CN101370450A - 用于人工晶状体眼睛和/或患有神经退行性变眼睛的治疗和预防性眼科透镜 - Google Patents
用于人工晶状体眼睛和/或患有神经退行性变眼睛的治疗和预防性眼科透镜 Download PDFInfo
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Abstract
本发明涉及用于人工晶状体眼和/或经历神经退行性变的眼睛的治疗性和预防性眼科透镜。更具体地说，本发明涉及用于人工晶状体眼和/或患有黄斑和视网膜退行性变眼的眼科透镜。本发明透镜的特征在于通过向常规的眼科透镜施用黄色素滤光材料来创建，以保护眼睛远离可见光谱的短波长(低于500nm)。本发明通过简单地使用一种眼科透镜，消除了现有的保护接受白内障手术眼睛的方法的困难和风险，并改善了经历神经退行性变眼睛的保护。本发明由常规眼科透镜和吸收光的350－500nm短波长的黄色素滤光材料组成，上述两者都适合用于人。
Description
发明领域
本发明涉及市场的眼科部分。
本发明的目地是一种用于人工晶状体眼睛(接受了白内障外科手术的那些)和/或有黄斑和视网膜退行性变眼睛的眼科透镜，通过向常规的眼科透镜施用黄色素来制备，以保护眼睛远离可见光谱的短波长(<500nm)。
技术背景
视觉是对在380-760nm波长范围内可见辐射的响应的结果。在环境中，太阳辐射是对视力的主要危险因素。太阳发射紫外(UV)射线和红外(IR)辐射，主要被大气层吸收。当太阳辐射穿过大气层到达地球表面时，其由紫外光-B射线(230-300nm)、紫外光和紫外光-A射线(300-380nm)、可见光射线(380-760nm)和红外光射线(760-1400nm)组成。红外光射线和可见光谱的大部分都可以自由的透射通过健康人的眼睛抵达视网膜，但是角膜和晶状体阻止可见光谱的大部分反应性波长(紫外光-B射线和光谱的蓝色部分)抵达视网膜。
随着年龄的增加，人晶状体改变其透射性质，通过加强其淡黄的颜色从而增加其过滤紫外光和蓝光射线的能力。因此，在大于65岁的人中，紫外光(<400nm)不能透射和蓝光(400-500nm)的透射明显减少。
视网膜能够以两种方式保护自己远离光的短波长：通过它的光感受器的不均匀分布，因此在黄斑凹处没有对蓝光敏感的光感受器；和通过在这个区域的黄色素的作用，其还发挥保护的作用。
人眼用于对抗光的短波长的这些自然保护系统-晶状体和视网膜结构-可以被某些疾病和/或外科步骤严重的影响：
-白内障、其唯一的外科疗法包括移除晶状体
-另外，经常发现的病理老化过程，所述病理老化过程导致视网膜结构的退行性变，产生年龄相关的黄斑退行性变(AMD)。
我们还考虑到，白内障和年龄相关的黄斑退行性变两者可能共存于大于65岁的人中。在这种上了年纪的受试者人群中，白内障是视力损失的主要原因和年龄相关的黄斑退行性变是目盲的主要原因。另外，由于我们预期寿命的增加，在其他因素中，我们预计这两种疾病将增加。这转化成了在研究领域和光学工业中对这些疾病和它们治疗方案的极大兴趣。
几个流行病学的研究已经评价了在白内障手术和年龄相关的黄斑退行性变之间的关系。Klein(Klein R，Klein BE，Wong TY，TomanySC，Cruickshanks KJ.The association of cataract and cataractsurgery with the long-term incident of age-related maculopathy.Arch Ophthalmol 120：1551-1558.2002)和Freeman(Freeman E，
B，West SK，Tielsch JM，Schein OD.Is there an associationbetween cataract surgery and age-related maculardegeneration.Am J Ophthalmolm 135(6)：849-856.2003)确证在接受了白内障手术的人中有产生年龄相关的黄斑退行性变症状的高风险。然而，在早期的Wang(Wang JJ，Mitchell P，Cumming RG，Lim R.Cataract andage-related maculopathy：the Blue Mountains Eye Study.Ophthalmic Epidemiol 6：317-326.1999)和McCarty(McCarty CA，Mukesh BN，Fu CL，Mitchell P，Wang JJ，Taylor HR.Risks factorsfor age-related maculopathy：the Visual Impairment Project.Arch Ophthalmol 119：1455-1462.2001)的研究中这种假设被否认了，可能是因为它们的诊断测定中使用的新技术较少。
允许精确、快速和非侵入探查视网膜的神经退行性变过程的技术例如光学相干断层摄影术是在最近才被引入的。这些技术对确证天然色素的吸收有害辐射的决定作用是必不可少的。
还开发了几种技术用于保护接受了白内障手术的眼睛远离光的短波长：
-市场上已经有几种包含黄色素的滤光材料，但没有最佳方法和/或装置将这些滤光材料应用到人眼作为预防和/或治疗手段，以替换和/或改善眼睛的自然保护。
-从20世纪90年代中期起，动过白内障摘出术的眼睛已经被植入包含黄色素的眼内透镜来作为滤光材料。这种方案需要外科手术，并有外科手术的所有风险和困难。还有大量的受试者在白内障手术期间被植入透明的透镜来替换天然透镜(天然晶状体)，因此这些人缺少了必要的保护。在这些患者中，缺乏黄色素的人工晶状体，需要补充一个系统，例如，本文给出的眼科透镜来提供黄色素。
已经开发了与这种技术状态相关的几个专利，虽然它们与本发明的目地显著的不同：
-具有选择性透射功能的光学透镜(专利号RE38402)，为眼镜或隐形眼镜的形式，橙色，改善视力和在光照强烈的地方减少眼睛损伤，基本上消除紫外射线和从400至500nm的蓝光。
-阻挡蓝光和紫外射线的偏振透镜(US 5400175)，由水平阻挡偏振光的偏光器和阻挡蓝光和紫外射线的滤光材料组成。
-用于某些活动的特定光学滤光材料，和使用这些滤光材料的光学零件(美国专利6893127)改善目标的可见性，例如在体育活动中。
-还有具有治疗作用的矫正隐形眼镜(专利FR2761785)，被设计为矫正近视和斜视，通过在某些区域使用染料来刺激或去刺激视网膜的特定区域。
-具有澄明边缘区域和偏振元件的偏振隐形眼镜(美国专利6874888)，其覆盖在瞳孔区域，和从而保护眼睛免受太阳射线和其他来源的潜在有害光的伤害。
-安全隐形眼镜(专利US2005024583)，其通过覆盖或处理来吸收或反射某些波长，包括一个或多个可识别的区域以确保选择的透镜是合乎需要的。
-用于白内障的有色隐形眼镜(专利JP11253480)，被设计用于解决太阳眼镜的问题，由一个在有色隐形眼镜中起到太阳眼镜作用的瞳和一个具有匹配虹膜颜色的结构的光圈组成。
-被设计成治疗蓝视或蓝色视力疾病的隐形眼镜(专利JP1204668)，其通过引入能够吸收320-450nm波长的黄色或橙色化合物来减少这种疾病的影响。蓝视是一种知觉缺损，其导致扭曲的彩色视觉。对患者来说，所有的物体看起来都是蓝色的。这种透镜试图改善这种知觉的影响，但决不是试图保护视网膜神经元远离小于550nm的短波长辐射。
这些专利主要是在它们的目地和效用上不同于本发明，因为没有一个被设计为用于保护接受了白内障手术的或患有神经退行性变的眼睛远离光的短波长。
发明内容
本发明的目地就人工晶状体受试者来说是从功能上补偿被移除的保护性色素(在手术期间随天然晶状体一起)，和就神经退行性变过程来说是利用眼科透镜作为支持来强化对蓝色和紫色光吸收的预防作用。如同提到的，在上了年纪的人群中这两种病变共存是非常常见的。
本发明由用于治疗患有神经退行性变过程的眼睛和/或人工晶状体眼睛的治疗性眼科透镜组成，通过向眼科透镜施用黄色素来制备，所述眼科透镜充当吸收光的350/500nm短波长的滤光材料。
因此，用于人工晶状体眼睛的治疗性眼科透镜由三个元件组成：
-供人眼使用的常规的眼科透镜
-用于装配眼科透镜的框架
-黄色素，在市售的那些当中，与吸收350至500nm短波长的透镜相适应，被应用到全部透镜，得到黄色的眼科透镜。这种透镜可以是适合于每个个体的特定尺寸和可以被装配到任意种类的眼镜框架上。
怎样制备本发明
有几种方法制备有色的眼科透镜，如在专利例如US20030164481和US6793339中描写的。通过下述实施例来说明其制备，不过不限于这种方法，有许多种替代和组合来制备这种透镜。
制备本发明的实施例：
-10.3mg的常规黄色染料，4-苯基偶氮苯酚溶剂黄7(solventyellow 7)(SY7)被溶于10.01g的单体溶液中，所述溶液包含66％苯乙胺(PEA)、30.5％苯乙基丙二酰胺(PEMA)和3.3％N-苄基双十二烷基胺(BDDA)，以得到0.103wt％的SY7浓度。
-其次，52.3mg的双4-叔-丁基环己基过氧化物碳酸氢盐被添加作为聚合催化剂。
-利用注射器，溶液被引入到模型中，所述模型由两个玻璃板制成，通过金属夹和1mm的特氟隆环将一个与另一个连接在一起。溶液被涂布成1mm厚的片。
-当模型被放置于65℃的烘箱中17小时时产生聚合。烘箱温度随后被增加到100℃再放置3小时。
-一旦已经聚合，片被从模型中移出，检查其吸收性质，然后给予其最终形状。
总之，通过把眼科透镜与黄色染料结合，上述两者目前都可以被应用于人眼睛，接受了白内障摘出术并植入了澄明眼内透镜的患者能够通过简单地使用眼科透镜，来补偿手术后眼睛的保护的缺乏，和具有视网膜神经退行性变的患者能够改善它们的自然保护。这种透镜的使用将避免与使用市售方案有关的问题(滤光材料没有合并入透镜和眼内透镜中)。
Claims (6)
1.用于人工晶状体眼睛的治疗性和预防性眼科透镜，通过把黄色素滤光材料和眼科透镜结合来创建，所述黄色素滤光材料吸收350/500nm的短波长。
2.如权利要求1所述的用于人工晶状体眼睛的治疗性和预防性眼科透镜，包括适合于被合并到透镜中的滤光材料，或黄色素。
3.如权利要求1和2所述的用于人工晶状体眼睛的治疗性和预防性眼科透镜，包括特征上适合于人眼使用的眼科透镜。
4.用于患有视网膜神经退行性变眼睛的治疗性和预防性眼科透镜，通过应用黄色素到眼科透镜来制备，所述黄色素吸收350/500nm的短波长。
5.如权利要求4所述的用于患有视网膜神经退行性变眼睛的治疗性和预防性眼科透镜，其包含适合应用到透镜的黄色素滤光材料。
6.如权利要求4和5所述的用于患有视网膜神经退行性变眼睛的治疗性和预防性眼科透镜，包括特征上适合于人眼使用的眼科透镜。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ESP200600052 | 2006-01-10 | ||
| ES200600052A ES2257976B2 (es) | 2006-01-10 | 2006-01-10 | Lente oftalmologica terapeutica y profilactica para ojos pseudoafaquicos y/o en proceso de neurodegeneracion. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101370450A true CN101370450A (zh) | 2009-02-18 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA200680052699XA Pending CN101370450A (zh) | 2006-01-10 | 2006-03-27 | 用于人工晶状体眼睛和/或患有神经退行性变眼睛的治疗和预防性眼科透镜 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1974702A4 (zh) |
| JP (1) | JP2009522076A (zh) |
| CN (1) | CN101370450A (zh) |
| AP (1) | AP2008004554A0 (zh) |
| AU (1) | AU2006334611A1 (zh) |
| BR (1) | BRPI0621180A2 (zh) |
| CA (1) | CA2636737A1 (zh) |
| EA (1) | EA012793B1 (zh) |
| ES (1) | ES2257976B2 (zh) |
| MX (1) | MX2008008930A (zh) |
| WO (1) | WO2007080198A1 (zh) |
| ZA (1) | ZA200806881B (zh) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2281301B1 (es) * | 2006-10-16 | 2008-07-16 | Universidad Complutense De Madrid | Dispositivo de iluminacion con filtro terapeutico y profilactico para ojos sanos, pseudo-afaquicos y/o en proceso de neurodegeneracion. |
| ES2281303B1 (es) * | 2006-12-04 | 2008-07-16 | Universidad Complutense De Madrid | Componente de prevencion para ojos sanos y de terapia y profilaxis para ojos pseudo-afaquicos y/o en proceso de neurodegeneracion en vehiculos. |
| ES2289957B1 (es) * | 2007-02-07 | 2008-12-01 | Universidad Complutense De Madrid | Fuente de iluminacion con emision reducida de longitudes de onda corta para la proteccion de ojos. |
| ES2296552B1 (es) * | 2007-06-01 | 2009-08-25 | Universidad Complutense De Madrid | Elemento de prevencion sobre superficies transparentes de edificios para la proteccion y terapia de ojos. |
| ES2298089B2 (es) * | 2007-07-19 | 2010-03-08 | Universidad Complutense De Madrid | Visor de casco de seguridad y prevencion con superficie tratada para la proteccion y terapia de ojos. |
| ES2303484B2 (es) * | 2007-10-15 | 2010-03-08 | Universidad Complutense De Madrid | Material de cobertura, revestimiento o pantalla para la proteccion y terapia de ojos contra los efectos de la luz azul. |
| ES2312284B1 (es) * | 2007-10-26 | 2010-01-08 | Universidad Complutense De Madrid | Gafas de seguridad y prevencion con superficie tratada para la proteccion y terapia de ojos en oficios y deportes. |
| ES2478693B1 (es) | 2012-12-21 | 2015-04-29 | Universidad Complutense De Madrid | Elemento bloqueante de longitudes de onda corta en fuentes de iluminación de tipo led |
| ES1094781Y (es) | 2013-06-03 | 2014-02-24 | Univ Complutense De Madrid (100 0%) | Dioptrio configurado para restringir las radiaciones electromagnéticas que dañan el sistema visual |
| EP3125005A1 (en) | 2015-07-29 | 2017-02-01 | Tecnología Sostenible y Responsable SL | Optical product comprising two pigments |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB1480492A (en) * | 1973-07-13 | 1977-07-20 | Jessen Inc Wesley | Aphakic spectacle lenses and method of making the same |
| US4390676A (en) * | 1976-11-15 | 1983-06-28 | Schering Corporation | Ultraviolet absorbing lenses |
| US4454170A (en) * | 1981-12-04 | 1984-06-12 | Corning Glass Works | Method for tinting a sheet of polyurethane |
| JPH0824694B2 (ja) * | 1988-02-09 | 1996-03-13 | ホーヤ株式会社 | 青視症補正用コンタクトレンズ |
| US5374663A (en) * | 1988-03-03 | 1994-12-20 | Hoya Corporation | Process for producing cyanopsia-correctable intraocular lens |
| JP2503068B2 (ja) * | 1989-02-22 | 1996-06-05 | ホーヤ株式会社 | 水晶体摘出者用眼鏡レンズ |
| US5298033A (en) * | 1989-03-14 | 1994-03-29 | Ciba-Geigy Corporation | Ultraviolet absorbing lenses and methods of manufacturing thereof |
| JP2813390B2 (ja) * | 1989-10-30 | 1998-10-22 | ホーヤ株式会社 | 水晶体摘出者用眼鏡レンズ |
| JPH0572574A (ja) * | 1991-09-13 | 1993-03-26 | Nikon Corp | 眼科患者用の眼鏡レンズ |
| US5470932A (en) * | 1993-10-18 | 1995-11-28 | Alcon Laboratories, Inc. | Polymerizable yellow dyes and their use in opthalmic lenses |
| MA23168A1 (fr) * | 1993-11-24 | 1994-12-31 | Sanmiguel Acebedo Cecilia | Structure perfectionnee pour lunettes protectrices |
| RU2127098C1 (ru) * | 1997-03-17 | 1999-03-10 | Розенблюм Юрий Захарович | Набор пробных очковых линз |
| DE29713395U1 (de) * | 1997-07-25 | 1998-12-03 | Mandel Peter Friedrich | Brille für die Farb-Therapie |
| US6793339B1 (en) * | 1997-10-21 | 2004-09-21 | Sola-International Holdings, Ltd. | Coated sunglass lens |
| US6811727B2 (en) * | 2002-01-09 | 2004-11-02 | Corning Incorporated | Ophthalmic filter materials |
| US20050041299A1 (en) * | 2003-08-20 | 2005-02-24 | Gallas James M. | Light filters using the oxidative polymerization product of 3-hydroxykynurenine (3-OHKyn) |
| US6811258B1 (en) * | 2003-06-23 | 2004-11-02 | Alan H. Grant | Eyeglasses for improved visual contrast using hetero-chromic light filtration |
| ES2281303B1 (es) * | 2006-12-04 | 2008-07-16 | Universidad Complutense De Madrid | Componente de prevencion para ojos sanos y de terapia y profilaxis para ojos pseudo-afaquicos y/o en proceso de neurodegeneracion en vehiculos. |
| ES2312284B1 (es) * | 2007-10-26 | 2010-01-08 | Universidad Complutense De Madrid | Gafas de seguridad y prevencion con superficie tratada para la proteccion y terapia de ojos en oficios y deportes. |
-
2006
- 2006-01-10 ES ES200600052A patent/ES2257976B2/es active Active
- 2006-03-27 EP EP06743412A patent/EP1974702A4/en not_active Ceased
- 2006-03-27 AU AU2006334611A patent/AU2006334611A1/en not_active Abandoned
- 2006-03-27 CN CNA200680052699XA patent/CN101370450A/zh active Pending
- 2006-03-27 CA CA 2636737 patent/CA2636737A1/en not_active Abandoned
- 2006-03-27 JP JP2008549890A patent/JP2009522076A/ja active Pending
- 2006-03-27 WO PCT/ES2006/000145 patent/WO2007080198A1/es active Application Filing
- 2006-03-27 AP AP2008004554A patent/AP2008004554A0/xx unknown
- 2006-03-27 EA EA200801699A patent/EA012793B1/ru not_active IP Right Cessation
- 2006-03-27 ZA ZA200806881A patent/ZA200806881B/xx unknown
- 2006-03-27 MX MX2008008930A patent/MX2008008930A/es not_active Application Discontinuation
- 2006-03-27 BR BRPI0621180-1A patent/BRPI0621180A2/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009522076A (ja) | 2009-06-11 |
| WO2007080198A1 (es) | 2007-07-19 |
| CA2636737A1 (en) | 2007-07-19 |
| MX2008008930A (es) | 2008-11-12 |
| BRPI0621180A2 (pt) | 2013-03-12 |
| WO2007080198A8 (es) | 2009-04-02 |
| EP1974702A4 (en) | 2009-12-23 |
| AP2008004554A0 (en) | 2008-08-31 |
| EP1974702A1 (en) | 2008-10-01 |
| AU2006334611A1 (en) | 2007-07-19 |
| EA012793B1 (ru) | 2009-12-30 |
| ES2257976B2 (es) | 2007-03-16 |
| ZA200806881B (en) | 2010-02-24 |
| EA200801699A1 (ru) | 2008-12-30 |
| ES2257976A1 (es) | 2006-08-01 |
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