CN101433634A - Pharmaceutical composition with functions for resisting oxidation and delaying consenescence and preparation method thereof - Google Patents
Pharmaceutical composition with functions for resisting oxidation and delaying consenescence and preparation method thereof Download PDFInfo
- Publication number
- CN101433634A CN101433634A CNA2007101774917A CN200710177491A CN101433634A CN 101433634 A CN101433634 A CN 101433634A CN A2007101774917 A CNA2007101774917 A CN A2007101774917A CN 200710177491 A CN200710177491 A CN 200710177491A CN 101433634 A CN101433634 A CN 101433634A
- Authority
- CN
- China
- Prior art keywords
- polygoni multiflori
- radix
- vitis viniferae
- semen vitis
- radix polygoni
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a pharmaceutical composition with functions of oxidation resistance and senility delaying, and a preparation method thereof. The pharmaceutical composition is prepared from ginseng, radix-polygoni multiflori and a grape seed extract according to certain weight proportion. The pharmaceutical composition can be prepared into any common orally-administered formulation. The traditional Chinese medicine composition has efficacies of oxidation resistance and senility delaying.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof, belong to medicine and field of health care food with antioxidation, deferring senility.
Background technology
Britain Harman took the lead in proposing free radical in 1956 relevant with body aging and disease, then delivered first piece of research report in nineteen fifty-seven, but set forth with contain the 0.5%-1% free radical scavenger forage feed mice life-saving.Because free radical theory can be explained all symptoms that occur in the body aging process more clearlyly, as senile plaque, wrinkle and immunity degradation etc., therefore receive much attention, be that people institute generally accepts.The old and feeble theoretical centre point of free radical thinks, and is old and feeble from producing free radical in the body homergy process at random and destructive exercising result causes that by free radical the main mechanism of body aging may be summarized to be following three aspects.
1, the cross-linked polymeric of life macromolecule and refer to the accumulation of brown element
Free radical acts on lipid peroxidation, and oxidation end-product malonaldehyde etc. can cause the cross-linked polymeric of life macromolecules such as protein, nucleic acid, and this phenomenon is old and feeble Fundamentals.Lipofuscin (Lipofuscin) is water insoluble so be difficult for being excluded, bulk deposition in cell so just, accumulation at Skin Cell, promptly form senile plaque, this is old old and feeble a kind of appearance symbol: and the accumulation of Skin Cell hypomnesis or dysnoesia then can occur even senile dementia occur.The cross-linked polymeric of collagen protein can make collagen protein decreased solubility, elasticity reduce and hydratability goes down, and causes senile skin to lose tension force and wrinkle increases and old inostosis ability weakens etc.The peroxidating of lipid causes lens pathological changes such as retina is fuzzy to occur, brings out senile visual disorder (as dim eyesight, cataract etc.) to occur.Owing to the destruction of free radical causes skin aging, wrinkle appears, and the accumulation of lipofuscin makes the decline of Skin Cell immunity cause the cutaneous tumor susceptibility to strengthen, and these all are the destruction of free radical.
2, the destruction of organ-tissue cell and minimizing
The destruction of organ-tissue cell and minimizing are one of symptoms of body aging.The for example obvious minimizing of neuronal cell quantity is the another major reason that causes old people's sensation and hypomnesis, heavy and dysnoesia.Organ-tissue cytoclasis or minimizing mainly are because gene mutation has changed the transmission of hereditary information, cause the resultant fault of protein and enzyme and the reduction of enzymatic activity.These accumulation has caused the aging and dead of organ-tissue cell.Unsaturated fatty acid on the biomembrane very easily is subjected to the invasion and attack generation peroxidization of free radical, and Oxidation has significant effects to aging, and free radical is by having quickened the senescence process of cell to the invasion and attack of lipid.
3, the reduction of immunologic function
Free radical acts on immune system, or acts on lymphocyte and make it impaired, causes that old people's cellular immunization and humoral immune function weaken, and immune discernment is descended autoimmune disease occurs.
So-called autoimmune disease is exactly that immune system is not only attacked pathogen and abnormal cell, has also invaded self normal healthy tissue simultaneously, external foreign body is used as by autologous tissue attacks.As the autoimmune disease of dispersivity scleroderma, systemic scleroma, ulcerative colitis, collagen pathological changes and CrohnnShi disease (Crohn) and so on, often with more chromosome breakage.Studies show that the pathological process of autoimmune disease and free radical have very big relation.
The free radical that scientists is found the infringement health is nearly all relevant with the stronger oxygen carrier of those activity, and they are called reactive oxygen free radical to the free radical that combines with these materials.Reactive oxygen free radical is actually a kind of oxidizing process to the infringement of human body.Therefore, reduce the infringement of free radical, will do from antioxidation.The approach that reduces free radical harm has two: the one, and, utilize unnecessary free radical in the endogenous free radical scavenging System Cleaning body; The 2nd, excavate exogenous antioxidant-free radical scavenger, the invasion of blocking-up radical pair human body.
Summary of the invention
The object of the invention just provides a kind of pharmaceutical composition that has antioxidation, removes free radical, deferring senility.
Another object of the present invention has provided this preparation of drug combination method.
The present invention is achieved by the following technical solutions:
The present invention is made by the following weight proportion raw material:
Radix Ginseng 3-9 part, Radix Polygoni Multiflori 6-12 part, Semen Vitis viniferae extract (procyanidin content 〉=95%) 0.01-0.06 part
Be preferably:
6 parts of Radix Ginsengs, 9 parts of Radix Polygoni Multiflori, 0.03 part of Semen Vitis viniferae extract (procyanidin content 〉=95%)
Preparation of drug combination method of the present invention is as follows:
With the Radix Ginseng of described weight proportion, Radix Polygoni Multiflori adds water respectively or ethanol extracts, and extracting solution is concentrated, drying makes dry extract, mixes, and is ground into powder, adds Semen Vitis viniferae extract (procyanidin content 〉=95%); Add various conventional adjuvant required when preparing different dosage form, as diluent, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, capsule, soft capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation, oral liquid etc.
The preferred for preparation method of Chinese medicine composition of the present invention is as follows:
Twice of the ethanol extraction that Radix Ginseng, the Radix Polygoni Multiflori of described weight proportion is added 10 times of amounts and 8 times of amounts 70% respectively, merge extractive liquid,, filter, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30, drying under reduced pressure down for 60 ℃, make dry extract, mix, be ground into powder, add Semen Vitis viniferae extract (procyanidin content 〉=95%); Add various conventional adjuvant required when preparing different dosage form, as diluent, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, capsule, soft capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation, oral liquid etc.
The using method of pharmaceutical composition of the present invention:
Oral; Day dose is in crude drug: Radix Ginseng 3-9g, Radix Polygoni Multiflori 6-12g, Semen Vitis viniferae extract (procyanidin content 〉=95%) 0.01-0.06g, and preferred: Radix Ginseng 6g, Radix Polygoni Multiflori 9g, Semen Vitis viniferae extract (procyanidin content 〉=95%) 0.03g; Every day 2-3 time.
Each drug mechanism is as follows among the present invention:
Radix Ginseng: Radix Ginseng has that strongly invigorating primordial QI, multiple arteries and veins take off admittedly, invigorating the spleen to benefit the lung, effect such as promote the production of body fluid, calm the nerves.The human neuronal cell line aging is accompanied by the cerebral cortex cell membrane fluidity and changes, and the contained saponin of Radix Ginseng can strengthen cell membrane fluidity, wears out thereby postpone or delay cerebral cortex, reduces the old memory impairment that takes place.Increasing membrane fluidity is ginsenoside's anti-aging effects mechanism one important indicator.The ginsenoside can obviously suppress lipid peroxide formation in the brain regulating liver-QI, the content of lipofuscin and serum lipid peroxide in minimizing cerebral cortex, liver and the cardiac muscle, also can increase simultaneously superoxide dismutase and the peroxidase content in blood, Radix Ginseng can be safeguarded brain glandular hormone secretory function, promote cell to form, also can improve the content of immunoglobulin, strengthen the reticuloendothelial system phagocytic function.The ginsenoside can remove and cause old and feeble free radical, delaying senility in the body.
Radix Polygoni Multiflori: have black beard and hair, improving healthy complexion, beneficial intensive culture blood, antidotal effect.Radix Polygoni Multiflori mainly contains three effective constituents: stilbene glycosides compound, anthraquinone analog compound and polymerization procyanidin.Contain lecithin and various trace elements in addition.Experimental result shows, Radix Polygoni Multiflori can obviously reduce Aged Mice brain and hepatic tissue mda content, increase monoamine transmitters content in the brain, enhance SOD activity, the activity that can also obviously suppress monoamine oxidase-B in Aged Mice brain and the hepatic tissue, thereby eliminate the damage of radical pair body, the generation of slow down aging and disease.The generation of lipid peroxide and deposition can cause a series of senile symptom, therefore the content of lipid peroxide is to estimate one of old and feeble leading indicator, Radix Polygoni Multiflori extract has very obvious suppression effect to the generation of mouse skin lipid peroxide, illustrate that Radix Polygoni Multiflori has the effect of delaying decrepitude of skin, can be used as the advantages of good skin antisenility cosmetics additive.In addition, Radix Polygoni Multiflori can also obviously improve the periphery lymphocyte DNA damage repair ability of senile rat, by suppressing monoamine oxidase-B activity in the brain, influences the content of organism central neurotransmitter, thereby regulates the nervus centralis activity, delays the aging of brain.
Semen Vitis viniferae: the Semen Vitis viniferae extract procyanidin is a kind of new and effective antioxidant that extracts from Semen Vitis viniferae, have excellent antioxygenic property and the significant free radical ability of removing, has antioxidation, functions such as antiinflammatory, antipathogen, blood circulation promoting, very strong activity in vivo is arranged, and absorb rapidly fully.
In the present composition, Radix Ginseng has played effects such as delaying brain and memory aging, Radix Polygoni Multiflori has played effects such as delaying skin and hair aging, Semen Vitis viniferae is strong free radical scavenger, has antiinflammatory, antipathogen, radioprotective, effects such as blood circulation promoting, three medicine compatibilities can reach comprehensive antidotal effect, and, three medicines all have very clear and definite antioxidation, remove the effect of free radical, wherein the strongest with the Semen Vitis viniferae antioxidation especially, three medicine compatibilities have strengthened antioxidation, remove the effect of free radical, fundamentally reached antidotal effect, and promote and keep health with human body.
In sum, the present composition has antioxidation, slow down aging, removing free radical, radioprotective, improves memory impairments.Can be used for preparing the medicine and the health product of antioxidation, slow down aging, removing free radical, radioprotective and improvement memory.
The present invention with respect to prior art have determined curative effect, have no side effect, taking convenience, cheap advantage.
Further set forth the beneficial effect of Chinese medicine composition of the present invention by following experiment.
Adopt the hepatomicrosome lipid peroxidation model of rat to detect present composition antioxidative activity, can significantly increase the GSH content of white mice, show that the present composition has defying age and antioxidant activity through laboratory observation; Can significantly increase the SOD enzymatic activity of white mice liver, when comparing with matched group, total SOD (T-SOD), cytosol SOD (Cu.Zn-SOD) and mitochondrion SOD (Mn-SOD) enzymatic activity all demonstrate the growth on the statistical significance when all dosage, show that the present composition has antioxidant activity; Reduced malonaldehyde (MDA) content of white mice effectively, shown that the present composition has prevention or the synthetic antioxidant activity of minimizing malonaldehyde (MDA) in the body.
The specific embodiment
Embodiment 1:
The preparation of the capsule of pharmaceutical composition of the present invention
A) take by weighing Radix Ginseng 60g, Radix Polygoni Multiflori 90g, Semen Vitis viniferae extract 0.3g is standby;
B) Radix Ginseng, Radix Polygoni Multiflori add the ethanol extraction twice of 10 times of amounts and 8 times of amounts 70% respectively, and merge extractive liquid, filters, and reclaims ethanol, are evaporated to relative density and measure 1.25-1.30 down for 60 ℃, and drying under reduced pressure makes dry extract;
C) dry extract is mixed, be ground into powder, add Semen Vitis viniferae extract (procyanidin content 〉=95%), the snap fit capsule of packing into.
Embodiment 2:
The preparation of the granule of Chinese medicine composition of the present invention
A) take by weighing Radix Ginseng 30g, Radix Polygoni Multiflori 60g, Semen Vitis viniferae extract 0.1g is standby;
B) Radix Ginseng, Radix Polygoni Multiflori add the ethanol extraction twice of 10 times of amounts and 8 times of amounts 70% respectively, and merge extractive liquid, filters, and reclaims ethanol, are evaporated to relative density and measure 1.25-1.30 down for 60 ℃, and drying under reduced pressure makes dry extract;
C) dry extract is mixed, be ground into powder, add Semen Vitis viniferae extract (procyanidin content 〉=95%), add ethanol and make adhesive, add appropriate amount of starch and make filler, make granule.
Embodiment 3:
The preparation of the granule of Chinese medicine composition of the present invention
A) take by weighing Radix Ginseng 90g, Radix Polygoni Multiflori 120g, Semen Vitis viniferae extract 0.6g is standby;
B) Radix Ginseng, Radix Polygoni Multiflori add the water extraction twice of 10 times of amounts and 8 times of amounts respectively, and merge extractive liquid, filters, and reclaims ethanol, are evaporated to relative density and measure 1.25-1.30 down for 60 ℃, and drying under reduced pressure makes dry extract;
C) dry extract is mixed, be ground into powder, add Semen Vitis viniferae extract (procyanidin content 〉=95%), add ethanol and make adhesive, add appropriate amount of starch and make filler, make granule.
Embodiment 4:
The preparation of the tablet of Chinese medicine composition of the present invention
A) take by weighing Radix Ginseng 60g, Radix Polygoni Multiflori 60g, Semen Vitis viniferae extract 0.2g is standby;
B) Radix Ginseng, Radix Polygoni Multiflori add the ethanol extraction twice of 10 times of amounts and 8 times of amounts 70% respectively, and merge extractive liquid, filters, and reclaims ethanol, are evaporated to relative density and measure 1.25-1.30 down for 60 ℃, and drying under reduced pressure makes dry extract;
C) dry extract is mixed, be ground into powder, add Semen Vitis viniferae extract (procyanidin content 〉=95%), add adjuvant and make granule, and dry, and compacting is in flakes.
Embodiment 5:
The preparation of the effervescent tablet of Chinese medicine composition of the present invention
A) take by weighing Radix Ginseng 70g, Radix Polygoni Multiflori 80g, Semen Vitis viniferae extract 0.2g is standby;
B) Radix Ginseng, Radix Polygoni Multiflori add the ethanol extraction twice of 10 times of amounts and 8 times of amounts 70% respectively, and merge extractive liquid, filters, and reclaims ethanol, are evaporated to relative density and measure 1.25-1.30 down for 60 ℃, and drying under reduced pressure makes dry extract;
C) dry extract is mixed, be ground into powder, add Semen Vitis viniferae extract (procyanidin content 〉=95%), add tartaric acid, sodium bicarbonate, sweeting agent, filler mixing, granulate with dehydrated alcohol, drying adds the lubricant mixing, tabletting, promptly.
Embodiment 6:
The preparation of the dispersible tablet of Chinese medicine composition of the present invention
A) take by weighing Radix Ginseng 80g, Radix Polygoni Multiflori 70g, Semen Vitis viniferae extract 0.3g is standby;
B) Radix Ginseng, Radix Polygoni Multiflori add the ethanol extraction twice of 10 times of amounts and 8 times of amounts 70% respectively, and merge extractive liquid, filters, and reclaims ethanol, are evaporated to relative density and measure 1.25-1.30 down for 60 ℃, and drying under reduced pressure makes dry extract;
C) dry extract is mixed, be ground into powder, add Semen Vitis viniferae extract (procyanidin content 〉=95%), add disintegrating agent, filler or diluent, mix homogeneously adds binding agent and makes soft material, system granule, drying, add part disintegrating agent, fluidizer or lubricant mixing, tabletting, promptly.
Claims (5)
1, a kind of pharmaceutical composition with antioxidation, delaying senility function, it is characterized in that said composition is to be made by following bulk drugs: Radix Ginseng 3-9 part, Radix Polygoni Multiflori 6-12 part, Semen Vitis viniferae extract (procyanidin content 〉=95%) 0.01-0.06 part.
2, pharmaceutical composition according to claim 1 is characterized in that, said composition is to be made by following bulk drugs: 6 parts of Radix Ginsengs, 9 parts of Radix Polygoni Multiflori, 0.03 part of Semen Vitis viniferae extract (procyanidin content 〉=95%).
3, claim 1 or 2 described preparation of drug combination methods is characterized in that this method is:
With the Radix Ginseng of described weight proportion, Radix Polygoni Multiflori adds water respectively or ethanol extracts, and extracting solution is concentrated, drying makes dry extract, mixes, and is ground into powder, adds Semen Vitis viniferae extract, is prepared into active component; The gained active component is mixed with adjuvant, make any medicament on the pharmaceutics.
4, according to the described preparation of drug combination method of claim 3, it is characterized in that this method is:
Twice of the ethanol extraction that Radix Ginseng, the Radix Polygoni Multiflori of described weight proportion is added 10 times of amounts and 8 times of amounts 70% respectively, merge extractive liquid,, filter, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure, make dry extract, mix, be ground into powder, add Semen Vitis viniferae extract, be prepared into active component; The gained active component is mixed with adjuvant, make any medicament on the pharmaceutics.
5, claim 1 or 2 described pharmaceutical compositions are used to prepare the application of the medicine or the health food of antioxidation and slow down aging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101774917A CN101433634A (en) | 2007-11-16 | 2007-11-16 | Pharmaceutical composition with functions for resisting oxidation and delaying consenescence and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101774917A CN101433634A (en) | 2007-11-16 | 2007-11-16 | Pharmaceutical composition with functions for resisting oxidation and delaying consenescence and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101433634A true CN101433634A (en) | 2009-05-20 |
Family
ID=40708374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007101774917A Pending CN101433634A (en) | 2007-11-16 | 2007-11-16 | Pharmaceutical composition with functions for resisting oxidation and delaying consenescence and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101433634A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104171797A (en) * | 2014-07-28 | 2014-12-03 | 无限极（中国）有限公司 | Application of ginseng and polygonum multiflorum compound polysaccharide in preparation of health foods with anti-aging effect |
| CN104368035A (en) * | 2013-08-13 | 2015-02-25 | 凌峰 | Biological dressing for eliminating white spots and scars on human body |
| CN105535131A (en) * | 2015-12-29 | 2016-05-04 | 西南交通大学 | Application of cooked rhubarb micropowder in preparing drug for Alzheimer's disease |
| CN115317399A (en) * | 2022-07-07 | 2022-11-11 | 湖北真福医药有限公司 | Anti-aging composition and preparation method and application thereof |
-
2007
- 2007-11-16 CN CNA2007101774917A patent/CN101433634A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104368035A (en) * | 2013-08-13 | 2015-02-25 | 凌峰 | Biological dressing for eliminating white spots and scars on human body |
| CN104171797A (en) * | 2014-07-28 | 2014-12-03 | 无限极（中国）有限公司 | Application of ginseng and polygonum multiflorum compound polysaccharide in preparation of health foods with anti-aging effect |
| CN105535131A (en) * | 2015-12-29 | 2016-05-04 | 西南交通大学 | Application of cooked rhubarb micropowder in preparing drug for Alzheimer's disease |
| CN115317399A (en) * | 2022-07-07 | 2022-11-11 | 湖北真福医药有限公司 | Anti-aging composition and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101842089A (en) | Methods for stimulating synthesis of pro-collagen or collagen and hyaluronic acid | |
| MX2012005609A (en) | Aloe vera sprout concentrate or extract having superior skin cell growth promotion, antioxidant, and anti-allergy effects. | |
| CN101450095A (en) | Medicine composition with blood-sugar reduction function and preparation method thereof | |
| CN104274509A (en) | Health product composition containing cordyceps sinensis and male flower of eucommia ulmoides as well as preparation method and application of health product composition | |
| CN107411987A (en) | A kind of clear acne compound essential oil of face and preparation method thereof | |
| CN101450151A (en) | Medicine composition with anti-oxidation and senescence prevention function and preparation method thereof | |
| CN101433634A (en) | Pharmaceutical composition with functions for resisting oxidation and delaying consenescence and preparation method thereof | |
| CN104224885A (en) | Traditional Chinese medicine composition for relieving physical fatigue | |
| CN104983844A (en) | Edible composition formula with mucous-membrane restoring function and preparation process of preparation thereof | |
| CN101450114A (en) | Medicine composition with anti-oxidation and senescence prevention function and preparation method thereof | |
| JPH09208484A (en) | Active oxygen-eliminator and composition containing the same | |
| CN101450150A (en) | Medicine composition with anti-oxidation and senescence prevention function and preparation method thereof | |
| CN102342903A (en) | Skincare composition as well as use and method of same for preventing and delaying skin aging | |
| CN103142916B (en) | Medicament for preventing and treating senile dementia and preparation method thereof | |
| CN101450088A (en) | Medicine composition with anti-oxidation and senescence prevention function and preparation method thereof | |
| CN111053731A (en) | Moisturizing toner | |
| CN101590087A (en) | A kind of composition and method of making the same of delaying female aging | |
| CN102462743B (en) | Chinese medicine composition with auxiliary protection action on chemical hepatic injury as well as preparation method and application thereof | |
| CN115444922A (en) | Anti-fatigue medicinal and edible composition and application thereof | |
| CN109010579A (en) | A kind of antioxidant and anti-aging Chinese traditional compound medicine and preparation method thereof | |
| CN1401365A (en) | Chinese health medicine | |
| DE202008015430U1 (en) | Composition for the treatment of indigestion | |
| CN101433597A (en) | Chinese medicinal composition with function for reducing blood sugar and preparation method thereof | |
| CN100370973C (en) | Traditional Chinese medicinal prepn. for treating obstruction of qi in the chest | |
| KR20050067837A (en) | Composition for slimming |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20090520 |