CN101416925A - Child edible mouth cleaning solution formulation, production technique and tooth-protection infection prevention effect - Google Patents
Child edible mouth cleaning solution formulation, production technique and tooth-protection infection prevention effect Download PDFInfo
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- CN101416925A CN101416925A CNA2008101719613A CN200810171961A CN101416925A CN 101416925 A CN101416925 A CN 101416925A CN A2008101719613 A CNA2008101719613 A CN A2008101719613A CN 200810171961 A CN200810171961 A CN 200810171961A CN 101416925 A CN101416925 A CN 101416925A
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- cleaning solution
- xylitol
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- mouth
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Abstract
The invention relates to a tooth-protecting measure for infants, in particular to edible oral cleaning fluid containing xylitol and active calcium irons, which is characterized in that the weight percentage of the xylitol is 1 to 64 and the concentration of the active calcium irons is not less than 50mg/100ml. The application method is that the edible oral cleaning fluid is sprayed to the teeth and the oral cavity, or sipped into the mouth. In addition, the effects in protecting the teeth and preventing infections are also attested.
Description
Technical field
The present invention relates to a kind of child edible mouth cleaning solution that contains xylitol.
Background technology
Because the calcification degree of deciduous teeth is lower; the child lacks self-oral cavity health care ability in addition; oral hygiene is in poor shape; therefore deciduous teeth dental caries prevalence is very high; and morbidity early; show according to the oral epidemiology investigation report: age group deciduous teeth dental caries prevalence had reached 48.19% in three years old, seriously jeopardized child oral cavity and whole body health and grew.The child in 2006 of Qinhuangdao women and children hospital goes into the garden health check-up and finds that the child who suffers from dental caries is very many, and ratio is greatly about more than 70%.What make that the doctor is taken aback is, one of them little girl of 5 years old, and 20 teeth in the mouth have 16 all to suffer from dental caries.
Comparatively the effectively preventing measure is by the maintenance oral hygiene of brushing teeth at present, but for infant, and since sprouting in four months about tooth to three year old, because of it can not be brushed teeth voluntarily, the oral hygiene that how to keep this age bracket child also really is a difficult problem.
The tooth protection leisure mode that a kind of adult likes: chew the xylitol sugar-free chewing gum, it is generally acknowledged since after the meal in the oral cavity food debris can produce acidic materials corrosion tooth, chew Xylitol chewing gum and can reduce acidic materials, and caries bacteria is reduced, reduced activity, thus the health care tooth helped.Because child also can not tell the viscose glue after chewing, so father and mother can not select this mode to keep child's oral hygiene yet.
In addition, also have various collutorys on the market, the fluoride mouthwash that contains sodium monofluorophosphate or sodium fluoride is arranged, contain the fixed collutory of chloroethene, contain triclosan collutory, contain the collutory of cetylpyridinium chloride, the collutory of these bacteriostatic agents rinse the mouth and bactericidal effect on be comparable to toothpaste, but be unsuitable for children equally.Because the excessive absorption fluorine element of human body can cause fluorosis, calomel poisoning produces dental fluorosis, is commonly called as " macula lutea tooth ", and the severe intoxication meeting produces osteofluorosis; Chloroethene may make tooth dyeing surely; Triclosan and cetylpyridinium chloride are not proposed to be used in the child yet.Chinese medicine collutory or Folium Camelliae sinensis tea polyphenols collutory do not have genotoxic potential to health, but may dye to tooth.
Xylitol (birch sugar) is a kind of natural carbohydrate, and it is present in the special plant part of tree, vegetable and fruit, exists on a small quantity with free form in addition and in the human body intermediate metabolites.The mankind have just known xylitol the nineties from 19th-century at least organic chemistry.Before more than 100 years, German and French researcher has at first chemically been produced xylitol.During nineteen thirties, finally determined the characteristic of xylitol and it has been purified.Although from chemical aspect, xylitol has quite long history, and it is considered to a kind of in several sweet carbohydrates for a long time.But a lot of countries of shortage owing to sugar increase xylitol interest during the Second World War.Studied its noninsulin dependent performance up to researcher, its biological characteristics just obtains understanding, up to nineteen seventies, a lot of countries are just with the sweeting agents of xylitol as diabetics, with parenteral alimentation promptly by blood vessel directly give with nutrition or treatment islets of langerhans disposition go into a coma relevant.Just begin in odontology, to use xylitol during nineteen seventies.The chewing gum of xylitol has at first appearred containing in Finland in 1975, and it is used to control dental caries.Xylitol is a kind of sugar alcohol of pentitol type, and it has 5 carbon atoms and 5 hydroxyls.Xylitol belongs to polyhydric alcohol, and polyhydric alcohol is not a sugar on the stricti jurise.But they are relevant with sugar on biochemistry, because produced by sugar, and can be converted into sugar.In addition, some chemical handbook are defined as the carbohydrate of crystallization, sweet taste with sugar, and it is the category that covers xylitol.When in bacteriology test, using this sugar alcohol, do not detect the mutation characteristic, i.e. the increasing of natural mutation frequency.In addition, internal and international authority estimates its toxicity, thinks that its toxicity is so low, to such an extent as to for acceptable daily intaking amount without any restriction.Referring to translate (English) sieve R.C. " 796 pages of xylitol of pharmaceutic adjuvant handbook (original work the 4th edition) that Chemical Industry Press publishes by Zheng Jun democracy.
Summary of the invention
The objective of the invention is to for 0-3 year child keeps oral hygiene that a kind of method is provided, specifically is a kind of product.To eliminate the potential hazard of fluoride accumulation property poisoning to the child, eliminate the dyeing of tea polyphenols or Chinese medicine to tooth, reduce oral cavity bacterium, the edible mouth cleaning solution of caries prevention.
Purpose of the present invention can be achieved through the following technical solutions: a kind of child's edible mouth cleaning solution is characterized in that;
Xylitol 1～64g
Edible water-soluble calcium salt (calcium ion concentration) 0.02～0.2g
Phosphopeptide caseinate 0～0.2g
Food preservative 0.05～0.5g
Pure water 36～99g
Each component sum is 100 in the compositions
The advantage materials of this product are simple, are comestible composition.Each composition effect is clear and definite, complements each other and is preventing and treating dental caries, repairing and better effects to be arranged aspect the impaired deciduous teeth.
When existing, can suppress the xylitol more than 1% breeding of common microorganism, referring to Chinese patent (application number 200480037774.6).When the water-soluble Ca salt of this prescription entered the oral cavity, calcium ion concentration was 50mg/100ml, far above normal blood calcium concentration 10mg/100ml, promoted the calcification again of tooth from concentration, and simultaneous phosphopeptide caseinate and xylitol all promote the absorption of calcium ion.Add and use food preservative, guarantee storing for a long time of this product.
Since 0-3 year child's physiology and cognition, the food that used oral cavity cleaning hygienic article preferably can be swallowed.This prescription has been abandoned may have certain toxic surfactant such as sodium lauryl sulphate to child; Abandoned too much essence; Abandoned tooth protection effectively but the child had the fluoride of genotoxic potential; Abandoned efficiently that antibacterial such as triclosan, chloroethene are fixed, cetylpyridinium chloride, bromo geramine; Having abandoned may be to painted Chinese medicine extract of tooth and tea polyphenols; Whether the formula for a product of simplifying effective? simple, understand, safe.
In general, the people of dental caries is arranged, show that the oral hygiene environment is poor, the parasitic malignant bacteria in oral cavity is many, and upper respiratory tract bacterial infection incidence rate also exceeds several times than the people who does not have dental caries.Use collutory prescription of the present invention, not only the dental caries attack degree reduces, and has prevented the outbreak of stomatitis and upper respiratory tract bacterial infection more magically.Concrete result of use example is arranged below.
Be embodiments of the invention below
Embodiment 1
Prescription is formed:
Xylitol 200g
Calcium lactate 2g
Ethylparaben 0.5g
Deionized water adds to 1000ml
Preparation process:
Taking by weighing xylitol 200g, calcium lactate 3g is scattered in about 600ml deionized water, in addition with an amount of warm deionized water dissolving ethylparaben 0.5g, and slowly adding is gone up in the liquid, adds deionized water to 1000ml, shakes up and promptly gets the child edible that contains xylitol mouth cleaning solution I.
Embodiment 2
Prescription is formed:
Xylitol 200g
Calcium lactate 3g
Ethylparaben 1g
Deionized water adds to 1000ml
Preparation process:
Taking by weighing xylitol 200g, calcium lactate 3g is scattered in about 600ml deionized water, in addition with an amount of warm deionized water dissolving ethylparaben 1g, and slowly adding is gone up in the liquid, adds deionized water to 1000ml, shakes up and promptly gets the child edible that contains xylitol mouth cleaning solution II.
Embodiment 3
Prescription is formed:
Xylitol 200g
Calcium lactate 3g
Potassium sorbate 2g
Deionized water adds to 1000ml
Preparation process:
Take by weighing xylitol 200g, calcium lactate 3g, potassium sorbate 2g is scattered in about 600ml deionized water, adds deionized water to 1000ml, shake up and promptly get the child edible that contains xylitol mouth cleaning solution III.
Embodiment 4
Prescription is formed:
Xylitol 200g
Calcium lactate 3g
Phosphopeptide caseinate 1.5g
Potassium sorbate 2g
Deionized water adds to 1000ml
Preparation process:
Take by weighing xylitol 200g, calcium lactate 3g, potassium sorbate 2g, phosphopeptide caseinate 1.5g add in about 600ml deionized water successively, jolting makes dissolving, adds deionized water to 1000ml, shakes up and promptly gets the child edible that contains xylitol mouth cleaning solution IV.
Embodiment 5
Prescription is formed:
Xylitol 200g
Calcium lactate 2g
Deionized water adds to 1000ml
Preparation process:
In hundred grades of toilets, take by weighing xylitol 200g, calcium lactate 2g and be scattered in about 600ml deionized water, jolting makes dissolving, adds deionized water to 1000ml, shakes up and promptly gets the child edible that contains xylitol mouth cleaning solution V.
Reference examples 1
Prescription is formed:
The about 0.5g of Sal
Tap water adds to about 50ml
Preparation process:
The little spoon of speciality adds 0.5g Sal to about 50ml tap water, and jolting makes dissolving, and is standby.
Effect example of the present invention
Two groups of children that suffer from the different dental caries of degree, first group 8 people, second group 10 people, the men and women does not limit, three months ages to three Saturdays month, the first group with the child edible that contains xylitol with mouth cleaning solution I (method be each feed after, injection or rinsing the mouth contain the child edible mouth cleaning solution I of xylitol), the second group is reference examples 1 (after method is each feed, spraying or the light salt brine of rinsing the mouth reference examples 1 configuration) with light salt brine
The dental caries order of severity and dental health state are divided into three grades: one-level, have only a dental caries or minority dental plaque, tooth holistic health state not bad (according to lesion degree again refinement describe scoring and be the 1-3 branch); Secondary has two dental caries or more than two but the dental caries number is no more than 1/5th of whole tooth, tooth holistic health state difference (according to lesion degree again refinement describe scoring and be the 4-6 branch); Three grades, the dental caries number surpasses 1/5th of whole tooth, tooth holistic health state very poor (according to lesion degree again refinement describe scoring and be the 7-9 branch); Tooth is healthy fully, can't see dental caries and dental plaque, is superfine, and integration is 0.
Table one
18 examples suffer from dental caries child's initial evaluation first group (1-No. 8) second group (9-No. 18) in various degree
| Sequence number | Age | Sex | Dental caries and dental health rank | The thin integration of the dental caries order of severity and dental health | Oral disease, upper respiratory tract infection (bacillary) attack times (memory) in the first half |
| 1 | Three months | The man | One-level | 2 | 1 (going up sense) |
| 2 | Three one full year of life | The woman | Secondary | 5 | 2 (1 stomatitis 1 of having a toothache) |
| 3 | Individual month of two Saturdays | The woman | One-level | 3 | 1 (on feel 1) |
| 4 | Individual month of three Saturdays | The man | Three grades | 8 | 2 (feeling 1 in the toothache 1) |
| 5 | Two seven months weeks | The man | One-level | 3 | 1 (stomatitis) |
| 6 | Individual month of three Tuesdays | The woman | Secondary | 6 | 2 (feeling 1 in the toothache 1) |
| 7 | Two 11 months weeks | The man | One-level | 3 | 1 (on feel 1) |
| 8 | Two nine months weeks | The woman | Secondary | 5 | 3 (feeling 1 on 1 stomatitis 1 of having a toothache) |
| 9 | Individual month of three Mondays | The man | Three grades | 7 | 3 (feeling 2 on the stomatitis 1) |
| 10 | Three weeks | The man | One-level | 3 | 1 (toothache 1) |
| 11 | Five months | The woman | One-level | 2 | 1 (feeling 1 on the stomatitis 1) |
| 12 | Two eight months weeks | The woman | Three grades | 9 | 2 (1 stomatitis 1 of having a toothache) |
| 13 | Two eight months weeks | The woman | One-level | 3 | 1 (toothache 1) |
| 14 | Individual month of three Thursdays | The man | Secondary | 6 | 3 (feeling 1 on 1 stomatitis 1 of having a toothache) |
| 15 | Individual month of three Saturdays | The woman | One-level | 3 | 1 (toothache 1) |
| 16 | Two nine months weeks | The woman | Secondary | 5 | 1 (feeling 1 on the stomatitis 1) |
| 17 | Two ten months weeks | The man | One-level | 3 | 1 (on feel 1) |
| 18 | Two 11 months weeks | The woman | Secondary | 6 | 2 (feeling 1 in the toothache 1) |
Table two
First group (adhere to spraying or child edible that rinsing the mouth contains xylitol with mouth cleaning solution I group) health check-up situation after six months
| Sequence number | Age | Sex | Dental caries and dental health rank | The thin integration of the dental caries order of severity and dental health | Oral disease, upper respiratory tract infection (bacillary) attack times (after the tooth protection measure) in nearly half a year |
| 1 | Nine months | The man | Superfine | 0 | 0 |
| 2 | Six months three one full year of life | The woman | Secondary | 4 | 0 |
| 3 | Three one full year of life | The woman | One-level | 1 | 0 |
| 4 | All around the year | The man | Three grades | 7 | 0 |
| 5 | Individual month of three Mondays | The man | One-level | 1 | 0 |
| 6 | Three eight months weeks | The woman | Secondary | 4 | 0 |
| 7 | Individual month of three Fridays | The man | One-level | 1 | 0 |
| 8 | Individual month of three Wednesdays | The woman | Secondary | 4 | 0 |
Table three
Second group (adhering to spraying or rinsing the mouth light salt brine group) health check-up situation after six months
| Sequence number | Age | Sex | Dental caries and dental health rank | The thin integration of the dental caries order of severity and dental health | Oral disease, upper respiratory tract infection (bacillary) attack times (saline is gargled back) in nearly half a year |
| 9 | Three seven months weeks | The man | Three grades | 9 | 1 (feeling 1 in the toothache 1) |
| 10 | Individual month of three Saturdays | The man | Secondary | 4 | 2 (on feel 2) |
| 11 | 11 months | The woman | One-level | 3 | 2 (feeling 1 in the toothache 1) |
| 12 | Individual month of three Tuesdays | The woman | Three grades | 9 | 3 (feeling 2 in the toothache 1) |
| 13 | Individual month of three Tuesdays | The woman | Secondary | 5 | 1 (stomatitis 1) |
| 14 | Three ten months weeks | The man | Secondary | 6 | 1 (toothache 1) |
| 15 | All around the year | The woman | Secondary | 5 | 2 (1 stomatitis 1 of having a toothache) |
| 16 | Individual month of three Wednesdays | The woman | Secondary | 5 | 2 (feeling 1 on the stomatitis 1) |
| 17 | Individual month of three Thursdays | The man | Secondary | 4 | 1 (feeling 1 on the stomatitis 1) |
| 18 | Individual month of three Fridays | The woman | Three grades | 8 | 3 (feeling 2 in the toothache 1) |
Result: 1, before using new tooth protection measure, injection or eight childs' of rinsing the mouth xylitol edible mouth cleaning solution group dental health rank (superfine is designated as 0) is 1.625, the thin integration of dental health is 4.375, adhering to using injection or rinsing the mouth xylitol edible mouth cleaning solution after six months, eight childs' of this group dental health rank (superfine is designated as 0) is 1.5, and the thin integration of dental health is 2.75; Before using new tooth protection measure, ten childs' of rinsing the mouth light salt brine group dental health rank is 1.6, and the thin integration of dental health is 4.7, is adhering to using the rinsing the mouth light salt brine after six months, ten childs' of this group dental health rank (superfine is designated as 0) is 2.2, and the thin integration of dental health is 5.8.
2, before using new tooth protection measure, spray or eight childs of rinsing the mouth xylitol edible mouth cleaning solution group all have one to three oral disease or upper respiratory tract infection (bacillary) outbreak in half a year, adhere to use spraying or rinsing the mouth xylitol edible mouth cleaning solution six months in, no oral disease and upper respiratory tract infection (bacillary) generation; Before using new tooth protection measure, ten childs of rinsing the mouth light salt brine group all have one to three oral disease or upper respiratory tract infection (bacillary) outbreak in half a year, in adhering to making rinsing the mouth light salt brine six months, being still all has one to three oral disease or upper respiratory tract infection (bacillary) outbreak;
Conclusion: adhere to spraying or rinsing the mouth xylitol edible mouth cleaning solution can be kept the tooth health state, caries prevention reduces the sickness rate of oral disease and upper respiratory tract infection (bacillary); Using the light salt brine rinsing the mouth does not have special meaning, does not have difference with not taking the tooth protection measure.
Claims (6)
1, a kind of child edible mouth cleaning solution is characterized in that
Xylitol 1～64g
Edible water-soluble calcium salt (calcium ion concentration) 0.02～0.2g
Phosphopeptide caseinate 0～0.2g
Food preservative 0.05～0.5g
Pure water 36～99g
Each component sum is 100 in the compositions
2, to contain xylitol percentage by weight minimum be 1% to mouth cleaning solution according to claim 1, is saturation solubility 64% to the maximum
3, mouth cleaning solution water-soluble Ca salt according to claim 1 can be calcium lactate, L-calcium lactate, calcium gluconate, calcium citrate etc., preferred calcium lactate or L-calcium lactate, and content is 0.2g～0.6g (in every 100ml collutory)
4, mouth cleaning solution according to claim 1 can add phosphopeptide caseinate, and content is no more than 0.2g (in every 100ml collutory)
5, the mouth cleaning solution according to claim 1 food preservative that can add can be a kind of in potassium sorbate, sodium benzoate, the ethylparaben, and content is conventional amount used 0.05g～0.5g (in every 100ml collutory)
6, mouth cleaning solution using method according to claim 1 is: after each feed, injection or rinsing the mouth xylitol mouth cleaning solution are to tooth or oral cavity an amount of (0.5 to 10ml)
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101719613A CN101416925B (en) | 2008-10-27 | 2008-10-27 | Child edible mouth cleaning solution formulation, production technique and tooth-protection infection prevention effect |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101719613A CN101416925B (en) | 2008-10-27 | 2008-10-27 | Child edible mouth cleaning solution formulation, production technique and tooth-protection infection prevention effect |
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| Publication Number | Publication Date |
|---|---|
| CN101416925A true CN101416925A (en) | 2009-04-29 |
| CN101416925B CN101416925B (en) | 2011-04-27 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102342396A (en) * | 2011-04-09 | 2012-02-08 | 常德市城头山绿色饮料有限公司 | Oral liquid containing xylitol zinc calcium |
| CN103330673A (en) * | 2013-07-09 | 2013-10-02 | 孙佳丽 | Edible mouthwash for childeren |
| CN105616324A (en) * | 2016-01-27 | 2016-06-01 | 珠海迈润实业有限公司 | Mouthwash containing plant formula and preparation method thereof |
| CN106109319A (en) * | 2016-07-28 | 2016-11-16 | 隋丽梅 | A kind of oral nursing liquid and preparation method thereof |
| CN113830398A (en) * | 2021-10-29 | 2021-12-24 | 南京鼓楼医院 | Portable gargle set |
-
2008
- 2008-10-27 CN CN2008101719613A patent/CN101416925B/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102342396A (en) * | 2011-04-09 | 2012-02-08 | 常德市城头山绿色饮料有限公司 | Oral liquid containing xylitol zinc calcium |
| CN102342396B (en) * | 2011-04-09 | 2013-06-12 | 常德市城头山绿色饮料有限公司 | Oral liquid containing xylitol zinc calcium |
| CN103330673A (en) * | 2013-07-09 | 2013-10-02 | 孙佳丽 | Edible mouthwash for childeren |
| CN105616324A (en) * | 2016-01-27 | 2016-06-01 | 珠海迈润实业有限公司 | Mouthwash containing plant formula and preparation method thereof |
| CN106109319A (en) * | 2016-07-28 | 2016-11-16 | 隋丽梅 | A kind of oral nursing liquid and preparation method thereof |
| CN113830398A (en) * | 2021-10-29 | 2021-12-24 | 南京鼓楼医院 | Portable gargle set |
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| CN101416925B (en) | 2011-04-27 |
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