CN101380388A - Traditional Chinese medicine preparation for treating vascular headache and preparation method and use thereof - Google Patents
Traditional Chinese medicine preparation for treating vascular headache and preparation method and use thereof Download PDFInfo
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- CN101380388A CN101380388A CNA2008101577523A CN200810157752A CN101380388A CN 101380388 A CN101380388 A CN 101380388A CN A2008101577523 A CNA2008101577523 A CN A2008101577523A CN 200810157752 A CN200810157752 A CN 200810157752A CN 101380388 A CN101380388 A CN 101380388A
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Abstract
The invention discloses a Chinese herba preparation which treats vascular headache, a preparation method and the application thereof. The preparation is prepared from the Chinese herba with the following weight portions: 11 to 15 portions of angelica, 11 to 15 portions of radix paeoniae alba, 8 to 12 portions of ligusticum wallichii, 8 to 12 portions of semen persicae, 8 to 12 portions of chrysanthemum, 8 to 12 portions of ramuli et spina uncariae, 6 to 10 portions of safflower, 6 to 10 portions of ligusticum sinense, 6 to 10 portions of earthworm and 6 to 10 portions of fructus lycii. The preparation method comprises the following steps: after being soaked in ordinary water, the angelica, ligusticum wallichii, ramuli et spina uncariae and the chrysanthemum are distilled under normal atmosphere, and distillate, filter herb residue and residual liquid are respectively collected; the filter herb residue and the medicinal materials left are decocted and boiled with water for three times; alcohol is recovered from the filtrate and concentrated to the relative density being 1.20 to 1.25 at the temperature of 70 to 80 DEC G; the concentration liquid and the distillate are combined and added with 100g of honey, and then water is added to cause the solution to be 1,000ml; the solution is homogenized, put statically, filtered, embedded, asepticized, then the Chinese herba preparation is prepared. The Chinese herba preparation is applied to preparing Chinese herba oral preparation which can prevent and cure vascular headache.
Description
Technical field
The present invention relates to tcm field, especially relate to a kind of Chinese medicine preparation and method for making and application for the treatment of vascular headache.
Background technology
The cause of disease of all headaches is referred to as the angiogenic headache from blood vessel.The angiogenic headache is divided into constitutional and Secondary cases two big classes.The headache that excuse portion vasomotor dysfunction causes is called the constitutional vascular headache; Headache due to the clear and definite cerebrovascular disease (as apoplexy, intracranial hematoma, cerebrovascular inflammation etc.) is arranged, be called the Secondary cases headache.
The constitutional vascular headache claims migraine again, is a kind of functional headache.Different manifestations according to headache can be divided into it five kinds of main types such as classical migraine, common migraine, gathering together property migraine, hemiplegia type migraine and ophthalmoplegic migraine again.
This invention relates generally to the constitutional vascular headache.Because this disease is commonly encountered diseases, frequently-occurring disease, harm humans health is given orthobiosis of people and is brought misery and inconvenience.
And medicine of the prior art, Western medicine such as somedon, NAOQING sheet, nimodipine etc. exist deficiencies such as long and potential untoward reaction of drug dependence and service time; There are deficiencies such as tangible gastrointestinal reaction in Chinese medicine such as ZHENGTIAN WAN etc.; Can not be fully up to expectations.So this class preparation of developmental research has important society and economic benefit.
Summary of the invention
The objective of the invention is to, utilize the technology of preparing of modern Chinese medicine, provide a kind of curative effect reliable, easy to use, the pure Chinese medicinal preparation that has no side effect makes every effort to accomplish alleviate rapidly or remove pain, eliminates relapse rate, improves quality of life.
The present invention implements by following technical solution;
Develop a kind of Chinese medicine preparation for the treatment of vascular headache, it is characterized in that making by the Chinese medicine of following components by weight percent:
Scheme 1,11～15 parts of Radix Angelicae Sinensis; 11～15 parts of the Radix Paeoniae Albas; 8～12 parts of Rhizoma Chuanxiongs; 8～12 parts in Semen Persicae; 8～12 parts of Flos Chrysanthemis; 8～12 parts of Ramulus Uncariae Cum Uncis; 6～10 parts on Flos Carthami; 6～10 parts of Rhizoma Ligusticis; 6～10 parts of Pheretimas; 6～10 parts of Fructus Lycii.
Scheme 2, or make by the Chinese medicine of following components by weight percent:
12～14 parts of Radix Angelicae Sinensis; 12～14 parts of the Radix Paeoniae Albas; 9～11 parts of Rhizoma Chuanxiongs; 9～11 parts in Semen Persicae; 9～11 parts of Flos Chrysanthemis; 9～11 parts of Ramulus Uncariae Cum Uncis; 7～10 parts on Flos Carthami; 7～10 parts of Rhizoma Ligusticis; 7～9 parts of Pheretimas; 7～9 parts of Fructus Lycii.
Scheme 3, can make by the Chinese medicine of following components by weight percent:
12～13 parts of Radix Angelicae Sinensis; 12～13 parts of the Radix Paeoniae Albas; 10～11 parts of Rhizoma Chuanxiongs; 10～11 parts in Semen Persicae; 10～11 parts of Flos Chrysanthemis; 10～11 parts of Ramulus Uncariae Cum Uncis; 8～10 parts on Flos Carthami; 8～10 parts of Rhizoma Ligusticis; 7～8 parts of Pheretimas; 7～8 parts of Fructus Lycii.
Scheme 4, can also make by the Chinese medicine of following components by weight percent:
13～14.5 parts of Radix Angelicae Sinensis; 13～14.5 parts of the Radix Paeoniae Albas; 9～10 parts of Rhizoma Chuanxiongs; 9～10 parts in Semen Persicae; 10～11 parts of Flos Chrysanthemis; 10～11 parts of Ramulus Uncariae Cum Uncis; 8～9 parts on Flos Carthami; 8～9 parts of Rhizoma Ligusticis; 7～8 parts of Pheretimas; 7～8 parts of Fructus Lycii.
The method for making of the Chinese medicine preparation of above-mentioned treatment vascular headache is characterized in that branch does several steps:
(1) take by weighing Radix Angelicae Sinensis, Rhizoma Chuanxiong, Ramulus Uncariae Cum Uncis and Flos Chrysanthemi, mix, add 4～5 times of amounts of medical material ordinary water, behind soaking at room temperature 2 ± 0.5h, air-distillation does not end when distillate has fragranced; Collect distillate respectively, filter collection medicinal residues and vinasse;
(2) with (1) medicinal residues and the Radix Paeoniae Alba, Semen Persicae, Flos Carthami, Rhizoma Ligustici, Pheretima and Fructus Lycii mix, and decoct with water three times; Add for the first time 7～8 times of amounts of medical material amount ordinary water, behind soaking at room temperature 0.5～1h, decoct 60～80min, filter; Medicinal residues add 5～6 times of amount ordinary waters and decoct 45～60min, filter; The secondary medicinal residues add 2～3 times of water gagings and decoct 30～40min again, filter;
(3) merge decoction liquor, filter, add (1) vinasse, mix;
(4) with (a 3) mixed liquor, relative density is 1.14～1.16 clear paste when being concentrated into 70～80 ℃;
(5) with (4) clear paste, leave standstill, add medicinal alcohol after being chilled to room temperature, make clear paste contain the alcohol amount and reach capacity 65%～70%, stir evenly, leave standstill 24h, filter;
(6) with (a 5) filtrate distillation, relative density is 1.20～1.25 when reclaiming ethanol and being concentrated into 70～80 ℃;
(7) (6) concentrated solution and (1) distillate are merged, add Mel 100g, add water to 1000ml, stir evenly, leave standstill, filter, embedding, sterilization, promptly.
Above-mentioned a kind of application for the treatment of the Chinese medicine preparation of vascular headache is characterized in that the application in the oral preparation of Chinese traditional medicinal of preparation treatment of vascular headache.
Beneficial effect:
The vascular headache of clinical diagnosis, actual is the class headache that the head vasomotor dysfunction causes.
The outbreak mechanism of vascular headache is fully clear and definite so far, and most researcheres think that to discharge 5-hydroxy tryptamine etc. relevant with the systolic and diastolic function obstacle of the outer blood vessel of intracranial and platelet aggregation.Therefore can effectively bring into play the vasculomotor effect of coordinating, correct cerebral artery vessel easypro contract disorder and spasm, eliminate, can fundamentally cure headache because of having an intense pain that vasomotion disorder, spasm tractive produce.
The traditional Chinese medical science is thought, " stagnation of QI and blood may bring about pain, not Rong Ze pain ", vascular headache relates to the pathomechanism of traditional Chinese medical science insufficiency of vital energy and blood and qi depression to blood stasis, therefore, in this Chinese medicine oral liquid, given activating blood circulation to dissipate blood stasis, inducing menstruation to relieve menalgia, yin and blood nourishing, transfer the Chinese medicine of smooth QI and blood compatible, played the effect that brings out the best in each other, see from clinical result and obtained satisfied curative effect.
Chinese medicine preparation of the present invention has blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, and yin and blood nourishing is transferred smooth QI and blood effect, and cerebrovascular is had dual regulation.Can alleviate rapidly or remove pain, relapse rate is low, and through clinical observation, treatment vascular headache curative effect produces a desired effect.
Observe evaluation curative effect, clinical cure 89 examples, effective 38 examples, invalid 7 examples by the grading standard of headache.Total effective rate 94.8%.
Model case
Mrs Zhao, 35 years old, the own headache of patient's private prosecution was after 13 years, when having an attack of one's old illness, have a headache as pinprick, both hands are sealed head, and pain is difficult to stand, with feeling sick, vomitting, tell the back headache and alleviate, take analgesic drug product for a long time, drug dose is increasing, health to oneself has caused very big injury, and sensation is more painful.Since taking this oral liquid, the state of an illness obviously alleviates, just sensation morbidity number of times minimizing after 15 days, and pain obviously alleviates, and medication is no longer felt headache after a course of treatment, and other symptoms all disappear.Follow up a case by regular visits to through half a year, do not recur so far.
Mrs Li, 44 years old, private prosecution suffered from vascular headache 5 years, premorbid often has symptoms such as hemianopsia, is blood vessel fluctuation sample during headache, sometimes with pale complexion, hyperhidrosis, feel sick, vegetative nerve symptom such as vomiting, heart beating, vexed more obvious.Sometimes sleep at noon, if environment is very quiet, just cannot get up, whole body does not all move, and mouth is wanted to open in a minute but be could not explain, has only slight the making a movement of finger and toe energy, plant man's sensation has been arranged, though a lot of medicines has also been taken in the treatment through too much tame hospital, but still can not thoroughly treat.After the patient had used this oral liquid, the feeling of headache alleviated, symptom before the time of taking a nap has not had to occur yet, treat a course of treatment after, disease was not shown effect once more.
The specific embodiment
Embodiment 1
Preparing a kind of Chinese medicine preparation for the treatment of vascular headache, is to be made by the Chinese medicine of following components by weight percent:
Consumption: Radix Angelicae Sinensis 15g; Radix Paeoniae Alba 15g; Rhizoma Chuanxiong 12g; Semen Persicae 12g; Flos Chrysanthemi 12g; Ramulus Uncariae Cum Uncis 12g; Flos Carthami 10g; Rhizoma Ligustici 10g; Pheretima 10g; Fructus Lycii 10g.
Method for making:
(1) Radix Angelicae Sinensis, Rhizoma Chuanxiong, Ramulus Uncariae Cum Uncis and the Flos Chrysanthemi that takes by weighing above-mentioned quantity mixes, and adds 4～5 times of amounts of medical material ordinary water, and behind soaking at room temperature 2 ± 0.5h, air-distillation does not end when distillate has fragranced; Collect distillate respectively, filter collection medicinal residues and vinasse; This routine above-mentioned dosage can obtain distillate 200---250ml, can obtain vinasse 5000---6000ml.
(2) with the Radix Paeoniae Alba of (1) medicinal residues with above-mentioned quantity, Semen Persicae, Flos Carthami, Rhizoma Ligustici, Pheretima and Fructus Lycii mixing decoct with water three times; Add for the first time 7～8 times of amounts of medical material total amount ordinary water, behind soaking at room temperature 0.5～1h, decoct 60～80min, filter; Medicinal residues add 5～6 times of amount ordinary waters and decoct 45～60min, filter; The secondary medicinal residues add 2～3 times of water gagings and decoct 30～40min again, filter;
(3) this routine above-mentioned dosage can obtain decoction liquor 25000---30000ml three times, merges three times decoction liquor, filters, and adds (1) vinasse, mixes;
(4) with (a 3) mixed liquor, relative density is 1.14～1.16 clear paste when being concentrated into 70～80 ℃, and this routine above-mentioned dosage can obtain clear paste 700---800ml;
(5) with (4) clear paste, leave standstill, add medicinal alcohol after being chilled to room temperature, make clear paste contain the alcohol amount and reach capacity 65%～70%, stir evenly, leave standstill 24h, filter; This routine above-mentioned dosage can obtain filtrate 950---1050ml;
(6) with (a 5) filtrate distillation, relative density is 1.20～1.25 when reclaiming ethanol and being concentrated into 70～80 ℃; This routine above-mentioned dosage can obtain concentrated solution 400---450ml;
(7) (6) concentrated solution and (1) distillate are merged, this routine above-mentioned dosage can obtain cumulative volume 600---700ml; Add Mel 100g, add water to total amount 1000ml, stir evenly, leave standstill, filter, embedding, sterilization, promptly.
The applicant uses oral liquid test of cure vascular headache 134 examples of Chinese medicine preparation of the present invention in Qingdao Municipal Hospital, has obtained satisfied curative effect, and situation is as follows:
Usage and dosage: with the oral liquid of Chinese medicine preparation preparation of the present invention, each 10～20ml, every day 2～3 times, 30 days course of treatment.
Result: observe the evaluation curative effect by the grading standard of headache, treatment vascular headache 134 examples, clinical cure 89 examples, effective 38 examples, invalid 7 examples.Total effective rate 94.8%.
Embodiment 2
Radix Angelicae Sinensis 11g; Radix Paeoniae Alba 11g; Rhizoma Chuanxiong 8g; Semen Persicae 8g; Flos Chrysanthemi 8g; Ramulus Uncariae Cum Uncis 8g; Flos Carthami 6g; Rhizoma Ligustici 6g; Pheretima 6g; Fructus Lycii 6g.All the other are with embodiment 1.
Embodiment 3
Consumption: Radix Angelicae Sinensis 13g; Radix Paeoniae Alba 13g; Rhizoma Chuanxiong 10g; Semen Persicae 10g; Flos Chrysanthemi 10g; Ramulus Uncariae Cum Uncis 10g; Flos Carthami 8g; Rhizoma Ligustici 8g; Pheretima 8g; Fructus Lycii 8g.All the other are with embodiment 1.
Embodiment 4
Consumption: Radix Angelicae Sinensis 14g; Radix Paeoniae Alba 14g; Rhizoma Chuanxiong 11g; Semen Persicae 11g; Flos Chrysanthemi 11g; Ramulus Uncariae Cum Uncis 11g; Flos Carthami 10g; Rhizoma Ligustici 10g; Pheretima 9g; Fructus Lycii 9g.All the other are with embodiment 1.
Embodiment 5
Consumption: Radix Angelicae Sinensis 12g; Radix Paeoniae Alba 12g; Rhizoma Chuanxiong 9; Semen Persicae 9g; Flos Chrysanthemi 9g; Ramulus Uncariae Cum Uncis 9g; Flos Carthami 7g; Rhizoma Ligustici 7g; Pheretima 7g; Fructus Lycii 7g.All the other are with embodiment 1.
Embodiment 6
Consumption: Radix Angelicae Sinensis 13g; Radix Paeoniae Alba 13g; Rhizoma Chuanxiong 10g; Semen Persicae 10g; Flos Chrysanthemi 10g; Ramulus Uncariae Cum Uncis 10g; Flos Carthami 8g; Rhizoma Ligustici 8g; Pheretima 8g; Fructus Lycii 8g.All the other are with embodiment 1.
Embodiment 7
Consumption: Radix Angelicae Sinensis, each 12g of the Radix Paeoniae Alba; Rhizoma Chuanxiong, Semen Persicae, Flos Chrysanthemi, each 10g of Ramulus Uncariae Cum Uncis; Flos Carthami, each 8g of Rhizoma Ligustici; Pheretima, each 7g of Fructus Lycii.All the other are with embodiment 1.
Embodiment 8
Consumption: Radix Angelicae Sinensis, each 13g of the Radix Paeoniae Alba; Rhizoma Chuanxiong, Semen Persicae, Flos Chrysanthemi, each 11g of an ancient unit of weight rattan; Flos Carthami, each 10g of Rhizoma Ligustici; Pheretima, each 8g of Fructus Lycii.All the other are with embodiment 1.
Embodiment 9
Consumption: Radix Angelicae Sinensis, each 13g of the Radix Paeoniae Alba; Rhizoma Chuanxiong, Semen Persicae, Flos Chrysanthemi, each 10g of an ancient unit of weight rattan; Flos Carthami, each 9g of Rhizoma Ligustici; Pheretima, each 8g of Fructus Lycii.All the other are with embodiment 1.
Embodiment 10
Consumption: Radix Angelicae Sinensis, each 14.5g of the Radix Paeoniae Alba; Rhizoma Chuanxiong, each 10g of Semen Persicae; Flos Chrysanthemi, each 11g of Ramulus Uncariae Cum Uncis; Flos Carthami, each 9g of Rhizoma Ligustici; Pheretima, each 8g of Fructus Lycii.All the other are with embodiment 1.
Embodiment 11
Consumption: Radix Angelicae Sinensis, each 13g of the Radix Paeoniae Alba; Rhizoma Chuanxiong, each 9g of Semen Persicae; Flos Chrysanthemi, each 10g of Ramulus Uncariae Cum Uncis; Flos Carthami, each 8g of Rhizoma Ligustici; Pheretima, each 7g of Fructus Lycii.All the other are with embodiment 1.
Embodiment 12
Consumption: Radix Angelicae Sinensis, each 13.5g of the Radix Paeoniae Alba; Rhizoma Chuanxiong, each 9.5g of Semen Persicae; Flos Chrysanthemi, each 10.5g of Ramulus Uncariae Cum Uncis; Flos Carthami, each 8.5g of Rhizoma Ligustici; Pheretima, each 7.5g of Fructus Lycii.All the other are with embodiment 1.
Claims (6)
1. Chinese medicine preparation for the treatment of vascular headache is characterized in that being made by the Chinese medicine of following components by weight percent:
11～15 parts of Radix Angelicae Sinensis; 11～15 parts of the Radix Paeoniae Albas; 8～12 parts of Rhizoma Chuanxiongs; 8～12 parts in Semen Persicae; 8～12 parts of Flos Chrysanthemis; 8～12 parts of Ramulus Uncariae Cum Uncis; 6～10 parts on Flos Carthami; 6～10 parts of Rhizoma Ligusticis; 6～10 parts of Pheretimas; 6～10 parts of Fructus Lycii.
2. according to the described a kind of Chinese medicine preparation for the treatment of vascular headache of claim 1, it is characterized in that making by the Chinese medicine of following components by weight percent:
12～14 parts of Radix Angelicae Sinensis; 12～14 parts of the Radix Paeoniae Albas; 9～11 parts of Rhizoma Chuanxiongs; 9～11 parts in Semen Persicae; 9～11 parts of Flos Chrysanthemis; 9～11 parts of Ramulus Uncariae Cum Uncis; 7～10 parts on Flos Carthami; 7～10 parts of Rhizoma Ligusticis; 7～9 parts of Pheretimas; 7～9 parts of Fructus Lycii.
3. according to the described a kind of Chinese medicine preparation for the treatment of vascular headache of claim 1, it is characterized in that making by the Chinese medicine of following components by weight percent:
12～13 parts of Radix Angelicae Sinensis; 12～13 parts of the Radix Paeoniae Albas; 10～11 parts of Rhizoma Chuanxiongs; 10～11 parts in Semen Persicae; 10～11 parts of Flos Chrysanthemis; 10～11 parts in an ancient unit of weight rattan; 8～10 parts on Flos Carthami; 8～10 parts of Rhizoma Ligusticis; 7～8 parts of Pheretimas; 7～8 parts of Fructus Lycii.
4. according to the described a kind of Chinese medicine preparation for the treatment of vascular headache of claim 1, it is characterized in that making by the Chinese medicine of following components by weight percent:
13～14.5 parts of Radix Angelicae Sinensis; 13～14.5 parts of the Radix Paeoniae Albas; 9～10 parts of Rhizoma Chuanxiongs; 9～10 parts in Semen Persicae; 10～11 parts of Flos Chrysanthemis; 10～11 parts of Ramulus Uncariae Cum Uncis; 8～9 parts on Flos Carthami; 8～9 parts of Rhizoma Ligusticis; 7～8 parts of Pheretimas; 7～8 parts of Fructus Lycii.
5. according to claim 1,2,3 or 4 described a kind of method for makings for the treatment of the Chinese medicine preparation of vascular headache, it is characterized in that branch does several steps:
(1) take by weighing Radix Angelicae Sinensis, Rhizoma Chuanxiong, Ramulus Uncariae Cum Uncis and Flos Chrysanthemi, mix, add 4～5 times of water gagings of medical material, behind soaking at room temperature 2 ± 0.5h, air-distillation does not end when distillate has fragranced; Collect distillate respectively, filter collection medicinal residues and vinasse;
(2) with (1) medicinal residues and the Radix Paeoniae Alba, Semen Persicae, Flos Carthami, Rhizoma Ligustici, Pheretima and Fructus Lycii mix, and decoct with water three times; Add for the first time 7～8 times of amounts of medical material amount ordinary water, soaking at room temperature 0.5～1h decocts 60～80min, filters; Medicinal residues add 5～6 times of amount ordinary waters and decoct 45～60min, filter; The secondary medicinal residues add 2～3 times of water gagings and decoct 30～40min again, filter;
(3) merge decoction liquor, filter, add (1) vinasse, mix;
(4) with (a 3) mixed liquor, relative density is 1.14～1.16 clear paste when being concentrated into 70～80 ℃;
(5) with (4) clear paste, leave standstill, add medicinal alcohol after being chilled to room temperature, make clear paste contain the alcohol amount and reach capacity 65%～70%, stir evenly, leave standstill 24h, filter;
(6) with (a 5) filtrate distillation, relative density is 1.20～1.25 when reclaiming ethanol and being concentrated into 70～80 ℃;
(7) (6) concentrated solution and (1) distillate are merged, add Mel 100g, add water to 1000ml, stir evenly, leave standstill, filter, embedding, sterilization, promptly.
6. according to claim 1,2,3 or 4 described a kind of application for the treatment of the Chinese medicine preparation of vascular headache, it is characterized in that the application in the oral preparation of Chinese traditional medicinal of preparation treatment of vascular headache.
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| CN200810157752A CN101380388B (en) | 2008-10-14 | 2008-10-14 | Traditional Chinese medicine preparation for treating vascular headache |
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| CN103028055A (en) * | 2012-12-05 | 2013-04-10 | 纪瑞 | Traditional Chinese medicine for treating migraine |
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| CN103028055A (en) * | 2012-12-05 | 2013-04-10 | 纪瑞 | Traditional Chinese medicine for treating migraine |
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