CN101391021A - Use of traditional Chinese medicine in preparing medicine for treating anxiety neurosis - Google Patents
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- CN101391021A CN101391021A CNA2007101522475A CN200710152247A CN101391021A CN 101391021 A CN101391021 A CN 101391021A CN A2007101522475 A CNA2007101522475 A CN A2007101522475A CN 200710152247 A CN200710152247 A CN 200710152247A CN 101391021 A CN101391021 A CN 101391021A
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Abstract
The invention provides a Chinese traditional medicine combination which is applied to preparing anxiety neurosis medicines. Proved in the clinical experiments, the medicine combination has functions of supplementing qi and nourishing yin, promoting coronary arteries circulation to remove obstruction in the heart-vessels, tranquillizing and regulating main nerves through three ways of nourishing, preserving and restraining, so as to effectively relieve worrying mood of the anxiety neurosis patients and improve regulation and control ability for various functions of organism and have no obvious side effects; thus being good for clinical promotion and application.
Description
Technical field
The present invention relates to a kind of new purposes of Chinese medicine composition, particularly, the present invention relates to the application of a kind of Chinese medicine composition in preparation treatment anxiety neurosis medicine, belong to the Chinese medicine application.
Background technology
Anxiety neurosis (Anxiety) claim anxiety neurosis again, it be with persistence anxiety, worry, fear or ictal be the dysthymic disorder of feature in terror, with behavior characteristicss such as autonomic nervous system symptom and motion uneasinesses.(He Min, Yuan Jiali. the clinical progress of Chinese medicine anxiety neurosis. 2006 the 33rd the 2nd phases of volume of Liaoning Journal of Traditional Chinese Medicine)
Anxiety neurosis is very common, reports that abroad sickness rate is about 4% in the general population, accounts for 6～27% of psychiatric department outpatient service.The U.S. estimates that lifelong Expectancy is 5% in the normal population, and domestic sickness rate is lower, average out to 7 ‰.Wartime, anxiety neurosis accounted for 1% of war neurosis.Often in the adolescence onset, men and women's ratio is 2:3.
Anxiety is following threat of having a premonition, and fears differently, and the latter then is the reaction to certain special threat of objective reality.Normal person's anxiety is that people anticipate a kind of adjustment reaction when certain danger or painful circumstances are about to take place or are biological defence phenomenon, is a kind of comprehensive emotion of complexity.Anxiety also can be a kind of symptom of all mental sickness.The pathologic anxiety is a kind of losing control of, and does not have the fear of clear and definite object or content, and its threat does not conform to severity of anxiety very much.
Modern medicine thinks that primary disease is relevant with qautobiology feature and socio-psychological factors, and anxiety neurosis is main relevant with the consitution inherited genetic factors with external environment stimulation, internal injury caused by excess of seven emotions, mainly is that heart spleen hepatic and renal function is lacked of proper care qi-blood disharmony forming.But onset is in any age, and onset can suddenly can be delayed, and the inducement of psychology or body aspect is often arranged before the disease.
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http://health.sohu.com/11/73/harticle15377311.shtml)
Pharmaceutical intervention is mainly used in the treatment of anxiety neurosis now, but there is defective in existing medicine, is a kind of effective medicine as tricyclic antidepressant to the treatment anxiety neurosis, but exist dependency, onset slowly, problem such as drug drug interaction.And the clinical Chinese medicine anxiety neurosis that confirmed has good efficacy, and few side effects.(clinical progress of Chinese medicine anxiety neurosis, He Min, Yuan Jiali, Liaoning Journal of Traditional Chinese Medicine.2006 the 33rd the 6th phases of volume)
The present invention is the improvement invention of carrying out on the basis of ZL02146572.X patent application, quotes in full the content of this patent document record at this.The invention provides the new application of a kind of Chinese medicine composition in the medicine of preparation treatment anxiety neurosis, prove by clinical trial, this pharmaceutical composition is applied to the patient of anxiety neurosis, effectively alleviated patient's anxiety, improved adjusting and the control ability of collective, can be used for the treatment of anxiety neurosis various functions.
Summary of the invention
The purpose of this invention is to provide the application of this Chinese medicine composition in preparation treatment anxiety neurosis medicine.It is characterized in that this Chinese medicine composition is made by following bulk drugs:
Radix Ginseng 45-180 part, Radix Ophiopogonis 50-200 part, Fructus Corni 125-450 part, Radix Salviae Miltiorrhizae 125-450 part, Semen Ziziphi Spinosae (parched) 95-400 part, Herba Taxilli 95-400 part, Radix Paeoniae Rubra 45-200 part, Eupolyphaga Seu Steleophaga 35-150 part, Radix Et Rhizoma Nardostachyos 45-200 part, Rhizoma Coptidis 25-90 part, Fructus Schisandrae Sphenantherae 35-150 part, Os Draconis 75-300 part.
The weight ratio of crude drug is preferably in the Chinese medicine composition of the present invention:
89 parts of Radix Ginsengs, 112 parts of Radix Ophiopogonis, 224 parts of Fructus Corni, 224 parts of Radix Salviae Miltiorrhizaes, 186 parts of Semen Ziziphi Spinosae (parched)s, 186 parts of Herba Taxillis, 89 parts of Radix Paeoniae Rubra, 75 parts of Eupolyphaga Seu Steleophagas, 89 parts of Radix Et Rhizoma Nardostachyos, 45 parts of Rhizoma Coptidis, 67 parts of Fructus Schisandrae Sphenantheraes, 149 parts of Os Draconis.
The weight ratio of crude drug also is preferably in the Chinese medicine composition of the present invention:
45 parts of Radix Ginsengs, 112 parts of Radix Ophiopogonis, 224 parts of Fructus Corni, 225 parts of Radix Salviae Miltiorrhizaes, 186 parts of Semen Ziziphi Spinosae (parched)s, 186 parts of Herba Taxillis, 89 parts of Radix Paeoniae Rubra, 45 parts of Radix Et Rhizoma Nardostachyos, 35 parts of Eupolyphaga Seu Steleophagas, 45 parts of Rhizoma Coptidis, 67 parts of Fructus Schisandrae Sphenantheraes, 149 parts of Os Draconis.
The weight ratio of crude drug also is preferably in the Chinese medicine composition of the present invention:
90 parts of Radix Ginsengs, 135 parts of Radix Ophiopogonis, 270 parts of Fructus Corni, 200 parts of Radix Salviae Miltiorrhizaes, 150 parts of Semen Ziziphi Spinosae (parched)s, 150 parts of Herba Taxillis, 100 parts of Radix Paeoniae Rubra, 100 parts of Eupolyphaga Seu Steleophagas, 95 parts of Radix Et Rhizoma Nardostachyos, 60 parts of Rhizoma Coptidis, 75 parts of Fructus Schisandrae Sphenantheraes, 150 parts of Os Draconis.
In the application of the present invention, the active component of this Chinese medicine composition is made by the following step:
A) people participates in 70% alcohol reflux three times, and merge extractive liquid, filters, and concentrates oven dry, the fine powder that is ground into;
B) Fructus Schisandrae Sphenantherae, Fructus Corni, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Radix Et Rhizoma Nardostachyos add 70% alcohol reflux 3 times jointly, and merge extractive liquid, filters spissated extractum;
C) fine powder that is broken into of Eupolyph aga sinesis Walker;
D) Radix Ophiopogonis, Semen Ziziphi Spinosae (parched), Herba Taxilli, Radix Paeoniae Rubra, Os Draconis decoct with water 2 times, merge extractive liquid,, spissated extractum.
E) with step b) and d) merging of gained extractum, the fine drug powder of adding step c) gained, oven dry is ground into fine powder, adds step a) gained fine drug powder, and mixing promptly gets this Chinese medicine composition active component.
In the application of the present invention, described Chinese medicine composition is a capsule, tablet, electuary, a kind of in powder or the oral liquid formulations, for above-mentioned dosage form can be realized, need when these dosage forms of preparation, to add the pharmacy acceptable auxiliary, for example: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic etc., filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc., disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc., lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc., suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc., binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc., sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc., correctives comprises: sweeting agent and various essence, and antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, the acetic acid chloroethene is fixed, the Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods.
The consumption of Chinese medicine composition of the present invention by active component crude drug gross weight, was 7-28 gram/days, but takes every day once, preferably divided and took for 2-4 time.
Along with the aggravation of all multifactor effects such as modern society's work, inter personal contact, economic pressures, the anxiety neurosis sickness rate is in rising trend.And the traditional Chinese medical science certainly will will have the side world of oneself in the characteristics and the advantage that have oneself aspect the treatment anxiety neurosis.The western medicine side reaction is big, costs an arm and a leg part patient's weak effect.Chinese medicine anxiety neurosis toxic and side effects is little, can carry out the whole body adjustment, can be used for clinical each phase anxiety patient, is easily accepted by extensive patients, so the effective Chinese prescription treatment of screening paroxysmal atrial fibrillation is the direction of the combination of Chinese and Western medicine.(clinical progress of Chinese medicine anxiety neurosis, He Min, Yuan Jiali, Liaoning Journal of Traditional Chinese Medicine.2006 the 33rd the 6th phases of volume)
Preparation of the present invention is under the network ens morbi instructs, mend, support, hold back the three therapeutic methods of traditional Chinese medicine and usefulness, select for use Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis supplementing QI and nourishing YIN, be equipped with Herba Taxilli benefit pectoral qi and help the motive to control morbidity originally, be equipped with Fructus Corni, Semen Ziziphi Spinosae nourishing blood to tranquillize the mind, medicine-feeding is share and is mended QI and blood in the network; Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Eupolyphaga Seu Steleophaga, Radix Et Rhizoma Nardostachyos and Radix Ginseng benefiting QI for activating blood circulation collateral dredging; Assistant is with the Rhizoma Coptidis clearing away heart-fire for tranquillization, the Os Draconis tranquillization with heavy prescription.All medicines share supplementing QI and nourishing YIN, promoting blood circulation to remove obstruction in the collateral, clearing away heart-fire for tranquillization, reconcile autonomic nervous function.。The clinical treatment that is applied to anxiety neurosis has obtained satisfied effect.
Essence is for a better understanding of the present invention observed pharmaceutical composition of the present invention " treatment anxiety neurosis " result of the test (used medicine is for pressing the prepared capsule of embodiment 1 method) below by clinical experiment
Experimental example: (this test data derives from Hebei Yi Ling hospital)
One, data and method:
1, all carry out the Hamilton Manifest Anxiety Scale before the physical data 50 routine anxiety neurosis patient and measure, the patient is conscious, do not have obvious aphasis, all can cooperate and answer a question.50 routine patients are divided into two groups at random, and 25 examples are organized in treatment, male 17 examples, women 8 examples, age 55-74 year, average (63 ± 5) year; Matched group 25 examples, male 18 examples, women 7 examples, age 54-73 year, average (64 ± 5) year.There are comparability at two groups sex, age.
2, Therapeutic Method is to the still treatment routinely of original base disease, and after Hamilton Manifest Anxiety Scale mensuration finished, the treatment group began with the made capsule of the present invention (by the preparation of embodiment 1 method), each 4, every day 3 times; 4 all 1 courses of treatment; Matched group is taken placebo, and each 4, every day 3 times, the course of treatment is with the treatment group.It is big conventional to observe treatment front and back three, blood biochemistry, electrocardiogram and adverse effect etc.
3, statistical procedures: all record data, and all (x ± s) expression relatively uses paired t-test before and after the treatment on the same group, relatively adopts the t check of design in groups between group with adding standard deviation.
Two, result
Graphical presentation is relatively seen in the scoring of Hamilton Manifest Anxiety Scale before and after two groups of treatments
Hamilton Manifest Anxiety Scale scoring before and after two groups of treatments (x ± s divides)
Three, conclusion
By above result of study, the capsule made of the present invention is applied to the treatment of anxiety neurosis as can be seen, has obtained satisfied effect, and the result shows and takes the capsule for treating anxiety patient that the present invention makes, and can obviously improve clinical symptoms, and untoward reaction is few.
Four, discuss
Anxiety neurosis belongs to sick categories such as the traditional Chinese medical science " hysteria ", " melancholia ", " palpitation with fear ", " palpitation with a distress feeling ", belongs to feelings will obstacle, and functional disorder has substantial connection with The heart controls mental activities.Its pathogenesis mostly be for a long time ponder over, melancholy not understanding, cause the motive to dissipate, nutrient blood secretly consumes, and can not support the mind, and anxiety symptoms such as psychentonia, frightened worry, uneasy in either sitting or lying, cardiopalmus, tachypnea, hyperhidrosis appear, so its treatment when with tonification in the heart QI and blood, arresting convulsion is calmed the nerves is principle of treatment.Preparation of the present invention is under the network ens morbi instructs, mend, support, hold back the three therapeutic methods of traditional Chinese medicine and usefulness, select for use Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis supplementing QI and nourishing YIN, be equipped with Herba Taxilli benefit pectoral qi and help the motive to control morbidity originally, be equipped with Fructus Corni, Semen Ziziphi Spinosae nourishing blood to tranquillize the mind, medicine-feeding is share and is mended QI and blood in the network; Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Eupolyphaga Seu Steleophaga, Radix Et Rhizoma Nardostachyos and Radix Ginseng benefiting QI for activating blood circulation collateral dredging; Assistant is with the Rhizoma Coptidis clearing away heart-fire for tranquillization, the Os Draconis tranquillization with heavy prescription.All medicines share supplementing QI and nourishing YIN, promoting blood circulation to remove obstruction in the collateral, clearing away heart-fire for tranquillization, reconcile autonomic nervous function.
The specific embodiment
Medicine of the present invention is to be prepared from by following examples, and following specific embodiment is an explanation of the invention.
Following embodiment is used to illustrate the preparation of Chinese medicine composition of the present invention, but it can not constitute any restriction to scope of the present invention.
Embodiment 1
For the ease of the application of this Chinese medicine composition, this Chinese medicine composition is prepared as capsule
Prescription:
Radix Ginseng 89g 112g Radix Ophiopogonis Fructus Corni 224g Radix Salviae Miltiorrhizae 224g
Semen Ziziphi Spinosae (parched) 186g Herba Taxilli 186g Radix Paeoniae Rubra 89g Eupolyphaga Seu Steleophaga 75g
Radix Et Rhizoma Nardostachyos 89g Rhizoma Coptidis 45g Fructus Schisandrae Sphenantherae 67g Os Draconis 149g
Preparation method:
A) in the above-mentioned prescription, Radix Ginseng is with 70% alcohol reflux three times, and 3 hours for the first time, each 2 hours later on, merge extractive liquid, filtered, and reclaims ethanol, concentrates, and oven dry is ground into fine powder, and is standby;
B) in the above-mentioned prescription, Fructus Schisandrae Sphenantherae, Fructus Corni, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Radix Et Rhizoma Nardostachyos are with 70% alcohol reflux three times, and merge extractive liquid, filters, and reclaims ethanol, concentrate extractum, standby;
C) in the above-mentioned prescription, Eupolyph aga sinesis Walker is broken into fine powder, and is standby;
D) in the above-mentioned prescription, Radix Ophiopogonis, Semen Ziziphi Spinosae (parched), Herba Taxilli, Radix Paeoniae Rubra, Os Draconis decoct with water secondary, and merge extractive liquid, filters, and the extracting solution of filtrate and Fructus Schisandrae Sphenantherae etc. merges, and concentrated extractum is standby;
E) with step b) and d) merging of gained extractum, the fine drug powder that adds the step c) gained is dried, and is ground into fine powder, adds step a) gained fine drug powder, mixing, 1000 capsules of packing into.
Usage and consumption: oral.One time 2～4,3 times on the one.
Claims (6)
1, the application of a kind of Chinese medicine composition in preparation treatment anxiety neurosis medicine is characterized in that this Chinese medicine composition is made by following bulk drugs:
Radix Ginseng 45-180 part, Radix Ophiopogonis 50-200 part, Fructus Corni 125-450 part, Radix Salviae Miltiorrhizae 125-450 part, Semen Ziziphi Spinosae (parched) 95-400 part, Herba Taxilli 95-400 part, Radix Paeoniae Rubra 45-200 part, Eupolyphaga Seu Steleophaga 35-150 part, Radix Et Rhizoma Nardostachyos 45-200 part, Rhizoma Coptidis 25-90 part, Fructus Schisandrae Sphenantherae 35-150 part, Os Draconis 75-300 part.
2, application as claimed in claim 1 is characterized in that, this Chinese medicine composition is made by following bulk drugs:
89 parts of Radix Ginsengs, 112 parts of Radix Ophiopogonis, 224 parts of Fructus Corni, 224 parts of Radix Salviae Miltiorrhizaes, 186 parts of Semen Ziziphi Spinosae (parched)s, 186 parts of Herba Taxillis, 89 parts of Radix Paeoniae Rubra, 75 parts of Eupolyphaga Seu Steleophagas, 89 parts of Radix Et Rhizoma Nardostachyos, 45 parts of Rhizoma Coptidis, 67 parts of Fructus Schisandrae Sphenantheraes, 149 parts of Os Draconis.
3, application as claimed in claim 1 is characterized in that, this Chinese medicine composition is made by following bulk drugs:
45 parts of Radix Ginsengs, 112 parts of Radix Ophiopogonis, 224 parts of Fructus Corni, 225 parts of Radix Salviae Miltiorrhizaes, 186 parts of Semen Ziziphi Spinosae (parched)s, 186 parts of Herba Taxillis, 89 parts of Radix Paeoniae Rubra, 45 parts of Radix Et Rhizoma Nardostachyos, 35 parts of Eupolyphaga Seu Steleophagas, 45 parts of Rhizoma Coptidis, 67 parts of Fructus Schisandrae Sphenantheraes, 149 parts of Os Draconis.
4, application as claimed in claim 1 is characterized in that, this Chinese medicine composition is made by following bulk drugs:
90 parts of Radix Ginsengs, 135 parts of Radix Ophiopogonis, 270 parts of Fructus Corni, 200 parts of Radix Salviae Miltiorrhizaes, 150 parts of Semen Ziziphi Spinosae (parched)s, 150 parts of Herba Taxillis, 100 parts of Radix Paeoniae Rubra, 100 parts of Eupolyphaga Seu Steleophagas, 95 parts of Radix Et Rhizoma Nardostachyos, 60 parts of Rhizoma Coptidis, 75 parts of Fructus Schisandrae Sphenantheraes, 150 parts of Os Draconis.
As the described application of claim 1-4, it is characterized in that 5, the active component of this Chinese medicine composition is made by the following step:
A) people participates in 70% alcohol reflux three times, and merge extractive liquid, filters, and concentrates oven dry, the fine powder that is ground into;
B) Fructus Schisandrae Sphenantherae, Fructus Corni, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Radix Et Rhizoma Nardostachyos add 70% alcohol reflux 3 times jointly, and merge extractive liquid, filters spissated extractum;
C) fine powder that is broken into of Eupolyph aga sinesis Walker;
D) Radix Ophiopogonis, Semen Ziziphi Spinosae (parched), Herba Taxilli, Radix Paeoniae Rubra, Os Draconis decoct with water 2 times, merge extractive liquid,, spissated extractum;
E) with step b) and d) merging of gained extractum, the fine drug powder of adding step c) gained, oven dry is ground into fine powder, adds step a) gained fine drug powder, and mixing promptly gets this Chinese medicine composition active component.
As each described application among the claim 1-4, it is characterized in that 6, the preparation formulation of described Chinese medicine composition is a kind of in capsule, tablet, electuary, powder or the oral liquid formulations.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102836330A (en) * | 2012-09-20 | 2012-12-26 | 张焕君 | Decoction for treating anxiety disorder |
| CN103735908A (en) * | 2014-01-16 | 2014-04-23 | 周立发 | Traditional Chinese medicine for treating anxiety |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1188159C (en) * | 2002-10-24 | 2005-02-09 | 河北以岭医药研究院有限公司 | Medicines composition for treating coronary heart disease ventricular premature beat and its prepn |
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2007
- 2007-09-20 CN CN2007101522475A patent/CN101391021B/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102836330A (en) * | 2012-09-20 | 2012-12-26 | 张焕君 | Decoction for treating anxiety disorder |
| CN102836330B (en) * | 2012-09-20 | 2013-09-11 | 张焕君 | Decoction for treating anxiety disorder |
| CN103735908A (en) * | 2014-01-16 | 2014-04-23 | 周立发 | Traditional Chinese medicine for treating anxiety |
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| CN101391021B (en) | 2012-04-18 |
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