CN101390997B - Jianmu capsule and preparation method thereof - Google Patents
Jianmu capsule and preparation method thereof Download PDFInfo
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- CN101390997B CN101390997B CN2008100721387A CN200810072138A CN101390997B CN 101390997 B CN101390997 B CN 101390997B CN 2008100721387 A CN2008100721387 A CN 2008100721387A CN 200810072138 A CN200810072138 A CN 200810072138A CN 101390997 B CN101390997 B CN 101390997B
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Abstract
The invention relates to a medicine preparation and a preparing method thereof, in particular to a capsule for benefiting eyes and the preparing method. The capsule for benefiting eyes is composed of Chinese traditional medicine raw materials: ampelopsis, bear gall powder, pale butterflybush flower and selfheal. The medicine has the benefits of clearing heat and consumptive thirst, calming liver and clearing eyes, promoting Blood circulation to remove Blood stasis and inducing diuresis and freeing channels; and has better curative effect for patients with eyes subhealth, such as redness and dryness in eyes, watching object unclearly, tearing against wind and eye fatigue, and also has better curative effect for the middle and aged eye disease occurrence and development without side effects. The preparing technique of the medicine for benefiting eyes is simple, the operation is easy, and the large-scale production can be realized conveniently.
Description
Technical field
What the present invention relates to is a kind of Chinese medicine preparation and method of making preparation, particularly a kind of strong capsule of eye and preparation method thereof.
Background technology
Having a pair of bright eyes, is that people look forward to, but along with the senescence gradually of population, there is ascendant trend in the sickness rate of various oculopathy of person in middle and old age such as diabetic retinopathy etc.; Teenager also increases because of operating pressure, and rhythm of life accelerates, and the influence of factors such as study, living environment, makes people's expectation not fully up to expectations.Eyes subhealth state patients such as computer oculopathy, xerophthalmia, air-conditioning oculopathy are also more and more, symptoms such as their existence blurring of vision, asthenopia, conjunctival congestion in various degree is dry and astringent, epiphora induced by wind.Eyes are in sub-health state for a long time, except that causing visual deterioration, also can progressively form ophthalmics such as conjunctivitis, glaucoma, cataract.Current medicine to eyes maintenance control except that antibiotic, antiviral with to subtract intraocular pressure class minority medicine be the oral medicine, is more common in the topical drug of eye drop, eye ointment and so on.Experiment showed, that Chinese medicine is having better action aspect generation that prevents and treats eyes subhealth state patient and person in middle and old age's oculopathy and the development.
Summary of the invention
The purpose of this invention is to provide a kind of oral Chinese medicine and oculopathy is had strong capsule of eye of good preventive and therapeutic effect and preparation method thereof.
The objective of the invention is to realize through following technical scheme.
A kind of strong capsule of eye is made by Ampelopsis grossedentata, Fel Ursi powder, Flos Buddlejae, Spica Prunellae raw material of Chinese medicine, and wherein the weight portion of each raw material of Chinese medicine is:
Ampelopsis grossedentata 4-8 Fel Ursi powders 0.2-0.4
Flos Buddlejae 2-4 Spica Prunellaes 4-8.
Optimum weight part is:
Ampelopsis grossedentata 6 Fel Ursi powders 0.3
Flos Buddlejae 3 Spica Prunellaes 6.
The method for preparing of this strong capsule of eye is following:
Get Fel Ursi powder by weight and be ground into fine powder; Get Ampelopsis grossedentata by weight, add 9-11 times of water gagings extractions 3-4 times, each 25-35 minutes, filter while hot, filtrate decompression concentrates, and puts and is chilled to room temperature, leaves standstill, and filters, and the taking precipitate oven dry gets Ampelopsis grossdentata (Hand.-Mazz.) W.T.Wang extract, pulverizes; Get Flos Buddlejae and Spica Prunellae by weight, add 9-11 times of amount 60%-80% ethanol extractions 3-4 times, reclaim ethanol, concentrating under reduced pressure, drying gets Flos Buddlejae, Spica Prunellae extract, pulverizes; Get Fel Ursi fine powder and above two kinds of extract flours, mix, granulate, filled capsules is processed.
This strong capsule of eye has heat clearing away quenches one's thirst, the suppressing the hyperactive liver function of improving eyesight, and symptoms such as, blurring of vision dry and astringent to conjunctival congestion, epiphora induced by wind, asthenopia have significant curative effect, have no side effect, and preparation technology are simple and direct, and easy operating is convenient to accomplish scale production.
The specific embodiment
Below in conjunction with embodiment the present invention is done further concrete the elaboration.
Originally Clear & Transparent crystalline lens becomes muddy in eyes, cataract that Here it is.Prevent the topmost approach of cataract to be, keep normal circulation of qi and blood in the body, the binocular QI and blood also can circulate unimpeded, and so, the muddiness of ophthalmic just can not rest on the crystalline lens.The one of the main reasons that causes xerophthalmia is the life-time service computer, uses the time of computer longer, and uncomfortable phenomenons such as the sour and astringent fatigue of eyes, blurred vision also increase day by day.The Another reason of xerophthalmia is the stricture of lacrimal passage or the obstructed lacrimal passage of ophthalmic, causes the aqueous humor outflow minimizing institute of eyes to cause.Glaucoma is a kind of disease of potentiality blinding, mainly is that intraocular pressure raises, and accumulates in the optic nerve at aqueous humor compressing eye rear portion unnecessary in the eyes, and long-time optic nerve can be compromised, and affects one's power of vision before this, finally loses vision.The traditional Chinese medical science is thought, takes the Chinese medicine of the logical blood stasis of blood alive, liver heat removing and eyesight improving, diuretic collateral dredging often, can prevent and treat the generation and the development of ophthalmic.
The performance effect that known following each Chinese medicine has:
1, Ampelopsis grossedentata (Ampelopsis grossedentata) is Vitaceae (Vitaceae) Ampelopsis (Ampelopsis) plant, is commonly called as " Ampelopsis grossedentata ", " white hair monkey ".Be distributed in provinces and regions such as China Fujian, Guangdong, Hunan.Put down in writing according to relevant Chinese herbal medicine books: the Ampelopsis grossedentata slightly warm in nature has effects such as dispelling wind detoxifcation, removing blood stasis to reduce swelling, hemostasis and pain-relieving, antiinflammatory.
2, Fel Ursi: the gallbladder of ursidae animal black bear or brown bear.Black bear (Selenarctos thibetanus G.Cuvier) has another name called Bears, pig Bears, black bear etc.Brown bear (Ursus arctos L.) has another name called brown bear, yellow bear, brown bear etc.Dry gallbladder keeps dry bile in the capsule, practise and claim " gallbladder core ", is bulk, graininess, Powdered or thick paste shape, is ground into powder and is Fel Ursi powder.Nature and flavor are bitter, and are cold.The function heat clearing away, spasmolytic makes eye bright, parasite killing.
" detailed outline " carries: " bring down a fever, clear away heart-fire, suppressing the hyperactive liver, nebula makes eye bright "." press Qian Yiyun, good person is well-illuminated for Fel Ursi ".
" Elementary Medicine " carries: " eye dripping goes the nebula open-blind ".
" what folks say " carries: bear gall pill " controlling conjunctival congestion hides from view: Fel Ursi a little, melt, go into one, two of Borneolum Syntheticums, the bronze, brass or copper ware point.Or tear itches, and it is a little to add Rhizoma Zingiberis Recens powder.”
3, Flos Buddlejae: different name native brocade flower, Flos Buddlejae, yellow meal flower, pimple skin tree flower, Os Gallus domesticus headdress flower.Nature and flavor are sweet, cold.Function is dispeled the wind, removing heat from blood, and the profit liver makes eye bright.Control conjunctival congestion and swelling pain, many tear photophobia, optic atrohic blindness cataracta, the mashed eye of wind string.
" Kaibao Bencao " carries: " main optic atrohic blindness skin nebula, red puckery many eye secretion and tears, blood vessel in the order that disappears, children's's bran bean and infantile malnutrition gas are attacked eye.”
" Bencao Jingshu " carries: " Flos Buddlejae is seen " herbal classic " and lead, and deficiency of the liver has due to the heat nothing but, and lid liver opening at eye; visual acuity is obtained from the sufficient blood supply of the eyes, deficiency of liver-blood then be optic atrohic blindness skin nebula, liver-heat then be red swollen; the eye secretion and tears blood vessel very, reach children's's bean skin ulcer residual poison, and infantile malnutrition gas is attacked eye; this medicine is sweet to enrich blood, and trembles with fear with heat extraction, and liver blood is sufficient and heal invariably at card.”
" book on Chinese herbal medicine is looked for the truth " carries: " Flos Buddlejae, flavor is thinner than gas, the medicine of assistant to nourish blood, more effectively here.”
4, Prunella: Exclusive Ming Maixia dry, iron-colored grass, stick stigma flowers, bulk flowers, grass hammer, mallet grass, June dried.The nature and flavor toil, cold.The function liver heat removing, eliminating stagnation.Control order pearl nyctalgia, photophobia is shed tears, the vertigo etc.
" the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " the row irritability is opened stagnation of liver-QI, ends bones and muscles pain, ophthal malgia.”
" the SHENGCAO property of medicine fully will " carries: " control scrofula, clear going up mended down, removes eye mask, pain relieving.”
Carry " briefly Ji crowd side ": tonifying liver is loose, and " treating the liver void order eyeball aches, and cold tears is more than, muscle arteries and veins pain, and eye photophobia fearness day.”
" detailed outline " carries: " the kind full cloud in building, Spica Prunellae control the order pearl painful to night what for the person, the magical effect ".
One of embodiment:
Get Fel Ursi powder 0.2-0.4 weight portion, be ground into fine powder; Get Ampelopsis grossedentata 4-8 weight portions, add 9-11 times of water gagings extractions 3-4 times, each 25-35 minutes, filter while hot, filtrate decompression concentrates, and puts and is chilled to room temperature, leaves standstill 9-10 hours, filters, and the taking precipitate oven dry gets Ampelopsis grossdentata (Hand.-Mazz.) W.T.Wang extract, pulverizes; Get Flos Buddlejae 2-4 weight portions and Spica Prunellae 4-8 weight portions, add 9-11 times of amount 60%-80% ethanol extractions 3-4 times, reclaim ethanol, concentrating under reduced pressure, drying gets Flos Buddlejae, Spica Prunellae extract, pulverizes; Get above Fel Ursi fine powder and Ampelopsis grossdentata (Hand.-Mazz.) W.T.Wang extract flour and Flos Buddlejae, Spica Prunellae extract flour, mix, granulate, filled capsules makes.
Two of embodiment:
Get Fel Ursi powder 0.2 weight portion, be ground into fine powder; Get Ampelopsis grossedentata 8 weight portions, add 9 times of water gagings extractions 4 times, each 25 minutes, filter while hot, filtrate decompression concentrates, and puts and is chilled to room temperature, leaves standstill 10 hours, filters, and the taking precipitate oven dry gets Ampelopsis grossdentata (Hand.-Mazz.) W.T.Wang extract, pulverizes; Get Flos Buddlejae 4 weight portions and Spica Prunellae 8 weight portions, add 11 times of amount 60% ethanol extractions 4 times, reclaim ethanol, concentrating under reduced pressure, drying gets Flos Buddlejae, Spica Prunellae extract, pulverizes; Get above Fel Ursi fine powder and Ampelopsis grossdentata (Hand.-Mazz.) W.T.Wang extract flour and Flos Buddlejae, Spica Prunellae extract flour, mix, granulate, filled capsules makes.
Three of embodiment:
Get Fel Ursi powder 0.4 weight portion, be ground into fine powder; Get Ampelopsis grossedentata 4 weight portions, add 11 times of water gagings extractions 3 times, each 35 minutes, filter while hot, filtrate decompression concentrates, and puts and is chilled to room temperature, leaves standstill 10 hours, filters, and the taking precipitate oven dry gets Ampelopsis grossdentata (Hand.-Mazz.) W.T.Wang extract, pulverizes; Get Flos Buddlejae 2 weight portions and Spica Prunellae 4 weight portions, add 9 times of amount 80% ethanol extractions 3 times, reclaim ethanol, concentrating under reduced pressure, drying gets Flos Buddlejae, Spica Prunellae extract, pulverizes; Get above Fel Ursi fine powder and Ampelopsis grossdentata (Hand.-Mazz.) W.T.Wang extract flour and Flos Buddlejae, Spica Prunellae extract flour, mix, granulate, filled capsules makes.
Most preferred embodiment:
Get Fel Ursi powder 0.3 weight portion, be ground into fine powder; Get Ampelopsis grossedentata 6 weight portions, add 10 times of water gagings extractions 3 times, each 30 minutes, filter while hot, filtrate decompression concentrates, and puts and is chilled to room temperature, leaves standstill 10 hours, filters, and the taking precipitate oven dry gets Ampelopsis grossdentata (Hand.-Mazz.) W.T.Wang extract, pulverizes; Get Flos Buddlejae 3 weight portions and Spica Prunellae 6 weight portions, add 10 times of amount 70% ethanol extractions 3 times, reclaim ethanol, concentrating under reduced pressure, drying gets Flos Buddlejae, Spica Prunellae extract, pulverizes; Get above Fel Ursi fine powder and Ampelopsis grossdentata (Hand.-Mazz.) W.T.Wang extract flour and Flos Buddlejae, Spica Prunellae extract flour, mix, granulate, filled capsules makes.
The strong capsule of eye sample of the present invention is referred to Chinese department of Chinese medicine institute institute of materia medica and is carried out the drug effect toxicological test; The result shows that these article have tangible reparation and inhibitory action to the optic neuropathy of rat diabetes property retinopathy varying model due to the streptozotocin; And do not have obvious toxicity, its test report is following:
Strong capsule of eye is to the influence of rat diabetes property retinopathy varying model
(summary) purpose: the strong capsule of eye extract of preliminary observation is to the change degree of diabetic retinopathy model big rat retinopathy.Method: the rats by intraperitoneal injection streptozotocin causes the diabetic renal papillary necrosis model, with strong capsule of eye extract gastric infusion, gets the rat optic nerve after 3 months in administration and does pathologic finding comparable group differences.Result: compare with model group; Strong capsule of eye extract high dose (0.2g/kg) and low dosage (o.125g/Kg) all show to have certain inhibitory action to the optic nerve of diabetic optic neuropathy rat model due to the streptozotocin, and the effect of its high dose obviously is superior to middle dosage.Conclusion: strong capsule of eye all shows to have certain inhibitory action to the optic neuropathy of diabetic optic neuropathy rat model due to the streptozotocin, and onset dosage is 0.25g/kg.
1, experiment material
1.1 medicine and reagent
Strong capsule of eye extract: Fuzhou Chang Fu-Sing New Drug Development Co., Ltd provides by Fujian, lot number: 060301; STZ (streptozotocin): Sigma Company products, lot number: 046K1206.
1.2 laboratory animal
Rat: the SD kind, male, body weight 160-200g.Cleaning agent, available from Beijing dimension tonneau China laboratory animal company limited, the quality certification number: SCXK (capital) 2002-0003
2, experimental technique
2.1 the setting of dosage
Strong capsule of eye extract clinical every day of plan is used accumulated dose: 0.6g.
The quite clinical plan of administration high dose is with 2 times of dosage: 0.25g/Kg.
The quite clinical plan of administration low dosage is with 12,5 times of dosage: 0.125g/Kg.
2.2 statistical method
Adopt SPSS-forwindws11.5 that data are carried out statistical analysis, enumeration data is added up with non parametric tests.
2.3 influence to diabetic optic neuropathy rat model optic neuropathy
The animal adaptability fed for 1 week, and 10 of picked at random are as the normal control group, and all the other carry out model copy.Rat fasting 12h; Order citrate buffer solution (PH=4.4) o.1mol/L is made into STZ 2% solution; Press the 50mg/Kg lumbar injection; The normal saline of water 10-12h pneumoretroperitoneum injection same dose is can't help in the control rats fasting, and the hematometry fasting glucose is got in docking after 3 days, records the above person of fasting glucose 16.7mmol/L and is the diabetes model rat.Eliminate the defective rat of blood glucose.Modeling success rat is divided into 3 groups at random, that is: model group, strong capsule of eye extract high and low dose group, 10 every group.Strong capsule of eye extract begins gastric infusion in modeling after 7 days, and the high and low dose group (0.25g/Kg, 0.125g/Kg) quite clinical plan is with 25 times and 12.5 times of dosage respectively, and the administration volume is 1ml/Kg.Matched group, model group are irritated stomach and are given same water by volume, successive administration 3 months, during rat freely take the photograph water and diet.1h anaesthetizes rat abdominal cavity after the last administration, wins eyeball and places 10% formalin fixing.Through gradient alcohol dehydration, paraffin embedding, slice thickness 5 μ m, histological examination is carried out in HB dyeing back under spectroscopy.
3, experimental result
3.1 retinal vessel and nerve fibre layer pathological changes
The normal control group: the normal rat retina is made up of 4 confluent monolayer cells, is followed successively by from inside to outside: PE confluent monolayer cells, layer of rods and cones cell, inner nuclear layer cell and ganglion-cell layer cell.Retinal vessel is distributed in the middle of each confluent monolayer cells of retina through branch repeatedly by Zinn's artery, a thicker vascularity is wherein arranged to retinochrome nerve fiber laminar surface.The positive little blood vessel of rat retinal nerve fibre layer finding is fewer, does not see obvious pathological changes.
Model group: the retina small vessel disease becomes and mainly to show the degeneration of petty action astillen, harden, thicken and tube chamber dwindles or inaccessible, little blood vessel hyperplasia, hemorrhage, congestion, pathological changes such as venule cystic dilatation and the degeneration of ganglion-cell layer nerve fiber.The little blood vessel 90% of this experiment diabetes model rat retina is with the upper tube wall degeneration, and the half blood vessel hardens, tube wall thickens, 40% little blood vessel hyperplasia; Slight microvascular bleeding takes place in 2 routine retinas; 3 routine venous congestions, 40% venule cystic dilatation, 1 routine nerve fiber degeneration.
High dose group: the little vascular wall degeneration of 28% animal with thicken 1 routine arteriolosclerosis, each 1 example of retinal hemorrhage and congestion, 1 routine venule cystic dilatation and congestion, the change of nerve fiber no abnormality seen.
Low dose group: 62% animal small artery tube wall degeneration, the little vascular wall of 75% animal hardens and thickens, 1 routine little blood vessel hyperplasia, 3 routine venule cystic dilatation and nerve fiber degeneration are not seen hemorrhage and congestion.
The result shows; Under this experiment condition; Strong capsule of eye extract high dose group (0.25g/Kg) and middle dose groups (0.125g/Kg) all show certain inhibitory action to diabetic optic neuropathy rat model optic neuropathy due to the streptozotocin, and the effect of its high dose obviously is superior to middle dosage.
4, experiment conclusion
Strong capsule of eye extract all shows to have certain inhibitory action to the optic neuropathy of diabetic optic neuropathy rat model due to the streptozotocin, and onset dosage is 0.25g.
Claims (4)
1. a strong capsule of eye that suppresses the diabetic optic neuropathy is characterized in that, is made by Ampelopsis grossedentata, Fel Ursi powder, Flos Buddlejae, Spica Prunellae raw material of Chinese medicine, and wherein the weight portion of each raw material of Chinese medicine is:
Ampelopsis grossedentata 4-8 Fel Ursi powder 0.2-0.4
Flos Buddlejae 2-4 Spica Prunellae 4-8.
2. according to the strong capsule of eye of the inhibition diabetic optic neuropathy of claim 1, it is characterized in that the weight portion of each raw material of Chinese medicine is:
Ampelopsis grossedentata 6 Fel Ursi powders 0.3
Flos Buddlejae 3 Spica Prunellaes 6.
3. a method for preparing that suppresses the strong capsule of eye of diabetic optic neuropathy is characterized in that, gets Fel Ursi powder 0.2-0.4 weight portion, is ground into fine powder; Get Ampelopsis grossedentata 4-8 weight portion, add 9-11 times of water gaging and extract 3-4 time, 25-35 minute at every turn, filter while hot, filtrate decompression concentrates, and puts and is chilled to room temperature, leaves standstill 9-10 hour, filters, and the taking precipitate oven dry gets Ampelopsis grossdentata (Hand.-Mazz.) W.T.Wang extract, pulverizes; Get Flos Buddlejae 2-4 weight portion and Spica Prunellae 4-8 weight portion, add 9-11 and doubly measure the 60%-80% ethanol extraction 3-4 time, reclaim ethanol, concentrating under reduced pressure, drying gets Flos Buddlejae, Spica Prunellae extract, pulverizes; Get above Fel Ursi fine powder and Ampelopsis grossdentata (Hand.-Mazz.) W.T.Wang extract flour and Flos Buddlejae, Spica Prunellae extract flour, mix, granulate, filled capsules is processed.
4. according to the method for preparing of the strong capsule of eye of the inhibition diabetic optic neuropathy of claim 3, it is characterized in that, get Fel Ursi powder 0.3 weight portion, be ground into fine powder; Get Ampelopsis grossedentata 6 weight portions, add 10 times of water gagings extractions 3 times, each 30 minutes, filter while hot, filtrate decompression concentrates, and puts and is chilled to room temperature, leaves standstill 10 hours, filters, and the taking precipitate oven dry gets Ampelopsis grossdentata (Hand.-Mazz.) W.T.Wang extract, pulverizes; Get Flos Buddlejae 3 weight portions and Spica Prunellae 6 weight portions, add 10 times of amount 70% ethanol extractions 3 times, reclaim ethanol, concentrating under reduced pressure, drying gets Flos Buddlejae, Spica Prunellae extract, pulverizes; Get above Fel Ursi fine powder and Ampelopsis grossdentata (Hand.-Mazz.) W.T.Wang extract flour and Flos Buddlejae, Spica Prunellae extract flour, mix, granulate, filled capsules is processed.
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| CN101390997B true CN101390997B (en) | 2012-07-04 |
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| CN104367810A (en) * | 2014-11-19 | 2015-02-25 | 济南伟传信息技术有限公司 | Traditional Chinese medicine decoction for relieving visual fatigue |
| CN109381571A (en) * | 2018-11-26 | 2019-02-26 | 韩佳志 | A kind of Chinese medicine compound prescription eye drops for improving eyesight and preparation method |
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