysfunctional uterine hemorrhage, cerebral hemorrhage and inside and outside hemorrhage such as other internal organs are hemorrhage, purpura, hematohidrosis, thrombocytopenia are hemorrhage.Shown that fully the present invention truly has the effect of above-mentioned uniqueness.Through sensitivity test and toxicological test: 1, through to moving back this medicine medicinal liquid of Mus lumbar injection and continuous 28 days and baring skin continuous use 7 days, no sensitization; 2, this medicine is not seen the obvious stimulation reaction to damaged skin, and can promote the damaged skin healing.3, this medicine absorbs LD50 greater than the 30/kg body weight to the disposable oral administration gastrointestinal of mice, every day, maximum tolerated dose was equivalent to 500 times (pers kilogram of body weight) of clinical application (every day, people's consumption was the 9g meter). and individual treated animal does not all have death. and whole body does not have poisoning symptom to be taken place, the skin that is tried face does not have pathological change .4, this medicine rat long term toxication results such as redness, pimple, suppuration, ulcer, necrosis and shows, rat outward appearance sign and behavioral activity, appetite and body weight are all no abnormal; It is normal that hematology and blood biochemical are learned the index result; Organ coefficient is no abnormal, and system becomes celestial and histopathologic examination shows the change of no pathology, testing result to sum up, and can think: this medicine long term toxicity test does not see that obvious toxic-side effects is arranged.

Show through pharmacodynamics test: 1, this medicine shows rat severed limb model therapeutical effect, has tangible minimizing hemorrhage two, promotes the effect of clotting time, and can prolong the time-to-live, and healing is good above.And be better than positive controls; 2, this medicine has the plasma in rabbit of reduction recalcification time, prothrombin time and the dissolved effect of prolongation euglobulin; 3, the effect of obvious shortening heparinization clotting time of mice is arranged; 4, stress therapeutical effect preferably be arranged the type gastric ulcer to the SD rat acute, and be better than the positive controls (P＜0.5) of same dose; 5, the effect of obvious suppression dimethylbenzene induced mice otitis disease model is arranged; 6, the effect that improves mouse tail tenderness value is arranged.

Through clinical proof: it is as follows that the hemorrhages different to 436 examples (epistaxis, bleeding from the gum, spitting of blood, traumatic hemorrhage, operative hemorrhage, cerebral hemorrhage, cancer are hemorrhage, hemoptysis of pulmonary tuberculosis, haematemesis, liver cirrhosis haematemesis, metrorrhagia, have blood in stool etc.) are treated statistics: treatment group: total effective rate 98%, hemostasis on the one accounts for 50%, hemostasis accounts for 30% in three days, hemostasis accounts for 20% in January, and January, surplus hemostasis accounted for 8%.Matched group: total effectively rule was stopped blooding in 70%, one day, and hemostasis accounts for 50% in 0%, three day, and hemostasis accounts for 10% in January, and January, surplus hemostasis accounted for 6%.Different ulcerate diseases (gastric ulcer, colonic ulcer, trauma ulcer, oral ulcer, cervical erosion etc.) treatment statistics to 256 examples is as follows: total effective rate is more than 95%, and week healing accounts for 60%, and January, healing accounted for 30%, and January, surplus healing accounted for 15%.Matched group: total effective rate 75%, one week cured 10%, cure 30% January, surplus healing in January accounts for curing in 96%, one week of treatment total effective rate of the infection disease (pharyngitis, internal organs inflammation, trauma infection contamination, scald infection, vaginal infection, surgical infection etc.) of example surplus 35% pair 320 and accounts for 56%, and January, healing accounted for 30%, surplus healing in January accounts for 10%. matched group total effective rates 65%, the healing of one week accounts for 15%, and January, healing accounted for 20%, and January, surplus healing accounted for 30%.

Claims (5)

1, a kind of pure Chinese medicine for the treatment of ulcerative hemorrhage is characterized in that it is the medicament of being made by following raw materials by weight proportions:

Radix Notoginseng 10～50 Radix Trichosanthis 15～45 Endoconcha Sepiaes 10～25 Margaritas 5～15

Cortex Moutan 15～35 Colla cornus cervis 10～30 Solenognathus 5～20 Endothelium Corneum Gigeriae Galli 10～30

Flat shellfish 10～25 Radix Cirsii Japonicis 30～60 sea snakes 10～30 osseocolla 10～30

Olibanum 6～20

2, the pure Chinese medicine of treatment ulcerative hemorrhage as claimed in claim 1 is characterized in that each crude drug is by weight ratio:

Radix Notoginseng 15～40 Radix Trichosanthis 15～35 Endoconcha Sepiaes 10～20 Margaritas 5～10

Cortex Moutan 15～30 Colla cornus cervis 10～25 Solenognathus 5～15 Endothelium Corneum Gigeriae Galli 10～25

Flat shellfish 10～20 Radix Cirsii Japonicis 30～50 sea snakes 10～25 osseocolla 15～30

Olibanum 10～20

3, the pure Chinese medicine of treatment ulcerative hemorrhage as claimed in claim 1 is characterized in that each crude drug is by weight ratio:

Radix Notoginseng 10～35 Radix Trichosanthis 15～30 Endoconcha Sepiaes 10～15 Margaritas 8～10

Cortex Moutan 15～25 Colla cornus cervis 10～20 Solenognathus 10～15 Endothelium Corneum Gigeriae Galli 10～20

Flat shellfish 10～15 Radix Cirsii Japonicis 35～50 sea snakes 10～20 osseocolla 15～25

Olibanum 10～15g

4, the pure Chinese medicine of treatment ulcerative hemorrhage as claimed in claim 1 is characterized in that each crude drug is by weight ratio:

Radix Notoginseng 20 Radix Trichosanthis 30 Endoconcha Sepiaes 15 Margaritas 10 Cortex Moutans 20 Colla cornus cervis 10

Solenognathus 10 Endothelium Corneum Gigeriae Galli 15 flat shellfish 10 Radix Cirsii Japonicis 50 sea snakes 15 osseocolla 15

Olibanum 15

5, the pure Chinese medicine its preparation method of treatment ulcerative hemorrhage as claimed in claim 1:

(1), with Radix Notoginseng, sea snake, Solenognathus, Colla cornus cervi, select, clean, after by the process of preparing Chinese medicine of traditional Chinese medical science allusion quotation process of preparing Chinese medicine method, develop impalpable powder respectively.

(2), Margarita (water is carried powder), osseocolla, Colla cornus cervi development smalls is mixed prior to a small amount of medicamental pulverata, be incorporated in its even stirring, fully mix homogeneously.

(3), medicine coarse powder such as Cortex Moutan, Radix Cirsii Japonici, Radix Trichosanthis, flat shellfish, Endothelium Corneum Gigeriae Galli, sea snake, through decoction and alcohol sedimentation technique, extract its effective ingredient.

(4), with the abundant mix homogeneously of all medicines, get final product.