CN101401819B - Donkey-hide gelatin effervescent particle and preparation method thereof - Google Patents
Donkey-hide gelatin effervescent particle and preparation method thereof Download PDFInfo
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- CN101401819B CN101401819B CN2008101597550A CN200810159755A CN101401819B CN 101401819 B CN101401819 B CN 101401819B CN 2008101597550 A CN2008101597550 A CN 2008101597550A CN 200810159755 A CN200810159755 A CN 200810159755A CN 101401819 B CN101401819 B CN 101401819B
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- citric acid
- corii asini
- colla corii
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Abstract
The invention discloses a donkey-hide glue effervescent granule and a method for preparing the same. The donkey-hide glue effervescent granule is characterized in that each 1,000g of donkey-hide glue effervescent granules are prepared from the following materials and auxiliary materials: 375 to 458g of donkey-hide glue, 472 to 578g of sugar, 15.0 to 25.0g of sodium bicarbonate, 1.0 and 5.0g of steviosin and 30.0 to 45.0g of citric acid. The method for preparing the donkey-hide glue effervescent granule comprises the following steps: 42g of the sugar is weighed up to prepare 70 percent syrup, the donkey-hide glue, the citric acid, the steviosin, the sodium bicarbonate and the residual sugar in recipe quantity are put in a fluidized bed one-step granulator for granulation, and the donkey-hide glue effervescent granule is obtained. In the invention, with the one-step granulating method, the working procedure is simplified, and all defects existing in prior preparing process are overcome; moreover, the donkey-hide glue effervescent granule and the method also have the advantages of simple operational procedures, good appearance of granules, good granule dissolvability, high rate of finished products, good taste of the granules and stable quality, and large granules or powder sifted out can be reutilized.
Description
(1) technical field
The present invention relates to a kind of effervescent granule and preparation method thereof, belong to the medicine preparation field.
(2) background technology
In the patent No. be: 90106302.9, patent name is to adopt two step granulations in " technology to make soaked donkey-hide gelatin infusion ", i.e. granulates method and alkali granule method, technological operation is very complicated, and labor productivity is lower; Because of doing wetting agent with ethanol, cohesive is relatively poor, and fine powder is more, and product yield is lower; Because of adopting granulates and alkali granule to granulate respectively, last mixed grain color is inconsistent, and product appearance is relatively poor, is not easy to be accepted by client; Because of acid, alkali in different granules, acid, alkali can not react rapidly and produce CO
2Gas and be the effervescent shape, the granule melting is relatively poor.Simultaneously, this patent can't be accomplished genuineness because sodium glutamate and essence are arranged.
(3) summary of the invention
The present invention provides donkey-hide gelatin effervescent particle that a kind of technology is simple, melting good, yield rate is high and preparation method thereof in order to remedy the deficiencies in the prior art.
The present invention is achieved through the following technical solutions:
A kind of donkey-hide gelatin effervescent particle, its special character is: every 1000g is made by following materials of weight proportions and adjuvant: Colla Corii Asini 375～458g, sucrose 472～578g, sodium bicarbonate 15.0～25.0g, steviosin 1.0～5.0g, citric acid 30.0～45.0g.
Donkey-hide gelatin effervescent particle of the present invention, it further improves and is: every 1000g is made by following materials of weight proportions and adjuvant: Colla Corii Asini 417g, sucrose 525g, sodium bicarbonate 19.6g, steviosin 1.2g, citric acid 37.2g.
The preparation method of donkey-hide gelatin effervescent particle of the present invention; its special character is: the sucrose of getting 42g is made 70% syrup; with Colla Corii Asini; sucrose; the citric acid pulverize separately; after sieving; get the Colla Corii Asini of recipe quantity; citric acid; steviosin; the sucrose of sodium bicarbonate and prescription surplus; with putting in the fluid bed one-step-granulating method; open intake valve; intake air temperature is controlled at 55～60 ℃; make material mix homogeneously under fluidized state; evenly spray into 70% syrup and 95% ethanol (70% syrup and 95% ethanol the two volume ratio be 1:2) binding agent then and granulate, make 1000g, promptly.
Donkey-hide gelatin effervescent particle of the present invention has following characteristics:
1, in the former patent (patent No.: 90106302.9) remove flavoring agent sodium glutamate (monosodium glutamate) and correctives essence on the prescription basis, keep the genuineness of Colla Corii Asini, make it to become green natural medicine.
2, change the stevioside in the original formulation into steviosin, the purity of sweeting agent is reached more than 95%, the impurity in the reduction stevioside is to the influence of human body.
3, change former patent Colla Corii Asini and sucrose ratio (the two ratio of former patent is 1:1), make it to meet soaked donkey-hide gelatin infusion quality standard WS
3-88 (Z-57)-94 (z).
The present invention adopts marumerization, both simplifies working process, and has overcome all shortcomings of former preparation technology again.Its following aspects that shows with conspicuous characteristics:
(1) operation sequence is simple: adopt fluid bed one-step palletizing (fluidized-bed spray granulation), mixing of materials, granulation, drying etc. are operated in finish in same the equipment, labor productivity improves more than 2 times.
(2) the particle appearance quality is good: the particle appearance of making is very good, and epigranular is complete, the color even unanimity.
(3) the granule melting is good: because acid, alkali mixes common granulation, soda acid coexists in the granule, be evenly distributed, so granule is met behind the water soda acid and reacted very soon and produce CO
2And being the effervescent shape, melting is very good.
(4) finished product rate height: owing to add a certain amount of 70% syrup in wetting agent ethanol, increased viscosity, caused pellet hardness suitable, yield rate is higher.
(5) bulky grain or the superfine powder that sift out can be recycled: because of the soda acid uniform distribution in granule or the powder that coexists, ratio does not change, and therefore capable of circulationly adds alcohol granulation and uses.
(6) the granule mouthfeel is better: because of in the granule with flavoring agent and essence, the granule taste and the mouthfeel of making are better, and be sour-sweet very suitable except that the original flavor that keeps Colla Corii Asini, easily accepted by client.
(7) steady quality: through 6 months accelerated tests and 24 months long-term stable experiments, every quality index was compared no significant difference with 0 month, showed that product quality is highly stable.
(4) specific embodiment
This embodiment is made by following materials of weight proportions and adjuvant: Colla Corii Asini 417g, sucrose 525g, sodium bicarbonate 19.6g, steviosin 1.2g, citric acid 37.2g.The technical process of its making is as follows:
1, the preparation of bonding agent: the sucrose of getting 42g is mixed with 70% syrup, adds 95% ethanol of two volumes amount again, mixing, promptly.
2, supplementary material is pulverized and sieved: behind Colla Corii Asini, sucrose, citric acid pulverize separately, sucrose is crossed 80 mesh sieves, and Colla Corii Asini, citric acid are crossed 100 mesh sieves respectively.
3, weighing: the sucrose, citric acid, steviosin and the sodium bicarbonate that take by weighing Colla Corii Asini, surplus in the prescription ratio.
4, granulate: Colla Corii Asini, sucrose, citric acid, steviosin and sodium bicarbonate; with putting in the fluid bed one-step-granulating method; open intake valve; intake air temperature is controlled at 55～60 ℃; make material mix homogeneously under fluidized state, evenly spray into 70% syrup-95% ethanol (1:2) binding agent then and granulate.
5, granulate: granule is put in the shaking screen, and sieve goes can not be by the bulky grain and the superfine powder that can pass through No. five sieves of a sieve, promptly.
6, packing: adopt particles packing machine to carry out the aluminum-plastic composite membrane packing.
Below be every index of present embodiment products obtained therefrom:
[character] this product is the granule of yellowish-brown; Sweet and sour.
This product 0.2g is got in [discriminating] (1), adds water 10ml and makes dissolving, filters, and gets filtrate 2ml, adds 2% sodium hydroxide solution and makes and be alkalescence, adds 5 of 0.5% copper-baths again, answers displaing amaranth.(2) get this product 0.2g, add water 10ml and make dissolving, filter, get filtrate 2ml, add 5 of 0.5% ethanol solution of ninhydrin, shake up, heating is about 10 minutes in boiling water bath, should show bluish violet after the cooling.
[inspection] pH value: get this product 2g, the accurate title, decide, and adds water 20ml, measures (an appendix VI of Chinese Pharmacopoeia version in 2005 H) in accordance with the law, should be 4.0～5.0.
Total ash: get this product 1.0g, measure (an appendix IX of Chinese Pharmacopoeia version in 2005 K) in accordance with the law, must not cross 2.5%.
Heavy metal: get the residue under the total ash item, check (an appendix IX of Chinese Pharmacopoeia version in 2005 E second method) in accordance with the law, must not cross 20/1000000ths.
Arsenic salt: get this product 2.0g, adding calcium hydroxide 1.0g mixes, and adds low amounts of water, stirs evenly, and after the drying, makes carbonization with little baked wheaten cake is bright earlier, blazingly makes complete ashing at 500 ℃～600 ℃ again, puts coldly, adds hydrochloric acid 5ml and water 23ml.Check (an appendix IX of Chinese Pharmacopoeia version in 2005 F) in accordance with the law, must not cross 1,000,000/.
Volatility alkaline matter: get this product 12g, the accurate title, decide, put in the 100ml measuring bottle, it is an amount of to add water, jolting makes dissolving and is diluted to scale, shakes up, and precision is measured 5ml, put in the kjeldahl flask, add 1% magnesium oxide suspension solution 5ml at once, rapid close plug feeds steam and distills, with 2% boric acid solution 5ml serves as to receive liquid, methylate is red-and bromocresol green mixes 5 of indicator solutions, stopped in 7 minutes from oozing first when condensing the globule, distilling, distillate is measured according to N2 method (an appendix IX of Chinese Pharmacopoeia version in 2005 L second method), promptly.
Contain the volatility alkaline matter in (N) in every bag of this product, must not cross 2.0mg.
[assay] gets the content under this product content uniformity item, and porphyrize is got about 0.5g, and accurate the title decides, and measures according to N2 method (appendix IXL first method of Chinese Pharmacopoeia version in 2005), promptly.
Every bag of this product contains total nitrogen (N) and must not measure and be less than 0.30g.
Claims (3)
1. donkey-hide gelatin effervescent particle, it is characterized in that: every 1000g is made by following materials of weight proportions and adjuvant: Colla Corii Asini 375～458g, sucrose 472～578g, sodium bicarbonate 15.0～25.0g, purity are greater than 95% steviosin 1.0～5.0g, citric acid 30.0～45.0g; This donkey-hide gelatin effervescent particle is prepared from by the following method: get 42g sucrose and make 70% syrup; with Colla Corii Asini, sucrose, citric acid pulverize separately; after sieving; get the sucrose of Colla Corii Asini, citric acid, steviosin, sodium bicarbonate and the prescription surplus of recipe quantity; with putting in the fluid bed one-step-granulating method; open intake valve; intake air temperature is controlled at 55～60 ℃; make material mix homogeneously under fluidized state; evenly spray into 70% syrup and 95% ethanol binding agent then; the two volume ratio of 70% syrup and 95% ethanol is 1: 2, granulates, and makes 1000g promptly.
2. donkey-hide gelatin effervescent particle according to claim 1 is characterized in that: every 1000g is made by following materials of weight proportions and adjuvant: Colla Corii Asini 417g, sucrose 525g, sodium bicarbonate 19.6g, steviosin 1.2g, citric acid 37.2g.
3. according to the preparation method of the described donkey-hide gelatin effervescent particle of claim 1, it is characterized in that:
Carry out as follows:
(1), the preparation of bonding agent: the sucrose of getting 42g is mixed with 70% syrup, adds 95% ethanol of two volumes amount again, mixing, promptly;
(2), supplementary material is pulverized and sieve: behind Colla Corii Asini, sucrose, citric acid pulverize separately, sucrose is crossed 80 mesh sieves, and Colla Corii Asini, citric acid are crossed 100 mesh sieves respectively;
(3), weighing: the sucrose, citric acid, steviosin and the sodium bicarbonate that take by weighing Colla Corii Asini, surplus in the prescription ratio;
(4), granulate: Colla Corii Asini, sucrose, citric acid, steviosin and sodium bicarbonate, with putting in the fluid bed one-step-granulating method, open intake valve, intake air temperature is controlled at 55～60 ℃, make material mix homogeneously under fluidized state, evenly spray into 70% syrup-95% ethanol binding agent then and granulate;
(5), granulate: granule is put in the shaking screen, and sieve goes can not be by the bulky grain and the superfine powder that can pass through No. five sieves of a sieve, promptly;
(6), packing: adopt particles packing machine to carry out the aluminum-plastic composite membrane packing.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008101597550A CN101401819B (en) | 2008-11-13 | 2008-11-13 | Donkey-hide gelatin effervescent particle and preparation method thereof |
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| CN2008101597550A CN101401819B (en) | 2008-11-13 | 2008-11-13 | Donkey-hide gelatin effervescent particle and preparation method thereof |
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| CN101401819A CN101401819A (en) | 2009-04-08 |
| CN101401819B true CN101401819B (en) | 2011-07-27 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102266352A (en) * | 2011-07-28 | 2011-12-07 | 陕西科技大学 | Ass-hide glue effervescent granules and preparation method thereof |
| CN102266353A (en) * | 2011-07-28 | 2011-12-07 | 陕西科技大学 | Donkey-hide gelatin effervescent granules and preparation method thereof |
| CN102283864A (en) * | 2011-07-28 | 2011-12-21 | 陕西科技大学 | Donkey-hide gelatin effervescent tablets and preparation method thereof |
| CN109010371A (en) * | 2018-08-17 | 2018-12-18 | 药圣堂（湖南）制药有限公司 | A kind of donkey-hide gelatin oral preparation and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1055112A (en) * | 1990-11-07 | 1991-10-09 | 山东中医学院 | Technology to make soaked donkey-hide gelatin infusion |
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2008
- 2008-11-13 CN CN2008101597550A patent/CN101401819B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1055112A (en) * | 1990-11-07 | 1991-10-09 | 山东中医学院 | Technology to make soaked donkey-hide gelatin infusion |
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