CN101390522A - Disinfecting liquid - Google Patents
Disinfecting liquid Download PDFInfo
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- CN101390522A CN101390522A CNA2007100357945A CN200710035794A CN101390522A CN 101390522 A CN101390522 A CN 101390522A CN A2007100357945 A CNA2007100357945 A CN A2007100357945A CN 200710035794 A CN200710035794 A CN 200710035794A CN 101390522 A CN101390522 A CN 101390522A
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- thimerosal
- solution
- available chlorine
- thimerosals
- iodate
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Abstract
A disinfection solution is characterized in that the disinfection solution is a mixture of 500 weight proportions of stock solution containing 84 disinfectant with the active chlorine more than or equal to 5%, soluble iodate containing 0.1-3.75 weight proportions of iodine, 1.25 weight proportions of surfactant, as well as 2 weight proportions of carbonate. In the practical application process, compared with the traditional 84 disinfectant, the disinfection solution has greater stability and bactericidal effect.
Description
Affiliated technical field
The present invention relates to thimerosal.
Background technology
84 thimerosals are that a kind of mechanisms such as hotel, hospital, family, kindergarten that are widely used in are used for the efficient chlorine-containing disinfectant of daily sterilization.At present, major part 84 thimerosal products on the market, mainly containing effective constituent is hypochlorite, its available chlorine content is about 8000mg/L.During use with conventional dilute with water, but its poor stability, available chlorine easily disengages, acts on of short duration in the aqueous solution.Therefore, in use, 84 disinfectant dilute solution valid expiration dates generally were no more than 24h, needed now with the current.
Summary of the invention
The object of the present invention is to provide the chlorine-containing disinfection liquid of a kind of good stability, long action time.
In order to achieve the above object, the technical solution adopted in the present invention is:
A kind of thimerosal is characterized in that: be the solution that mixes by following component,
The main component content of component
84 thimerosal stostes, 500 weight portions that contain available chlorine 〉=5%
Amount of iodine 0.1-3.75 is heavy
The iodate of solubility
Amount part
Surfactant 1.25 weight portions
Carbonate 2.0 weight portions
Described a kind of thimerosal is characterized in that: stabilizing agent is the iodate of solubility.
Described a kind of thimerosal is characterized in that: described iodate is a Potassiumiodate.
Described a kind of thimerosal is characterized in that: surfactant is the two the combination of fatty alcohol and PVP(polyvinyl pyrrolidone).
Described a kind of thimerosal is characterized in that: carbonate is sodium carbonate
Following Potassiumiodate is called for short KIO
3, fatty alcohol is called for short OK-PL, and PVP(polyvinyl pyrrolidone) is called for short PVP, and sodium carbonate is called for short Na
2CO
3
2. know-why: 84 thimerosals reach the sterilization purpose by following three kinds of approach: 1) hypochlorous oxidation.2) newborn oxygen effect.3) chlorination and sterilization.
2.1.84 thimerosal is that the bactericidal property performance is best under the condition of 6-8 at pH value, just can be used to kill hepatitis B during the available chlorine content in the disinfectant 〉=1000mg/L, when when using liquid to reduce to 1000mg/L, being used as the soaking disinfection of contact patient skin article, just be considered as losing efficacy.
2.2.84 the available chlorine content in the thimerosal is not a definite value, it is under different conditions, and the content difference of available chlorine changes with the variation of self and environment, for example; 84 antiseptic solutions with a kind of 0.5% are 163.1mg/L at 0 ℃ of following available chlorine content, then are 439.6mg/L in the time of 30 ℃, 84 solution of different product, and its stability also has difference, and this is by its unsettled chemical property decision.
2.3. as 84 thimerosals in using, because its concentration is low, need place the bigger solution of adding a cover, degraded is fast, consumption is many, and sterilizing objects mostly belongs to organic matters such as rubber, pottery, glass, chemical fibre, plastics, therefore, available chlorine is subjected to organic influence again easily, yet the consumption of the actual that part of available chlorine that really is used for sterilization is quite small.
The present invention utilizes and contains the available chlorine composition in 84 thimerosals, under the constant relatively condition of temperature, concentration, add an amount of iodate as stabilizing agent, this stabilizing agent is the carrier of solubility, can regulate the pH value of adaptation, this carrier mass is a kind of oxidant simultaneously, and can form complexing between energy and the surfactant, and hypochlorous acid is uniformly distributed in the carrier, improve stability, NaCO
3The chloric acid that hypochlorous acid produces in oxidation disinfection or decomposable process can be reacted again and form hypochlorous acid once more, reach recycling effect.When above-mentioned thimerosal with after bacterium combines, both are by synergy, not only strengthen hypochlorous bactericidal action, reduced the consumption of available chlorine, and prolonged the sterilization timeliness, guarantee the lasting release of its available chlorine, and surfactant also can form hydration shell and reduces its volatilization.
3. select the reason and the mechanism of action of this stabilizing agent and surfactant:
3.1. have strong polarity group in the molecule hydrophilic interaction is arranged, and have significant binding ability between the hypochlorous acid, can generate complex compounds, have solubilization, can increase some water-fast material water-soluble at all with many different compounds.
3.2. the chemical substance after forming has peptizaiton, and the available chlorine in the solution is uniformly dispersed, and keeps stable.
3.3.PVP have good adsorption capacity, be adsorbed on many interfaces, and reduce surface tension to a certain extent.
3.4. N-H in this stabilizing agent and the surfactant or O-H bond energy and hypochlorous acid form intermolecular association, this association energy is controlled hypochlorous release and action intensity, plays prolongation of effect and slow releasing function .KIO
3Form PVP-I with the PVP complexing, thereby the oxidisability of solution is strengthened, thereafter, PVP increased the stability of solution again with formation lipiodol after the Combination aliphatic acid hydrogenation combine addition reaction, make that hypochlorous molecule evenly distributes in the solution, make its not only possess hydrophilic property but also have lipophile, and NaCO
3To form hypochlorous acid once more recycling in addition for the chloric acid that hypochlorous acid can be produced in oxidation disinfection or decomposable process again.
3.5. after hypochlorous acid cooperates, have the PH balance, concentration balance, dissolution equilibrium and temperature balance.
4. technique effect
4.1. thimerosal of the present invention, more traditional 84 thimerosals stability is high, bactericidal effect is strong.
4.2. thimerosal of the present invention, changed tradition 84 use change liquid every day one, now with the current mode of operation, change from one day one to extend to and changed in three days one, and guaranteed Disinfection Effect.Improved the operating efficiency of preparation.
4.3. thimerosal of the present invention, preparation steps is few, and is simple to operate, and specification requirement is not high.
In a word, increase stability, reduce its volatilization, prolong the action time of 84 sterilization dilutions, can reduce the waste of 84 thimerosals, save cost, reduce spending, as 84 clinical practice dilutions, 24h extends to 72h by Use Limitation, with regard to its domestic hospital budget: be used for the quantity of 84 medicining liquid dippings sterilization, 1,868 3 grades of hospitals of family consume 80 bottles of calculating of 500ml84 thimerosal average every day with the whole nation, and need 14.9 ten thousand bottles every day; With 20 bottles of 84 thimerosals of the whole nation 6200 tame second-grade hospital mean consumption every day 500ml, need 12.4 ten thousand bottles; The whole nation each clinic of basic hospital, health care, epidemic prevention station etc. are with 50,000 families, and 6 bottles of calculating of the per day consumption of every family need 300,000 bottles every day; Amount to 57.3 ten thousand bottles of 500ml84 thimerosals (incomplete statistics).Price with 4 yuan every bottle can be saved about 429.75 ten thousand yuan average every day, and the cost of this product only needs to add the few stable agent in every bottle 84 thimerosal, only needs 0.5 yuan/bottle.Not only save cost, also avoided unnecessary manpower waste, increase work efficiency, have bigger economic benefit and social benefit.
1. safe effect
In order to test the safety in utilization of thimerosal, designed following experiment:
(1) to the skin acute toxicity experience.
Above-mentioned thimerosal and 84 thimerosals are made into 0.5%, 1%, 2% concentration, with 10 rabbit body weight between the 1.5-1.8 kilogram, backbone both sides local skin unhairing to 1.40cm
2About, become 0.5%, 1%, 2%84 antiseptic solutions to drip respectively behind depilation district, rabbit both sides 4h two kinds of solution allocation.Observer's rabbit skin has or not redness, rubescent phenomenon.
1 above-mentioned thimerosal and 84 thimerosals are to the damage test of rabbit skin as a result
X
2=3.12, P〉0.05, show the indifference opposite sex
(2) eye irritant test.The solution dilution that above-mentioned thimerosal and 84 thimerosals is contained above-mentioned concentration splashes into tame lagophthalmos conjunctiva for 10 times, observes its phenomenon behind the 4h.
2 liang of group solution are to the eye irritant tests of rabbit as a result
X
2=35.45, P＜0.01 shows otherness
(3) be divided into control group and experimental group with 1.5% 84 solution and 1.5% the above sterilization dilution, firm acerebral frog is soaked respectively wherein, observe the neural reflex situation of its four limbs in 5 minutes.
3 liang of group solution are tested the neural reflex of frog as a result
X
2=3.10, P〉0.05, show the still indifference opposite sex
2. to the damage effect of article
1) infringement of organic article is tested.With a rubber tube with quality, grouping, segmentation are cut into the arm-rest belt of the consistent 20cm of being of length, be soaked in respectively in the 84 sterilization dilutions that add 1:50 and the above-mentioned sterilization dilution with the amount of iodine 0.09ppm of concentration, divide control group and experimental group, add a cover immersion 2 days, dry, hang, hang 1kg weight 24h down, measure the length of its increase.The result is as follows:
5.1 two groups of solution are tested organic infringement
P＜0.01 shows variant
2) metal attack is tested.Equal-sized stainless steel substrates, carbon steel coupon, aluminium flake are positioned over above-mentioned sterilization dilution and the 84 sterilization dilutions of 1:50 respectively, be made as experimental group and control group respectively, in 18 ℃ environment, soak 72h, weigh after drying, observe relatively metal surface with magnifying glass, and calculate its corrosion of metal speed.
5.2 two groups of solution are to rate of metal corrosion
P〉0.05, show the still indifference opposite sex
From on can illustrate; above-mentioned thimerosal is less to the infringement of organic article than 84 thimerosals; to the carbon steel coupon mild corrosion; aluminium flake and Stainless Steel sheet are not corroded substantially; as can be seen; join the aluminium flake of experimental group and the covering that Stainless Steel sheet surface has formed very thin one deck white, this with the stabilizing agent that adds in the middle of contain that the activating agent of protecting article surface and intermolecular space structure reach metastable relation and the protection thing that forms.
3. bactericidal effect
The above thimerosal and 84 thimerosals are respectively applied for the immersion arm-rest belt by the concentration of 1:50: it is 1 secondary frequencies that per 20 30cm, bore 1cm arm-rest belt are immersed in the 3000ml solution 30 minutes; It is 2 times that every 24h soaks frequency.Uninterrupted continuously the immersion 96 hours according to the time of sterilizing objects, calculated its bactericidal effect.
3.1 method
Get Escherichia coli (8099), staphylococcus aureus (ATCC6538), bacillus subtilis var (ATCC9372) gemma and be prepared into bacteria suspension, stand-by.The HBsAg inactivation test contains the HBsAg suspension of volume fraction 5% calf serum with 20ul, and is standby.
3.1.1 carrier quantitation is bactericidal assay regularly
With the thimerosal of two kinds of concentration water bath preheating 5-10 minute, again the bacterium sheet is put into thimerosal, act on to the stipulated time: join after 5 minutes, 15 minutes, 30 minutes in the neutralizer test tube that fills 5ml Tween 80+sodium thiosulfate+phosphate buffer, middle deactivation shake in 10 minutes is played test tube 80 times, getting eluent 0.5ml inoculates in the brave red agar plate, put into 37 ℃ incubator and cultivate 48h, the record clump count is calculated comprehensive sterilizing rate.
The bactericidal effect results of 1. liang of group clinical practice thimerosals as a result
P＜0.01, the property that shows that there were significant differences
6.1.2 failure test to HBsAg
Under 18-22 ℃ condition, two kinds of sterilization drops respectively getting 5 microlitres respectively have on the HBsAg sheet in dying, and evenly cover, and act on to the stipulated time, the bacterium sheet are moved in the test tube of 1.0ml, and the mensuration that 0.1ml carries out the OD value is got in neutralization 10 minutes, and relatively.
1. liang of group clinical practice thimerosals are to HBsAg inactivation test result as a result
P＜0.01 shows variant
Below comprehensively explanation, above-mentioned thimerosal is eager to excel than the bactericidal effect of 84 thimerosals, and can keep 72h and use 6 secondary frequencies.Mainly with in the above-mentioned thimerosal solution added the anion surfactant that can delay the hypochlorous acid reaction velocity, the lipiodol of formation and PVP-I have increased the stability of solution again, thereby bactericidal activity is strengthened.
4. clinical application effect is observed
Above-mentioned thimerosal and 84 thimerosals are respectively applied for by the concentration of 1:50 soak arm-rest belt, atomization conduit, rag.It is 1 secondary frequencies that per 20 30cm of arm-rest belt, bore 1cm arm-rest belt are immersed in the 3000ml solution 30 minutes; It is 1 secondary frequencies that the average per 6 cover oxygen atomization devices of atomization conduit are soaked in the 8000ml solution, rag then 2 bilayers rag that is 20 * 10cm to be soaked in the 3000ml solution be 1 secondary frequencies; It is 2 times that every 24h soaks frequency, and uninterrupted continuously the immersion 96 hours measured two kinds of sterilizations and used the available chlorine content of liquid in different time sections, and compare, and the result is as follows:
The effect of two kinds of solution relatively
P＜0.01 shows restricted otherness
Through 240 parts of clinical practices, available chlorine every day of antiseptic solution detect 95% up to standard, and the sampling Detection qualification rate 100% of every month thimerosal further illustrates the validity of above-described thimerosal.
Embodiment-
A kind of thimerosal is the solution that is mixed by following part by weight by following component,
The main component content of component
The 84 thimerosal stoste 500g that contain available chlorine 〉=5%
Potassiumiodate amount of iodine 0.1g
Fatty alcohol 0.625g
PVP(polyvinyl pyrrolidone) 0.625g
Sodium carbonate 2.0g
Amount of iodine 0.1g is equivalent to Potassiumiodate 0.167g.
Embodiment two
A kind of thimerosal is characterized in that: be the solution that mixes by following component,
The main component content of component
The 84 thimerosal stoste 500g that contain available chlorine 〉=5%
Potassiumiodate amount of iodine 1g
Fatty alcohol 0.625g
PVP(polyvinyl pyrrolidone) 0.625g
Sodium carbonate 2.0g
Amount of iodine 1g is equivalent to Potassiumiodate 1.67g.
Embodiment three
A kind of thimerosal is characterized in that: be the solution that mixes by following component,
The main component content of component
The 84 thimerosal stoste 500g that contain available chlorine 〉=5%
Potassiumiodate amount of iodine 2g
Fatty alcohol 0.625g
PVP(polyvinyl pyrrolidone) 0.625g
Sodium carbonate 2.0g
Amount of iodine 3.75g is equivalent to Potassiumiodate 6.25g.
Claims (5)
1, a kind of thimerosal is characterized in that: be the solution that mixes by following component,
The main component content of component
500 weight portions of 84 thimerosal stostes that contain available chlorine 〉=5%
Amount of iodine 0.1-3.75
The iodate of solubility
Weight portion
0.625-1.25 individual weight
Surfactant
Part
2.0 weight portions of carbonate
2, a kind of thimerosal according to claim 1 is characterized in that: described stabilizing agent is the iodate of solubility.
3, a kind of thimerosal according to claim 2 is characterized in that: described iodate is a Potassiumiodate.
4, a kind of thimerosal according to claim 2 is characterized in that: described surfactant is the two the combination of fatty alcohol and PVP(polyvinyl pyrrolidone).
5, a kind of thimerosal according to claim 3 is characterized in that: described carbonate is sodium carbonate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100357945A CN101390522A (en) | 2007-09-20 | 2007-09-20 | Disinfecting liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100357945A CN101390522A (en) | 2007-09-20 | 2007-09-20 | Disinfecting liquid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101390522A true CN101390522A (en) | 2009-03-25 |
Family
ID=40491185
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007100357945A Pending CN101390522A (en) | 2007-09-20 | 2007-09-20 | Disinfecting liquid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101390522A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113171307A (en) * | 2021-04-20 | 2021-07-27 | 福州美美环保科技有限公司 | Manufacturing technology of acidic oxidation potential water disinfection wet tissue |
-
2007
- 2007-09-20 CN CNA2007100357945A patent/CN101390522A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113171307A (en) * | 2021-04-20 | 2021-07-27 | 福州美美环保科技有限公司 | Manufacturing technology of acidic oxidation potential water disinfection wet tissue |
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| PB01 | Publication | ||
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Open date: 20090325 |