CN102380072B - Externally applied cold wash traditional Chinese medicine composition for activating blood and reliving pain and application thereof - Google Patents
Externally applied cold wash traditional Chinese medicine composition for activating blood and reliving pain and application thereof Download PDFInfo
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Abstract
The invention relates to the technical field of traditional Chinese medicine compositions and particularly relates to an externally applied cold wash traditional Chinese medicine composition for activating blood and reliving pain. The externally applied cold wash traditional Chinese medicine composition comprises the following active pharmaceutical ingredients by weight: 15 g of diverse wormwood herb, 15 g of sapanwood, 15 g of radix salviae miltiorrhizae, 15 g of red paeony root, 15 g of safflower, 15g of largeleaf gentian root, 15 g of dahurian angelica root, 15 g of clematis root, 15 g of twotooth achyranthes root, 15 g of ailanthus-like pricklyash bark, 15 g of Chinese angelica root-tip, 6 g of frankincense, 6 g of rhubarb, 6 g of forsythia, 6 g of tree peony bark, 6 g of Szechwan Chinaberry fruit, 30 g of glabrous greenbrier rhizome and 30 g of motherwort. The invention further discloses the application of the externally applied cold wash traditional Chinese medicine composition for activating blood and reliving pain in the preparation of medicaments for cold wash treatment of early acute ankle joint soft tissue injury. The treatment method of matching the traditional Chinese medicine composition with cold wash has great treatment effect for the acute early ankle joint soft tissue injury, the blood perfusion at the part with the injury can be rapidly reduced, the effects of eliminating stasis, realizing detumescence and relieving the pain can be realized, and the pain of a patient can be rapidly relieved; furthermore, the cold wash treatment method is simple and easy to grasp, and the treatment can be performed at home, thereby increasing the timeliness and the effectiveness of the treatment.
Description
Technical field
The present invention relates to the Chinese medicine technical field of compositions, particularly a kind of external cold wash traditional Chinese medicinal composition for blood circulation invigorating, also relate to the application of described Chinese medicine composition.
Background technology
The acute ankle soft tissue injury is Orthopedic Clinical commonly encountered diseases and frequently-occurring disease, and especially adolescent patient is more, and they urgently wish and can recover the ankle joint normal function in the shorter time.For a long time, the traditional Chinese medical science is generally used Chinese traditional herbal medicine treatment acute ankle soft tissue injury.But modern medicine advocates according to the early stage pathological characteristic of acute ankle damage the Therapeutic Method of using the ice bag cold compress, and the method has the effect of reducing swelling and alleviating pain.A large amount of clinical practice and Results of Animals prove, the curative effect of Chinese traditional herbal medicine treatment sprained ankle is subjected to the impact of factors.We study discovery, and the degree of sprained ankle, beginning administration time, medication every day number of times, the time length of each fumigation and wash method and the factors such as temperature of fumigation and wash method medicinal liquid directly affect therapeutic effect.Yet, at present Chinese traditional herbal medicine treatment acute ankle damage, still use traditional first smoked after washing method, fluid temperature is higher when smoked, do not meet the early stage pathological characteristic of acute injury and Therapeutic Principle, had a strong impact on the curative effect of external washout with traditional Chinese herbs treatment acute ankle damage.The pathological characteristic early stage according to the acute ankle soft tissue injury and the Therapeutic Method of ice bag cold compress are used Chinese medicine cold wash treatment acute ankle soft tissue injury, and the ice bag cold compress that clinical efficacy is more single is better.Because the effect of the existing ice bag cold compress of this Therapeutic Method Physical temperature-lowering, possesses simultaneously the effect of Chinese medicine blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain.But have not yet to see now the relevant report of using the Chinese medicine cold wash and being applicable to cold wash Chinese medicine.
Summary of the invention
Be applicable to the problem of the Chinese medicine of cold wash in order to solve above nothing, the invention provides a kind of be applicable to cold wash, the external traditional Chinese medicinal composition for blood circulation invigorating.
The present invention also provides the application of described external cold wash traditional Chinese medicinal composition for blood circulation invigorating.
The present invention is achieved by the following measures:
A kind of external cold wash traditional Chinese medicinal composition for blood circulation invigorating, the weight proportion of raw materials used medicine is as follows:
Herba Artemisiae Anomalae 15g, Lignum Sappan 15g, Radix Salviae Miltiorrhizae 15g, Radix Paeoniae Rubra 15g, Flos Carthami 15g, Radix Gentianae Macrophyllae 15g,
Radix Angelicae Dahuricae 15g, Radix Clematidis 15g, Radix Achyranthis Bidentatae 15g, Cortex erythrinae 15g, Radix Angelicae Sinensis 15g, Olibanum 6g,
Radix Et Rhizoma Rhei 6g, Fructus Forsythiae 6g, Cortex Moutan 6g, each 6g of Fructus Toosendan, Rhizoma Smilacis Glabrae 30g, Herba Leonuri 30g.
Crude drug is mixed be fried into the medicinal liquid that contains crude drug 0.15g/ml.
The application of described external cold wash traditional Chinese medicinal composition for blood circulation invigorating in the early stage acute ankle soft tissue injury medicine of preparation cold wash treatment.
The early stage acute ankle soft tissue injury of cold wash treatment refers to occur in rear 3 days in damage, uses 20 ℃ of medicinal liquid washout affected parts, and each 30 minutes, every day 2 times.
Herba Artemisiae Anomalae: the hemostasis of curing the wound, removing blood stasis stimulates the menstrual flow, promoting digestion and removing stagnation, the effect of the appetizing of being amusing.
Lignum Sappan: promoting the circulation of blood blood stasis dispelling, reducing swelling and alleviating pain.
Radix Salviae Miltiorrhizae: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind.
Radix Paeoniae Rubra: control that the stagnant amenorrhea of the stasis of blood, hernia abdominal mass gather, hypochondriac pain, epistaxis, carbuncle, injury from falling down.
Flos Carthami: the latus rectum of invigorating blood circulation, eliminating stasis to stop pain.
Radix Gentianae Macrophyllae: Eradicates rheumatism, Shujin network, clearind deficient heat.
The Radix Angelicae Dahuricae:: wind-damp dispelling, the evacuation of pus of invigorating blood circulation, granulation promoting pain relieving.
Radix Clematidis: expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, the loose hypochondriac lump.
Radix Achyranthis Bidentatae: invigorating the liver and kidney; Bone and muscle strengthening; Promoting blood circulation to restore menstrual flow; Ignite (blood) descending; Inducing diuresis for treating stranguria syndrome.
Cortex erythrinae: wind-damp dispelling, the meridian dredging, parasite killing.
Radix Angelicae Sinensis: blood circulation promoting and blood stasis dispelling.
Olibanum: regulating qi and activating blood, analgesic therapy chases after poison.
Radix Et Rhizoma Rhei: attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Detoxifcation.
Fructus Forsythiae: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens.
Cortex Moutan: heat clearing away, removing heat from blood, diuretic, damp eliminating.
Fructus Toosendan: soothing liver-QI, promoting the circulation of QI to relieve pain, anthelmintic.
Rhizoma Smilacis Glabrae: detoxifcation, dehumidifying, sharp joint.
Herba Leonuri: promoting blood flow to regulate menstruation, inducing diuresis to remove edema, heat-clearing and toxic substances removing.
Beneficial effect of the present invention:
Chinese medicine composition of the present invention coordinates the Therapeutic Method of cold wash to have good therapeutical effect to acute early stage ankle joint soft tissue injury, can reduce rapidly damage location blood perfusion amount, plays the effect of dissipating blood stasis, detumescence and pain relieving, alleviates fast patient's pain; And the cold wash Therapeutic Method is simple and easy to grasp, and the treatment of can being in has increased the timely and effective property for the treatment of.
The specific embodiment
For a better understanding of the present invention, further illustrate below in conjunction with specific embodiment.
Embodiment 1:
A kind of external cold wash traditional Chinese medicinal composition for blood circulation invigorating, the weight proportion of raw materials used medicine is as follows:
Herba Artemisiae Anomalae 15g, Lignum Sappan 15g, Radix Salviae Miltiorrhizae 15g, Radix Paeoniae Rubra 15g, Flos Carthami 15g, Radix Gentianae Macrophyllae 15g,
Radix Angelicae Dahuricae 15g, Radix Clematidis 15g, Radix Achyranthis Bidentatae 15g, Cortex erythrinae 15g, Radix Angelicae Sinensis 15g, Olibanum 6g,
Radix Et Rhizoma Rhei 6g, Fructus Forsythiae 6g, Cortex Moutan 6g, each 6g of Fructus Toosendan, Rhizoma Smilacis Glabrae 30g, Herba Leonuri 30g.
Preparation method: crude drug is mixed being fried into the medicinal liquid that contains crude drug 0.15g/ml.
The clinical effectiveness checking
1 materials and methods
1.1 laboratory animal and grouping
60 of cleaning level rats are male, and body weight (200 ± 20) g is provided by Shandong Traditional Chinese Medicine University's Experimental Animal Center, the laboratory animal quality certification number: SCXK (Shandong) 20060099.Use the lottery random packet, be divided into 5 groups, 12 every group.
A group, modeling observation group;
B group: each 30 minutes of ice bag external application, every day 2 times;
C group: each 60 minutes of ice bag external application, every day 2 times;
D group: each 30 minutes of external cold wash traditional Chinese medicinal composition for blood circulation invigorating medicinal liquid cold wash of the present invention, every day 2 times;
E group: each 60 minutes of external cold wash traditional Chinese medicinal composition for blood circulation invigorating medicinal liquid cold wash of the present invention, every day 2 times;
Each experiment is all accurately weighed, Continuous Observation 3 days.
Animal model and grouping
Adopt the weight method modeling of falling, concrete grammar: Rat Right lower limb unhairing, be fixed on the Mus plate, the counterweight that 0.2kg is heavy freely drops on same position on Rat Right lower limb ankle from the 20cm eminence by the steel pipe suitable with its diameter, hit 2 times continuously, produce and red, swollenly have wound surface but without the soft tissue injury animal model of fracture.
Medication
The A group takes drugless medication for matched group;
The B group is wrapped up ice bag with the cotton pad of suitable depth, and making the cotton pad surface temperature is 20 degree, each 30 minutes of cold compress affected part, every day 2 times;
The C group is wrapped up ice bag with the cotton pad of suitable depth, and making the cotton pad surface temperature is 20 degree, each 60 minutes of cold compress affected part, every day 2 times;
The medicinal liquid that D group will be fried in shallow oil is chilled to 20 degree, and to the affected part cold wash each 30 minutes, every day 2 times;
The medicinal liquid that E group will be fried in shallow oil is chilled to 20 degree, and to the affected part cold wash each 60 minutes, every day 2 times.
Experimental apparatus
Laser doppler seanning, Sweden's lark prestige (Perimed) Medical Instruments company produces PeriFlux 5000 systems, comprising: PF 5010 LDPM(laser-Dopplers), PF 5020 TEMP(temperature conditioning units), PROBE407 probe, PF105-3 glue.Air conditioning labor, 25.0～27.0 ℃ of room temperatures, indoor without direct sunlight and obvious cross-ventilation; Slide gauge, tape measure.
Observation index
Rear 5 minutes of instant, the first day of each group before measuring modeling, after the modeling success, second day, each time in the 3rd day treatment modeling position regional flow groundwater increment.
Statistical procedures
Adopt SPSS13.0 statistics software, select the t check to carry out data analysis, enumeration data adopts X 2 test, and the clinical-grade data adopts Ridit check, inspection level α=0.05.
Result
Before table 1 modeling with modeling after respectively organize the blood perfusion amount (
± s)
| ? | The A group | The B group | The C group | The D group | The E group |
| Before modeling | 465.8 ± 44.4 | 455.6 ± 18.0 | 473.92 ± 35.9 | 452.75 ± 29.7 | 450.6 ± 28.2 |
| After modeling | 865 ± 58.8 | 869.5 ± 60.6 | 862.1 ± 72.7 | 862.7 ± 68.3 | 855.6 ± 54.9 |
| After first day is treated for the first time | 637.1 ± 20.4 | 688.3 ± 87.9 | 634.4 ± 108.8 | 569.3 ± 13.7 | 433.42 ± 22.0 |
| After first day is treated for the second time | 636.9 ± 20.6 | 626.8 ± 61.7 | 592.6 ± 24.2 | 451.2 ± 20.0 | 410.7 ± 7.9 |
| After second day is treated for the first time | 617.3 ± 20.2 | 581.33 ± 26.9 | 531.9 ± 30.3 | 448.6 ± 22.7 | 408.3 ± 34.7 |
| After second day is treated for the second time | 607.6 ± 19.8. | 558.6 ± 29.6 | 526.8 ± 21.4 | 446.9 ± 21.4 | 409.9 ± 34.4 |
| After treatment for the first time in the 3rd day | 586.1 ± 21.4 | 550.5 ± 21.5 | 523.8 ± 28.5 | 445.8 ± 24.0 | 408.7 ± 26.0 |
| After treatment for the second time in the 3rd day | 576.2 ± 21.3 | 534.9 ± 25.6 | 518.7 ± 21.7 | 441.8 ± 14.7 | 401 ± 23.4 |
2.1 respectively organize the blood perfusion amount before modeling relatively
Respectively organize the blood perfusion amount before the rat modeling relatively without significant difference (P〉0.05).
Respectively organize the blood perfusion amount after modeling relatively
Respectively organize the blood perfusion amount after rat modeling success relatively without significant difference (P〉0.05).
Before modeling with modeling after blood perfusion amount testing result
The rat weight falls after the method modeling, and each compares remarkable increase (P＜0.01) before organizing modeling position blood perfusion amount and modeling.See Table 1.
Respectively organize blood perfusion amount testing result after after modeling, first day is treated for the first time
Ice bag external application and medicinal liquid cold wash all can reduce modeling position blood perfusion amount.Two groups of medicinal liquid cold wash are respectively organized successful (p＜0.05) than other, and 60 minutes groups are better than 30 minutes groups (p＜0.05).
Respectively organize blood perfusion amount testing result after after modeling, first day is treated for the second time
Ice bag external application for the second time and medicinal liquid cold wash continue to reduce rat modeling position blood perfusion amount.Two groups of medicinal liquid cold wash are respectively organized successful (p＜0.05) than other, and 60 minutes groups are better than 30 minutes groups (p＜0.05)
2.6 respectively organize blood perfusion amount testing result after after modeling, second day is treated for the first time
After modeling, second day is treated D for the first time, and the E group is treated for the first time with first day than first day and treated for the second time modeling position blood perfusion amount minimizing (P＜0.05).60 minutes groups of medicinal liquid cold wash effect continue to be better than 30 minutes groups (P＜0.05).
Respectively organize blood perfusion amount testing result after after modeling, second day is treated for the second time
After after modeling, second day is treated for the second time with modeling after second day treat for the first time each group comparison no significant difference of rear modeling position blood perfusion amount (P〉0.05).Medicinal liquid cold wash successful, and 60 minutes groups continue to be better than 30 minutes groups (P＜0.05).
Respectively organized blood perfusion amount testing result after treatment for the first time on the 3rd day after modeling
After modeling after treatment for the first time in the 3rd day with modeling after second day treat for the second time each group of rear modeling position blood perfusion amount and compare no significant difference (P〉0.05).Medicinal liquid cold wash effect is more obvious, and 60 minutes groups continue to be better than 30 minutes groups (P＜0.05).
Respectively organized blood perfusion amount testing result after treatment for the second time on the 3rd day after modeling
After modeling after treatment for the second time in the 3rd day with modeling after after treatment for the first time in the 3rd day each group of modeling position blood perfusion amount compare no significant difference (P〉0.05).D, E organizes medicinal liquid cold wash successful (P＜0.05).
Acute soft tissue injury belongs to Chinese medicine " muscle and tendon injury " category, is the pathological reaction after local QI and blood meridian damage.Modern medicine think the reason of acute soft tissue injury be on the one hand external force directly cause the microstructure damage of local organization cell and tiny blood vessels break, hemorrhage, and histiocyte congestion and edema and degeneration necrosis cause impaired regional flow groundwater increment and increase and cause swelling, pain; Be that after damage, local organization discharges inflammatory mediator, the metabolite gathering causes interior environment change on the other hand, cause the damaging cells dysbolismus, thereby increase the weight of local symptom and sign and pathological change.To be medicine act on the wound part by Transdermal absorption to Chinese medicine external, thereby keep local metastable blood drug level, plays the effect of dissipating blood stasis, detumescence and pain relieving.
This experiment is by setting up rat soft tissue injury model, process the modeling position by ice bag external application and Chinese medicine composition medicinal liquid cold wash of the present invention, the blood perfusion amount in affected part after using Laser doppler seanning measurement modeling front and back and employing ice bag external application and Chinese medicine composition medicinal liquid cold wash of the present invention to treat, judge the impact of blood perfusion amount is larger after which kind of Therapeutic Method is on the rat modeling, and result shows: after modeling, rat modeling position blood perfusion amount increases; Ice bag cold compress and medicinal liquid cold wash all can reduce modeling position blood perfusion amount, but medicinal liquid cold wash group modeling position blood perfusion amount reduces more obvious; No matter be ice bag external application or medicinal liquid cold wash, group blood perfusion amount reduced more obvious in 60 minutes.Second and third day after modeling, each organizes the blood perfusion amount contrast of modeling position does not have statistical significance (P〉0.05).
This experiment proved that external traditional Chinese medicinal composition for blood circulation invigorating cold wash of the present invention can significantly reduce the blood perfusion amount at rat modeling position after modeling, and with the cold wash time lengthening, modeling position blood perfusion amount reduces more obvious, be more applicable for the early stage acute ankle soft tissue injury of cold wash treatment, can be used for preparing the medicine of the early stage acute ankle soft tissue injury of cold wash treatment.
Claims (3)
1. external cold wash traditional Chinese medicinal composition for blood circulation invigorating is characterized in that the weight proportion of raw materials used medicine is as follows:
Herba Artemisiae Anomalae 15g, Lignum Sappan 15g, Radix Salviae Miltiorrhizae 15g, Radix Paeoniae Rubra 15g, Flos Carthami 15g, Radix Gentianae Macrophyllae 15g,
Radix Angelicae Dahuricae 15g, Radix Clematidis 15g, Radix Achyranthis Bidentatae 15g, Cortex erythrinae 15g, Radix Angelicae Sinensis 15g, Olibanum 6g,
Radix Et Rhizoma Rhei 6g, Fructus Forsythiae 6g, Cortex Moutan 6g, Fructus Toosendan 6g, Rhizoma Smilacis Glabrae 30g, Herba Leonuri 30g;
Crude drug is mixed be fried into the medicinal liquid that contains crude drug 0.15g/ml.
2. the application of external cold wash traditional Chinese medicinal composition for blood circulation invigorating claimed in claim 1 in the early stage acute ankle soft tissue injury medicine of preparation cold wash treatment.
3. application according to claim 2 is characterized in that the early stage acute ankle soft tissue injury of cold wash treatment refers to occur in rear 3 days to use medicinal liquid to wash the affected part at 20 ℃ in damage, each 30-60 minute, and every day 2 times.
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