CN101421267B - 制备吡啶杂环cgrp拮抗剂中间体的方法 - Google Patents

制备吡啶杂环cgrp拮抗剂中间体的方法 Download PDF

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Publication number
CN101421267B
CN101421267B CN2007800129491A CN200780012949A CN101421267B CN 101421267 B CN101421267 B CN 101421267B CN 2007800129491 A CN2007800129491 A CN 2007800129491A CN 200780012949 A CN200780012949 A CN 200780012949A CN 101421267 B CN101421267 B CN 101421267B
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CN
China
Prior art keywords
carboxylic acid
oxo
piperidines
amino
chloropyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2007800129491A
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English (en)
Chinese (zh)
Other versions
CN101421267A (zh
Inventor
M·麦洛林
M·帕卢基
K·马肯托尼奥
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CN101421267A publication Critical patent/CN101421267A/zh
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Publication of CN101421267B publication Critical patent/CN101421267B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2007800129491A 2006-04-10 2007-04-06 制备吡啶杂环cgrp拮抗剂中间体的方法 Expired - Fee Related CN101421267B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79070206P 2006-04-10 2006-04-10
US60/790,702 2006-04-10
PCT/US2007/008701 WO2007120590A2 (fr) 2006-04-10 2007-04-06 Procédé de préparation d'un intermédiaire antagoniste du peptide cgrp d'hétérocycle de pyridine

Publications (2)

Publication Number Publication Date
CN101421267A CN101421267A (zh) 2009-04-29
CN101421267B true CN101421267B (zh) 2011-10-19

Family

ID=38520297

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2007800129491A Expired - Fee Related CN101421267B (zh) 2006-04-10 2007-04-06 制备吡啶杂环cgrp拮抗剂中间体的方法

Country Status (7)

Country Link
US (1) US20090176986A1 (fr)
EP (1) EP2007763A2 (fr)
JP (1) JP2009533438A (fr)
CN (1) CN101421267B (fr)
AU (1) AU2007238894A1 (fr)
CA (1) CA2649158A1 (fr)
WO (1) WO2007120590A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2007731B1 (fr) 2006-04-10 2009-07-22 Merck & Co., Inc. Procédé de préparation d'un intermédiaire d'antagoniste du peptide cgrp de caprolactame
US7829699B2 (en) 2006-04-10 2010-11-09 Merck Sharp & Dohme Corp. Process for the preparation of CGRP antagonist
US8143403B2 (en) 2008-04-11 2012-03-27 Bristol-Myers Squibb Company CGRP receptor antagonists
US8044043B2 (en) 2008-04-11 2011-10-25 Bristol-Myers Squibb Company CGRP receptor antagonists
WO2010020628A1 (fr) * 2008-08-20 2010-02-25 Boehringer Ingelheim International Gmbh Nouveau procédé de production de l-pipéridin-4-yl-1,3-dihydro-imidazo-[4,5-b]-pyridin-2-one et de son mono- et dichlorhydrate
US8314117B2 (en) * 2009-10-14 2012-11-20 Bristol-Myers Squibb Company CGRP receptor antagonists
US8669368B2 (en) 2010-10-12 2014-03-11 Bristol-Myers Squibb Company Process for the preparation of cycloheptapyridine CGRP receptor antagonists
US8748429B2 (en) 2011-04-12 2014-06-10 Bristol-Myers Squibb Company CGRP receptor antagonists
SI2820016T1 (sl) 2012-02-27 2017-11-30 Bristol-Myers Squibb Company N-(5s,6s,9r)-5-amino-6-(2,3-difluorofenil)-6,7,8,9-tetrahidro-5h- ciklohepta (b)piridin-9-il-4-(2-okso-2, 3-dihidro-1h-imidazo(4,5-b) piridin-1-il) piperidin-1-karboksilat, hemisulfatna sol
TW201718574A (zh) * 2015-08-12 2017-06-01 美國禮來大藥廠 Ｃｇｒｐ受體拮抗劑

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004092168A1 (fr) * 2003-04-15 2004-10-28 Merck & Co., Inc. Antagonistes de recepteur du cgrp
WO2005013894A2 (fr) * 2003-06-26 2005-02-17 Merck & Co., Inc. Antagonistes du recepteur du cgrp de

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004092168A1 (fr) * 2003-04-15 2004-10-28 Merck & Co., Inc. Antagonistes de recepteur du cgrp
WO2005013894A2 (fr) * 2003-06-26 2005-02-17 Merck & Co., Inc. Antagonistes du recepteur du cgrp de

Also Published As

Publication number Publication date
JP2009533438A (ja) 2009-09-17
US20090176986A1 (en) 2009-07-09
CA2649158A1 (fr) 2007-10-25
WO2007120590A3 (fr) 2007-12-13
CN101421267A (zh) 2009-04-29
EP2007763A2 (fr) 2008-12-31
AU2007238894A1 (en) 2007-10-25
WO2007120590A2 (fr) 2007-10-25

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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20111019

Termination date: 20120406