CN101421296B - 用于治疗过敏的属于欧蓍草（Parietaria judaica）脂质转移家族的低变应原的嵌合蛋白质 - Google Patents

用于治疗过敏的属于欧蓍草（Parietaria judaica）脂质转移家族的低变应原的嵌合蛋白质 Download PDF

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CN101421296B
CN101421296B CN2007800133849A CN200780013384A CN101421296B CN 101421296 B CN101421296 B CN 101421296B CN 2007800133849 A CN2007800133849 A CN 2007800133849A CN 200780013384 A CN200780013384 A CN 200780013384A CN 101421296 B CN101421296 B CN 101421296B
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CN101421296A (zh
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胡安-安德烈斯·阿斯图里亚斯-奥特加
阿尔贝托·马丁尼兹-葛雷特
罗伯托·冈萨雷斯·里奥哈
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Roxall Medicina Espana SA
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Bial Industrial Farmaceutica SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A61K39/36—Allergens from pollen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/577—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 tolerising response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C07K14/625—Extraction from natural sources
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

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  • Health & Medical Sciences (AREA)
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  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Gastroenterology & Hepatology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
CN2007800133849A 2006-04-12 2007-04-11 用于治疗过敏的属于欧蓍草（Parietaria judaica）脂质转移家族的低变应原的嵌合蛋白质 Expired - Fee Related CN101421296B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201210468984.7A CN103059140B (zh) 2006-04-12 2007-04-11 用于治疗过敏的属于欧蓍草(Parietaria judaica)脂质转移家族的低变应原的嵌合蛋白质

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES200600955 2006-04-12
ES200600955A ES2307381B1 (es) 2006-04-12 2006-04-12 Proteinas quimericas hipoalergenicas pertenecientes a la familia de transportadoras de lipidos de parietaria judaica utiles para el tratami ento de alergias.
PCT/IB2007/001025 WO2007116316A1 (en) 2006-04-12 2007-04-11 Hypoallergenic chimeric proteins belonging to the lipid transfer family of parietaria judaica for use in the treatment of allergies

Related Child Applications (1)

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CN201210468984.7A Division CN103059140B (zh) 2006-04-12 2007-04-11 用于治疗过敏的属于欧蓍草(Parietaria judaica)脂质转移家族的低变应原的嵌合蛋白质

Publications (2)

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CN101421296A CN101421296A (zh) 2009-04-29
CN101421296B true CN101421296B (zh) 2013-01-02

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CN201210468984.7A Expired - Fee Related CN103059140B (zh) 2006-04-12 2007-04-11 用于治疗过敏的属于欧蓍草(Parietaria judaica)脂质转移家族的低变应原的嵌合蛋白质
CN2007800133849A Expired - Fee Related CN101421296B (zh) 2006-04-12 2007-04-11 用于治疗过敏的属于欧蓍草（Parietaria judaica）脂质转移家族的低变应原的嵌合蛋白质

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CN201210468984.7A Expired - Fee Related CN103059140B (zh) 2006-04-12 2007-04-11 用于治疗过敏的属于欧蓍草(Parietaria judaica)脂质转移家族的低变应原的嵌合蛋白质

Country Status (10)

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US (2) US8697083B2 (enExample)
EP (3) EP2392592B1 (enExample)
JP (3) JP5373597B2 (enExample)
CN (2) CN103059140B (enExample)
BR (1) BRPI0710649A2 (enExample)
CA (1) CA2646900C (enExample)
ES (2) ES2307381B1 (enExample)
MX (1) MX2008013050A (enExample)
PT (1) PT2007798E (enExample)
WO (1) WO2007116316A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2307381B1 (es) * 2006-04-12 2009-10-23 Bial Industrial Farmaceutica S.A. Proteinas quimericas hipoalergenicas pertenecientes a la familia de transportadoras de lipidos de parietaria judaica utiles para el tratami ento de alergias.
IT1395735B1 (it) * 2009-08-04 2012-10-19 Lofarma Spa Proteina ibrida ipoallergenica e suoi usi
RU2470298C2 (ru) * 2011-04-01 2012-12-20 Федеральное бюджетное учреждение науки "Уфимский научно-исследовательский институт медицины труда и экологии человека" (ФБУН "Уфимский НИИ медицины труда и экологии человека") Способ ранней (донозологической) диагностики развития сенсибилизации к аллергенам воздуха рабочей зоны птицеводческого комплекса

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10037759A1 (de) 2000-08-03 2002-07-04 Gruenenthal Gmbh Screeningverfahren
IT1317905B1 (it) 2000-09-11 2003-07-15 Consiglio Nazionale Ricerche Varianti di allergeni ns-ltps, loro usi e composizioni che lecomprendono.
IT1318690B1 (it) 2000-09-12 2003-08-27 Consiglio Nazionale Ricerche Varianti dell'allergene maggiore par j 2 di parietaria judaica.
US20030175312A1 (en) * 2000-11-16 2003-09-18 Alk-Abello A/S Novel mutant allergens
EP1221317A1 (en) * 2000-12-28 2002-07-10 SHAN-Beteiligungsgesellschaft m.b.H. Vaccines containing hybrid polypeptides consisting of at least two different allergenic proteins
WO2002088317A2 (en) * 2001-05-01 2002-11-07 The Regents Of The University Of California Fusion molecules and methods for treatment of immune diseases
US7265208B2 (en) * 2001-05-01 2007-09-04 The Regents Of The University Of California Fusion molecules and treatment of IgE-mediated allergic diseases
ATE307141T1 (de) * 2003-01-21 2005-11-15 Biomay Prod & Handel Verfahren zur vorbereitung von hypoallergenen mosaikproteine
ITRM20030247A1 (it) * 2003-05-20 2004-11-21 Bonura Angela Varianti ipoallergeniche degli allergeni maggiori
ITRM20040103A1 (it) * 2004-02-27 2004-05-27 Consiglio Nazionale Ricerche Proteine di fusione comprendenti allergeni della famiglia delle ns-ltps, loro usi e composizioni farmaceutiche che le comprendono.
AT501101B1 (de) * 2004-12-02 2008-01-15 Biomay Ag Protein-allergen-derivat
ES2307381B1 (es) * 2006-04-12 2009-10-23 Bial Industrial Farmaceutica S.A. Proteinas quimericas hipoalergenicas pertenecientes a la familia de transportadoras de lipidos de parietaria judaica utiles para el tratami ento de alergias.

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ASTURIAS J A ET AL.Par j 1 and Par j 2, the major allergens from Parietaria judaica pollen, have similar immunoglobulin E epitopes.《CLINICAL AND EXPERIMENTAL ALLERGY》.2003,第33卷(第4期),518-524. *
COLOMBO P ET AL.Identification of an immunodominant IgE epitope of the Parietaria judaica major allergen.《JOURNAL OF IMMUNOLOGY》.1998,第160卷(第6期),2780-2785. *

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Publication number Publication date
CA2646900C (en) 2016-06-14
JP2009533046A (ja) 2009-09-17
ES2307381B1 (es) 2009-10-23
ES2550705T3 (es) 2015-11-11
BRPI0710649A2 (pt) 2011-08-23
MX2008013050A (es) 2009-01-14
EP2392592A1 (en) 2011-12-07
EP2007798A1 (en) 2008-12-31
CN103059140A (zh) 2013-04-24
ES2307381A2 (es) 2008-11-16
ES2307381R (es) 2008-12-01
CN103059140B (zh) 2016-09-28
EP2363409A1 (en) 2011-09-07
PT2007798E (pt) 2015-11-13
CA2646900A1 (en) 2007-10-18
US20140286972A1 (en) 2014-09-25
US9522939B2 (en) 2016-12-20
JP6148088B2 (ja) 2017-06-14
US20090304727A1 (en) 2009-12-10
US8697083B2 (en) 2014-04-15
JP2013233149A (ja) 2013-11-21
EP2007798B1 (en) 2015-09-30
CN101421296A (zh) 2009-04-29
JP2016104796A (ja) 2016-06-09
EP2392592B1 (en) 2016-12-14
WO2007116316A1 (en) 2007-10-18
JP5373597B2 (ja) 2013-12-18

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Address after: The Spanish

Patentee after: Bial Ind Farmaceutica S. A.

Address before: Bilbao

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CF01 Termination of patent right due to non-payment of annual fee