CN110897163A - Oral liquid for activating stem cells to achieve anti-aging effect and preparation process thereof - Google Patents
Oral liquid for activating stem cells to achieve anti-aging effect and preparation process thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
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Abstract
The invention discloses an oral liquid for activating stem cells to achieve anti-aging, which comprises the following components in parts by weight: 4-12 grams of Chinese yam, 3-9 grams of rhizoma polygonati, 0.6-1.2 grams of ginkgo, 3-6 grams of consweetner, 5-12 grams of schisandra chinensis, 6-9 grams of fructus cnidii, 3-8 grams of semen plantaginis, 0.4-0.6 gram of milt and auxiliary materials.
Description
Technical Field
The invention relates to a health food oral liquid and a preparation process thereof, in particular to an oral liquid which can promote the proliferation and differentiation of stem cells and the proliferation of hematopoietic stem cells in a human body and realize an anti-aging effect and is used for activating the stem cells to realize the anti-aging effect, belonging to the technical field of health foods.
Background
Bone marrow is the generation base of stem cells, stem cells are a type of pluripotent cells with self-replication capacity, and can be differentiated into various functional cells and tissues under certain conditions to continuously renew damaged and aged tissue cells in a human body, but the division and differentiation frequency of the stem cells is determined by the age of the human body, the division and differentiation frequency of the stem cells is faster as the human body ages, and then more stem cells are in the human body, but the division and differentiation frequency of the stem cells is reduced along with the increase of the age of the human body, so that the stem cells in the human body are gradually reduced, and thus the hormone secretion amount for stimulating the synthesis of the stem cells and hemoglobin also starts to be gradually reduced.
The average life of stem cells in the elderly is shorter than that of stem cells in the young and the middle-aged, so that the activities and metabolism of enzymes in erythroblasts are reduced, the damage and aging degree of the stem cells in a reticuloendothelial system are increased, the red bone marrow in the human body is gradually reduced, the function of hematopoietic stem cells is reduced, the immune function of the human body is rapidly reduced, the aging speed of the human body is accelerated, and various diseases are easy to occur.
In order to achieve the aim of resisting aging, a nutritional health-care product for improving the health level of middle-aged and elderly people and young people and prolonging the service life appears on the market, for example, qi and blood replenishing and anti-fatigue oral liquid, 'Changshenglu' oral liquid and the like which can be directly purchased on the market, but the existing anti-aging nutritional health-care product can only be used as auxiliary food for resisting aging and can not effectively activate the activity of stem cells in a human body, so that damaged and aged tissue cells in the human body can not be quickly updated, and the significance of the anti-aging nutritional health-care product on improving the immune function of the human body and delaying the aging of the human body is not great.
Disclosure of Invention
The invention aims to provide the oral liquid which can promote the proliferation and differentiation of stem cells and the proliferation of hematopoietic stem cells in a human body and realize the anti-aging effect and is used for activating the stem cells to realize the anti-aging effect.
In order to solve the technical problems, the invention provides the following technical scheme:
an oral liquid for activating stem cells to achieve anti-aging effect comprises the following components in parts by weight: 4-12 g of yam, 3-9 g of rhizoma polygonati, 0.6-1.2 g of ginkgo, 3-6 g of kangshu, 5-12 g of schisandra, 6-9 g of fructus cnidii, 3-8 g of semen plantaginis, 0.4-0.6 g of fish extract and auxiliary materials.
The following is a further optimization of the above technical solution of the present invention:
the oral liquid comprises the following components in parts by weight: 4 g of Chinese yam, 3 g of rhizoma polygonati, 0.6 g of ginkgo, 3 g of kangshu, 5 g of schisandra chinensis, 6 g of fructus cnidii, 3 g of semen plantaginis, 0.4 g of fish extract and auxiliary materials.
Further optimization: the oral liquid comprises the following components in parts by weight: 8 g of Chinese yam, 6 g of rhizoma polygonati, 0.9 g of ginkgo, 4.5 g of kangshu, 8.5 g of schisandra fruit, 7.5 g of fructus cnidii, 5.5 g of semen plantaginis, 0.5 g of fish extract and auxiliary materials.
Further optimization: the oral liquid comprises the following components in parts by weight: 12 g of yam, 9 g of rhizoma polygonati, 1.2 g of ginkgo, 6 g of kangshu, 12 g of schisandra, 9 g of fructus cnidii, 8 g of semen plantaginis, 0.6 g of fish extract and auxiliary materials.
Further optimization: the auxiliary material is at least one of vitamin B1 and vitamin B12, the proportioning weight of the vitamin B1 is 0.3 g, and the proportioning weight of the vitamin B12 is 0.3 g.
The invention also provides a preparation process of the oral liquid for activating stem cells to achieve anti-aging, which specifically comprises the following steps:
1) accurately weighing the Chinese yam and the rhizoma polygonati according to the weight parts, and pretreating the components;
2) steaming the pretreated rhizoma Dioscoreae and rhizoma Polygonati with a digester, and sieving to obtain nutrient solution A;
3) accurately weighing ginkgo, schisandra, fructus cnidii and semen plantaginis according to the weight parts; and pretreating the component;
4) adding the pretreated ginkgo, the schisandra chinensis, the fructus cnidii and the semen plantaginis into alcohol for soaking, and filtering after soaking to prepare nutrient solution B for later use;
5) taking fresh water fish of more than 4 jin and cutting into blocks, quickly freezing for 2-3 months, pulping by a pulping machine, extracting DNA active factors in the pulp by a centrifugal machine, quickly freezing the DNA active factors for 2 months, pulping again, taking liquid, mixing for use, and finally obtaining refined fish products;
6) weighing 10kg of purified water, putting the purified water into a tank mixer, and putting the nutrient solution A, the nutrient solution B, the fish essence filtrate, the kangshu and the auxiliary materials into the tank mixer to be uniformly mixed and stirred, so as to prepare the oral liquid for activating stem cells to realize anti-aging.
The following is a further optimization of the above technical solution of the present invention:
the pretreatment step in the step 1) is as follows: a) selecting non-medicinal parts from the Chinese yam and the sealwort which are symmetrically measured, and supplementing the proportion; b) washing rhizoma Dioscoreae and rhizoma Polygonati with flowing water; c) drying the cleaned rhizoma Dioscoreae and rhizoma Polygonati in a drying oven at 70-80 deg.C. .
Further optimization: the cooking time of the cooking pot in the step 2) is 40 minutes, and the cooking temperature is controlled to be 50 ℃ and kept for 2 hours; the sieving is carried out by adopting a sieve with 80-100 meshes.
Further optimization: the pretreatment step in the step 3) is as follows: a) selecting non-medicinal parts from semen Ginkgo, fructus Schisandrae chinensis, fructus Cnidii, and semen plantaginis, and supplementing the proportion; b) washing semen Ginkgo, fructus Schisandrae chinensis, fructus Cnidii, and semen plantaginis with flowing water.
Further optimization: the alcohol in the step 4) is edible 95-alcohol-degree alcohol, and the soaking time is 3-4 months.
The invention adopts the technical scheme, has ingenious conception and reasonable structure, uses related Chinese yam, rhizoma polygonati, ginkgo, flavone and schisandra chinensis in regenerative medicine and traditional Chinese medicine food theory for reference in recent years, has the activation effect on proliferation, homing and differentiation of stem cells by using DNA of active factor fish, has the effects of resisting aging, resisting oxidation, resisting anemia, prolonging life, preventing cancer and prolonging life, can improve the function of metabolic balance, and plays a certain role in improving various diseases caused by immune dysfunction.
The oral liquid can quickly activate stem cells of a human body, and can enhance the metabolic activity of the physique, increase the proliferation and migration of hematopoietic stem cells, increase the number of the stem cells, achieve the effects of resisting aging, controlling cancer and tumor, regulating the immune system of the human body, playing the functions of resisting aging, resisting oxidation and preventing cancer, relieving various pathological changes caused by immune dysfunction, improving the body metabolism, eliminating sub-health and delaying aging under any condition without influencing other conditions.
The invention is further illustrated with reference to the following figures and examples.
Drawings
FIG. 1 is a flow chart of a manufacturing process in an embodiment of the present invention.
Detailed Description
Example 1: as shown in fig. 1: an oral liquid for activating stem cells to achieve anti-aging effect comprises the following components in parts by weight: 4 g of Chinese yam, 3 g of rhizoma polygonati, 0.6 g of ginkgo, 3 g of kangshu, 5 g of schisandra chinensis, 6 g of fructus cnidii, 3 g of semen plantaginis, 0.4 g of fish extract and auxiliary materials.
The auxiliary material is vitamin B1, and the weight of the vitamin B1 is 0.3 g.
The fish essence is DNA active factors extracted from freshwater fish.
The preparation method of the oral liquid for activating stem cells to achieve anti-aging specifically comprises the following steps:
1) weighing: accurately weighing the Chinese yam and the rhizoma polygonati in the components.
2) Sorting: the yam and the sealwort which are weighed accurately are selected, the non-medicinal parts doped in the yam and the sealwort are selected, and the selected weights are supplemented to make the weights meet the proportion.
3) Cleaning: washing the sorted Chinese yam and rhizoma polygonati with drinking running water for 3 times.
4) And (3) drying: spreading the cleaned rhizoma Dioscoreae and rhizoma Polygonati on a stainless steel baking tray, and drying in a drying oven at 70 deg.C.
5) And (3) cooking: and (2) steaming the dried Chinese yam and the dried rhizoma polygonati by using a steaming and boiling pot, injecting purified water into the steaming and boiling pot, wherein the weight of the purified water is 2000 g, then adding the Chinese yam and the dried rhizoma polygonati into the steaming and boiling pot, wherein the steaming and boiling time is 40 minutes, the heating temperature in the steaming and boiling pot is 70 ℃, then controlling the steaming and boiling temperature to be 50 ℃ and keeping for 2 hours, and taking juice for later use.
6) Sieving: filtering the juice of rhizoma Dioscoreae and rhizoma Polygonati with 80 mesh sieve to obtain nutrient solution A.
7) Weighing: accurately weighing the ginkgo, the Chinese magnoliavine fruit, the common cnidium fruit and the plantain seed in the components according to the parts by weight.
8) Sorting: accurately weighed ginkgo, schisandra chinensis, fructus cnidii and semen plantaginis are sorted, non-medicinal parts doped in the ginkgo, the schisandra chinensis, the fructus cnidii and the semen plantaginis are sorted, and the sorted weights are supplemented to make the weights meet the proportion.
9) Cleaning: washing the selected ginkgo, the schisandra, the fructus cnidii and the semen plantaginis by using drinking running water, wherein the washing times are 3 times.
10) Soaking: soaking semen Ginkgo, fructus Schisandrae chinensis, fructus Cnidii, and semen plantaginis in 100ml edible 95% (v/v) ethanol for 3 months.
11) And (3) filtering: filtering the soaked juice of semen Ginkgo, fructus Schisandrae chinensis, fructus Cnidii, and semen plantaginis with 80 mesh sieve to obtain nutrient solution B.
12) Preparing a fish extract product: taking a whole fresh water silver carp with weight of 4 jin, cutting the silver carp into a plurality of meat blocks after cleaning, quickly freezing the silver carp blocks for 2 months, pulping the quick-frozen silver carp blocks by using a pulping machine, extracting DNA active factors in the pulp by using a centrifugal machine, quickly freezing the DNA active factors for 2 months, pulping by using the pulping machine, taking the liquid, mixing for use, and finally obtaining a fish fine product.
13) Uniformly mixing, weighing 10kg of purified water, putting the purified water into a tank mixer, putting the nutrient solution A, the nutrient solution B, the fish essence filtrate, the kangshu and the vitamin B1 into the tank mixer, fully and uniformly mixing and stirring, wherein the ratio of the nutrient solution A to the nutrient solution B is 1:1, and fully and uniformly mixing and stirring the nutrient solution A and the nutrient solution B by the tank mixer to prepare the oral liquid for activating stem cells to achieve anti-aging;
when the materials are fully and uniformly mixed and stirred in the tank mixer, the stirring time is 3 hours;
14) bottling: the prepared oral liquid for activating stem cells to achieve anti-aging is filled into a bottle with the capacity of 10 ml.
15) Sterilization and disinfection: and (3) putting the bottled oral liquid for activating stem cells to achieve anti-aging into a sterilization pot for sterilization, wherein the set temperature of the sterilization pot is 145 ℃, and the sterilization and disinfection action time is 6 h.
16) Labeling a finished product: labeling and boxing the oral liquid to finish the preparation.
Example 2: as shown in fig. 1: an oral liquid for activating stem cells to achieve anti-aging effect comprises the following components in parts by weight: 8 g of Chinese yam, 6 g of rhizoma polygonati, 0.9 g of ginkgo, 4.5 g of kangshu, 8.5 g of schisandra fruit, 7.5 g of fructus cnidii, 5.5 g of semen plantaginis, 0.5 g of fish extract and auxiliary materials.
The auxiliary material is vitamin B12, and the weight of the vitamin B12 is 0.3 g.
The preparation method of the oral liquid for activating stem cells to achieve anti-aging specifically comprises the following steps:
1) weighing: accurately weighing the Chinese yam and the rhizoma polygonati in the components.
2) Sorting: the yam and the sealwort which are weighed accurately are selected, the non-medicinal parts doped in the yam and the sealwort are selected, and the selected weights are supplemented to make the weights meet the proportion.
3) Cleaning: washing the sorted Chinese yam and rhizoma polygonati with drinking running water for 4 times.
4) And (3) drying: spreading the cleaned rhizoma Dioscoreae and rhizoma Polygonati on a stainless steel baking tray, and drying in a drying oven at 75 deg.C.
5) And (3) cooking: and (2) steaming the dried Chinese yam and the dried rhizoma polygonati by using a steaming and boiling pot, injecting purified water into the steaming and boiling pot, wherein the weight of the purified water is 2000 g, then adding the Chinese yam and the dried rhizoma polygonati into the steaming and boiling pot, the steaming and boiling time is 45 minutes, the heating temperature in the steaming and boiling pot is 75 ℃, then controlling the steaming and boiling temperature to be 55 ℃ and keeping for 2.5 hours, and taking juice for later use.
6) Sieving: filtering the juice of rhizoma Dioscoreae and rhizoma Polygonati with 90 mesh sieve to obtain nutrient solution A.
7) Weighing: accurately weighing semen Ginkgo, fructus Schisandrae chinensis, fructus Cnidii, and semen plantaginis.
8) Sorting: accurately weighed ginkgo, schisandra chinensis, fructus cnidii and semen plantaginis are sorted, non-medicinal parts doped in the ginkgo, the schisandra chinensis, the fructus cnidii and the semen plantaginis are sorted, and the sorted weights are supplemented to make the weights meet the proportion.
9) Cleaning: washing the selected ginkgo, the schisandra, the fructus cnidii and the semen plantaginis by using drinking running water, wherein the washing times are 4 times.
10) Soaking: soaking semen Ginkgo, fructus Schisandrae chinensis, fructus Cnidii, and semen plantaginis in 100ml edible 95% (v/v) ethanol for 3.5 months.
11) And (3) filtering: and filtering the soaked juice of the ginkgo, the schisandra, the fructus cnidii and the plantain seed by using a 90-mesh screen to obtain nutrient solution B for later use.
12) Preparing a fish extract product: taking fresh water carp with the whole weight of 5 jin, cleaning the fresh water carp, dividing the carp into a plurality of blocks, quickly freezing the carp blocks for 2.5 months, pulping the quick-frozen carp blocks by using a pulping machine, extracting DNA active factors in the pulp by using a centrifugal machine, quickly freezing the DNA active factors for 2 months, pulping by using the pulping machine again, taking the liquid, mixing for use, and finally obtaining the fish essence.
13) Uniformly mixing, weighing 10kg of purified water, putting the purified water into a tank mixer, putting the nutrient solution A, the nutrient solution B, the fish essence filtrate, the kangshu and the vitamin B12 into the tank mixer, fully and uniformly mixing and stirring, wherein the ratio of the nutrient solution A to the nutrient solution B is 1:1, and fully and uniformly mixing and stirring the nutrient solution A and the nutrient solution B by the tank mixer to prepare the oral liquid for activating stem cells to achieve anti-aging;
when the materials are fully and uniformly mixed and stirred in the tank mixer, the stirring time is 3.5 h;
14) bottling: the prepared oral liquid for activating stem cells to achieve anti-aging is filled into a bottle with the capacity of 10 ml.
15) Sterilization and disinfection: and (3) putting the bottled oral liquid for activating stem cells to achieve anti-aging into a sterilization pot for sterilization, wherein the set temperature of the sterilization pot is 150 ℃, and the sterilization and disinfection action time is 6.5 h.
16) Labeling a finished product: labeling and boxing the oral liquid to finish the preparation.
Example 3: as shown in fig. 1: an oral liquid for activating stem cells to achieve anti-aging effect comprises the following components in parts by weight: 12 g of yam, 9 g of rhizoma polygonati, 1.2 g of ginkgo, 6 g of kangshu, 12 g of schisandra, 9 g of fructus cnidii, 8 g of semen plantaginis, 0.6 g of fish extract and auxiliary materials.
The auxiliary materials comprise vitamin B1 and vitamin B12, the proportioning weight of the vitamin B1 is 0.15 g, and the proportioning weight of the vitamin B12 is 0.15 g.
The preparation method of the oral liquid for activating stem cells to achieve anti-aging specifically comprises the following steps:
1) weighing: accurately weighing the Chinese yam and the rhizoma polygonati in the components.
2) Sorting: the yam and the sealwort which are weighed accurately are selected, the non-medicinal parts doped in the yam and the sealwort are selected, and the selected weights are supplemented to make the weights meet the proportion.
3) Cleaning: washing the sorted Chinese yam and rhizoma polygonati with drinking running water for 5 times.
4) And (3) drying: spreading the cleaned rhizoma Dioscoreae and rhizoma Polygonati on a stainless steel baking tray, and drying in a drying oven at 80 deg.C.
5) And (3) cooking: and (2) steaming the dried Chinese yam and the dried rhizoma polygonati by using a steaming and boiling pot, injecting 2000 g of purified water into the steaming and boiling pot, adding the Chinese yam and the dried rhizoma polygonati into the steaming and boiling pot, steaming for 50 minutes, heating the Chinese yam and the dried rhizoma polygonati at 80 ℃, keeping the steaming and boiling temperature at 60 ℃ for 3 hours, and taking juice for later use.
6) Sieving: filtering the juice of rhizoma Dioscoreae and rhizoma Polygonati with 100 mesh sieve to obtain nutrient solution A.
7) Weighing: accurately weighing semen Ginkgo, fructus Schisandrae chinensis, fructus Cnidii, and semen plantaginis.
8) Sorting: accurately weighed ginkgo, schisandra chinensis, fructus cnidii and semen plantaginis are sorted, non-medicinal parts doped in the ginkgo, the schisandra chinensis, the fructus cnidii and the semen plantaginis are sorted, and the sorted weights are supplemented to make the weights meet the proportion.
9) Cleaning: washing the selected ginkgo, the schisandra, the fructus cnidii and the semen plantaginis by using drinking running water, wherein the washing times are 5 times.
10) Soaking: soaking semen Ginkgo, fructus Schisandrae chinensis, fructus Cnidii, and semen plantaginis in 100ml edible 95% (v/v) ethanol for 4 months.
11) And (3) filtering: and filtering the soaked juice of the ginkgo, the schisandra, the fructus cnidii and the plantain seed by using a 100-mesh screen to obtain nutrient solution B for later use.
12) Preparing a fish extract product: taking fresh water grass carp with the whole weight of 5 jin, cleaning, dividing the grass carp into a plurality of blocks, quickly freezing the grass carp blocks for 3 months, pulping the quick-frozen grass carp blocks by using a pulping machine, extracting DNA active factors in the pulp by using a centrifugal machine, quickly freezing the DNA active factors for 2 months, pulping by using the pulping machine again, taking the liquid, mixing for use, and finally obtaining the fish essence.
13) Uniformly mixing, namely weighing 10kg of purified water, putting the purified water into a tank mixer, then putting the nutrient solution A, the nutrient solution B, the fish extract filtrate, the kangshu, the vitamin B1 and the vitamin B12 into the tank mixer, fully and uniformly mixing and stirring, wherein the ratio of the nutrient solution A to the nutrient solution B is 1:1, and fully and uniformly mixing and stirring the nutrient solution A and the nutrient solution B by the tank mixer to prepare the oral liquid for activating the stem cells to realize the anti-aging effect;
when the materials are fully and uniformly mixed and stirred in the tank mixer, the stirring time is 4 hours;
14) bottling: the prepared oral liquid for activating stem cells to achieve anti-aging is filled into a bottle with the capacity of 10 ml.
15) Sterilization and disinfection: and (3) putting the bottled oral liquid for activating stem cells to achieve anti-aging into a sterilization pot for sterilization, wherein the set temperature of the sterilization pot is 155 ℃, and the sterilization and disinfection action time is 7 hours.
16) Labeling a finished product: labeling and boxing the oral liquid to finish the preparation.
Example 4, the raw materials of the effective components in the above examples 1 to 3 may also be extracts extracted from the raw materials in proportion, including yam extract, ginkgo biloba extract, flavone, B-sitosterol and salidroside.
The flavone, B-sitosterol and salidroside are respectively extracts of semen Ginkgo and rhizoma Dioscoreae.
The raw materials adopted in the invention can be referred to food raw material quality identification standards formulated by the people's republic of China in 2000 and relevant departments such as supervision and management of health, medicine and food in various provinces, cities and regions in China.
Fruit fly survival experiment:
selecting 500 young healthy male drosophila melanogaster, dividing into 5 groups according to random distribution, namely a control 1 group, a control 2 group, an example 1 group, an example 2 group and an example 3 group, respectively filling the 5 culture tubes, wherein the number of the drosophila melanogaster in each culture tube is 100, then injecting qi-replenishing and blood-fatigue-resisting oral liquid into the culture tubes of the control 1 group, injecting 'Changsheng' oral liquid into the culture tubes of the control 2 group, and respectively injecting the oral liquid for activating stem cells and realizing aging resistance prepared in the example 1 group, the example 2 group and the example 3 group into the oral liquid for activating stem cells and realizing aging resistance prepared in the example 1, the example 2 and the example 3.
The qi and blood replenishing and fatigue resisting oral liquid injected into the culture tubes of the group 1 in comparison is the prior art and is prepared by the following steps of: 201810593921.1A Chinese medicinal oral liquid for invigorating qi and blood and relieving fatigue.
The "changsheng lo" oral liquid injected into the culture tubes of the control group 2 was an "changsheng lo" oral liquid produced by Shandong Changtong biotech GmbH, Inc., in the prior art.
And observing once in the morning and evening every day, recording the number of the dead fruit flies in the culture tube, and further calculating the service life of the fruit flies. The life span of each group is compared, and half death time, the maximum life span and the average life span of the groups are recorded to verify the anti-aging effect of the oral liquid.
The results are shown in table 1, which is the effect of the oral liquid in each group on the life of the fruit flies:
as can be seen from the above table, when the oral liquid for activating stem cells to achieve anti-aging prepared in example 1, example 2 and example 3 is used for culturing drosophila, the average life span of the drosophila is prolonged by 30.45%, 51.85% and 70.85%, and the prolonging effect respectively reaches a significant level and a very significant level;
and the maximum life of the fruit flies is prolonged by 30.50%, 50.07% and 63.12%, so that half of death time, the maximum life and the average life are prolonged, and the anti-aging effect is obvious.
A white mouse blood sampling simulation experiment:
taking 60 healthy Kunming mice, half of which are female and half of which are male, and then randomly dividing the mice into 5 groups, namely a control 1 group, a control 2 group, an example 1 group, an example 2 group and an example 3 group, wherein the control 1 group is prepared by supplying qi-replenishing and blood-anti-fatigue oral liquid to the mice; control group 2 was prepared by administering "Changshenglu" oral liquid to mice; the oral liquid for activating stem cells to achieve anti-aging prepared in example 1, example 2 and example 3 was administered to mice in example 1, example 2 and example 3, respectively.
The qi and blood replenishing and fatigue resisting oral liquid injected into the culture tubes of the group 1 in comparison is the prior art and is prepared by the following steps of: 201810593921.1A Chinese medicinal oral liquid for invigorating qi and blood and relieving fatigue.
The "changsheng lo" oral liquid injected into the culture tubes of the control group 2 was an "changsheng lo" oral liquid produced by Shandong Changtong biotech GmbH, Inc., in the prior art.
The oral solution was then gavaged once daily for 10 consecutive days starting on test day 1, and orbital blood was collected on day 11, hemoglobin (Hb) was measured by cyhaloferrispectrophotometry, and Red Blood Cell (RBC) count was measured by turbidimetry, with the results shown in the table below.
The following table shows the influence of the oral liquids on peripheral blood Hb and RBC of mice:
as can be seen from the above table, when the oral liquid prepared in examples 1 to 3 of the present invention was administered, Hb and RBC in peripheral blood of mice were significantly increased, compared to control 1 and control 2.
For volunteers use:
the oral liquid for activating stem cells to realize anti-aging is taken by a volunteer young man, male man, 40 years old, Weifang Anqiu Yanjiayucun man in 6 months in 2018 due to poor sleep, memory decline, body withering and thinness and sallow complexion, the spirit turns good after 60 days, the sleep turns better, and then the oral liquid is taken for two months, so that the energy is sufficient, the memory is enhanced, the complexion is ruddy, and the whole person is very young.
The volunteer king a certain, female, 50 years old, and the person in Henan head village in the garden subarea of the Weifang City; according to 8-month hospital detection in 2018, anemia exists, the face is sallow in color, hands and feet are not warm, stomach distension exists, and the sleeping face quality at night is poor.
Any one volunteer, male, 53 years old, Weifang city Jingshan depression Zhen ren, retired employee; in 2019, due to palpitation and shortness of breath, haggard face, face fullness and age spots, memory decline, frequent micturition and urgent micturition, dizziness and tinnitus, weak digestive function and easy diarrhea when people eat uncooked food, when the oral liquid for activating stem cells to realize anti-aging is taken, 100 days are needed, the defecation is normal, the urgent micturition and frequent micturition are effectively improved, the tinnitus is improved, the face test is ruddy and soft, wrinkles become shallow and less, and the face looks young.
The volunteer king a certain person, male, 28 years old, Weifang Anqiu city xi Liuhang village person, 4 months in 2019 has hypertension, high blood fat, mild coronary heart disease, smoking and drinking hobbies through hospital detection due to body obesity, 100 days after taking the oral liquid for activating stem cells to realize anti-aging, the smoking and drinking times are reduced, the weight is gradually reduced, the body is very good, the waist pain is greatly relieved, and the face is red, glossy and bright, so that the face looks very young.
It will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in the embodiments described above without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims.
Claims (10)
1. An oral liquid for activating stem cells to achieve anti-aging, which is characterized in that: the oral liquid comprises the following components in parts by weight: 4-12 g of yam, 3-9 g of rhizoma polygonati, 0.6-1.2 g of ginkgo, 3-6 g of kangshu, 5-12 g of schisandra, 6-9 g of fructus cnidii, 3-8 g of semen plantaginis, 0.4-0.6 g of fish extract and auxiliary materials.
2. The oral liquid for activating stem cells to achieve anti-aging according to claim 1, wherein: the oral liquid comprises the following components in parts by weight: 4 g of Chinese yam, 3 g of rhizoma polygonati, 0.6 g of ginkgo, 3 g of kangshu, 5 g of schisandra chinensis, 6 g of fructus cnidii, 3 g of semen plantaginis, 0.4 g of fish extract and auxiliary materials.
3. The oral liquid for activating stem cells to achieve anti-aging according to claim 2, wherein: the oral liquid comprises the following components in parts by weight: 8 g of Chinese yam, 6 g of rhizoma polygonati, 0.9 g of ginkgo, 4.5 g of kangshu, 8.5 g of schisandra fruit, 7.5 g of fructus cnidii, 5.5 g of semen plantaginis, 0.5 g of fish extract and auxiliary materials.
4. The oral liquid for activating stem cells to achieve anti-aging according to claim 3, wherein: the oral liquid comprises the following components in parts by weight: 12 g of yam, 9 g of rhizoma polygonati, 1.2 g of ginkgo, 6 g of kangshu, 12 g of schisandra, 9 g of fructus cnidii, 8 g of semen plantaginis, 0.6 g of fish extract and auxiliary materials.
5. The oral liquid for activating stem cells to achieve anti-aging according to claim 4, wherein: the auxiliary material is at least one of vitamin B1 and vitamin B12, the proportioning weight of the vitamin B1 is 0.3 g, and the proportioning weight of the vitamin B12 is 0.3 g.
6. The process for preparing the oral liquid for activating stem cells to achieve anti-aging according to claims 1 to 5, wherein the oral liquid comprises the following components: the preparation process specifically comprises the following steps:
1) accurately weighing the Chinese yam and the rhizoma polygonati according to the weight parts, and pretreating the components;
2) steaming the pretreated rhizoma Dioscoreae and rhizoma Polygonati with a digester, and sieving to obtain nutrient solution A;
3) accurately weighing ginkgo, schisandra, fructus cnidii and semen plantaginis according to the weight parts; and pretreating the component;
4) adding the pretreated ginkgo, the schisandra chinensis, the fructus cnidii and the semen plantaginis into alcohol for soaking, and filtering after soaking to prepare nutrient solution B for later use;
5) taking fresh water fish of more than 4 jin and cutting into blocks, quickly freezing for 2-3 months, pulping by a pulping machine, extracting DNA active factors in the pulp by a centrifugal machine, quickly freezing the DNA active factors for 2 months, pulping again, taking liquid, mixing for use, and finally obtaining refined fish products;
6) weighing 10kg of purified water, putting the purified water into a tank mixer, and putting the nutrient solution A, the nutrient solution B, the fish essence filtrate, the kangshu and the auxiliary materials into the tank mixer to be uniformly mixed and stirred, so as to prepare the oral liquid for activating stem cells to realize anti-aging.
7. The preparation process of the oral liquid for activating stem cells to achieve anti-aging according to claim 6, wherein the oral liquid comprises the following components: the pretreatment step in the step 1) is as follows: a) selecting non-medicinal parts from the Chinese yam and the sealwort which are symmetrically measured, and supplementing the proportion; b) washing rhizoma Dioscoreae and rhizoma Polygonati with flowing water; c) drying the cleaned rhizoma Dioscoreae and rhizoma Polygonati in a drying oven at 70-80 deg.C.
8. The preparation process of the oral liquid for activating stem cells to achieve anti-aging according to claim 7, wherein the oral liquid comprises the following components: the cooking time of the cooking pot in the step 2) is 40 minutes, and the cooking temperature is controlled to be 50 ℃ and kept for 2 hours; the sieving is carried out by adopting a sieve with 80-100 meshes.
9. The preparation process of the oral liquid for activating stem cells to achieve anti-aging according to claim 8, wherein the oral liquid comprises the following components: the pretreatment step in the step 3) is as follows: a) selecting non-medicinal parts from semen Ginkgo, fructus Schisandrae chinensis, fructus Cnidii, and semen plantaginis, and supplementing the proportion; b) washing semen Ginkgo, fructus Schisandrae chinensis, fructus Cnidii, and semen plantaginis with flowing water.
10. The preparation process of the oral liquid for activating stem cells to achieve anti-aging according to claim 9, wherein the oral liquid comprises the following components: the alcohol in the step 4) is 100ml of edible 95-alcohol-degree alcohol, and the soaking time is 3-4 months.
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| CN1104104A (en) * | 1993-12-23 | 1995-06-28 | 詹炳炎 | Kidney-nourishing and anti-senile medicine |
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