CN101394868B - 重组腺病毒5型/35型和痘病毒mva活病毒载体疫苗的联用诱导强大的免疫应答的方法 - Google Patents
重组腺病毒5型/35型和痘病毒mva活病毒载体疫苗的联用诱导强大的免疫应答的方法 Download PDFInfo
- Publication number
- CN101394868B CN101394868B CN2007800072811A CN200780007281A CN101394868B CN 101394868 B CN101394868 B CN 101394868B CN 2007800072811 A CN2007800072811 A CN 2007800072811A CN 200780007281 A CN200780007281 A CN 200780007281A CN 101394868 B CN101394868 B CN 101394868B
- Authority
- CN
- China
- Prior art keywords
- hiv
- viral vector
- recombinant viral
- adenovirus
- types
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10345—Special targeting system for viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006061007 | 2006-03-07 | ||
JP061007/2006 | 2006-03-07 | ||
PCT/JP2007/053469 WO2007102326A1 (fr) | 2006-03-07 | 2007-02-26 | Induction d'une immunité forte au moyen d'une combinaison d'un vecteur d'adénovirus de type 5/type 35 et vecteur mva de virus vaccinal |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101394868A CN101394868A (zh) | 2009-03-25 |
CN101394868B true CN101394868B (zh) | 2011-08-10 |
Family
ID=38474764
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2007800072811A Expired - Fee Related CN101394868B (zh) | 2006-03-07 | 2007-02-26 | 重组腺病毒5型/35型和痘病毒mva活病毒载体疫苗的联用诱导强大的免疫应答的方法 |
Country Status (3)
Country | Link |
---|---|
JP (1) | JPWO2007102326A1 (fr) |
CN (1) | CN101394868B (fr) |
WO (1) | WO2007102326A1 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0823497D0 (en) | 2008-12-24 | 2009-01-28 | Isis Innovation | Immunogenic composition and use thereof |
CN101781636A (zh) * | 2009-01-19 | 2010-07-21 | 中国人民解放军第二军医大学东方肝胆外科医院 | 一种含11型腺病毒纤毛蛋白基因的增殖型重组溶瘤腺病毒、其构建方法及其用途 |
CN101670102A (zh) * | 2009-09-15 | 2010-03-17 | 中国科学院广州生物医药与健康研究院 | 联合使用痘病毒载体hiv疫苗与腺病毒载体hiv疫苗的方法及其应用 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004035006A2 (fr) * | 2002-10-18 | 2004-04-29 | The Aaron Diamond Aids Research Center | Methodes et compositions d'immunisation contre le virus vih |
US20040146528A1 (en) * | 2001-03-08 | 2004-07-29 | Bernard Moss | MVA expressing modified HIV envelope, gag, and pol genes |
US20040175365A1 (en) * | 1997-06-09 | 2004-09-09 | Oxxon Therapeutics Ltd. | Methods and reagents for vaccination which generate a CD8 T cell immune response |
WO2005052165A1 (fr) * | 2003-11-28 | 2005-06-09 | Aristo K.K. | Vecteur d'adenovirus chimerique de type 5, 11 ou 35 utilise dans la prevention d'une infection par le virus de l'immunodeficience humaine |
-
2007
- 2007-02-26 WO PCT/JP2007/053469 patent/WO2007102326A1/fr active Application Filing
- 2007-02-26 CN CN2007800072811A patent/CN101394868B/zh not_active Expired - Fee Related
- 2007-02-26 JP JP2008503780A patent/JPWO2007102326A1/ja active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040175365A1 (en) * | 1997-06-09 | 2004-09-09 | Oxxon Therapeutics Ltd. | Methods and reagents for vaccination which generate a CD8 T cell immune response |
US20040146528A1 (en) * | 2001-03-08 | 2004-07-29 | Bernard Moss | MVA expressing modified HIV envelope, gag, and pol genes |
WO2004035006A2 (fr) * | 2002-10-18 | 2004-04-29 | The Aaron Diamond Aids Research Center | Methodes et compositions d'immunisation contre le virus vih |
WO2005052165A1 (fr) * | 2003-11-28 | 2005-06-09 | Aristo K.K. | Vecteur d'adenovirus chimerique de type 5, 11 ou 35 utilise dans la prevention d'une infection par le virus de l'immunodeficience humaine |
Non-Patent Citations (6)
Title |
---|
K-Q Xin et al.Prime-boost vaccination with plasmid DNA and achimericadenovirus type 5 vector with type 35 fiber inducesprotectiveimmunity against HIV.Gene Therapy12.2005,121769-1777. * |
Rama Rao Amara et al.Control of a Mucosal Challenge and Prevention of AIDS byaMultiprotein DNA/MVA Vaccine.Science292.2001,29269-74. * |
赵怀龙等.HIV-1疫苗活病毒载体研究进展.中国生物制品学杂志18 4.2005,18(4),347-349. |
赵怀龙等.HIV-1疫苗活病毒载体研究进展.中国生物制品学杂志18 4.2005,18(4),347-349. * |
钟国才等.HIV-1疫苗研究新策略.中国艾滋病性病11 6.2005,11(6),468-473. |
钟国才等.HIV-1疫苗研究新策略.中国艾滋病性病11 6.2005,11(6),468-473. * |
Also Published As
Publication number | Publication date |
---|---|
WO2007102326A1 (fr) | 2007-09-13 |
CN101394868A (zh) | 2009-03-25 |
JPWO2007102326A1 (ja) | 2009-07-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2018267669B2 (en) | Methods and compositions for inducing protective immunity against human immunodeficiency virus infection | |
ES2307093T3 (es) | Desarrollo de un vacuna preventiva para la infeccion por filovirus en primates. | |
CN110494159A (zh) | 在接受抗逆转录病毒治疗的对象中诱导针对人类免疫缺陷病毒感染的免疫应答的方法 | |
Zavala et al. | A striking property of recombinant poxviruses: efficient inducers of in vivo expansion of primed CD8+ T cells | |
CN1764474B (zh) | 免疫原性组合物及方法 | |
Sharpe et al. | Induction of simian immunodeficiency virus (SIV)-specific CTL in rhesus macaques by vaccination with modified vaccinia virus Ankara expressing SIV transgenes: influence of pre-existing anti-vector immunity | |
JP2013046613A (ja) | ワクチン組成物 | |
JP6462861B2 (ja) | フィロウイルス感染に対する防御免疫の誘導を目的とする方法及び組成物 | |
CN107106673A (zh) | 用于增强免疫应答的方法和组合物 | |
US20110142880A1 (en) | Lentivirus-based immunogenic vectors | |
Peters | The basis for HIV immunotherapeutic vaccines | |
CN108715866A (zh) | 一种重组病毒载体、疫苗及其制备方法与应用 | |
Bayer et al. | Improved vaccine protection against retrovirus infection after co-administration of adenoviral vectors encoding viral antigens and type I interferon subtypes | |
Roshorm et al. | T cells induced by recombinant chimpanzee adenovirus alone and in prime‐boost regimens decrease chimeric E co HIV/NDK challenge virus load | |
Kaulfuß et al. | Induction of complex immune responses and strong protection against retrovirus challenge by adenovirus-based immunization depends on the order of vaccine delivery | |
CN101394868B (zh) | 重组腺病毒5型/35型和痘病毒mva活病毒载体疫苗的联用诱导强大的免疫应答的方法 | |
Otten et al. | Induction of broad and potent anti-human immunodeficiency virus immune responses in rhesus macaques by priming with a DNA vaccine and boosting with protein-adsorbed polylactide coglycolide microparticles | |
Stratov et al. | Vaccines and vaccine strategies against HIV | |
Vanniasinkam et al. | DNA immunization using a non-viral promoter | |
Voltan et al. | Live recombinant vectors for AIDS vaccine development | |
Bayer et al. | Evaluation of the Friend Virus model for the development of improved adenovirus-vectored anti-retroviral vaccination strategies | |
Lemiale et al. | Lentiviral vectors for HIV disease prevention and treatment | |
CN101658670A (zh) | 基于n1l和b8r基因缺失的痘苗病毒载体的艾滋病疫苗 | |
Fultz et al. | Immunogenicity in pig-tailed macaques of poliovirus replicons expressing HIV-1 and SIV antigens and protection against SHIV-89.6 P disease | |
Peng et al. | Pseudotyped single-cycle simian immunodeficiency viruses expressing gamma interferon augment T-cell priming responses in vitro |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110810 Termination date: 20210226 |