CN101379993B - Bactericidal water dispersion granule of triabendazole - Google Patents
Bactericidal water dispersion granule of triabendazole Download PDFInfo
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- CN101379993B CN101379993B CN2008101462106A CN200810146210A CN101379993B CN 101379993 B CN101379993 B CN 101379993B CN 2008101462106 A CN2008101462106 A CN 2008101462106A CN 200810146210 A CN200810146210 A CN 200810146210A CN 101379993 B CN101379993 B CN 101379993B
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- probenazole
- water dispersion
- dispersant
- bactericide
- disintegrant
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Abstract
The invention discloses a bactericide containing probenazole, belonging to the field of plant protection. The bactericide consists of probenazole technical product of pesticides, wetting agent, dispersant, disintegrant and filler which can be made into water dispersible granules; compared with liquid preparation, the bactericide is easier to transport, and is more environment-friendly and safer in the process of production and use. The bactericide aims at controlling gray mold of vegetables, and has unique treating effect on anthracnose and Cladosporium cucumerinum of fruit trees as well as black rot of tobacco at the same time.
Description
Technical field:
The invention belongs to technical field of pesticide, relate to a kind of bactericide that contains the probenazole water dispersion granule, the gray mold of main control vegetables, the black rot to anthracnose, scab and the tobacco of fruit tree has unique therapeutic action equally simultaneously, fresh-keeping after taking into account fruit tree and plucking.
Background technology:
Probenazole is the very strong bactericide of absorption in a kind of benzimidazole, former medicine rat acute per os LD
50Be 6100 milligrams/kilogram, the lagophthalmos eyeball is had slight spread effect, skin is had no stimulation.No carcinogenic, teratogenesis, mutagenesis have certain toxic effect to fish under test dose, and blue strontium fish LC50 is 18.5 mg/litre (48h).Being transformed into carbendazim easily and another kind has volatile butyl isocyanate after entering plant corpus, is its main Fungicidal substance.This medicament has characteristics such as interior suction, fungicidal spectrum is wide, pesticide resistance is strong, but is not very common in application in recent years.
General probenazole preparation mainly is based on pulvis, and pulvis exists dust big in process of production, and environmental pollution is bigger, with after medicine spot, factor such as residual appear easily.And water dispersion granule is that wetting powder or suspending agent are a granulated into water dispersion granule again, and the key technology of processing is to prevent that powder from becoming coarse dust at granulation process medium silt flocculation again, do not accompany powder in the product, good fluidity, easy to use, environmental pollution is little, to the person poultry safety.
In sum, a kind of probenazole water dispersion granule that pollutes little, stable height, lasting period length of research is a goal in research of the present invention.
Summary of the invention:
The object of the present invention is to provide a kind of probenazole water dispersion granule little, that stability is high, the lasting period is long that pollutes.
Active ingredient of the present invention is probenazole, also comprise wetting agent, dispersant, disintegrant and filler in the composition, its percentage by weight is as follows: probenazole 1%～80%, through the prescription screening, the ratio of greater inequality of this composition is 30%～60%, wetting agent 1%～5%, dispersant 3%～15%, disintegrant 1%～10%, filler surplus.
Filler of the present invention is one or more in glucose, lactose, the sucrose.
Wetting agent of the present invention, dispersant are one or more among Glycerin, mixed triester with caprylic acid capric acid, Crodaret, F68, PEG600, Tween80, Span20, the Span80 etc.
Disintegrant of the present invention is one or more in polyvinylpyrrolidone, ammonium sulfate or the soluble starch.
The invention allows for the preparation method of probenazole water dispersion granule, concrete steps are as follows:
A kind of is that ratio takes by weighing probenazole, wetting agent, dispersant, disintegrant and filler according to required weight, with water is medium, and porphyrize in sand mill is made suspending agent, carry out granulation then, its method has spray drying granulation, thermopnore drying-granulating, freeze drying granulation; Another kind is that ratio takes by weighing probenazole, wetting agent, dispersant, disintegrant and filler one and reinstates comminution by gas stream or ultra-fine grinding according to required weight, make wetting powder, carry out granulation then, its method has rotary table granulation, extruder grain, mixed at high speed granulation, thermopnore granulation and compression granulation etc.
Bake out temperature described in the present invention is 55 ℃～80 ℃.
The invention has the advantages that: the easier carrying of the relative liquid preparation of the present invention, reduced environmental pollution, make people's safety and environmental protection more in production and use; Physico chemical property of the present invention are stable, good dispersion in the water, and the suspensibility height more helps plant absorbing, improves drug effect greatly; The present invention also helps protection probenazole active ingredient.
Specific embodiment:
Embodiment 1:
Take by weighing the former medicine 40g of probenazole, phenethyl phenol polyethenoxy ether formaldehyde 3g, sodium lignin sulfonate 6g, sodium sulphate 6g, precipitated calcium carbonate 42g, it is pressed conventional method mixes, after stirring, obtain female powder, female powder and polyethylene glycol 3g are mixed through the airslide disintegrating mill pulverizing, granulation then, oven dry obtains 40% probenazole water dispersion granule through sieve, through the check effective ingredient is that content is 40%, moisture≤2.5%, and pH 7.1, sieve by 75 μ m, suspensibility 〉=65%, lasting row (the 1min)≤10ml that bubbles, wettability≤1min, dust≤3.0%, the acceleration heat storage stability is qualified.The dosage that is used to prevent and treat eliminating vegetable botrytis in force is 700～875mg/kg, and control efficiency is 67.56%～73.23%.
Embodiment 2:
Take by weighing the former medicine 50g of probenazole, phenethyl phenol polyethenoxy ether sodium sulfate 2g, sodium lignin sulfonate 8g, Attapulgite 8g, kaolin 28g after it is mixed, pulverizes through airslide disintegrating mill and to obtain female powder, female powder and 4g polyethylene glycol are mixed, and granulation then, oven dry obtain 50% probenazole water dispersion granule through sieve.Through checking effective ingredient is that content is 50.1%, moisture≤2.5%, and pH7.3, by 75 μ m sieve, suspensibility 〉=65%, lasting row (the 1min)≤10ml that bubbles, wettability≤1min, dust≤3.0%, the acceleration heat storage stability is qualified.The dosage that is used to prevent and treat eliminating vegetable botrytis in force is 700～875mg/kg, and the effect of control is 76.45%～83.67%.
Embodiment 3:
Take by weighing the former medicine 60g of probenazole, neopelex 5g, sodium lignin sulfonate 12g, sodium carbonate 8g, diatomite 13g after it is mixed, pulverizes through airslide disintegrating mill and to obtain female powder, female powder and 2g polyethylene glycol binding agent are mixed, and granulation then, oven dry obtain 60% probenazole water dispersion granule through sieve.Through checking effective ingredient is that content is 60.3%, moisture≤2.5%, and pH7.3, by 75 μ m sieve, suspensibility 〉=65%, lasting row (the 1min)≤10ml that bubbles, wettability≤1min, dust≤3.0%, the acceleration heat storage stability is qualified.The dosage that is used to prevent and treat eliminating vegetable botrytis in force is 700～875mg/kg, and control efficiency is 85.45%～89.85%.
Claims (2)
1. probenazole water dispersion granule is characterized in that: by probenazole, wetting agent, dispersant, disintegrant and filler are formed, its percentage by weight is as follows: probenazole 1%～80%, wetting agent 1%～5%, dispersant 3%～15%, disintegrant 1%～10%, surplus are filler; Described filler is one or more in glucose, lactose, the sucrose; Described wetting agent, dispersant are one or more among Glycerin, mixed triester with caprylic acid capric acid, Crodaret, F68, PEG600, Tween80, Span20, the Span80; Described disintegrant is one or more in polyvinylpyrrolidone, ammonium sulfate or the soluble starch.
2. probenazole water dispersion granule according to claim 1 is used to prevent and treat the purposes of eliminating vegetable botrytis, fruit tree anthracnose, scab, tobacco black rot.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101462106A CN101379993B (en) | 2008-08-06 | 2008-08-06 | Bactericidal water dispersion granule of triabendazole |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101462106A CN101379993B (en) | 2008-08-06 | 2008-08-06 | Bactericidal water dispersion granule of triabendazole |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101379993A CN101379993A (en) | 2009-03-11 |
| CN101379993B true CN101379993B (en) | 2011-07-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN2008101462106A Expired - Fee Related CN101379993B (en) | 2008-08-06 | 2008-08-06 | Bactericidal water dispersion granule of triabendazole |
Country Status (1)
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| CN (1) | CN101379993B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109645112A (en) * | 2019-02-19 | 2019-04-19 | 山东省果树研究所 | A kind of bactericidal composition and its application of probenazole-containing and procymidone |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6030924A (en) * | 1997-05-07 | 2000-02-29 | American Cyanamid Company | Solid formulations |
| EP0756822B1 (en) * | 1995-07-31 | 2002-04-03 | Calgon Corporation | Composition useful as an antimicrobial agent |
| US20050159316A1 (en) * | 2004-01-16 | 2005-07-21 | Chia-Chung Chen | Ingredients and manufacturing method of water dispersible pesticide granules |
| US20060013846A1 (en) * | 2002-10-22 | 2006-01-19 | Kumiai Chemical Industry Co., Ltd. | Agricultural or horticultural particulate composition comprising wettable granular agent |
-
2008
- 2008-08-06 CN CN2008101462106A patent/CN101379993B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0756822B1 (en) * | 1995-07-31 | 2002-04-03 | Calgon Corporation | Composition useful as an antimicrobial agent |
| US6030924A (en) * | 1997-05-07 | 2000-02-29 | American Cyanamid Company | Solid formulations |
| US20060013846A1 (en) * | 2002-10-22 | 2006-01-19 | Kumiai Chemical Industry Co., Ltd. | Agricultural or horticultural particulate composition comprising wettable granular agent |
| US20050159316A1 (en) * | 2004-01-16 | 2005-07-21 | Chia-Chung Chen | Ingredients and manufacturing method of water dispersible pesticide granules |
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| CN101379993A (en) | 2009-03-11 |
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Assignee: Shanxi Thompson Biological Technology Co., Ltd. Assignor: Zhang Shaowu Contract record no.: 2011610000200 Denomination of invention: Bactericidal water dispersion granule of triabendazole Granted publication date: 20110720 License type: Exclusive License Open date: 20090311 Record date: 20111116 |
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110720 Termination date: 20150806 |
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