CN112675058A - Antibacterial and cool oral cleaning composition and application thereof - Google Patents
Antibacterial and cool oral cleaning composition and application thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of oral care, and particularly relates to an antibacterial and cool oral cleaning composition and application thereof, wherein the oral cleaning composition comprises the following components in parts by weight: 0.5-5 parts of algefacient, 0.02-6 parts of bacteriostatic agent, 0.1-15 parts of emulsifier, 0-10 parts of PH regulator, 1-5 parts of edible essence, 0.01-10 parts of oil solvent and 30-90 parts of hydrosolvent. According to the antibacterial and cool oral cleaning composition and the application thereof, the oil solvent and the water solvent are added at the same time, the emulsifier is added, and the oil-in-water type mixed solution is formed through emulsification, so that the good taste is ensured, meanwhile, some oil-soluble cooling agents, bacteriostatic agents and the like can be added, the release time is longer, and the long-term cooling and antibacterial effects can be provided.
Description
Technical Field
The invention belongs to the technical field of oral care, and particularly relates to an antibacterial and cool oral cleaning composition and application thereof.
Background
With the change of health concepts and the improvement of living standard of people, the oral care concept also goes deep into the heart of people, various oral problems such as decayed teeth, dental plaque, dental calculus and the like in work and life not only affect personal image and physical and mental health, but also bring social and communication barriers, and especially, patients who receive treatment in hospitals due to other diseases are often accompanied with dry mouth, halitosis, oral ulcer and the like, the oral problems are generally caused by that food residues in the oral cavity are decomposed and digested by various bacteria, the bacteria are easy to grow on the surfaces of teeth, and a layer of biomembrane, namely dental plaque, is formed on the surfaces of the teeth after the bacteria are deposited; acid generated after the acid-producing bacteria decompose food residues can corrode teeth to cause dental caries, and halitosis can be caused if the acid-producing bacteria generate volatile sulfides or nitrides; food residues are calcified to form dental calculus, bacteria are attached to the dental calculus and generate toxin, cells of alveolar bones are changed into osteoclasts, the alveolar bones are damaged, gums are exposed, and various pathogenic bacteria invade gingiva and tooth roots to cause oral diseases such as periodontitis, ulcer infection and the like.
The types of oral care products are increasingly subdivided, and compared with the traditional oral care products such as toothbrushes, toothpicks and dental floss, the oral cleaning care solution can penetrate into the places which are difficult to clean, such as tooth gaps, tongue roots and the like, and has the advantages of convenience and rapidness in use, comprehensive cleaning range, lasting fresh effect, pleasure in body and mind and the like. The oral cleaning and nursing liquid in the current market can be divided into three types according to the main components: antibiotics such as chlorhexidine, chemical and Chinese medicinal preparations such as fluorine and thymol, and pure natural ingredients such as theanine and tannin, which are different from each other, are used to clean, care, treat and prevent oral cavity problems by killing microorganisms. Meanwhile, literature researches find that besides the bacteriostatic agent, the oral pH environment also influences the growth of bacteria, when the pH of the oral cavity of a patient is acidic, the oral pH environment is suitable for the growth of microorganisms, and the oral pH environment can be neutralized by using an alkaline care solution generally, so that the growth of part of bacteria can be effectively inhibited. And the acidic or neutral care solution is more suitable for oral care of the general population.
Modern people are pursuing high-quality life more and more, and especially people who suffer from oral diseases often want to clean the oral cavity and refresh breath by various means, and keep good oral cavity state at any time. Oral health is an important component of human health, and good oral care habits comprise selecting proper oral care products, brushing teeth frequently, improving eating habits, regular oral examination, tooth cleaning and the like, and are a long-term lesson. For oral care, a suitable oral care product can simultaneously meet the functions of bacteriostasis, disinfection, residue cleaning, breath freshening, body and mind pleasure and the like.
Disclosure of Invention
In order to solve the problems, the invention discloses an antibacterial and cool oral cleaning composition and application thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
the antibacterial and cooling oral cleaning composition comprises the following components in parts by weight: 0.5-5 parts of algefacient, 0.02-6 parts of bacteriostatic agent, 0.1-15 parts of emulsifier, 0-10 parts of PH regulator, 1-5 parts of edible essence, 0.01-10 parts of oil solvent and 30-90 parts of hydrosolvent.
Preferably, the antibacterial and cooling oral cleaning composition comprises the following components in parts by weight: 0.5-3 parts of freshener, 1-6 parts of bacteriostatic agent, 2-8 parts of emulsifier, 0-10 parts of pH regulator, 1-3 parts of edible essence, 5-10 parts of oil solvent and 60-90 parts of hydrosolvent.
Preferably, the antibacterial and refreshing oral cleaning composition further comprises 0.01-10 parts of a sweetening agent and 0.001-0.01 part of an edible pigment.
Preferably, the antibacterial and refreshing oral cleaning composition further comprises 0.1-1 part of foaming agent and 0.1-2 parts of antioxidant.
Preferably, the freshener is one or more of natural freshener and synthetic freshener;
the bacteriostatic agent is one or more of triclosan, chlorhexidine acetate, chlorhexidine gluconate, benzyl alcohol, benzoic acid, sodium benzoate, glycyrrhizic acid, hydrogen peroxide, chlorobutanol, and salicylic acid;
the emulsifier is one or more of polyoxyethylene ether, polyoxypropylene ether, ethylene oxide and propylene oxide block copolymer, polyol fatty acid ester, polyvinyl alcohol fatty alcohol polyoxyethylene ether (AEO), emulsifier SE-10, poloxamer, emulsifier TX-10/NP-10/OP-10, alkylolamide and alkyl polyglycoside APG;
the pH regulator is one or more of sodium citrate, potassium citrate, monosodium citrate, sodium lactate, tartaric acid, calcium hydroxide, potassium hydroxide, sodium hydroxide, trisodium bicarbonate, sodium carbonate, potassium carbonate and potassium bicarbonate;
the edible essence is one or more of thymol, oleum Menthae Dementholatum, oleum Foeniculi, oleum Cinnamomi, oleum Eucalypti, orange oil, lemon oil, citrus oil, methyl salicylate, ethyl salicylate, herba Hyperici Japonici extract, cacao extract, strawberry extract, apple juice concentrate, fructus Mangifera Indicae concentrate, and orange juice concentrate;
the oil solvent is one or more of propanol, propylene glycol, glycerol, phenylpropanol and triacetin;
the hydrosolvent is one or more of distilled water, deionized water, purified water, reverse osmosis water and ultrapure water;
the sweetener is one or more of stevioside, erythritol, isomalt, lactitol, mannitol, sorbitol, xylitol, thaumatin, mogroside, arabinose, maltitol, acesulfame, aspartame, alitame and saccharin sodium;
the edible pigment is one or more of amaranth, carmine, new red, lemon yellow, sunset yellow, indigo, brilliant blue, red and allure red;
the foaming agent is fatty alcohol-polyoxyethylene ether sodium sulfate or lauryl sodium sulfate;
the antioxidant is one or more of vitamin C, vitamin E, carotene, carotenoid and its derivatives, ascorbic acid and its sodium salt.
Preferably, the natural freshener is one or more of natural borneol, natural mint extract and natural camphor; the synthetic freshener is an oil-soluble freshener.
Preferably, the natural mint extract is one or more of menthol, menthyl lactate, water-insoluble mint oil and water-soluble mint oil; the oil-soluble freshener is one or more of WS series freshener, menthone glycerol acetal and menthone glycerol ketal.
Preferably, the above-mentioned coolants are WS-series coolants used in combination with natural coolants.
Preferably, the antibacterial and refreshing oral cleaning composition is prepared by the following method:
(1) weighing the components in proportion, adding the oil-soluble components into an oil solvent, and stirring until the components are completely dissolved to obtain oil-phase components;
(2) adding water-soluble components into partial water solvent, and stirring until the components are completely dissolved to obtain water-phase components;
(3) adding the emulsifier into the rest water solvent, stirring and emulsifying to obtain an emulsion;
(4) adding the emulsion into the oil phase component, stirring to mix well, adding the water phase component, stirring to mix well, adding pH regulator, sweetener, edible pigment, etc., and stirring to dissolve completely.
An antibacterial and refreshing oral cleaning composition is used as oral cleaning care solution after being diluted by a specified multiple, or as additive of toothpaste, dentifrice, mouthwash, chewing gum, denture cleanser and pet tooth cleaning gel.
The invention has the following beneficial effects:
(1) according to the antibacterial and cool oral cleaning composition and the application thereof, the oil solvent and the water solvent are added at the same time, the emulsifier is added, and the oil-in-water type mixed solution is formed through emulsification, so that the good taste is ensured, meanwhile, some oil-soluble freshener, bacteriostatic agent and the like can be added, the release time is longer, and the long-term cool and bacteriostatic effects can be provided;
(2) the composition of the invention does not contain alcohol, and is friendly to alcohol allergic people and driving people;
(3) the composition of the invention uses WS series algefacients and natural algefacients to be mixed, can overcome the defect of poor algefacient effect of the natural algefacients, improve algefacient feeling and layering feeling and keep longer algefacient feeling;
(4) by reasonably blending the edible essence, the sweetening agent, the freshener, the bacteriostatic agent and other raw materials in proportion, the oral liquid can provide various tastes, taste choices and good experiences for patients with oral problems;
(5) the composition adopts triclosan as a bacteriostatic agent, has strong bacteriostatic ability, is beneficial to removing dental plaque and further protects the health of teeth;
(6) the oral cleaning composition can be diluted to be used as oral spray or mouthwash, and can also be added with toothpaste, tooth powder, mouthwash, chewing gum, denture cleanser, pet tooth cleaning gel and the like for use, so that various application requirements can be met.
Detailed Description
The present invention will now be described in further detail with reference to examples.
Example 1
(1) Mixing eucalyptus oil 0.6 part, thymol 0.6 part, triclosan 0.5 part, and propylene glycol 6 part, stirring at room temperature for 10min at 100r/min until completely dissolved to obtain oil phase component;
(2) mixing 1.5 parts of water-soluble triclosan, 2.0 parts of water-soluble peppermint oil and 40 parts of purified water, stirring at room temperature for 5min at the stirring speed of 100r/min until the water-soluble triclosan, the water-soluble peppermint oil and the purified water are completely dissolved to obtain a water-phase component;
(3) taking 3.6 parts of poloxamer and 40 parts of purified water, mixing, stirring at room temperature for 30min at the stirring speed of 200r/min, and emulsifying uniformly to obtain an emulsion;
(4) adding the emulsion into the oil phase component, stirring for 10min at 200r/min until the mixture is uniformly mixed, then adding the water phase component, stirring for 10min at 200r/min until the mixture is uniformly mixed, then adding 0.5 part of acesulfame, 1 part of xylitol, 0.005 part of brilliant blue and 0.5 part of sodium bicarbonate, continuously stirring for 5min at 100r/min until the mixture is completely dissolved, and standing until bubbles disappear.
The blue clear oral cleaning composition can be obtained, the pH value is alkaline, the pH value is indirectly changed by adjusting the using amount of the sodium bicarbonate, the oral cleaning composition is suitable for patients with neutral or acidic oral pH values, and the oral cleaning composition has the effects of cooling, refreshing, strong cleaning, strong bacteriostasis and infection prevention.
Example 2
(1) Mixing 0.6 part of menthol, 0.6 part of eucalyptus oil, 0.6 part of thymol, 0.6 part of lemon oil, 0.6 part of triclosan and 6 parts of propylene glycol, stirring at room temperature for 10min at a stirring speed of 100r/min until the menthol, the eucalyptus oil, the thymol and the propylene glycol are completely dissolved to obtain an oil phase component;
(2) mixing 2.0 parts of water-soluble triclosan and 40 parts of purified water, stirring at room temperature for 5min at a stirring speed of 100r/min until the water-soluble triclosan and the purified water are completely dissolved to obtain a water phase component;
(3) taking 3.6 parts of poloxamer and 40 parts of purified water, mixing, stirring at room temperature for 30min at the stirring speed of 200r/min, and emulsifying uniformly to obtain an emulsion;
(4) adding the emulsion into the oil phase component, stirring for 10min at 200r/min until the mixture is uniformly mixed, then adding the water phase component, stirring for 10min at 200r/min until the mixture is uniformly mixed, then adding 0.5 part of acesulfame, 1 part of xylitol and 0.005 part of brilliant blue, continuously stirring for 5min at 100r/min until the acesulfame, and standing until bubbles disappear.
The oral cleaning composition with the taste of the lemon mint can be obtained, has an acidic pH value, is suitable for patients with neutral or alkaline oral pH values, and has the effects of faint scent, coolness, refreshment, strong cleaning, strong bacteriostasis and infection prevention.
Example 3
(1) Mixing 0.6 part of menthol, 0.6 part of eucalyptus oil, 0.6 part of thymol, 0.6 part of triclosan and 10 parts of propanol, stirring at room temperature for 10min at a stirring speed of 100r/min until completely dissolving to obtain an oil phase component;
(2) mixing 3.6 parts of benzoic acid, 1.2 parts of sodium benzoate and 40 parts of purified water, stirring at room temperature for 5min at the stirring speed of 100r/min until the benzoic acid, the sodium benzoate and the purified water are completely dissolved to obtain a water phase component;
(3) taking 4.8 parts of poloxamer and 40 parts of purified water, mixing, stirring at room temperature for 30min at the stirring speed of 200r/min, and emulsifying uniformly to obtain an emulsion;
(4) adding the emulsion into the oil phase component, stirring for 10min at 200r/min until the mixture is uniformly mixed, then adding the water phase component, stirring for 10min at 200r/min until the mixture is uniformly mixed, then adding 0.5 part of acesulfame potassium, 5 parts of sorbitol, 0.5 part of saccharin sodium and 0.005 part of brilliant blue, continuously stirring for 5min at 100r/min until the mixture is completely dissolved, and standing until bubbles disappear.
This example resulted in a mint flavored oral cleansing composition with a mild mouth feel.
Example 4
(1) Mixing 0.3 part of menthol, 30.3 parts of refrigerant WS, 0.6 part of eucalyptus oil, 0.6 part of thymol, 0.6 part of triclosan and 10 parts of propanol, stirring at room temperature for 10min at a stirring speed of 100r/min until the menthol, the refrigerant WS, the eucalyptus oil and the propanol are completely dissolved to obtain an oil phase component;
(2) mixing 3.6 parts of benzoic acid, 1.2 parts of sodium benzoate and 40 parts of purified water, stirring at room temperature for 5min at the stirring speed of 100r/min until the benzoic acid, the sodium benzoate and the purified water are completely dissolved to obtain a water phase component;
(3) taking 4.8 parts of poloxamer and 40 parts of purified water, mixing, stirring at room temperature for 30min at the stirring speed of 200r/min, and emulsifying uniformly to obtain an emulsion;
(4) adding the emulsion into the oil phase component, stirring for 10min at 200r/min until the mixture is uniformly mixed, then adding the water phase component, stirring for 10min at 200r/min until the mixture is uniformly mixed, then adding 0.5 part of acesulfame potassium, 5 parts of sorbitol, 0.5 part of saccharin sodium and 0.005 part of brilliant blue, continuously stirring for 5min at 100r/min until the mixture is completely dissolved, and standing until bubbles disappear.
This example resulted in a mint flavored oral cleansing composition with a mild mouth feel.
Example 5
(1) Mixing refrigerant WS-30.4 parts, Borneolum 0.5 parts, thymol 0.6 parts, strawberry extract 0.6 parts, triclosan 1 parts, and propylene glycol 10 parts, stirring at room temperature for 10min at a stirring speed of 100r/min until completely dissolved to obtain oil phase component;
(2) mixing 1.5 parts of hydrogen peroxide, 1.5 parts of chlorhexidine gluconate, 2.0 parts of water-soluble peppermint oil and 30 parts of distilled water, stirring for 5min at room temperature at a stirring speed of 100r/min until the components are completely dissolved to obtain a water phase component;
(3) mixing 4 parts of polyoxyethylene ether and 30 parts of distilled water, stirring at room temperature for 30min at the stirring speed of 200r/min, and emulsifying uniformly to obtain an emulsion;
(4) adding the emulsion into the oil phase component, stirring for 10min at 200r/min until the mixture is uniformly mixed, then adding the water phase component, stirring for 10min at 200r/min until the mixture is uniformly mixed, then adding 1 part of stevioside, 1 part of erythritol, 0.005 part of carmine and 0.5 part of sodium bicarbonate, continuously stirring for 5min at 100r/min until the stevioside, the erythritol, the carmine and the sodium bicarbonate are completely dissolved, and standing until bubbles disappear.
The oral cleaning composition with the red and clear strawberry taste can be obtained, the pH value is alkaline, the pH value is indirectly changed by adjusting the using amount of the sodium bicarbonate, and the oral cleaning composition is suitable for patients with neutral or acidic oral pH values, and has the effects of cooling, refreshing, strongly cleaning, strongly inhibiting bacteria and preventing infection.
Example 6
(1) Mixing refrigerant WS-30.6 parts, menthol 0.6 part, thymol 0.6 part, orange juice concentrate 0.6 part, methyl salicylate 0.6 part, triclosan 0.6 part and glycerol 10 part, stirring at room temperature for 10min at a stirring speed of 100r/min, and stirring until completely dissolving to obtain oil phase component;
(2) mixing 2 parts of water-soluble triclosan, 2 parts of water-soluble peppermint oil and 45 parts of distilled water, stirring at room temperature for 5min at the stirring speed of 100r/min until the water-soluble triclosan, the water-soluble peppermint oil and the distilled water are completely dissolved to obtain a water phase component;
(3) taking 3.6 parts of polyol fatty acid ester, 1.2 parts of alkylolamide and 45 parts of distilled water, mixing, stirring at room temperature for 30min, wherein the stirring speed is 200r/min, and emulsifying uniformly to obtain an emulsion;
(4) adding the emulsion into the oil phase component, stirring for 10min at 200r/min until the mixture is uniformly mixed, then adding the water phase component, stirring for 10min at 200r/min until the mixture is uniformly mixed, then adding 0.5 part of arabinose, 1 part of maltitol, 0.005 part of sunset yellow and 0.5 part of sodium bicarbonate, continuously stirring for 5min at 100r/min until the mixture is completely dissolved, and standing until bubbles disappear.
The orange-yellow clear orange-flavor oral cleaning composition can be obtained, the pH value is alkaline, the pH value is indirectly changed by adjusting the using amount of the sodium bicarbonate, and the oral cleaning composition is suitable for patients with neutral or acidic oral pH values, and has the effects of cooling, refreshing, strongly cleaning, strongly inhibiting bacteria and preventing infection.
Example 7
(1) Mixing eucalyptus oil 0.6 part, thymol 0.6 part and propylene glycol 6 part, stirring at room temperature for 10min at 100r/min until completely dissolved to obtain oil phase component;
(2) mixing 2 parts of water-soluble triclosan, 2.0 parts of water-soluble peppermint oil and 40 parts of purified water, stirring at room temperature for 5min at the stirring speed of 100r/min until the water-soluble triclosan, the water-soluble peppermint oil and the purified water are completely dissolved to obtain a water phase component;
(3) taking 3.6 parts of poloxamer and 40 parts of purified water, mixing, stirring at room temperature for 30min at the stirring speed of 200r/min, and emulsifying uniformly to obtain an emulsion;
(4) adding the emulsion into the oil phase component, stirring for 10min at 200r/min until the mixture is uniformly mixed, then adding the water phase component, stirring for 10min at 200r/min until the mixture is uniformly mixed, then adding 0.5 part of acesulfame, 1 part of xylitol, 0.005 part of brilliant blue and 0.5 part of sodium bicarbonate, continuously stirring for 5min at 100r/min until the mixture is completely dissolved, and standing until bubbles disappear.
The blue clear oral cleaning composition can be obtained, the pH value is alkaline, the pH value is indirectly changed by adjusting the using amount of the sodium bicarbonate, the oral cleaning composition is suitable for patients with neutral or acidic oral pH values, and the oral cleaning composition has the effects of cooling, refreshing, strong cleaning, strong bacteriostasis and infection prevention.
Example 8
(1) Mixing refrigerant WS-30.4 parts, Borneolum 0.5 parts, thymol 0.6 parts, strawberry extract 0.6 parts, triclosan 1 parts, and propylene glycol 10 parts, stirring at room temperature for 10min at a stirring speed of 100r/min until completely dissolved to obtain oil phase component;
(2) mixing 1.5 parts of hydrogen peroxide, 1.5 parts of chlorhexidine gluconate, 2.0 parts of water-soluble peppermint oil, 0.5 part of vitamin C, 0.1 part of sodium dodecyl sulfate and 30 parts of distilled water, stirring at room temperature for 5min at a stirring speed of 100r/min, and stirring until the components are completely dissolved to obtain a water phase component;
(3) mixing 4 parts of polyvinyl alcohol, fatty alcohol and polyoxyethylene ether and 30 parts of distilled water, stirring at room temperature for 30min at the stirring speed of 200r/min, and emulsifying uniformly to obtain an emulsion;
(4) adding the emulsion into the oil phase component, stirring for 10min at 200r/min until the mixture is uniformly mixed, then adding the water phase component, stirring for 10min at 200r/min until the mixture is uniformly mixed, then adding 1 part of stevioside, 1 part of erythritol, 0.005 part of carmine and 0.5 part of sodium bicarbonate, continuously stirring for 5min at 100r/min until the stevioside, the erythritol, the carmine and the sodium bicarbonate are completely dissolved, and standing until bubbles disappear.
The oral cleaning composition with the red and clear strawberry taste can be obtained, the pH value is alkaline, the pH value is indirectly changed by adjusting the using amount of the sodium bicarbonate, and the oral cleaning composition is suitable for patients with neutral or acidic oral pH values, and has the effects of cooling, refreshing, strongly cleaning, strongly inhibiting bacteria and preventing infection.
Doctors can prescribe care solutions with different pH values for patients according to the oral conditions of the patients, and the patients can select different tastes.
Application example one:
the application example is used for the oral cleaning care solution.
Taking 5mL of the oral cleaning composition in example 1, adding normal saline or purified water or boiled and cooled drinking water for dilution by 12 times, preparing 60mL of oral cleaning care solution, and filling the oral cleaning care solution into a container to normally wash or rinse the oral cavity.
Application example two:
the application example is used for toothpaste.
10mL of the oral cleaning composition in example 1, 45g of calcium carbonate, 30g of glycerol, 0.1g of saccharin sodium, 0.1g of sodium benzoate, 1g of silica powder, 1g of disodium lauroamphodiacetate and a proper amount of purified water are uniformly mixed, and then 100g of toothpaste with antibacterial and breath freshening effects can be respectively obtained.
And (3) evaluating the coolness:
the composition prepared in example 6 was diluted 12-fold to obtain an oral cleaning and care solution. 100 volunteers were randomly recruited to perform double-blind trial evaluation on the cooling effect of the diluted oral cleaning care solution, and the evaluation criteria were as follows: the cool feeling lasts for 10-20 minutes: 1 minute; the cool feeling lasts for 20-40 minutes: 2 min; the cooling sensation lasts for 40-60 minutes: 3 min; the cooling feeling lasts for 60-80 minutes: 4, dividing; the cool feeling lasts for 80-100 minutes: 5 min; the cooling sensation lasts for 100-: 6 minutes; the cool feeling lasts for more than 120 minutes: 7 minutes. After trial training on 100 volunteers, the oral cleaning compositions prepared in examples 1-7 were evaluated.
And (4) evaluation results: the average score of the evaluation of the cooling sensation of 100 volunteers with respect to the oral cleaning composition obtained in example 6 was 6.8, indicating that the oral cleaning composition can maintain the cooling sensation for a long period of time. The oil-soluble freshener is dissolved in the oil phase, and forms a stable oil-in-water structure through emulsification, so that the release of the freshener is delayed, and the oil phase components can be better attached to oral mucosa due to good adhesiveness and modeling, so that a lasting cooling effect is achieved. In addition, the sensory evaluation of the cooling sensation was performed using a 12-fold dilution, and if the user pursues a longer cooling sensation, the dilution can be selected to be appropriately reduced.
Evaluation of cooling sensation:
the compositions prepared in examples 3 and 4 were diluted 12-fold to obtain oral cleaning solutions, which were labeled as solution No. 1 and solution No. 2, respectively. Then, 50 volunteers were recruited to evaluate the cooling effect of the diluted oral cleaning solution, wherein 48 patients considered that the cooling effect of the No. 2 solution (i.e., example 4) was more abundant and more hierarchical, and 2 patients considered that the two solutions were not very different. It is demonstrated that when menthol (natural freshener) and a freshener WS-3(WS series freshener) are mixed for use, it is helpful to obtain richer mouthfeel and to improve the refreshing feeling and the layering feeling.
And (3) testing the antibacterial persistence:
120 patients with oral problems were recruited as volunteers and randomly divided into three groups of 40 persons, the first group was rinsed for 1 minute with 12-fold dilution of the oral cleaning composition prepared in example 1, the second group was rinsed for 1 minute with 12-fold dilution of the oral cleaning composition prepared in example 7, the third group was rinsed for 1 minute with a commercially available oil-free water-soluble oral care solution, the conditions of major pathogenic bacteria (gram negative bacteria such as Escherichia coli, gram positive bacteria such as Staphylococcus aureus) in the oral cavity were detected before rinsing, and the detection was performed every 2 hours after rinsing for 12 hours, and the antibacterial data were obtained as shown in Table 1:
TABLE 1 variation of oral pathogens in three groups of volunteers within 12h
As can be seen from table 1, the first group showed far better duration of inhibition than the second and third groups. The bacteriostatic agent in the embodiment 1 comprises an oil-soluble bacteriostatic agent and a water-soluble bacteriostatic agent, wherein the oil-soluble bacteriostatic agent is dissolved in an oil phase, the water-soluble bacteriostatic agent is dissolved in a water phase, and then a stable oil-in-water structure is formed through emulsification, so that the release of the bacteriostatic agent is favorably delayed, and the oil phase component can be better attached to the oral mucosa due to good adhesiveness and modeling, so that a lasting bacteriostatic effect is achieved. In example 7, only the water-soluble bacteriostatic agent is added, although the oil-in-water structure is beneficial to corrosion inhibition of the bacteriostatic agent, the oil-soluble bacteriostatic agent is not present, so that the adhesion effect and the film forming effect are poor, and the durability is poor. The long-lasting effect of example 7 is far less than that of example 1, but the water retention structure obtained by emulsification of the oil and water phases is still superior to that of the pure water-soluble solutions (third group).
In light of the foregoing description of the preferred embodiment of the present invention, many modifications and variations will be apparent to those skilled in the art without departing from the spirit and scope of the invention. The technical scope of the present invention is not limited to the content of the specification, and must be determined according to the scope of the claims.
Claims (10)
1. An antibacterial cooling oral cleaning composition, which is characterized in that: the paint comprises the following components in parts by weight: 0.5-5 parts of algefacient, 0.02-6 parts of bacteriostatic agent, 0.1-15 parts of emulsifier, 0-10 parts of PH regulator, 1-5 parts of edible essence, 0.01-10 parts of oil solvent and 30-90 parts of hydrosolvent.
2. A bacteriostatic cooling oral cleaning composition according to claim 1 wherein: the paint comprises the following components in parts by weight: 0.5-3 parts of freshener, 1-6 parts of bacteriostatic agent, 2-8 parts of emulsifier, 0-10 parts of pH regulator, 1-3 parts of edible essence, 5-10 parts of oil solvent and 60-90 parts of hydrosolvent.
3. A bacteriostatic cooling oral cleaning composition according to claim 1 wherein: also comprises 0.01 to 10 portions of sweetening agent and 0.001 to 0.01 portion of edible pigment.
4. A bacteriostatic cooling oral cleaning composition according to claim 3 wherein: also comprises 0.1 to 1 portion of foaming agent and 0.1 to 2 portions of antioxidant.
5. A bacteriostatic cooling oral cleaning composition according to claim 4 characterized in that: the freshener is one or more of natural freshener and synthetic freshener;
the bacteriostatic agent is one or more of triclosan, chlorhexidine acetate, chlorhexidine gluconate, benzyl alcohol, benzoic acid, sodium benzoate, glycyrrhizic acid, hydrogen peroxide, chlorobutanol, and salicylic acid;
the emulsifier is one or more of polyoxyethylene ether, polyoxypropylene ether, ethylene oxide and propylene oxide block copolymer, polyol fatty acid ester, polyvinyl alcohol fatty alcohol polyoxyethylene ether (AEO), emulsifier SE-10, poloxamer, emulsifier TX-10/NP-10/OP-10, alkylolamide and alkyl polyglycoside APG;
the pH regulator is one or more of sodium citrate, potassium citrate, monosodium citrate, sodium lactate, tartaric acid, calcium hydroxide, potassium hydroxide, sodium hydroxide, trisodium bicarbonate, sodium carbonate, potassium carbonate and potassium bicarbonate;
the edible essence is one or more of thymol, oleum Menthae Dementholatum, oleum Foeniculi, oleum Cinnamomi, oleum Eucalypti, orange oil, lemon oil, citrus oil, methyl salicylate, ethyl salicylate, herba Hyperici Japonici extract, cacao extract, strawberry extract, apple juice concentrate, fructus Mangifera Indicae concentrate, and orange juice concentrate;
the oil solvent is one or more of propanol, propylene glycol, glycerol, phenylpropanol and triacetin;
the hydrosolvent is one or more of distilled water, deionized water, purified water, reverse osmosis water and ultrapure water;
the sweetener is one or more of stevioside, erythritol, isomalt, lactitol, mannitol, sorbitol, xylitol, thaumatin, mogroside, arabinose, maltitol, acesulfame, aspartame, alitame and saccharin sodium;
the edible pigment is one or more of amaranth, carmine, new red, lemon yellow, sunset yellow, indigo, brilliant blue, red and allure red;
the foaming agent is fatty alcohol-polyoxyethylene ether sodium sulfate or lauryl sodium sulfate;
the antioxidant is one or more of vitamin C, vitamin E, carotene, carotenoid and its derivatives, ascorbic acid and its sodium salt.
6. A bacteriostatic cooling oral cleaning composition according to claim 5 wherein: the natural freshener is one or more of natural borneol, natural mint extract and natural camphor; the synthetic freshener is an oil-soluble freshener.
7. A bacteriostatic cooling oral cleaning composition according to claim 6 wherein: the natural mint extract is one or more of menthol, menthyl lactate, non-water-soluble mint oil and water-soluble mint oil; the oil-soluble freshener is one or more of WS series freshener, menthone glycerol acetal and menthone glycerol ketal.
8. A bacteriostatic cooling oral cleaning composition according to claim 7 wherein: the refrigerant is WS series refrigerant and natural refrigerant.
9. A bacteriostatic cooling oral cleaning composition according to any one of claims 1 to 8 wherein: the preparation method comprises the following steps:
(1) weighing the components in proportion, adding the oil-soluble components into an oil solvent, and stirring until the components are completely dissolved to obtain oil-phase components;
(2) adding water-soluble components into partial water solvent, and stirring until the components are completely dissolved to obtain water-phase components;
(3) adding the emulsifier into the rest water solvent, stirring and emulsifying to obtain an emulsion;
(4) adding the emulsion into the oil phase component, stirring to mix well, adding the water phase component, stirring to mix well, adding pH regulator, sweetener, edible pigment, etc., and stirring to dissolve completely.
10. Use of a bacteriostatic cooling oral cleaning composition according to any one of claims 1 to 8 wherein: diluting the oral cleaning composition by specified times, and using as oral cleaning care solution, or as additive of toothpaste, dentifrice, mouthwash, chewing gum, denture cleanser, and dentifrice for pet.
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| CN113559008A (en) * | 2021-08-31 | 2021-10-29 | 吉林大学 | Antibacterial mouth wash containing dihydroquercetin and preparation method thereof |
| CN113679625A (en) * | 2021-08-11 | 2021-11-23 | 上海驻净电子科技有限公司 | Oral care agent with lasting fragrance |
| CN113768802A (en) * | 2021-08-11 | 2021-12-10 | 上海驻净电子科技有限公司 | Cool agent for refreshing blasting and refreshing |
| CN113827506A (en) * | 2021-10-20 | 2021-12-24 | 安徽克菱保健科技有限公司 | Oral care mousse with functions of inhibiting bacteria, preventing decayed teeth, whitening teeth, resisting allergy and removing peculiar smell |
| CN114652475A (en) * | 2022-03-23 | 2022-06-24 | 上海歌鹭日化科技有限公司 | Method for screening, developing and using mouthwash adaptive to tooth rinser |
| CN115227603A (en) * | 2022-08-02 | 2022-10-25 | 上海佩格医院管理有限公司 | Edible oral sustained-release matrix and preparation method and application thereof |
| CN115769883A (en) * | 2022-12-09 | 2023-03-10 | 南通亚香食品科技有限公司 | Compound cooling agent for food and preparation method thereof |
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| CN113827506A (en) * | 2021-10-20 | 2021-12-24 | 安徽克菱保健科技有限公司 | Oral care mousse with functions of inhibiting bacteria, preventing decayed teeth, whitening teeth, resisting allergy and removing peculiar smell |
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| CN115769883A (en) * | 2022-12-09 | 2023-03-10 | 南通亚香食品科技有限公司 | Compound cooling agent for food and preparation method thereof |
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