CN101411398B - Composite organic iron formulation - Google Patents
Composite organic iron formulation Download PDFInfo
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- CN101411398B CN101411398B CN2008100739520A CN200810073952A CN101411398B CN 101411398 B CN101411398 B CN 101411398B CN 2008100739520 A CN2008100739520 A CN 2008100739520A CN 200810073952 A CN200810073952 A CN 200810073952A CN 101411398 B CN101411398 B CN 101411398B
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Abstract
The invention discloses a compound organic iron preparation which is characterized in that the preparation comprises ferrous fumarate, methionine and ferric lactate. The preparation process comprises the following steps: taking raw materials according to the weight proportion and mixing the raw materials evenly; and carrying out detection and packaging the end product. The compound organic iron preparation which is usually added into the feedstuff for sows in the proportion of 5:800 to 1,500 can be used for supplementing iron for baby pigs through feeding sows heavy in pig and milking sows with the feedstuff. The compound organic iron preparation can reach the effect of completely replacing injected iron for the precaution of anemic baby pigs, improve the reproductive performance of the sows, reduce the mortality of baby pigs and the impact on the reproductive performance of the sows caused by postpartum anemia and weakness, and simultaneously improve the litter weight of baby pigs. The compound organic iron preparation is suitable for the intensive hog industry.
Description
Technical field
The present invention relates to a kind of feed addictive, especially the additive of sow feed.
Background technology
Iron is one of essential trace element of animal body, is the part that constitutes ferroheme, myoglobins, cytochromes etc., with the hematopoiesis of animal, to take processes such as oxygen, production capacity closely related.In the tradition breeding way, anaemia very easily takes place newborn piglet, and its reason is: 1, the iron reserves are lower in the newborn piglet body, are about about 50mg, can keep a week general reluctantly; 2, concentration of iron is very low in the sow colostrum; The content 1.33mg/L of normal Ruzhong iron; Piglet birth back the first two, three weeks the main breast milks that rely on as food, obtain iron quantity not sufficient 1mg every day through breast milk, and the iron requirement of keeping its body normal condition is every day at least 7～16mg; 3, the newborn piglet growth rapidly; One week of birth, the back body weight doubled, and total blood volume increases sharply, and growth has fast strengthened the requirement of iron; Iron reserves and breast milk supply iron can not keep the normal level of hemoglobin in the blood in the body, and the biochemical functions of iron can not normally be brought into play; 4, because the raising of pig farm production intensification degree, make newborn piglet not reach soil or the iron of other form except that breast milk usually, can not get the additional of enough non-feed external source iron; 5, the utilization rate of iron is lower in the plant feed, and the piglet malabsorption is like an absorptivity 1-5% of iron in corn, soybean and the wheat.
Piglet anaemia the lighter shows as mucocutaneous pale and growth retardation, and severe patient can be because of the anoxic die by visitation of God.According to interrelated data, the death of piglet hypoferric anemia accounts for about 40% of whole death toll, and the newborn piglet iron deficiency is an intensive pig production industry question of common concern.Therefore, how to mend iron to piglet effectively, receive scientific research personnel's concern always.The common piggy injection chalybeate that in pig starter feed, replenishes iron or give nascent 3 ages in days.But; The iron absorptivity that replenishes in the feed is extremely low, and the human and material resources that the iron mode needs labor are mended in intramuscular injection, and grab pig by force; Give birth just 3 days also very fragile piggy injections of life; Piglet is got a fright cause strong stress reaction, the injection site can influence carcass quality, and some injects bad also dying instantly.Moreover such benefit iron mode to the reproductive performance that improves sow with impel sow to recover no any help postpartum.Animal nutrition research thinks, can the key of mending iron be in-pig and prenatal piglet are absorbed to some extent and the problem of absorptivity.
Summary of the invention
The additive that the purpose of this invention is to provide a kind of pig feed--composite organic iron formulation through cooperate feed in-pig and lactating sow with pig feed, can more effectively transmit irony through placenta and breast milk; Improve the iron reserves and the content of hemoglobin of newborn piglet, improve newborn iron content, effectively prevent the newborn piglet anaemia; Can also improve the birth weight of piglet; Young number a little less than the minimizing impels sow to recover sooner postpartum, improves the reproductive performance of sow.
The technical solution adopted for the present invention to solve the technical problems is: the composite organic iron formulation that comprises ferrous fumarate, methionine iron, ferric lactate can come comprehensive collaborative performance to mend the iron action principle through the differing absorption passage.One: cell membrane is the natural cover for defense of cell internal and external environment, is made up of protein and lipoid.Iron ion will pass cell membrane, needs a kind of carrier molecule that it is wrapped, and forms a kind of organic fat-soluble surface, just can pass cell membrane.And ferrous fumarate, methionine iron, ferric lactate etc. all are to exist with complexing iron form, have fat-solublely, can get into cell membrane smoothly, get in the animal body to be absorbed fully.Two: their absorbing path is different: methionine iron passes placenta and transmits iron through the amino acid nutrient absorption pattern; And ferrous fumarate forms blood iron form transmission iron through blood; The lactic acid iron rule forms newborn Tie Tong and crosses milk transmission iron.Ferrous fumarate, methionine iron, ferric lactate etc. play a role in the sow body separately, transmit iron through different forms to newborn piglet, finally mend iron to piglet effectively.Three: fumaric acid, methionine, lactic acid all are the important nutrient of biochemical reaction in the animal body; Not external material, outside animal body, form complex compound and save ability in the animal do not have antagonism fully with iron; Can not produce the phase mutual interference, more can not make animal produce rejection.Be specially:
A kind of composite organic iron formulation is characterized in that it comprises the raw material composition of following weight portion ratio:
Ferrous fumarate 40～90 methionine irons 5～30 ferric lactates 5～30.
Manufacture craft is:
(1) gets raw material in above-mentioned weight portion ratio, mix;
(2) detect;
(3) packed products.
In the feed of the sow of feeding that composite organic iron formulation of the present invention generally is added on the amount of 1～5:800～1500 ratios; Sow heavy in pig and lactating sow are mended iron to piglet through feeding; Can reach fully and substitute intramuscular injection iron Prevention of Piglet Anemia by Adding; And can improve the reproductive performance of sow, reduce the piglet death rate and influence production performance, improve the piglet litter weight simultaneously because of the sow postpartum anemia is weak.
The specific embodiment
According to several kinds of organoferric characteristics of finished product ferrous fumarate, methionine iron, ferric lactate on sale on the market and trophism; Carry out scientific and rational mode and screen cost-effective prescription, ferrous fumarate 40～90, methionine iron 5～30, ferric lactate 5～30.In manufacturing process, stir through scientific matching with in mixer, obtain qualified composite organic iron formulation through detecting the packing on packaging platform of qualified back.
Embodiment 1
Step 1: ratio is got 300 kilograms of 400 kilograms of ferrous fumarates, 300 kilograms of methionine irons and ferric lactates by weight, puts into mixer and mixes and stirred 5 minutes, and three kinds of raw materials are mixed;
Step 2: detect;
Step 3: packed products.
Embodiment 2
Step 1: ratio is got 50 kilograms of 900 kilograms of ferrous fumarates, 50 kilograms of methionine irons and ferric lactates by weight, puts into mixer and mixes and stirred 5 minutes, and three kinds of raw materials are mixed;
Step 2: detect;
Step 3: packed products.
Embodiment 3
Step 1: ratio is got 100 kilograms of 600 kilograms of ferrous fumarates, 300 kilograms of methionine irons and ferric lactates by weight, puts into mixer and mixes and stirred 5 minutes, and three kinds of raw materials are mixed;
Step 2: detect;
Step 3: packed products.
In above embodiment 1～3, can be made into the composite organic iron formulation of different content, can feed respectively with the concrete condition of mending iron according to the kind of pig.In the feed of the sow of feeding that this composite organic iron formulation is added on the amount of 1～5:800～1500 ratios, sow heavy in pig and lactating sow are mended iron to piglet through feeding.
Practical function
In April, 2008, on certain pig farm, Guigang, Guangxi, choose 21 health, blood relationship is identical, farrowing performance, parity are approaching, and with the Du Luoke breeding, 85 days sow of gestation (long * big) and the 21 nest piglets that given birth to thereof make an experiment.The completely random design is adopted in test, and crossbreeding sow is divided into 3 groups at random, every group of 7 repetitions, and each repeats 1 sow.For the 21 nest piglets that derive from above 3 groups of sows, also corresponding setting becomes three processed group.Piglet 7 ages in days begin to feed to give opens foodstuff, finishes up to the wean of 21 ages in days.The concrete experiment as follows:
1 materials and methods
1.1 basal diet with mend that the iron mode sees Table 1, table 2.
Table 1 in-pig, milking sow and suckling pig basal diet prescription (%) and trophic level
Annotate: moisture, crude protein, coarse ash, crude fibre, crude fat, calcium, total phosphorus are measured value, and other is a calculated value.
Table 2 is mended iron mode experimental design
Annotate: " the mother's honey iron " in the table 2 is the trade name of composite organic iron formulation of the present invention, and addition is 0.1%, and is as follows.
1.2 feeding and management
Sow and piglet hypervisor are undertaken by pig farm normal management system.Different with content outer other is very much all identical in the source of deironing in the premix.One on in-pig one hurdle, the personal management, 2 times on the one by quantitative 3kg/ sun to three test group respectively with the source of iron in the table 2 with add iron level and feed milking sow and piglet free choice feeding and drinking-water.All test sows are by the gestation material of feeding in antenatal 4 thoughtful antenatal 1 weeks of such scheme, the lactation material of feeding in antenatal 1 thoughtful 3 weeks of postpartum.Piglet 7 ages in days begin feed supplement.
1.3 sample collection and preparation
Piglet 7 ages in days and the every nest of 21 ages in days are all chosen 6 piglets and are carried out jugular vein blood sampling 2 to 3ml, and anticoagulant heparin, part blood sample are used to measure red blood cell count(RBC), content of hemoglobin and hematocrit immediately, the centrifugal preparation plasma analysis of another part iron content; The 1st day collection colostrum appearance and normal breast kind each 2ml of each collection in the 21st day in lactation.All plasma samples and breast appearance be stored in-20 ℃ subsequent use.
1.4 mensuration project
1.4.1 production performance
Record childbirth during with 21 ages in days every nest produce dead, the young number of living, litter weight and every piglet weighs and the daily gain during weaned piglet; Observe piglet health status, the state of mind, skin color and have or not diarrhoea.The standard of diarrhoea: ight soil is shapeless, and adheres at the visible significantly dried or wet loose stool of anal orifice.
Diarrhea rate (%)=each a processed group accumulative total only total number * 21 of raising of a number * 100%/each processed group of pig of suffering from diarrhoea
1.4.2 iron nutritive index
Measure red blood cell count(RBC), content of hemoglobin, hematocrit and the blood plasma iron content of piglet 7 ages in days, 21 ages in days, and the iron content of sow colostrum and normal breast.
1.6 sample analysis
Red blood cell count(RBC), HC and the hematocrit of the CD-1800 cellanalyzer working sample of producing with U.S. Abbott; Source of iron, diet, blood plasma and breast appearance are used dense HNO
3Digest the back with the general TSA-990 atomic absorption spectrophotometer iron content wherein of analysing company's production in Beijing with the HCl wet method.
1.7 data
Put test data in order with EXCEL, adopt SAS software test data to be carried out variance analysis, and carry out multiple ratio with the Duncan method by the completely random design.
2 results and analysis
2.1 different iron preparations are to the influence of breast milk iron nutritive index
The result lists in table 3.Can know by table 3, test 1 group and all be significantly higher than control group (P < 0.05), but test 1 group and test and do not have significant difference between 2 groups (P>0.05) with the sow the 7th day of 2 groups of tests and the 21st day newborn iron content." mother's honey iron " is added in this explanation in basal diet, can significantly improve sow breast iron content, the anaemia of effectively preventing newborn piglet.
Table 3 milking sow breast iron content
Annotate: same column shoulder mark same letter is represented difference not significantly (P>0.05), the different letter representation significant differences of shoulder mark (P 0.05); Lowercase representes that the level of signifiance is 0.05, and capitalization representes that the level of signifiance is 0.01.Numerical value is mean+SD in the table.
2.2 different iron preparations are to the influence of suckling pig iron nutritive index
The result lists in table 4.Can know by table 4, when piglet 7 ages in days and 21 ages in days, test 1 group with the piglet iron nutritive index of 2 groups of tests all the utmost point be significantly higher than control group (P < 0.01), but test 1 group and test and do not have significant difference between 2 groups (P>0.05).
The concentration of hemoglobin is one of important indicator of weighing piglet iron nutritional status, and it has excellent specificity.Some researchs show that the hemoglobin 80g/L of piglet is above to be normal, and 80g/L is in critical anemia state, is anaemia below the 80g/L; It is generally acknowledged that the normal reference range value of piglet RBC number is 4.0-6.5 * 10
12Individual/L, the normal reference range value of hematocrit is 25%-40%." mother's honey iron " is added in this result of the test explanation in in-pig and milking sow diet, can effectively improve piglet iron nutrition condition, prevention piglet anaemia, mends the iron effect and obviously is superior to ferrous sulfate.
HC, RBC number and hematocrit when table 4 suckling pig 7 ages in days and 21 ages in days
| Hemoglobin RBC number hematocrit is handled age in days (g/L) (10 12Individual/L) (%) |
| Control group 7 54.25 ± 5.27 A 3.30±0.62 A 19.90±2.56 ATest 1 group 7 74.70 ± 5.01 B 4.27±0.80 B 25.59±5.32 BTest 2 group 7 75.75 ± 6.53 B 4.47±0.66 B 26.26±4.97 B |
| Control group 2 162.52 ± 4.58 A 3.56±0.65 A 22.26±4.56 ATest 1 group 21 86.25 ± 6.78 B 5.16±0.81 C 28.70±7.10 BTest 2 group 21 89.75 ± 7.33 B 5.24±0.91 C 30.19±6.35 B |
Annotate: same column shoulder mark same letter is represented difference not significantly (P>0.05), the different letter representation significant differences of shoulder mark (P 0.05); Lowercase representes that the level of signifiance is 0.05, and capitalization representes that the level of signifiance is 0.01.Numerical value is mean+SD in the table.
2.3 different iron preparations are to the influence of piglet growth performance
The result lists in table 5.Can know that by table 5 between the different tests group, test 1 group of weaned piglet survival rate with 2 groups of tests and all be higher than control group, diarrhea rate then is lower than control group.Test 1 group and be significantly higher than control group (P < 0.05), but test 1 group and test between 2 groups difference not remarkable (P>0.05) with 21 days weaning weights of 2 groups of tests and daily gain." the sweet iron of mother " is added in this explanation in in-pig and milking sow diet can significantly improve piglet 21 age in days weaning weights and daily gain (P < 0.05).
Situation is bred in the wean of table 5 test piglet 21 ages in days
| The project control group is tested 1 group and is tested 2 groups |
| Produce piglet several 74 76 73 numbers of weaned (%) 81.5 89.5 88.9 diarrhea rates (%) 3.02 2.24 2.38 nascent counterpoise (kg) 1.37 ± 0.35 1.42 ± 0.32 1.40 ± 0.3921 age in days counterpoises (kg) 4.91 ± 1.18 of living c 5.32±1.17 b 5.39±1.28 bDaily gain (g) 169 ± 68 c 185±56 b 190±53 b |
Annotate: colleague's shoulder mark identical table differential different not significantly (P>0.05), shoulder mark different table differential different significantly (P < 0.05); Lowercase representes that the level of signifiance is 0.05, and capitalization representes that the level of signifiance is 0.01.Numerical value is mean+SD in the table.
3 conclusions
In sum, in farrowing sow later stage and milking sow diet, add " mother's honey iron ", can significantly improve the content of iron in the breast milk, improve piglet iron nutrition condition, improve piglet growth performance, can satisfy newborn piglet iron nutritional need fully than ferrous sulfate; Through in feed, adding composite organic iron formulation---" mother's honey iron " can replace the direct benefit iron mode of piglet intramuscular injection iron preparation to prevent piglet anaemia fully.
Ferrous fumarate, methionine iron, ferric lactate are organic iron, and steady chemical structure is easy to use; Have advantages such as environmental protection, highly effective and safe; The equal symbol national standard of sanitary index can not remain in the body of pig, can not discharge yet and cause environmental pollution; Can guarantee people's health, environmental protection.
Claims (1)
1. composite organic iron formulation is characterized in that:
Ratio is got 5～30 parts of 40～90 parts of ferrous fumarates, 5～30 parts of methionine irons and ferric lactates by weight, and these three kinds of raw materials are mixed processes composite organic iron formulation;
The mixed proportion of described composite organic iron formulation and latter half of gestation and sow in lactation feed is 1～5: 800～1500.
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| CN2008100739520A CN101411398B (en) | 2008-12-03 | 2008-12-03 | Composite organic iron formulation |
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| CN2008100739520A CN101411398B (en) | 2008-12-03 | 2008-12-03 | Composite organic iron formulation |
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| CN101411398A CN101411398A (en) | 2009-04-22 |
| CN101411398B true CN101411398B (en) | 2012-01-04 |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105192318A (en) * | 2015-10-27 | 2015-12-30 | 南宁市泽威尔饲料有限责任公司 | Composite organic iron supplementing agent |
| CN107223784A (en) * | 2017-06-30 | 2017-10-03 | 云南农业大学 | A kind of newborn piglet is adjusted and its application method with iron |
| CN113615772A (en) * | 2021-08-02 | 2021-11-09 | 四川农业大学 | Oral iron supplement for suckling piglets and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3259500A (en) * | 1961-10-11 | 1966-07-05 | Kentucky Res Foundation | Method for inhibiting anemia in young pigs by feeding the sow an iron agent |
| CN1290488A (en) * | 2000-08-16 | 2001-04-11 | 黄逸强 | Hydroxy methionine iron feed additives and its preparing method |
| CN1911244A (en) * | 2006-08-28 | 2007-02-14 | 浙江大学 | Slow-released type iron-complement agent, prepn. method and use thereof |
-
2008
- 2008-12-03 CN CN2008100739520A patent/CN101411398B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3259500A (en) * | 1961-10-11 | 1966-07-05 | Kentucky Res Foundation | Method for inhibiting anemia in young pigs by feeding the sow an iron agent |
| CN1290488A (en) * | 2000-08-16 | 2001-04-11 | 黄逸强 | Hydroxy methionine iron feed additives and its preparing method |
| CN1911244A (en) * | 2006-08-28 | 2007-02-14 | 浙江大学 | Slow-released type iron-complement agent, prepn. method and use thereof |
Non-Patent Citations (1)
| Title |
|---|
| 张彬等.不同铁源对哺乳仔猪生长、代谢和环境的影响.《应用生态学报》.2000,第11卷(第1期),91-94. * |
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