CN101422569A - Health-care preparation capable of increasing the multiplication function of marrow hemopoietic stem cells to fight against senium and anaemia - Google Patents
Health-care preparation capable of increasing the multiplication function of marrow hemopoietic stem cells to fight against senium and anaemia Download PDFInfo
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- CN101422569A CN101422569A CNA2008102336651A CN200810233665A CN101422569A CN 101422569 A CN101422569 A CN 101422569A CN A2008102336651 A CNA2008102336651 A CN A2008102336651A CN 200810233665 A CN200810233665 A CN 200810233665A CN 101422569 A CN101422569 A CN 101422569A
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Abstract
The invention relates to a health product preparation which improves the proliferation ability of bone marrow hematopoietic stem cells to achieve the purposes of anti-aging and anti-anaemia and according to weights, the health product preparation is prepared with the following medicinal material components: 60g to 90g of donkey hide gelatin, 60g to 90g of sophora flowers, 120g to 250g of astragalus, 120g to 250g of rhizoma pollgonati, 90g to 150g of prepared radix rehmanniae, 20g to 55g of glycyrrhiza, 15g to 30g of lactose, 25g to 60g of pre-gelatinized starch and 15g to 30g of maltodextrin. The health product preparation plays the roles of strengthening human immunity, antioxidation and anti-aging, anti-anaemia and improving growth and development and has an auxiliary protection function for chemical liver injury. After being taken by various populations according to requirements, the preparation achieves the purposes of building up bodies, resisting diseases, delaying aging and improving growth and development by strengthening immunity and antioxidation function and has an auxiliary protection function for chemical liver injury, and the preparation is also beneficial to body trouble or various diseases.
Description
Technical field
The present invention relates to a kind of nutraceutical with medical health care function, especially a kind of marrow hemopoietic stem cells multiplication capacity that can improve reaches defying age, anti-anemia health-care preparation.
Background technology
At present, comprise that the various anemia sickness rate of nutritional anemia are high, except that nutritional anemia, anemia also can be divided into because of erythropoiesis reduce and because of hematoclasis too much or lose anemia extremely; The aging of human body is a kind of normal phenomenon, but occurs owing to subhealth state disease, climacteric syndrome etc. cause people's the old and feeble abnormality of the non-natural law, to this, uses existing Drug therapy generally can not reach ideal effect.
Existing functional food such as the Donga Colla Corii Asini that improves nutritional anemia, heart K mends snow or beneficial blood and gives birth to or the like, and health-care effect is not remarkable, can only be as complementary food.Shang Weijian relates to bibliographical information of the present invention or product.
Summary of the invention
The purpose of this invention is to provide a kind of marrow hemopoietic stem cells multiplication capacity that can improve and reach defying age, anti-anemia health-care preparation, its by the exciting human marrow hemopoietic stem cells from source property multiplication capacity, reach and strengthen human immunity, defying age and antioxidation, anti-anemia function.
The present invention reaches by the following technical programs:
A kind of raising marrow hemopoietic stem cells multiplication capacity reaches defying age, anti-anemia health-care preparation, it is characterized in that making by following medical material component by weight: Colla Corii Asini 60 grams～90 grams, Flos Sophorae 60 grams～90 grams, the Radix Astragali 120 grams～250 grams, Rhizoma Polygonati 120 grams～250 grams, Radix Rehmanniae Preparata 90 grams～150 grams, Radix Glycyrrhizae 20 grams～55 grams, lactose 15 grams～30 grams, pregelatinized Starch 25 grams～60 grams, maltodextrin 15 grams～30 grams.
Described health preparation component also is all chemical compounds, bioactive ingredients and all kinds of molecular cluster and the derivant of extracting in each proportioning raw material.
As the preparation method of above-mentioned health-care preparation, its feature exists:
1). make a gesture of measuring by set of dispense and to get the Radix Astragali, Rhizoma Polygonati, Radix Glycyrrhizae, Radix Rehmanniae Preparata and Flos Sophorae medical material respectively and choose, remove impurity and non-medicinal part and polishing proportional quantity in the medical material;
2). clean three times with drinking circulating water choosing qualified medical material, after the Flos Sophorae medical material that is used for beating fecula dewatered with centrifuge, the control temperature was carried out drying at 60 ± 5 ℃, is dried to moisture content 3～8%;
3). dry good medical material and Colla Corii Asini are crossed 80 mesh sieves after being crushed to 80 orders, the medicated powder after sieving was sterilized 5～8 minutes with cobalt 60, and is standby;
4). be used for the medical material Radix Astragali, Rhizoma Polygonati, Radix Glycyrrhizae and Radix Rehmanniae Preparata that decocting boils, directly decoct with water after the cleaning three times, for the first time, decoct with water 2 hours by 10 times of amounts of crude drug, for the second time, 8 times of amounts by crude drug decoct with water 2 hours, for the third time, decoct with water 1 hour by 8 times of amounts of crude drug, filter, merging filtrate is condensed into the extractum of relative density 1.2～1.25 at 70～80 ℃ with filtrate, and is standby;
5). after fecula that above-mentioned steps (3) and (4) are made and extractum and pharmaceutic adjuvant adopt groove to mix machine to mix 50 minutes, carry out drying, baking temperature is 90 ± 5 ℃, crushed after being dried is crossed 40 mesh sieves, and carry out granulate and cross 40 mesh sieves, the conventional preparation process of employing is prepared into any in capsule, soft capsule, tablet, syrup, oral liquid or the granule powder, and used pharmaceutic adjuvant is maltodextrin, pregelatinized Starch and lactose.
The preparation method of described health-care preparation, during the preparation tablet, earlier HPMC1.4kg and PEG-60000.4kg are successively joined in the 20kg60 ℃ of purified water, the limit edged stirs, the ethanol preparation that fully adds 20Kg95% after the swelling again obtains wrapping the tunica albuginea slurry of film-coat, and this process adds 2Kg titanium dioxide and 1Kg Pulvis Talci in coating preparation in preceding 24 hours before the coating, cross colloid mill after stirring, play circulation;
Take by weighing purified water 10.5Kg, agitator is stretched into 2/3 place under the liquid level, start agitator, make liquid level form whirlpool, the coating materials GMI 2Kg of red powder constantly is sprinkling upon on the whirlpool liquid level with speed stably, continue again to stir 45 minutes to coating materials molten fully diffusing prepare the color film slurry of bag film-coat; Substrate after the compacting is put into high-efficiency coating machine, adopt conventional preparation process, the tunica albuginea slurry for preparing is sprayed to the sheet bed, after 2～3 hours, again the color film slurry for preparing is sprayed to the sheet bed, after 2～3 hours, unilateral smooth exquisiteness.
The Chinese crude drug Quality Identification standard record that each the component raw material medicine that is adopted among the present invention all can be formulated referring to relevant departments such as the Pharmacopoeia of the People's Republic of China (2000 edition) and domestic each province, city, district's health, drug and food supervision and management.
The present invention is in conjunction with Chinese medical theory and System Science, on using for reference the research and development anti-AIDS and treating the relevant empirical basis of cancer new drug, further deeply develop, develop, has heat-clearing and toxic substances removing, the effect of QI and blood regulating, supporting vital QI and dispersing blood stasis, its mechanism be by the exciting human marrow hemopoietic stem cells from source property multiplication capacity, reach enhance immunity, defying age and antioxidation, anti-anemia effect.It can strengthen body immunity, antioxidant and anti-aging, anti-anemia, improve growth promoter, chemical liver injury is had assistant protection function, after all kinds of crowds take on request, by enhancing immunity and anti-oxidation function reach building body, resist disease, slow down aging; Improve growth promoter, chemical liver injury is had assistant protection function, also helpful to the uncomfortable or all kinds of disease that causes because of immunologic hypofunction.
Description of drawings
Fig. 1 is the preparation technology's flow chart of embodiment among the present invention.
The specific embodiment
Describe the detailed production craft step of preparation tablet in detail below in conjunction with accompanying drawing 1.
1. take by weighing Flos Sophorae 80 grams by weight respectively, the Radix Astragali 185 grams, Rhizoma Polygonati 185 grams, Radix Rehmanniae Preparata 133 grams, Radix Glycyrrhizae 31 grams are chosen, and impurity in the medical material and non-medicinal part are removed; And the polishing formula ratio, for guaranteeing the fecula formula ratio, the medical material Flos Sophorae can suitably increase inventory.
2. clean 3 times with drinking circulating water choosing qualified medical material, after the Flos Sophorae medical material that is used for beating fecula dewatered with centrifuge, on the rustless steel baking tray that tiles, it was dry to put into the medicinal material drying case, and temperature is controlled at 60 ℃; Can be dried to moisture content 3～8%, look easy pulverizing of medical material drying time and be advisable.
3. get Colla Corii Asini 80 grams and dry good medical material after coarse pulverization to 10 order, fine powder are broken to 80 orders, cross 80 mesh sieves; Medicated powder after sieving was sterilized 5～8 minutes with cobalt C60, standby.
4. be used for the medical material Radix Astragali, Rhizoma Polygonati, Radix Glycyrrhizae, Radix Rehmanniae Preparata that decocting boils, do not need to dewater, decoct with water three times, for the first time, 10 times of amounts by crude drug decoct with water 2 hours, for the second time, decoct with water 2 hours by 8 times of amounts of crude drug, for the third time, 8 times of amounts by crude drug decoct with water 1 hour, filter merging filtrate, under 70-80 ℃, filtrate is condensed into the extractum of relative density 1.25-1.30, standby.
5. the fecula and the adjuvant that obtain of extractum that above-mentioned the 4th step is obtained and the 3rd step evenly stirs, the molding of last tablet manufacturing line pressure sheet, and said adjuvant is maltodextrin 25 grams, pregelatinized Starch 25 grams and lactose 27 grams.After mixing machine and mix 50 minutes with groove, be taped against and carry out drying in the stainless steel disc, baking temperature is 90 ℃, and dry back is crushed to 40 orders with pulverizer, and carries out granulate by 40 orders and sieve.
6. wrap the preparation of film-coat: HPMC1.4kg and PEG-6000 0.4kg are successively joined in the 20kg60 ℃ of purified water with the tunica albuginea slurry, the limit edged stirs, the ethanol that fully adds 20Kg 95% after the swelling again, this process is in coating preparation in preceding 24 hours, add 2Kg titanium dioxide 1Kg Pulvis Talci before the coating, cross colloid mill after stirring, play circulation.
The preparation that the bag film-coat is starched with the color film: take by weighing purified water 10.5Kg, agitator is stretched into 2/3 place under the liquid level, start agitator, make liquid level form whirlpool, the coating materials GMI2Kg of red powder shape constantly is sprinkling upon on the whirlpool liquid level with speed stably, continues again to stir and loose to coating materials is molten fully in 45 minutes.
7. the substrate after will suppressing is put into high-efficiency coating machine, preparation process starts each system of coating equipment routinely, adjust parameters such as spray speed, intake, inlet temperature, pot speed, exhaust air rate, the tunica albuginea slurry for preparing is sprayed to the sheet bed, after 2～3 hours, make unilateral smooth exquisiteness, again the color film slurry for preparing is sprayed to the sheet bed, after 2～3 hours, make unilateral exquisiteness, color and luster is even.
More than amount to six kinds of materials and three kinds of adjuvants, according to medicine and the active characteristics of adjuvant, through powder process, water is carried and pharmaceutical technology such as mixing is handled, the drug rate by 99.90%, every tablet net weight 0.4 gram, and keep moisture content 4～8%, can produce 1000 tablets.
According to the health product that the present invention makes, its trade name is defined as " Ai Siyi " health care sheet.Be used for the volunteer human body, shown many positive functional result.As menoxenia, the withered and yellow women of face, take 2～4 every day, just transfer after 20～30 days, have rosy cheeks, pore shrinks, the colour of skin bleaches along menstrual period.Middle-aged and elderly people: take 2～4 every night, can improve sleep and diet situation, keep good physical ability and mental status, and obviously help the non-drug therapy of some Senile disease; Be in the compensatory phase person of liver function for various, take 3～8 every day, can obviously improve patient's symptom, improve liver function.After all kinds of cancer patients took 3～6 every day, quality of life made moderate progress, and spiritual appetite takes a turn for the better, and life quality obviously improves, and prolong life cycle; Cooperate cancer patient operation back radiation and chemotherapy, take 6～8 " Ai Siyi " every day, it is anti-puts, the function of the side effect due to the chemotherapy is fairly obvious, patient is not basically under the prerequisite by the doctor trained in Western medicine auxiliary treatment, can withstand that postoperative is put, the treatment of chemotherapy, and improve the routine blood test index, put, the untoward reaction of chemotherapy drops to minimum.
The conclusion of the statement of Xi'an Jiaotong University Medical College's clinical pharmacology institute " Ai Siyi health care sheet (SE) is to the experimental study of bone marrow depression mouse bone marrow cells hematopoietic stem cell function effect " is: " CTX can obviously suppress the propagation of mouse bone marrow cells hematopoietic stem cell, makes CD in the mouse bone marrow cells
34+ hemopoietic progenitor cell percentage ratio descends, and significantly reduces quantity and the HGB content of WBC, RBC and PLT in the mice peripheral blood, and mouse bone marrow cells suppresses the model success.SE can obviously promote bone marrow depression model mice bone marrow stem cell propagation, significantly promotes CD in the bone marrow
34The quantity of hemocyte and HGB content in+cell percentage ratio and the peripheral blood, especially particularly evident to the lifting of WBC and PLT ".
Process Beijing Disease Prevention and Control Centre is according to the anti-oxidation function method of inspection in the Ministry of Public Health " health food check and assessment technique standard " (version in 2003), Ai Siyi health care sheet (SE sheet) mensuration of anti-oxidation function, three biochemical indicators of surveying: the positive result of superoxide dismutase in the mice serum (SOD) vitality test have been carried out; The positive result of mice whole blood glutathione peroxidase (GSH-px) determination of activity; The positive result of lipid peroxide in the mice serum (MDA) assay.
Evaluation criterion according to Ministry of Public Health " health food check and assessment technique standard " (version in 2003) is judged the positive result of this given the test agent antioxidation zoopery.
Claims (5)
1, a kind of raising marrow hemopoietic stem cells multiplication capacity reaches defying age, anti-anemia health-care preparation, it is characterized in that making by following medical material component by weight: Colla Corii Asini 60 grams～90 grams, Flos Sophorae 60 grams～90 grams, the Radix Astragali 120 grams～250 grams, Rhizoma Polygonati 120 grams～250 grams, Radix Rehmanniae Preparata 90 grams～150 grams, Radix Glycyrrhizae 20 grams～55 grams, lactose 15 grams～30 grams, pregelatinized Starch 25 grams～60 grams, maltodextrin 15 grams～30 grams.
2, health-care preparation as claimed in claim 1 is characterized in that said preparation made by following medical material component by weight: Colla Corii Asini 80 grams, Flos Sophorae 80 grams, the Radix Astragali 185 grams, Rhizoma Polygonati 185 grams, Radix Rehmanniae Preparata 133 grams, Radix Glycyrrhizae 31 grams, lactose 27 grams, pregelatinized Starch 25 grams, maltodextrin 25 grams.
3, health-care preparation as claimed in claim 1 or 2 is characterized in that all chemical compounds, bioactive ingredients and all kinds of molecular cluster and derivant that said health preparation component is also extracted in each proportioning raw material.
4, the preparation method of health-care preparation as claimed in claim 1 or 2, its feature exists:
1). make a gesture of measuring by set of dispense and to get the Radix Astragali, Rhizoma Polygonati, Radix Glycyrrhizae, Radix Rehmanniae Preparata and Flos Sophorae medical material respectively and choose, remove impurity and non-medicinal part and polishing proportional quantity in the medical material;
2). clean three times with drinking circulating water choosing qualified medical material, after the Flos Sophorae medical material that is used for beating fecula dewatered with centrifuge, the control temperature was carried out drying at 60 ± 5 ℃, is dried to moisture content 3～8%;
3). dry good medical material and Colla Corii Asini are crossed 80 mesh sieves after being crushed to 80 orders, the medicated powder after sieving was sterilized 5～8 minutes with cobalt 60, and is standby;
4). be used for the medical material Radix Astragali, Rhizoma Polygonati, Radix Glycyrrhizae and Radix Rehmanniae Preparata that decocting boils, directly decoct with water after the cleaning three times, for the first time, decoct with water 2 hours by 10 times of amounts of crude drug, for the second time, 8 times of amounts by crude drug decoct with water 2 hours, for the third time, decoct with water 1 hour by 8 times of amounts of crude drug, filter, merging filtrate is condensed into the extractum of relative density 1.2～1.25 at 70～80 ℃ with filtrate, and is standby;
5). after fecula that above-mentioned steps (3) and (4) are made and extractum and pharmaceutic adjuvant adopt groove to mix machine to mix 50 minutes, carry out drying, baking temperature is 90 ± 5 ℃, crushed after being dried is crossed 40 mesh sieves, and carry out granulate and cross 40 mesh sieves, the conventional preparation process of employing is prepared into any in capsule, soft capsule, tablet, syrup, oral liquid or the granule powder, and used pharmaceutic adjuvant is maltodextrin, pregelatinized Starch and lactose.
5, the preparation method of health-care preparation as claimed in claim 4, when it is characterized in that preparing tablet, earlier HPMC1.4kg and PEG-60000.4kg are successively joined in the 20kg60 ℃ of purified water, the limit edged stirs, the ethanol preparation that fully adds 20Kg95% after the swelling again obtains wrapping the tunica albuginea slurry of film-coat, and this process adds 2Kg titanium dioxide and 1Kg Pulvis Talci in coating preparation in preceding 24 hours before the coating, cross colloid mill after stirring, play circulation;
Take by weighing purified water 10.5Kg, agitator is stretched into 2/3 place under the liquid level, start agitator, make liquid level form whirlpool, the coating materials GMI 2Kg of red powder constantly is sprinkling upon on the whirlpool liquid level with speed stably, continue again to stir 45 minutes to coating materials molten fully diffusing prepare the color film slurry of bag film-coat; Substrate after the compacting is put into high-efficiency coating machine, adopt conventional preparation process, the tunica albuginea slurry for preparing is sprayed to the sheet bed, after 2～3 hours, again the color film slurry for preparing is sprayed to the sheet bed, after 2～3 hours, unilateral smooth exquisiteness.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008102336651A CN101422569B (en) | 2008-12-02 | 2008-12-02 | Health-care preparation capable of increasing the multiplication function of marrow hemopoietic stem cells to fight against senium and anaemia |
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| CN2008102336651A CN101422569B (en) | 2008-12-02 | 2008-12-02 | Health-care preparation capable of increasing the multiplication function of marrow hemopoietic stem cells to fight against senium and anaemia |
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| CN101422569A true CN101422569A (en) | 2009-05-06 |
| CN101422569B CN101422569B (en) | 2011-07-20 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102266350A (en) * | 2011-07-20 | 2011-12-07 | 黄必录 | Scheme for reversing stem cell aging |
| CN103127276A (en) * | 2011-11-29 | 2013-06-05 | 北京清美联创干细胞科技有限公司 | Anti-aging health care preparation by promoting proliferation and differentiation in stem cells |
| CN110897163A (en) * | 2019-12-26 | 2020-03-24 | 山东尧旺健康科技有限公司 | Oral liquid for activating stem cells to achieve anti-aging effect and preparation process thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1194863A (en) * | 1998-04-28 | 1998-10-07 | 王成余 | Powder for invigorating Qi and promoting generation of blood |
| CN1733136A (en) * | 2005-08-18 | 2006-02-15 | 李朝霞 | Medicine for invigorating qi and nourishing blood comprising donkey-hid gelatin and angelica and process for preparing the same |
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2008
- 2008-12-02 CN CN2008102336651A patent/CN101422569B/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102266350A (en) * | 2011-07-20 | 2011-12-07 | 黄必录 | Scheme for reversing stem cell aging |
| CN103127276A (en) * | 2011-11-29 | 2013-06-05 | 北京清美联创干细胞科技有限公司 | Anti-aging health care preparation by promoting proliferation and differentiation in stem cells |
| CN110897163A (en) * | 2019-12-26 | 2020-03-24 | 山东尧旺健康科技有限公司 | Oral liquid for activating stem cells to achieve anti-aging effect and preparation process thereof |
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| CN101422569B (en) | 2011-07-20 |
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