CN101406569B - Chinese medicinal composition for treating cerebrovascular disease, and preparation thereof - Google Patents
Chinese medicinal composition for treating cerebrovascular disease, and preparation thereof Download PDFInfo
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- CN101406569B CN101406569B CN2008101599965A CN200810159996A CN101406569B CN 101406569 B CN101406569 B CN 101406569B CN 2008101599965 A CN2008101599965 A CN 2008101599965A CN 200810159996 A CN200810159996 A CN 200810159996A CN 101406569 B CN101406569 B CN 101406569B
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Abstract
The invention relates to a traditional Chinese medicine composition for treating cerebrovascular disease. The traditional Chinese medicine composition is prepared from the raw material drugs in weight portion: 15 to 60 portions of radix astragali, 5 to 30 portions of parsnip, 5 to 30 portions of red peony, 10 to 20 portions of medlar, 10 to 30 portions of himalayan teasel root, 10 to 15 portions of achyranthes, 10 to 15 portions of scorpion, 6 to 30 portions of chilopod, 5 to 15 portions of earthworm, 10 to 18 portions of pangolin, 10 to 30 portions of sapanwood and 10 to 30 portions of common st.paulswort herb. The method for preparing the traditional Chinese medicine composition comprises the following steps: according to the proportion, the raw material drugs are weighed, are added with water and are decocted for two times; the decoction time is between 1 and 2 hours; decocted liquid from two times is mixed, filtered and condensed to form a paste shape; and various preparation forms are prepared according to the prior method. The traditional Chinese medicine composition has the efficacies of nourishing qi, activating blood and invigorating spleen and stomach and has no toxic side effect, simple preparation method and low price.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of cerebrovascular disease and preparation method thereof, belong to medical technical field.
Background technology
Cerebrovascular disease claims cerebrovascular accident again, be by the brain blood circulation obstacle, cause with the local nerve afunction is a class disease of principal character, disability rate and mortality rate are all higher, clinically hemiplegia, hemianesthesia, speech office's source property neurologic impairment symptoms that take place suddenly such as unclear that show as more.Hypertension, arteriosclerosis are the main paathogenic factor of primary disease, so be more common in middle-aged and elderly people.Generally be divided into ischemic cerebrovascular and hemorrhagic apoplexy according to its pathological change, ischemic cerebrovascular is because of the pathological changes of cerebral arteries itself such as cerebral arteriosclerosis, cause local cerebral arteries tube chamber to narrow down even obstruction fully, or formation thrombosis, cause this cerebral blood flow supply discontinuity, as cerebral thrombosis, cerebral embolism etc., this type of accounts for about 60% of cerebrovascular sum; Hemorrhagic apoplexy is that the hardened small artery of brain has formed microaneurysm owing to long-term hypertension, when blood pressure causes microaneurysm to be broken because of certain reason raises suddenly, causes cerebral hemorrhage.
Suffering from this type of disease often needs to take medicine for a long time, but the toxic and side effects of patient Chang Yin medicine and misery.Theory of Chinese medical science thinks that primary disease is owing to hyperactive liver-YANG causing syndrome of liver-wind, and QI and blood is also contrary, and the criminal's of flinging brain will be managed benefiting QI for activating blood circulation, consciousness and resuscitation restoring when therefore treating.
Summary of the invention
The object of the present invention is to provide that a kind of therapeutic effect is good, toxic and side effects is little, the Chinese medicine composition of the treatment cerebrovascular disease of instant effect.
Another object of the present invention provides the preparation method of above-mentioned Chinese medicine composition.
The present invention is achieved by the following measures:
The Chinese medicine composition of treatment cerebrovascular disease of the present invention, make by following raw medicaments in portion by weight:
Radix Astragali 15-60 part, Radix Saposhnikoviae 5-30 part, Radix Paeoniae Rubra 5-30 part, Fructus Lycii 10-20 part, Radix Dipsaci 10-30 part, Radix Achyranthis Bidentatae 10-15 part, Scorpio 10-15 part, Scolopendra 6-30 part, Pheretima 5-15 part, Squama Manis 10-18 part, Lignum Sappan 10-30 Fen ， Herba Siegesbeckiae 10-30 part.
The Chinese medicine composition of above-mentioned treatment cerebrovascular disease, it is preferably filled a prescription and is: made by following raw medicaments in portion by weight:
Radix Astragali 20-40 part, Radix Saposhnikoviae 10-25 part, Radix Paeoniae Rubra 10-25 part, Fructus Lycii 12-18 part, Radix Dipsaci 15-25 part, Radix Achyranthis Bidentatae 10-15 part, Scorpio 10-15 part, Scolopendra 10-25 part, Pheretima 5-15 part, Squama Manis 10-18 part, Lignum Sappan 15-25 Fen ， Herba Siegesbeckiae 15-25 part.
The preparation method of the Chinese medicine composition of above-mentioned treatment cerebrovascular disease, adopt following steps:
Weighting raw materials decocts with water 2 times by weight ratio, and decocting time is 1～2 hour, merges 2 times decoction liquor, filters, and is concentrated into paste, makes various dosage forms according to a conventional method.
The preparation method of the Chinese medicine composition of described treatment cerebrovascular disease, also can adopt following steps:
(1) non-insects medicine is decocted with water 2 times, decocting time is 1～2 hour, merges 2 times decoction liquor, filters, and being concentrated into relative density is 1.08～1.10g/cm
3, make various dosage forms;
(2) the insects medicine is pulverized, and makes various dosage forms.
Select for use the effect of the crude drug of respectively distinguishing the flavor of as follows in the prescription of the present invention:
Radix Astragali has the merit of benefiting QI for strengthening the superficies, promoting pus discharge and tissue regeneration strengthening, inducing diuresis to remove edema, inrigorating qi and promoting blood circulation, is applicable to the numb limbs and tense tendons of blood stagnancy due to deficiency of QI, or the hemiplegia of apoplexy sequela appearance.
Radix Saposhnikoviae is controlled affection of exogenous wind-cold, and headache is dizzy, stiffness of the nape, and anemofrigid-damp arthralgia, joint is ached, and the extremity contraction is anxious, tetanus.
Radix Paeoniae Rubra has the effect of clearing away heat and cooling blood, eliminating stasis to stop pain, purging liver-fire, and modern study shows, has the expansion coronary vasodilator, resists myocardial ischemia, antiplatelet aggregation, antithrombotic formation, microcirculation improvement and reduce the effect of portal hypertension.
The Fructus Lycii the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, blood-enriching tranquillizing, promoting the production of body fluid to quench thirst, nourishing the lung to arrest cough.
The Radix Dipsaci invigorating the liver and kidney, reuniting the fractured tendons and bones, blood circulation regulating.
Radix Achyranthis Bidentatae has the merit of blood circulation promoting and blood stasis dispelling, liver and kidney tonifying, strong muscles and bones, inducing diuresis for treating stranguria syndrome, conducting blood to flow downwards, can reduce whole blood viscosity, packed cell volume, erythrocyte aggregation index, prolongation clotting time and of short duration hypotensive activity.
Lignum Sappan have invigorate blood circulation cure the wound, the merit of inducing menstruation to relieve menalgia.
Herba Siegesbeckiae has effects such as wind-damp dispelling, heat-clearing and toxic substances removing.Be applicable to rheumatic arthralgia, apoplexy and hemiplegia, facial hemiparalysis, or damp and hot sore, rheumatism prurigo, modern study shows certain antiinflammatory, blood pressure lowering, the thrombotic effect of inhibition.
Scorpio, Scolopendra have the effect of endogenous wind stopping relieving convulsion, detoxicating and resolving stagnation of pathogens, removing obstruction in the collateral to relieve pain.
Effects such as Pheretima has clearing heat for calming endogenous wind, relievings asthma, collateral dredging, diuresis have anticoagulation, antithrombotic, Fibrinolytic effect to blood system.
The power of Squama Manis promoting blood circulation to remove blood stasis is extremely strong, can pass through meridians and the sick institute that goes directly, the hard eliminating stagnation of bursting again.Modern study shows to have the blood vessel of expansion, blood flow increasing, prolongation clotting time, blood viscosity lowering, effects such as leukocyte increasing, antiinflammatory, raising anoxia endurance.
The invention has the beneficial effects as follows: medicine of the present invention has the effect that benefiting QI for activating blood circulation, dredge the meridian passage, spleen reinforcing are good for the stomach, and have no side effect, and preparation method is simple, and is cheap.
The specific embodiment
Embodiment 1
The Chinese medicine composition of treatment cerebrovascular disease of the present invention, filling a prescription is:
Radix Astragali 15kg, Radix Saposhnikoviae 5kg, Radix Paeoniae Rubra 5kg, Fructus Lycii 10kg, Radix Dipsaci 10kg, Radix Achyranthis Bidentatae 10kg, Scorpio 10kg, Scolopendra 6kg, Pheretima 5kg, Squama Manis 10kg, Lignum Sappan 10kg ， Herba Siegesbeckiae 10kg.
Preparation method is: weighting raw materials in proportion, decoct with water 2 times, and decocting time is 1 hour, merges 2 times decoction liquor, filters, and is concentrated into paste, makes tablet according to a conventional method, after the assay was approved packing.Every contains content 0.5g, one time 4～6,3 times on the one, 3 months is a course of treatment.
Embodiment 2
The Chinese medicine composition of treatment cerebrovascular disease of the present invention, filling a prescription is:
Radix Astragali 30kg, Radix Saposhnikoviae 18kg, Radix Paeoniae Rubra 18kg, Fructus Lycii 15kg, Radix Dipsaci 20kg, Radix Achyranthis Bidentatae 12kg, Scorpio 12kg, Scolopendra 18kg, Pheretima 10kg, Squama Manis 14kg, Lignum Sappan 20kg ， Herba Siegesbeckiae 20kg.
Preparation method is:
(1) non-insects medicine is decocted with water 2 times, each 1.5 hours, collecting decoction filtered, and it is 1.08 that filtrate is concentrated into suitable density, makes oral liquid according to a conventional method;
(2) the insects medicine is pulverized, crossed 100 mesh sieves, make capsule.
The every ml of oral liquid contains the about 0.2g of crude drug, each 10ml, every day 3 times.
Every of capsule contains content 0.2g, and each 3, every day 3 times, 3 months is a course of treatment.
Embodiment 3
The Chinese medicine composition of treatment cerebrovascular disease of the present invention, filling a prescription is:
Radix Astragali 60kg, Radix Saposhnikoviae 30kg, Radix Paeoniae Rubra 30kg, Fructus Lycii 20kg, Radix Dipsaci 30kg, Radix Achyranthis Bidentatae 15kg, Scorpio 15kg, Scolopendra 30kg, Pheretima 15kg, Squama Manis 18kg, Lignum Sappan 30kg ， Herba Siegesbeckiae 30kg.
Preparation method is:
(1) non-insects medicine is decocted with water 2 times, each 1.5 hours, collecting decoction filtered, and filtrate is concentrated into suitable density and is 1.10, and is standby;
(2) the insects medicine is pulverized, crossed 100 mesh sieves, add in (1) gained filtrate, stir, make pill according to a conventional method, after the assay was approved packing.Every ball contains the about 3g of content, each 1 ball, and every day 3 times, be a course of treatment March.
Test case 1
The long term toxicity test of medicine of the present invention
Choose healthy Wistar rat, body weight is 180 ± 20g, male and female half and half, and every day, the oral administration amount was 2g/kg, in 26 weeks of continuous use, administration finishes the back and continues to observe for 4 weeks.Every day, the general behavior of observation experiment animal showed, the appetite body weight of record animal.In 13 weeks of medication, 26 weeks and 30 when week blood drawings detect the hematology, blood biochemical is learned index, and in medication during 13 weeks every group put to death 10 animals at random, when 26 weeks, put to death 20 animals at random for every group, 30 weeks were put to death the residue animals.Animal is cutd open inspection, and taking internal organ is weighed and is carried out histopathological examination.The result shows: compare with the blank group, the action of rat, hair, body weight, routine blood test, hepatic and renal function and organ coefficient all do not have marked difference, histological examination showed, and different nothings such as the heart, liver, spleen, lung, kidney obviously change, illustrate that long term toxicity is lower, takes safety.
Test case 2
Medicine of the present invention is to the influence of rat brain edema
Get 45 of healthy Wistar rats, male and female half and half, body weight 220g ± 14.1g is divided into 3 groups at random, every group 15, first group is the blank group, irritates stomach and gives isopyknic normal saline, second group is medicine group of the present invention, and the 3rd group of positive matched group irritated stomach and given nimodipine, successive administration 3 days, 1h after the last administration is with the ligation of rat brain common carotid artery, sacrificed by decapitation behind the ligation 3h is opened cranium and is got brain, claims weight in wet base, calculate cerebral index, oven dry claims dry weight then, calculates brain water content.Brain water content=(weight in wet base-dry weight)/weight in wet base * 100%, heavy * 100/ body weight of cerebral index=brain the results are shown in Table 1.
The influence of table 1 pair rat brain edema
| Group | Dosage | Brain water content % | P |
| The blank group | Normal saline | 79.3±1.35 | ? |
| Medicine group of the present invention | 1g/kg | 77.1±1.89 | <0.05 |
| The nimodipine group | 140mg/kg | 76.9±2.01 | <0.05 |
As seen from table, compare with the blank group, medicine of the present invention has the obvious suppression effect to the cerebral edema that rat ligation bilateral common carotid arteries causes, and the rat brain index is also had tangible reduction effect.
Test case 3
Medicine of the present invention is to the thrombotic influence of rats in vitro
Get 45 of healthy male Wistar rats, body weight 240g ± 15.3g is divided into 3 groups at random, every group 15, group 1 is the blank group, gives the equal-volume normal saline, group 2 is medicine group of the present invention, group 3 is aspirin group 50mg/kg, successive administration 7 days, 1h after the last administration, anesthetized rat, separate abdominal aortic blood, the determination experiment index the results are shown in Table 2.
The thrombotic influence of table 2 pair rats in vitro
| Group | Thrombosis length (mm) | Wet weight of thrombus (mg) | Thrombosis dry weight (mg) |
| The blank group | 21.78±1.39 | 124.57±10.23 | 18.19±1.21 |
| Medicine group of the present invention | 16.53±1.26 | 110.76±10.05 | 17.11±1.28 |
| The aspirin group | 14.25±1.33 | 98.27±9.84 | 16.21±1.45 |
As shown in Table 2, compare with the blank group, medicine of the present invention has tangible shortening trend (P＜0.05) to thrombosis length, wet weight of thrombus and dry weight is also had alleviate effect (P＜0.05) significantly, and the be formed with significant inhibitory effect of medicine of the present invention to external thrombus is described.
Test case 4
Medicine of the present invention is to the protective effect of rat focal ischemia
1 experimental technique: 60 of healthy Wistar rats are divided into 4 groups at random, model control group, sham operated rats, medicine group of the present invention, nimodipine group, 15 every group.Each is organized respectively at administration before the modeling, every day 1 time, successive administration 5 days.1h after the last administration, reference literature adopt the modeling of line bolt method, and sham operated rats is not except that inserting fishing line blocking-up middle cerebral artery, and all the other are operated with the operation group.
2 observation index:
(1) the nervous symptoms scoring adopts Longa5 to divide the system standard: 0 minute, and impassivity functional impairment symptom; 1 minute, can not full extension offside fore paw; 2 minutes, turn-take laterally; 3 minutes, fall to offside; 4 minutes, can not walk loss of consciousness voluntarily.
(2) activity of SOD in serum and MDA assay: 24h after modeling, the chloral hydrate anesthesia rat, abdominal aortic blood, centrifugalize serum is pressed the test kit operation.
3 experimental results
(1) influence to nervous symptoms sees Table 3.
The protective effect of table 3 pair rat focal ischemia
As shown in Table 4,24h after the modeling compares with model control group, and medicine of the present invention is significantly improved to rat nerve injury symptom, P＜0.05.
(2) influence to activity of SOD in serum and MDA content sees Table 4.
The influence of table 4 pair activity of SOD in serum and MDA content
| Group | Dosage | SOD?u/ml | MDA?nmol/ml |
| Sham operated rats | Normal saline | 274.32±30.73 | 6.51±0.37 |
| Model control group | Normal saline | 215.36±24.15 | 9.45±1.21 |
| Medicine group of the present invention | 1g/kg | 268.13±22.87 | 7.46±1.28 |
| The nimodipine group | 140mg/kg | 267.59±22.69 | 7.33±1.25 |
As shown in Table 4, compare with model group, medicine of the present invention has the effect of remarkable rising to rat blood serum SOD activity, and difference has significance, P＜0.05.MDA content is had the trend of reduction, and difference has significance, P＜0.05.
Test case 5
The clinical experiment of medicine of the present invention is observed
(1) object of observation: year March in May, 2000 to 2003, choose district hospital's outpatient service cerebrovascular disease patient 130 examples in the Jinan City, paresis 52 examples wherein, imperfection paralysis 48 examples, panplegia 30 examples.42～78 years old age, 61 years old mean age.
(2) treatment: the oral pill of the present invention of patient, each 1 ball, every day 3 times, 30 days is a course of treatment, takes 3 courses of treatment continuously.Forbid other drug during the treatment, do not see obvious toxic-side effects.
(3) curative effect determinate standard:
" healing ": symptom disappears substantially, and muscular strength is normal, and motion freely.
" produce effects ": medication is after 7 days to 30 days, and symptom is clearly better, and continues to take medicine to return to and takes care of oneself.
" effectively ": medication is after 7 days to 12 days, and symptom takes a turn for the better to some extent.
Engineering noise: medication is after 7 days to 12 days, and symptom is not felt any better.
(4) clinical efficacy is relatively:
Paresis cures 100%; The imperfection paralysis cures 20.5%, produce effects 30.1%, effective 22.3%; Panplegia cures 23.9%, produce effects 25.7%, effective 12.6%.
3 medical records for example
So-and-so sex of king: man, age 45, home address: Jinan City's Tianqiao District.
Concise and to the point medical history: hemiplegia, left limb dysfunction 6 months (once in Jinan City's overline bridge hospital, because of cerebral embolism was in hospital 1 month).
Main symptom: lower limb hip joint: swing can translation 3 minutes, the lower limb toe joint: slightly moving 3 minutes.Integration capability: can stand and take a step, need the people to take care of at any time 3 fens.
Hemorheology index: whole blood viscosity value: shear rate (200): 5.35, shear rate (30): 6.89, shear rate (5): 11.55, shear rate (1): 23.86.
Obey medicine of the present invention after 2 months: main symptom: lower limb hip joint: refer to high 45 degree above (1 minute).Lower limb toe joint: stretch and bend freely but power weak (1 minute).Integration capability: live on one's own life, simple work, and partial function (1 minute) is arranged.
Hemorheology index: whole blood viscosity value: shear rate (200): 3.42, shear rate (30): 5.11, shear rate (5): 8.23, shear rate (1): 17.18.
Claims (4)
1. a Chinese medicine composition for the treatment of cerebrovascular disease is characterized in that: made by following raw materials by weight proportions: Radix Astragali 15-60 part, Radix Saposhnikoviae 5-30 part, Radix Paeoniae Rubra 5-30 part, Fructus Lycii 10-20 part, Radix Dipsaci 10-30 part, Radix Achyranthis Bidentatae 10-15 part, Scorpio 10-15 part, Scolopendra 6-30 part, Pheretima 5-15 part, Squama Manis 10-18 part, Lignum Sappan 10-30 Fen ， Herba Siegesbeckiae 10-30 part.
2. the Chinese medicine composition of treatment cerebrovascular disease according to claim 1 is characterized in that: made by following raw materials by weight proportions:
Radix Astragali 20-40 part, Radix Saposhnikoviae 10-25 part, Radix Paeoniae Rubra 10-25 part, Fructus Lycii 12-18 part, Radix Dipsaci 15-25 part, Radix Achyranthis Bidentatae 10-15 part, Scorpio 10-15 part, Scolopendra 10-25 part, Pheretima 5-15 part, Squama Manis 10-18 part, Lignum Sappan 15-25 Fen ， Herba Siegesbeckiae 15-25 part.
3. the preparation method of the Chinese medicine composition of the described treatment cerebrovascular disease of claim 1, it is characterized in that adopting following steps: weighting raw materials by weight ratio, decoct with water 2 times, decocting time is 1～2 hour, merge 2 times decoction liquor, filter, be concentrated into paste, make various dosage forms according to a conventional method.
4. the preparation method of the Chinese medicine composition of the described treatment cerebrovascular disease of claim 1 is characterized in that adopting following steps:
(1) non-insects medicine is decocted with water 2 times, decocting time is 1～2 hour, merges 2 times decoction liquor, filters, and being concentrated into relative density is 1.08～1.10, makes various dosage forms;
(2) the insects medicine is pulverized, and makes various dosage forms.
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| CN2008101599965A CN101406569B (en) | 2008-11-14 | 2008-11-14 | Chinese medicinal composition for treating cerebrovascular disease, and preparation thereof |
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| CN2008101599965A CN101406569B (en) | 2008-11-14 | 2008-11-14 | Chinese medicinal composition for treating cerebrovascular disease, and preparation thereof |
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| CN101406569B true CN101406569B (en) | 2011-01-12 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3415145A2 (en) | 2017-06-12 | 2018-12-19 | Arjil Biotech Holding Company Limited | Method for treating stroke or reducing nerve injury |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1086430A (en) * | 1993-05-27 | 1994-05-11 | 高齐崧 | The compound method of the health that collapses from physical exhaustion |
| CN1488391A (en) * | 2003-08-28 | 2004-04-14 | 刘新民 | Medicine for treating waist and lower extremities pain |
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2008
- 2008-11-14 CN CN2008101599965A patent/CN101406569B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1086430A (en) * | 1993-05-27 | 1994-05-11 | 高齐崧 | The compound method of the health that collapses from physical exhaustion |
| CN1488391A (en) * | 2003-08-28 | 2004-04-14 | 刘新民 | Medicine for treating waist and lower extremities pain |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3415145A2 (en) | 2017-06-12 | 2018-12-19 | Arjil Biotech Holding Company Limited | Method for treating stroke or reducing nerve injury |
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