CN105941309A - Method improving perinatal cow immunity and milk yield - Google Patents
Method improving perinatal cow immunity and milk yield Download PDFInfo
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- CN105941309A CN105941309A CN201610299213.8A CN201610299213A CN105941309A CN 105941309 A CN105941309 A CN 105941309A CN 201610299213 A CN201610299213 A CN 201610299213A CN 105941309 A CN105941309 A CN 105941309A
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- 239000008267 milk Substances 0.000 title claims abstract description 25
- 210000004080 milk Anatomy 0.000 title claims abstract description 25
- 238000000034 method Methods 0.000 title claims abstract description 23
- 230000036039 immunity Effects 0.000 title claims abstract description 14
- 230000009984 peri-natal effect Effects 0.000 title claims abstract description 12
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims abstract description 167
- 235000019152 folic acid Nutrition 0.000 claims abstract description 85
- 239000011724 folic acid Substances 0.000 claims abstract description 84
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims abstract description 83
- 229960000304 folic acid Drugs 0.000 claims abstract description 83
- 210000004767 rumen Anatomy 0.000 claims abstract description 5
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- 230000037396 body weight Effects 0.000 claims description 11
- 201000010099 disease Diseases 0.000 claims description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 11
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- 240000002791 Brassica napus Species 0.000 claims description 3
- 235000004977 Brassica sinapistrum Nutrition 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- 244000068988 Glycine max Species 0.000 claims description 3
- 235000010469 Glycine max Nutrition 0.000 claims description 3
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- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
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- 230000002708 enhancing effect Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 229940014144 folate Drugs 0.000 description 1
- 150000002224 folic acids Chemical class 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/02—Breeding vertebrates
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
Abstract
The invention relates to the animal husbandry field, and specifically discloses a method improving perinatal cow immunity and milk yield; the method comprises the following steps: feeding folic acid for the perinatal cow, wherein the folic acid daily taken unit is relatively set with the cow weight at the following ratio: 120-240mg/500kg; the folic acid is coated so as to prevent rumen decomposition. The method feeds folic acid for the perinatal cow so as to improve cow milk yield and immunity, and thus reducing somatic cell number and cow mastitis risks. Mass objective test researches find out the best folic acid feeding scale, and complete feeding method is provided, thus providing references for cow breeding.
Description
Technical field
The present invention relates to herding field, specifically, relate to feeding of Diseases of Cow.
Background technology
Folic acid (folic acid) be also FA, belongs to vitamin B group, is a kind of water-soluble
Property vitamin.It it is very important one carbon unit carrier in animal body.Participate in DNA in vivo
Synthesis with part important amino acid and metabolic process, have an effect on T lymphocyte and generate and ratio,
Promote the generation of immunoglobulin, enhancing human body immunity power.For a long time, researchers think
It is each that milch cow itself can meet milch cow by feedstuff and the rumen microorganism enough folic acid of synthesis
Plant the demand of vital movement, but it is more and more higher to be as cow producing milk performance, depends merely on feedstuff and milk
The folic acid of cattle self synthesis is the most far from sufficient for the highest Milk Production.And
The trimester of pregnancy the most perinatal cow disease of milch cow takes place frequently and has become as restriction Cow product
One of key factor of performance, therefore explores and how to mend practicality and high efficiency to Diseases of Cow
Filling the Optimum that folic acid and folic acid supplements is a problem demanding prompt solution.
Folic acid achieves very abundant result in the research of the nonruminant such as poultry and pig, and
And be widely used, but the most non-in the effect of the ruminant Folic Acids such as milch cow
The most careful research, because the digestive physiology that ruminant is special (rumen microorganism) makes folic acid
The supplementary bottleneck that encounters, sluggish folic acid progress on ruminant.
Although disclosing a kind of feedstuff being coated folic acid at present, can be used for feeding of milch cow, with gram
Take the defect that folic acid is decomposed by cud.But dairy cow nutrition character (is produced by the scale of feeding of described feedstuff
Milk amount) and the impact of immunologic function do not appear in the newspapers.
Summary of the invention
In order to solve problems of the prior art, it is an object of the invention to provide a kind of to enclosing
Term, milch cow supplemented the folic acid of suitable concentration with the method improving its immunity and milk yield.
In order to realize the object of the invention, technical scheme is as follows:
Present invention firstly provides a kind of method improving Diseases of Cow immunity and milk yield,
To perinatal Cow-feeding folic acid, the daily intake of folic acid relative to the body weight of milch cow is
120～240mg/500kg, described folic acid carries out being coated process to avoid rumen bypass to decompose.
As preferably, the daily intake of folic acid is 120mg/500kg relative to the body weight of milch cow.
Specifically, Diseases of Cow is fed the time of folic acid, at least will be from milch cow expected date of confinement
Front 14d rises and feeds to calving 7d, the most at least feeds 21d.
In order to preferably improve the effect that folic acid feeds, and reduce the cost feeding folic acid generation,
Before preferably being selected from milch cow expected date of confinement, 21d rises and feeds folic acid to 7d after calving.
When feeding, folic acid is first coated, and the folic acid after being coated mixes with feedstuff laggard
Row feeds.Specifically, weigh the folic acid of 120～240mg, coated after, essence agreeable to the taste with 100g
Material mixing, obtains the feedstuff containing folic acid.This forage volume is far smaller than feedstuff needed for milch cow every day
Amount, therefore, it is ensured that milch cow meets aforementioned condition to the intake of folic acid.
Described feedstuff includes by weight: Semen Maydis 2.2 parts, bean cake 0.4 part, Herba avenae fatuae 5 parts,
Rapeseed cake 0.8 part, corn silage 12 parts, maize alcohol lees and soluble substance (DDGS) 0.6 part,
Semen Maydis corium farinosum 0.5 part (purchased from Shenyang Hao Tong company), soybean cover granule 0.4 part are (purchased from Jin Tianyuan
Company), premix material 0.1 part (purchased from ternary company, cattle premix material after 2.7% dry milk), cottonseed meal
0.5 part.
The purpose that is coated of folic acid is to ensure that folic acid is not decomposed by the cud of milch cow, as long as can realize
The method for coating of this purpose is used equally to realize the present invention.
The present invention separately provides a coated method of folic acid, open according to ZL200910093813.9
Production method, methionine therein is replaced to folic acid.I.e. prepare rumen-protected leaf
Acid, it is made up of core and shell two parts, and described shell is rumen-undegraded fat powder, the activity of described core
Composition is folic acid.
The present invention have studied folic acid through a large amount of objective tests and exempts from milk production of cow, raising milch cow
Effect in terms of epidemic disease power and reduction Contents in Cows cell number.
Further provide for folic acid answering in terms of improving milk production of cow and improving milch cow immunity
With, i.e. coated to perinatal Cow-feeding folic acid, the daily intake of folic acid is relative to milk
The body weight of cattle is 120mg/500k.
Further provide for folic acid application in terms of reducing Contents in Cows cell number, i.e. to perinatal
The folic acid that Cow-feeding is coated, the daily intake of folic acid relative to the body weight of milch cow is
120～240mg/500kg.
The beneficial effects of the present invention is:
Present invention discover that and Diseases of Cow is fed folic acid, milk yield and the raising of milch cow can be improved
Immunity, and reduce somatic number thus reduce the risk that milch cow suffers from mastitis.The present invention is through big
The suitableeest folic acid scale of feeding has been screened in amount objective test research, and provides complete feeding method,
Raising for milch cow provides reference.
Accompanying drawing explanation
Fig. 1 is colostrum IgG comparison diagram in a tire in experimental example 1 of the present invention, two tire cattle.
Fig. 2 is midwifery rate comparison diagram in experimental example 1 of the present invention.
Fig. 3 is morbidity number comparison diagram in experimental example 1 of the present invention.
Fig. 4 is mastitis morbidity number comparison diagram in experimental example 1 of the present invention.
Fig. 5 is DHI data results figure in experimental example 1 of the present invention.
Fig. 6 is to feed each group serum cytokines comparison diagram before folic acid in experimental example 1 of the present invention.
Fig. 7 is to feed serum cytokines comparison diagram after folic acid 14d in experimental example 1 of the present invention.
Detailed description of the invention
Below in conjunction with embodiment, the preferred embodiment of the present invention is described in detail.Need
Being understood by providing merely to play descriptive purpose of following example, it is right to be not used to
The scope of the present invention limits.Those skilled in the art without departing substantially from spirit of the invention and
In the case of spirit, the present invention can be carried out various amendment and replacement.
Experimental technique used in following embodiment if no special instructions, is routine side
Method.
Material used in following embodiment, reagent etc., if no special instructions, all can be from business
Industry approach obtains.
Embodiment 1
1, the preparation of feedstuff
As a example by being 500kg by test Niu Tichong, by the folic acid that is coated of 480mg, (folic acid contains respectively
Amount is 50%, i.e. 240mg) mix homogeneously with the feedstuff of 100g, standby.Stegophyll acid-specific
Consumption is adjusted in proportion according to test Niu Tichong.
Described feedstuff includes by weight: Semen Maydis 2.2 parts, bean cake 0.4 part, Herba avenae fatuae 5 parts,
Rapeseed cake 0.8 part, corn silage 12 parts, maize alcohol lees and soluble substance (DDGS) 0.6 part,
Semen Maydis corium farinosum 0.5 part (purchased from Shenyang Hao Tong company), soybean cover granule 0.4 part are (purchased from Jin Tianyuan
Company), premix material 0.1 part (purchased from ternary company, cattle premix material after 2.7% dry milk), cottonseed meal
0.5 part.
The described folic acid that is coated is according to method disclosed in ZL200910093813.9, by egg therein
Propylhomoserin replaces to what folic acid prepared.
2, feeding method
Feedstuff step 1 mixed is poured in tendon Bovis seu Bubali rubber drum, allows perinatal milch cow lick,
Observation is searched for food situation, and the feedstuff finally licked by Niu Wufa scrapes the sky before being poured on cattle pen with forage grass
It is allowed to lick totally on the ground.
From first 21 days of milch cow expected date of confinement, feed to calving 7 days, feed a step 1 every day
The feedstuff prepared.
Embodiment 2
The present embodiment is with the difference of embodiment 1, as a example by being 500kg by test Niu Tichong, point
Not by the feedstuff being coated folic acid (folate content is 50%, i.e. 120mg) and 100g of 240mg
Mix homogeneously, standby.
Experimental example 1
This experimental example is for illustrating that scale of feeding is on milk production of cow and the impact of immunity.
1, subjects: in ten thousand cattle farms of Hebei Shou Nong modern agriculture Science and Technology Ltd.,
According to following standard Selection experiment cattle:
(1) with expected date of confinement for the antenatal 21-28d of standard；
(2) cattle is only distributed to concentrate and conveniently feeds；
(3) do not affect cattle farm normally to produce as far as possible.
Final standard compliant test cattle totally 123.
2, test packet: according to parity, body weight, the principle that the condition such as expected date of confinement is basically identical
These 123 cattle are divided into A group, B group and C group, and concrete packet and body weight are distributed such as table 1
Shown in:
Cattle group result tested by table 1
3, test method:
A group: carry out the preparation of feedstuff described in embodiment 1 and feed；
B group: carry out the preparation of feedstuff described in embodiment 2 and feed；
C group: feed without the agreeable to the taste concentrate being coated folic acid.
Before expected date of confinement, 21d starts to feed until 7d after calving, it is ensured that feed enough 14d before calving
(there will be calving in advance and leakage hello situation during feeding, the cattle of the inadequate 14d of natural law will be fed
Only eliminate), feed 7d after calving.
3.1 sample collectings and index determining
After being grouped, to all experiment blood collections of Niu Jinhang, separate serum and tunica albuginea
Layer, and detect the content of IgG in serum with hand-hold refractometer.Then according to the side of the present invention
Method feeds 14d to test Niu Lianxu, then carries out a blood collection, still separates serum with white
Film layer, the content of detection serum IgG.When gathering its colostrum after test cattle calving (after calving the
Once milk gained for colostrum), and use the content of hand-hold refractometer detection colostrum IgG.
Feed 7d puerperal again and carry out third time blood sample collection, separate serum and tunica albuginea layer, and examine
Survey the content of serum IgG.Blood sample collection result is as shown in table 2:
Table 2 blood sample collection result
3.2 index determining
Respectively to serum IgG, colostrum IgG, the DHI number in 2nd month to 4th month puerperal
The serum cytokines sampled according to this and for the first time and for the second time is detected and analyzed.
4, detection and analysis result:
4.1 colostrum IgG results
As it is shown in figure 1, A, B group colostrum IgG is higher than C group, wherein B group in two tire cattle
Colostrum IgG content notable (P ＜ 0.05) can carry higher than C group, supplementing of this explanation folic acid
The quality of high colostrum.
4.2 midwifery rate and sickness rate
As shown in Figure 2, Figure 3, Figure 4, midwifery rate, morbidity number and mastitis morbidity number C group
Will be higher than folic acid interpolation group (A, B group), this explanation folic acid can improve cow force of labor,
Reduce postpartum morbidity.But this conclusion also needs to further enlarged sample to be verified.
4.3 DHI data results
Follow the tracks of and collect all DHI data testing 2nd month to 4th month puerperal of cattle, enter
Row relative analysis.
Result is as shown in Figure 5:
Milk yield: 2nd month puerperal and B group in 3rd month puerperal are all notable (P ＜ 0.05)
Higher than C group and A group, and three months data all show that B group milk yield is the highest, and C group is secondly
But A group is minimum；
Correction milk amount: 2nd month puerperal and 4th month B group all notable (P ＜ 0.05) is high
In C group and A group, and three months data all show that B group milk yield is the highest, and C group is the most so
And A group is minimum；
Somatic number: three months puerperal was all that same rule A, B are significantly lower than C group.
Somatic number is the important indicator of monitoring mammitis of cow, and its index the highest explanation milch cow suffers from breast
Scorching risk is the highest, and in this result of the test, C group somatic number is apparently higher than folic acid supplementation group, though
Not up to significant level, but folic acid is for improving milch cow immunity, prevents mastitis from occurring
If effect has embodied it is obvious that extend the prolongation of folic acid in the future, fine folic acid
Supplemental amount can reach the effect become apparent from.
4.4 serum cytokines analysis results
As shown in Figure 6, before feeding folic acid, each group serum cytokines does not shows at each group difference
Write, selected test cattle is described and is grouped representative.
As it is shown in fig. 7, serum cytokines there occurs that change, IL-6 contain after feeding folic acid 14d
Amount A group and B group all notable (P ＜ 0.05) are higher than C group, and the serum folic acid content of A group
Significantly (P ＜ 0.05) is higher than C group.
5. conclusion
Can be drawn by above result of the test, the folic acid magnitude of recruitment of B group can significantly improve and enclose
Term milch cow immunity and the level of milk yield, Diseases of Cow is exempted from by the folic acid magnitude of recruitment of A group
Epidemic disease power improves certain effect, but is likely to have a negative impact milk yield simultaneously.
Although, the most with a general description of the specific embodiments the present invention has been made in detail
Most description, but on the basis of the present invention, it can be made some modifications or improvements, this is to this
It is apparent from for skilled person.Therefore, on the basis without departing from spirit of the present invention
Upper these modifications or improvements, belong to the scope of protection of present invention.
Claims (9)
1. the method improving Diseases of Cow immunity and milk yield, it is characterised in that
To perinatal Cow-feeding folic acid, the daily intake of folic acid relative to the body weight of milch cow is
120～240mg/500kg, described folic acid carries out being coated process to avoid rumen bypass to decompose.
Method the most according to claim 1, it is characterised in that folic acid daily ingestion of
The body weight measuring relative milch cow is 120mg/500kg.
3. according to the method described in any one of claim 1～2, it is characterised in that pre-from milch cow
Before term, 14d rises and feeds folic acid to 7d after calving.
Method the most according to claim 4, it is characterised in that before milch cow expected date of confinement
21d rises and feeds folic acid to 7d after calving.
Method the most according to claim 4, it is characterised in that when feeding, by coated
Folic acid mix with feedstuff after feed.
Method the most according to claim 5, it is characterised in that described feedstuff is by weight
Meter includes: Semen Maydis 2.2 parts, bean cake 0.4 part, Herba avenae fatuae 5 parts, rapeseed cake 0.8 part, corn silage
12 parts, maize alcohol lees and soluble substance 0.6 part, Semen Maydis corium farinosum 0.5 part, soybean cover granule 0.4 part,
Premix material 0.1 part, cottonseed meal 0.5 part.
7. folic acid application in terms of improving milk production of cow, it is characterised in that to perinatal stage
Cow-feeding folic acid, the daily intake of folic acid is 120mg/500kg relative to the body weight of milch cow,
Feed after described folic acid is coated.
8. folic acid application in terms of improving milch cow immunity, it is characterised in that to perinatal stage
Cow-feeding folic acid, the daily intake of folic acid is 120mg/500kg relative to the body weight of milch cow,
Feed after described folic acid is coated.
9. folic acid application in terms of reducing Contents in Cows cell number, it is characterised in that to enclosing product
The Cow-feeding folic acid of phase, the daily intake of folic acid relative to the body weight of milch cow is
120～240mg/500kg, feed after described folic acid is coated.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106538469A (en) * | 2016-10-27 | 2017-03-29 | 赵林 | A kind of high-yield cultivation method of milch cow |
| CN107242188A (en) * | 2017-04-25 | 2017-10-13 | 蚌埠市和平乳业有限责任公司 | A kind of method for improving cow producing milk function |
| CN111670864A (en) * | 2020-07-09 | 2020-09-18 | 河北冀丰动物营养科技有限责任公司 | Feeding method for improving perinatal period dairy cow health |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104824476A (en) * | 2015-05-29 | 2015-08-12 | 浙江农林大学 | Rumen bypass protection folic acid, cow beverage containing rumen bypass protection folic acid and application of cow beverage |
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| CN107242188A (en) * | 2017-04-25 | 2017-10-13 | 蚌埠市和平乳业有限责任公司 | A kind of method for improving cow producing milk function |
| CN111670864A (en) * | 2020-07-09 | 2020-09-18 | 河北冀丰动物营养科技有限责任公司 | Feeding method for improving perinatal period dairy cow health |
| CN111670864B (en) * | 2020-07-09 | 2021-11-23 | 河北冀丰动物营养科技有限责任公司 | Feeding method for improving perinatal period dairy cow health |
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