CN101450114A - Medicine composition with anti-oxidation and senescence prevention function and preparation method thereof - Google Patents
Medicine composition with anti-oxidation and senescence prevention function and preparation method thereof Download PDFInfo
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- CN101450114A CN101450114A CNA2007101785574A CN200710178557A CN101450114A CN 101450114 A CN101450114 A CN 101450114A CN A2007101785574 A CNA2007101785574 A CN A2007101785574A CN 200710178557 A CN200710178557 A CN 200710178557A CN 101450114 A CN101450114 A CN 101450114A
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- polygoni multiflori
- radix polygoni
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Abstract
The invention discloses a pharmaceutical composition with antioxidanting and aging-delaying function and preparation method thereof. The pharmaceutical composition is made from fleece-flower root, tocopherol and isoflavones according to a certain weight proportion; and it can be made into any common oral taken preparation form. The traditional Chinese medicine composition in the invention achieves the functions of antioxidanting and aging-delaying.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof, belong to medicine and field of health care food with antioxidation, deferring senility.
Background technology
Britain Harman took the lead in proposing free radical in 1956 relevant with body aging and disease, then delivered first piece of research report in nineteen fifty-seven, but set forth with contain the 0.5%-1% free radical scavenger forage feed mice life-saving.Because free radical theory can be explained all symptoms that occur in the body aging process more clearlyly, as senile plaque, wrinkle and immunity degradation etc., therefore receive much attention, be that people institute generally accepts.The old and feeble theoretical centre point of free radical thinks, and is old and feeble from producing free radical in the body homergy process at random and destructive exercising result causes that by free radical the main mechanism of body aging may be summarized to be following three aspects.
1, the cross-linked polymeric of life macromolecule and refer to the accumulation of brown element
Free radical acts on lipid peroxidation, and oxidation end-product malonaldehyde etc. can cause the cross-linked polymeric of life macromolecules such as protein, nucleic acid, and this phenomenon is old and feeble Fundamentals.Lipofuscin (Lipofuscin) is water insoluble so be difficult for being excluded, bulk deposition in cell so just, accumulation at Skin Cell, promptly form senile plaque, this is old old and feeble a kind of appearance symbol: and the accumulation of Skin Cell hypomnesis or dysnoesia then can occur even senile dementia occur.The cross-linked polymeric of collagen protein can make collagen protein decreased solubility, elasticity reduce and hydratability goes down, and causes senile skin to lose tension force and wrinkle increases and old inostosis ability weakens etc.The peroxidating of lipid causes lens pathological changes such as retina is fuzzy to occur, brings out senile visual disorder (as dim eyesight, cataract etc.) to occur.Owing to the destruction of free radical causes skin aging, wrinkle appears, and the accumulation of lipofuscin makes the decline of Skin Cell immunity cause the cutaneous tumor susceptibility to strengthen, and these all are the destruction of free radical.
2, the destruction of organ-tissue cell and minimizing
The destruction of organ-tissue cell and minimizing are one of symptoms of body aging.The for example obvious minimizing of neuronal cell quantity is the another major reason that causes old people's sensation and hypomnesis, heavy and dysnoesia.Organ-tissue cytoclasis or minimizing mainly are because gene mutation has changed the transmission of hereditary information, cause the resultant fault of protein and enzyme and the reduction of enzymatic activity.These accumulation has caused the aging and dead of organ-tissue cell.Unsaturated fatty acid on the biomembrane very easily is subjected to the invasion and attack generation peroxidization of free radical, and Oxidation has significant effects to aging, and free radical is by having quickened the senescence process of cell to the invasion and attack of lipid.
3, the reduction of immunologic function
Free radical acts on immune system, or acts on lymphocyte and make it impaired, causes that old people's cellular immunization and humoral immune function weaken, and immune discernment is descended autoimmune disease occurs.
So-called autoimmune disease is exactly that immune system is not only attacked pathogen and abnormal cell, has also invaded self normal healthy tissue simultaneously, external foreign body is used as by autologous tissue attacks.As the autoimmune disease of dispersivity scleroderma, systemic scleroma, ulcerative colitis, collagen pathological changes and CrohnnShi disease (Crohn) and so on, often with more chromosome breakage.Studies show that the pathological process of autoimmune disease and free radical have very big relation.
The free radical that scientists is found the infringement health is nearly all relevant with the stronger oxygen carrier of those activity, and they are called reactive oxygen free radical to the free radical that combines with these materials.Reactive oxygen free radical is actually a kind of oxidizing process to the infringement of human body.Therefore, reduce the infringement of free radical, will do from antioxidation.The approach that reduces free radical harm has two: the one, and, utilize unnecessary free radical in the endogenous free radical scavenging System Cleaning body; The 2nd, excavate exogenous antioxidant-free radical scavenger, the invasion of blocking-up radical pair human body.
Summary of the invention
The object of the invention just provides a kind of pharmaceutical composition that has antioxidation, removes free radical, deferring senility.
Another object of the present invention has provided this preparation of drug combination method.
The present invention is achieved by the following technical solutions:
The present invention is made by the following weight proportion raw material:
Radix Polygoni Multiflori 6-12 part, vitamin E 0.001-0.005 part, soybean isoflavone 0.01-0.1 part
Be preferably:
9 parts of Radix Polygoni Multiflori, 0.003 part of vitamin E, 0.04 part of soybean isoflavone
Preparation of drug combination method of the present invention is as follows:
Radix Polygoni Multiflori is added water or ethanol extracts, extracting solution is concentrated, drying makes dry extract, is ground into powder, adds vitamin E, soybean isoflavone; Add various conventional adjuvant required when preparing different dosage form, as diluent, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, capsule, soft capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation, oral liquid etc.
The preferred for preparation method of Chinese medicine composition of the present invention is as follows:
The Radix Polygoni Multiflori of described weight proportion is added the ethanol extraction twice of 10 times of amounts and 8 times of amounts 70%, and merge extractive liquid, filters, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30, drying under reduced pressure down for 60 ℃, make dry extract, be ground into powder, add vitamin E, soybean isoflavone; Add various conventional adjuvant required when preparing different dosage form, as diluent, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, capsule, soft capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation, oral liquid etc.
The using method of pharmaceutical composition of the present invention:
Oral; Day dose is in crude drug: Radix Polygoni Multiflori 6-12g, vitamin E 0.001-0.005g, soybean isoflavone 0.01-0.1g, and preferred: Radix Polygoni Multiflori 9g, vitamin E 0.003g, soybean isoflavone 0.04g; Every day 2-3 time.
Each drug mechanism is as follows among the present invention:
Radix Polygoni Multiflori: have black beard and hair, improving healthy complexion, beneficial intensive culture blood, antidotal effect.Radix Polygoni Multiflori mainly contains three effective constituents: stilbene glycosides compound, anthraquinone analog compound and polymerization procyanidin.Contain lecithin and various trace elements in addition.Experimental result shows, Radix Polygoni Multiflori can obviously reduce Aged Mice brain and hepatic tissue mda content, increase monoamine transmitters content in the brain, enhance SOD activity, the activity that can also obviously suppress monoamine oxidase-B in Aged Mice brain and the hepatic tissue, thereby eliminate the damage of radical pair body, the generation of slow down aging and disease.The generation of lipid peroxide and deposition can cause a series of senile symptom, therefore the content of lipid peroxide is to estimate one of old and feeble leading indicator, Radix Polygoni Multiflori extract has very obvious suppression effect to the generation of mouse skin lipid peroxide, illustrate that Radix Polygoni Multiflori has the effect of delaying decrepitude of skin, can be used as the advantages of good skin antisenility cosmetics additive.In addition, Radix Polygoni Multiflori can also obviously improve the periphery lymphocyte DNA damage repair ability of senile rat, by suppressing monoamine oxidase-B activity in the brain, influences the content of organism central neurotransmitter, thereby regulates the nervus centralis activity, delays the aging of brain.
Soybean isoflavone: soybean isoflavone is chemically relevant with estrogen activity as analog, show and suppress and collaborative two-ways regulation effect: when human body inner estrogen level is on the low side, isoflavone occupies estrogen receptor, the weak estrogen effect of performance shows the effect that improves estrogen level; When human body inner estrogen level was too high, isoflavone occupied acceptor site in " competition " mode, the weak estrogen effect of performance simultaneously, thereby show the effect that reduces body inner estrogen level on the whole.The affinity of it and brain, prostate, bladder, cardiovascular, these receptors of osseous tissue is strong, and a little less than the affinity to uterus, ovary, mammary gland etc., and its activity has only the 1/1000-1/100000 of estrogen.Thereby avoided complementing estrogen may bring out the risk of cancer.Soybean isoflavone has the prevention menopausal syndrome, prevents, improves osteoporosis, Breast Cancer Prevention, and angiocardiopathy preventing, the prevention degenerative brain disorder, beauty treatment, slow down aging improve the discomfort in menstrual period, improve the effect of women's life quality.
Vitamin E: vitamin E is a kind of vitamin with anti-oxidation function, is a kind of strong effectively free radical scavenger of body, so can improve the immunity of body.Vitamin E deficiency can cause that phagocyte engulfs the function of antibacterial and suppressed, and vitamin E also can stimulate the body production of antibodies, to keeping body's immunological function, prophylactic playing an important role.
In the present composition, Radix Polygoni Multiflori has played effects such as delaying skin and hair aging, soybean isoflavone has weak estrogen-like effects, can delay and prevent that female aging, vitamin E from being free radical scavenger, three medicine compatibilities can reach comprehensive antidotal effect, the effect that three medicine compatibilities have strengthened antioxidation, removed free radical, fundamentally reached antidotal effect, and promoted and keep health with human body, be particularly suitable for the women and take.
In sum, the present composition has antioxidation, slow down aging, removing free radical, radioprotective, improves memory impairments.Can be used for preparing the medicine and the health product of antioxidation, slow down aging, removing free radical, radioprotective and improvement memory.
The present invention with respect to prior art have determined curative effect, have no side effect, taking convenience, cheap advantage.
Further set forth the beneficial effect of Chinese medicine composition of the present invention by following experiment.
Adopt the hepatomicrosome lipid peroxidation model of rat to detect present composition antioxidative activity, can significantly increase the GSH content of white mice, show that the present composition has defying age and antioxidant activity through laboratory observation; Can significantly increase the SOD enzymatic activity of white mice liver, when comparing with matched group, total SOD (T-SOD), cytosol SOD (Cu.Zn-SOD) and mitochondrion SOD (Mn-SOD) enzymatic activity all demonstrate the growth on the statistical significance when all dosage, show that the present composition has antioxidant activity; Reduced malonaldehyde (MDA) content of white mice effectively, shown that the present composition has prevention or the synthetic antioxidant activity of minimizing malonaldehyde (MDA) in the body.
The specific embodiment
Embodiment 1:
The preparation of the capsule of pharmaceutical composition of the present invention
A) take by weighing Radix Polygoni Multiflori 90g, soybean isoflavone 0.4g, vitamin E 0.03g is standby;
B) Radix Polygoni Multiflori adds the ethanol extraction twice of 10 times of amounts and 8 times of amounts 70%, and merge extractive liquid, filters, and reclaims ethanol, is evaporated to relative density and measures 1.25-1.30 down for 60 ℃, and drying under reduced pressure makes dry extract;
C) dry extract is broken into powder, adds soybean isoflavone, vitamin E, mix the snap fit capsule of packing into appropriate amount of auxiliary materials.
Embodiment 2:
The preparation of the granule of Chinese medicine composition of the present invention
A) take by weighing Radix Ginseng 30g, Radix Polygoni Multiflori 60g, soybean isoflavone 0.1g, vitamin E 0.03g are standby;
B) Radix Polygoni Multiflori adds the ethanol extraction twice of 10 times of amounts and 8 times of amounts 70%, and merge extractive liquid, filters, and reclaims ethanol, is evaporated to relative density and measures 1.25-1.30 down for 60 ℃, and drying under reduced pressure makes dry extract;
C) dry extract is broken into powder, adds soybean isoflavone, vitamin E, add ethanol and make adhesive, add appropriate amount of starch and make filler, make granule.
Embodiment 3:
The preparation of the granule of Chinese medicine composition of the present invention
A) take by weighing Radix Ginseng 90g, Radix Polygoni Multiflori 120g, soybean isoflavone 1g, vitamin E 0.03g are standby;
B) Radix Polygoni Multiflori adds the water extraction twice of 10 times of amounts and 8 times of amounts, and merge extractive liquid, filters, and reclaims ethanol, is evaporated to relative density and measures 1.25-1.30 down for 60 ℃, and drying under reduced pressure makes dry extract;
C) dry extract is broken into powder, adds soybean isoflavone, vitamin E, add ethanol and make adhesive, add appropriate amount of starch and make filler, make granule.
Embodiment 4:
The preparation of the tablet of Chinese medicine composition of the present invention
A) take by weighing Radix Ginseng 60g, Radix Polygoni Multiflori 60g, soybean isoflavone 0.4g, vitamin E 0.03g are standby;
B) Radix Polygoni Multiflori adds the ethanol extraction twice of 10 times of amounts and 8 times of amounts 70%, and merge extractive liquid, filters, and reclaims ethanol, is evaporated to relative density and measures 1.25-1.30 down for 60 ℃, and drying under reduced pressure makes dry extract;
C) dry extract is broken into powder, adds soybean isoflavone, vitamin E, add adjuvant and make granule, and dry, and compacting is in flakes.
Embodiment 5:
The preparation of the effervescent tablet of Chinese medicine composition of the present invention
A) take by weighing Radix Ginseng 70g, Radix Polygoni Multiflori 80g, soybean isoflavone 0.4g, vitamin E 0.03g are standby;
B) Radix Polygoni Multiflori adds the ethanol extraction twice of 10 times of amounts and 8 times of amounts 70%, and merge extractive liquid, filters, and reclaims ethanol, is evaporated to relative density and measures 1.25-1.30 down for 60 ℃, and drying under reduced pressure makes dry extract;
C) dry extract is broken into powder, adds soybean isoflavone, vitamin E, add tartaric acid, sodium bicarbonate, sweeting agent, filler mixing, granulate with dehydrated alcohol, drying adds the lubricant mixing, tabletting, promptly.
Embodiment 6:
The preparation of the dispersible tablet of Chinese medicine composition of the present invention
A) take by weighing Radix Ginseng 80g, Radix Polygoni Multiflori 70g, soybean isoflavone 0.4g, vitamin E 0.03g are standby;
B) Radix Polygoni Multiflori adds the ethanol extraction twice of 10 times of amounts and 8 times of amounts 70%, and merge extractive liquid, filters, and reclaims ethanol, is evaporated to relative density and measures 1.25-1.30 down for 60 ℃, and drying under reduced pressure makes dry extract;
C) dry extract is broken into powder, adds soybean isoflavone, vitamin E, add disintegrating agent, filler or diluent, mix homogeneously adds binding agent and makes soft material, the system granule, and drying adds part disintegrating agent, fluidizer or lubricant mixing, tabletting, promptly.
Claims (5)
1, a kind of pharmaceutical composition with antioxidation, delaying senility function is characterized in that, said composition is to be made by following bulk drugs: Radix Polygoni Multiflori 6-12 part, vitamin E 0.001-0.005 part, soybean isoflavone 0.01-0.1 part.
2, pharmaceutical composition according to claim 1 is characterized in that, said composition is to be made by following bulk drugs: 9 parts of Radix Polygoni Multiflori, 0.003 part of vitamin E, 0.04 part of soybean isoflavone.
3, claim 1 or 2 described preparation of drug combination methods is characterized in that this method is:
Radix Polygoni Multiflori is added water or ethanol extracts, extracting solution is concentrated, drying makes dry extract, is ground into powder, adds soybean isoflavone, vitamin E, is prepared into active component; The gained active component is mixed with adjuvant, make any medicament on the pharmaceutics.
4, according to the described preparation of drug combination method of claim 3, it is characterized in that this method is:
Radix Polygoni Multiflori is added the ethanol extraction twice of 10 times of amounts and 8 times amount 70%, and merge extractive liquid, filters, and reclaims ethanol, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract, be ground into powder, add soybean isoflavone, vitamin E, be prepared into active component; The gained active component is mixed with adjuvant, make any medicament on the pharmaceutics.
5, claim 1 or 2 described pharmaceutical compositions are used to prepare the application of the medicine or the health food of antioxidation and slow down aging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101785574A CN101450114A (en) | 2007-11-30 | 2007-11-30 | Medicine composition with anti-oxidation and senescence prevention function and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101785574A CN101450114A (en) | 2007-11-30 | 2007-11-30 | Medicine composition with anti-oxidation and senescence prevention function and preparation method thereof |
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| CN101450114A true CN101450114A (en) | 2009-06-10 |
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| CNA2007101785574A Pending CN101450114A (en) | 2007-11-30 | 2007-11-30 | Medicine composition with anti-oxidation and senescence prevention function and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102342414A (en) * | 2011-10-10 | 2012-02-08 | 武汉东方天琪生物工程有限公司 | Nutritional supplement for regulating endocrine based on gastrointestinal tract function improvement and preparation method thereof |
| WO2013053075A1 (en) * | 2011-10-10 | 2013-04-18 | Huang Daiyong | Nutritional supplement for endocrine modulation on the basis of gastrointestinal tract function improvement and preparation method |
| CN103099210A (en) * | 2012-08-29 | 2013-05-15 | 江门市新会区光华生物科技有限公司 | Polygonum multiflorum nutrient tablet and making method thereof |
| CN109588714A (en) * | 2019-02-20 | 2019-04-09 | 吉林大学 | A kind of panax ginseng fruit powder chewable tablet and preparation method thereof with anti-senescence function |
-
2007
- 2007-11-30 CN CNA2007101785574A patent/CN101450114A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102342414A (en) * | 2011-10-10 | 2012-02-08 | 武汉东方天琪生物工程有限公司 | Nutritional supplement for regulating endocrine based on gastrointestinal tract function improvement and preparation method thereof |
| WO2013053075A1 (en) * | 2011-10-10 | 2013-04-18 | Huang Daiyong | Nutritional supplement for endocrine modulation on the basis of gastrointestinal tract function improvement and preparation method |
| CN103099210A (en) * | 2012-08-29 | 2013-05-15 | 江门市新会区光华生物科技有限公司 | Polygonum multiflorum nutrient tablet and making method thereof |
| CN103099210B (en) * | 2012-08-29 | 2014-08-13 | 江门市新会区光华生物科技有限公司 | Polygonum multiflorum nutrient tablet and making method thereof |
| CN109588714A (en) * | 2019-02-20 | 2019-04-09 | 吉林大学 | A kind of panax ginseng fruit powder chewable tablet and preparation method thereof with anti-senescence function |
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Open date: 20090610 |