CN101193611B - 用于假性无晶状体眼睛和/或处于神经变性过程的眼睛的治疗性接触镜 - Google Patents
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Abstract
本发明涉及用于假性无晶状体眼和/或遭受黄斑或视网膜变性的眼睛的接触透镜。本发明透镜的特征在于其通过在标准接触透镜上应用具有黄色色素的滤光器而制成，以便可保护眼睛免受可见光谱中短波光线(小于500nm)的损害。本发明通过应用接触透镜轻松消除了现有技术在用于为经受白内障手术的眼睛提供保护和改善遭受神经变性过程的眼睛的保护方面的难点和危险。本发明将标准接触透镜和能吸收在350nm-500nm之间短波光线的黄色滤光器结合，接触透镜和滤光器均适于人眼内应用。
Description
发明目的
本发明涉及眼科学领域。
本发明的目标是用于假性无晶状体眼睛(那些经受白内障手术的人)和/或遭受黄斑和视网膜变性的眼睛的接触镜，在标准接触镜上应用黄色滤光器从而保护眼睛免受可见光谱中短波长(小于500nm)光的侵害。
背景技术
视觉是对可见光，即380-760nm光线辐射的反应的结果。在环境中，阳光辐射带来主要视力损害。太阳发射主要由大气吸收的UV射线和IR辐射。当阳光穿过大气层到达地球表面时，其由UV-B射线(230-300nm)、UV或UV-A射线(300-380nm)、可见光(380-760nm)、以及IR射线(760-1400nm)组成。在通常的健康状态，人眼直接传递IR射线和绝大多数可见光到视网膜，而角膜和晶状体阻挡了可见光谱中大多数活跃波长的光(UV-B射线和可见光谱中的蓝光部分)到达视网膜。
作为其功能，人的晶状体随着年龄而改变其传递特性，其黄色增加并且其UV射线和蓝光的滤过能力增强。为此，在年龄超过65岁的人群中，紫色光(＜400nm)不再传递而蓝光(400-500nm)的传递显著减少。
视网膜也可以两种方式保护自身免受短波侵害：通过光感受器的不均匀分布，使得在黄斑凹陷没有对蓝光敏感的光感受器；并且通过在该区域存在的黄色色素的作用，其还可以实施保护措施。
人类眼睛防止最短波长光线的侵害的自然保护，即由于晶状体和视网膜的保护，可能会受某种病理的或外科干涉而严重影响：
-白内障，只能进行涉及摘除晶状体的外科治疗。
-病理性老龄化引起了视网膜结构的退化，导致与年龄有关的黄斑变性(AMD)频繁发生。
此外，年龄超过65岁具有白内障和AMD两种疾病的人们需要注意，在这个人群中白内障是视力降低的主要原因而AMD则是致盲的主要原因。另外，由于人均寿命的增加，必须考虑这两种疾病的预期增长，从而在研究领域和其在光学工业的应用方面投入更多的关注。
包括Klein的著作(Klein R，Klein BE，Wong TY，Tomany SC，CruickshanksKJ：“白内障和白内障手术与老龄化黄斑病变的长期发生率的关系”，ArchOphthalmol 120：1551-1558.2002)和Freeman的著作(FreemanE，
B，WestSK，Tielsch JM，ScheinOD：“在白内障手术和老龄化黄斑变性之间是否存在联系”，Am J Ophthalmol 135(6)：849-856.2003)在内，一些流行病学方面的研究在著作中评估了白内障手术和老龄化黄斑变性之间的联系。这些作者认为在接受白内障手术的患者中AMD症状发展的危险更大。然而，Wang(WangJJ，Mithell P，Cumming RG，Lim R：“白内障和老龄化黄斑病变：蓝岭眼科研究”，Ophthalmic Epidemiol 6：317-326.1999)和McCarty(McCarty CA，MukeshEN，Fu CL，Mitchell P，Wang JJ，Taylor HR：“老龄化黄斑病变的危险因素：视力损害研究”，Arch Ophthalmology 119：1455-1462.2001)在以往的研究中否认这种假设，可能由于缺乏用于诊断评估的先进技术。诸如眼科相干X线断层摄影术等最新技术的应用能用以准确、及时以及非侵入性监控视网膜神经变性过程的进展，并且这个事实对于了解能够吸收有害射线的天然色素的决定性影响非常重要。
已经研发了一些用于保护经受白内障手术的眼睛免受短波射线影响的技术：
-市场上有几种类型的包含黄色染料的滤光器在销售，然而，并没有获得最佳的方法和/或仪器以将这种滤光器应用于人眼作为预防和治疗措施以代替和/或改善眼睛的自然保护。
-从90年代中期开始，具有黄色滤光器的眼内透镜就应用于遭受白内障手术的眼睛中。这个选择包括具有所有并发危险和难度的手术介入。此外，有-大群接受白内障手术的人用植入眼内的透明眼内透镜以取代晶状体，其缺乏保护所需的黄色色素。在这种情况下，缺乏黄色色素的人造晶状体必须用支持系统的介入来补充黄色色素，例如本专利申请的接触透镜物体。
已经申请了数个关于本技术状态的专利，但它们都与本发明有较大区别：
-具有治疗作用的矫正接触透镜(法国专利FR2761785)，设计成在特定区域运用染料刺激或减刺激特定视网膜区域以矫正近视或斜视。
-激光安全接触透镜(专利号US20050024583)，依靠某种涂层或处理，吸收或反射特定波长的光并容纳一个或多个鉴别区域以便保证选择的透镜是适应所需应用的一款。
-用于白内障的有色接触透镜(专利号JP11253480)，设计成解决太阳镜的问题，包括瞳孔，如同那些效仿太阳镜效果的有色透镜和具有虹膜颜色图案的有色虹膜。
-有色的接触透镜(专利号JP3294819)，设计成保护眼睛免受光线损害并且在万一意外脱落时易于发现。它由玻璃体或其它具有透明颜色的有色元件组成。
-用于矫正青视症或蓝视病的接触透镜(专利号JP1204668)，依靠引进能吸收波长在320-450nm之间的光的黄色或橙色细件，以便减少这种病理的影响。青视症是引起色觉紊乱的感觉障碍。患者看到的每件事物都带有蓝色，透镜设法减少这种感觉影响，并且决不试图保护视网膜神经元免受小于550nm的短波射线的有害刺激。
-特定区域染色的接触透镜(专利号EP0204347)，用于色素性视网膜炎的患者，用均匀染色表面覆盖角膜，从而波长520nm的最大透射为5％并在660nm时最小值提高到50％。
这些专利在其用途和效果方面与本发明有显著区别，因为没有一个是设计用于保护遭受白内障手术的眼睛和/或保护神经变性过程免受短波射线损害的。
发明描述
本发明的目的在假性无晶状体对象的情况下，功能性地补偿保护色素的摘除(在手术中摘除)，并且在神经变性过程的情况中，提高运用接触透镜作为支持物吸收蓝色和紫色光的预防性效果。如上所述，在同一组人群中，即年纪较大的人群中共存这两种情况是非常普遍的。
为此，本发明包括用于治疗遭受神经变性过程的眼睛和/或假性无晶状体眼睛的治疗性接触透镜，通过在接触透镜上应用具有能吸收350-500nm间短波射线的黄色色素的滤光器而获得上述结果。
因此，用于假性无晶状体眼睛的治疗性接触透镜包括两种元件的组合：
-由透镜体、虹膜区域和角膜区域组成的标准接触透镜，适用于人眼内。
-应用在市场可获得的具有黄色色素的滤光器，滤光器适用于透镜并且对于人眼无害，吸收从350到500nm的短波，横跨透镜全部区域-包括体部、虹膜区域和角膜区域，形成黄色染色接触透镜。该透镜能够提供适于每个个体的不同的半径曲率、直径和屈光力。
发明实施方式
有色接触透镜的可能实施方式为本领域技术人员公知并且最普通的方法是专利US4582402和US5414477的内容。本发明的实施方式在下面的例子中进一步解释，然而，当存在用于透镜制造的变化形式或组合时并不限制其范围：
关于发明生产的示例：
-传统黄色染料4-苯基偶氮苯酚或黄色溶媒7(SY7)10.3mg，溶解于10.01g包括66％PEA，30.5％PEMA和3.3％BDDA的单体溶液中，形成SY7的浓度为0.103wt％。
-加入52.3mg双4-叔丁基环己基过氧化二碳酸酯作为聚合催化剂。
-运用注射器，将溶液引入通过两个由金属夹以及1mm的聚四氟乙烯密封圈连接在一起的重叠的玻璃盘成型的模具中。溶液蔓延成为1mm膜。
-将模具放入65℃烤箱17小时后开始发生聚合反应。然后烤箱的温度升高到100℃再持续3小时。
-聚合一旦完成，就从模具中取出薄膜，进行适当的测量并做最后剪裁。
总之，接触透镜和黄色染料的组合，都适用于人的眼睛，将允许经受白内障手术的患者在透明眼内透镜的帮助下，通过接触透镜的简单应用矫正手术眼的脱保护，并且还能改善经受神经变性过程的眼睛，从而增加眼睛的自然保护。从而可避免市场上存在的可选技术的缺陷(不具备施用装置的滤光器以及眼内透镜)。
Claims (6)
1.用于假性无晶状体眼睛的治疗性接触透镜，其特征在于在接触透镜上应用滤光器，该滤光器具有吸收350-500nm短波的适用于人眼内的黄色色素。
2.根据权利要求1的用于假性无晶状体眼睛的治疗性接触透镜，其中所述黄色色素选自4-苯基偶氮苯酚或黄色溶媒7。
3.根据权利要求1或2的用于假性无晶状体眼睛的治疗性接触透镜，其中所述接触透镜是具有适于应用于人眼内特性的接触透镜。
4.用于遭受视网膜神经变性过程的眼睛的治疗性接触透镜，其特征在于在接触透镜上结合应用滤光器，该滤光器具有吸收350-500nm短波的适用于人眼内的黄色色素。
5.根据权利要求4的用于遭受视网膜神经变性过程的眼睛的治疗性接触透镜，其中所述黄色色素选自4-苯基偶氮苯酚或黄色溶媒7。
6.根据权利要求4或5的用于遭受视网膜神经变性过程的眼睛的治疗性接触透镜，其中所述接触透镜是具有适于应用于人眼内特性的接触透镜。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200500937A ES2247946B2 (es) | 2005-04-19 | 2005-04-19 | Lente de contacto terapeutica para ojos pseudo-afaquicos y/o en proceso de neurodegeneracion. |
| ESP200500937 | 2005-04-19 | ||
| PCT/ES2005/000431 WO2006111588A1 (es) | 2005-04-19 | 2005-07-28 | Lente de contacto terapéutica para ojos pseudo-afáquicos y/o en proceso de neurodegeneración |
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| Publication Number | Publication Date |
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| CN101193611A CN101193611A (zh) | 2008-06-04 |
| CN101193611B true CN101193611B (zh) | 2010-06-09 |
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| CN2005800500016A Expired - Fee Related CN101193611B (zh) | 2005-04-19 | 2005-07-28 | 用于假性无晶状体眼睛和/或处于神经变性过程的眼睛的治疗性接触镜 |
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| Country | Link |
|---|---|
| US (1) | US7524060B2 (zh) |
| EP (1) | EP1878411A1 (zh) |
| JP (1) | JP2008538711A (zh) |
| CN (1) | CN101193611B (zh) |
| AU (1) | AU2005330628B2 (zh) |
| BR (1) | BRPI0520229A2 (zh) |
| CA (1) | CA2605940A1 (zh) |
| EA (1) | EA011798B1 (zh) |
| EG (1) | EG24768A (zh) |
| ES (1) | ES2247946B2 (zh) |
| HK (1) | HK1123966A1 (zh) |
| MX (1) | MX2007012981A (zh) |
| WO (1) | WO2006111588A1 (zh) |
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| US8403478B2 (en) * | 2001-11-02 | 2013-03-26 | High Performance Optics, Inc. | Ophthalmic lens to preserve macular integrity |
| US8500274B2 (en) | 2000-11-03 | 2013-08-06 | High Performance Optics, Inc. | Dual-filter ophthalmic lens to reduce risk of macular degeneration |
| US20120075577A1 (en) | 2006-03-20 | 2012-03-29 | Ishak Andrew W | High performance selective light wavelength filtering providing improved contrast sensitivity |
| US20070216861A1 (en) * | 2006-03-20 | 2007-09-20 | Andrew Ishak | Ophthalmic system combining ophthalmic components with blue light wavelength blocking and color-balancing functionalities |
| US8360574B2 (en) * | 2006-03-20 | 2013-01-29 | High Performance Optics, Inc. | High performance selective light wavelength filtering providing improved contrast sensitivity |
| US9377569B2 (en) | 2006-03-20 | 2016-06-28 | High Performance Optics, Inc. | Photochromic ophthalmic systems that selectively filter specific blue light wavelengths |
| US8882267B2 (en) | 2006-03-20 | 2014-11-11 | High Performance Optics, Inc. | High energy visible light filter systems with yellowness index values |
| US8113651B2 (en) * | 2006-03-20 | 2012-02-14 | High Performance Optics, Inc. | High performance corneal inlay |
| DE102007014122A1 (de) * | 2006-10-09 | 2008-04-10 | Ashland-Südchemie-Kernfest GmbH | Radikalische Kalthärtung von auf modifizierten Poly(Meth)Acrylaten mit reaktiven ethylenischen Gruppen basierenden Kunstharzen |
| FR2908897B1 (fr) * | 2006-11-17 | 2009-03-06 | Essilor Int | Lentilles ophtalmiques colorees multi-teintes. |
| FR2908896B1 (fr) * | 2006-11-17 | 2009-02-06 | Essilor Int | Lentilles ophtalmiques colorees multi-teintes pour myopes. |
| US7976157B2 (en) | 2007-05-08 | 2011-07-12 | Gunnar Optiks, Llc | Eyewear for reducing symptoms of computer vision syndrome |
| ES2303484B2 (es) | 2007-10-15 | 2010-03-08 | Universidad Complutense De Madrid | Material de cobertura, revestimiento o pantalla para la proteccion y terapia de ojos contra los efectos de la luz azul. |
| ES2312284B1 (es) * | 2007-10-26 | 2010-01-08 | Universidad Complutense De Madrid | Gafas de seguridad y prevencion con superficie tratada para la proteccion y terapia de ojos en oficios y deportes. |
| WO2009079726A1 (en) * | 2007-12-26 | 2009-07-02 | Paulo Ferrara De Almeida Cunha | Intracomeal ring |
| ES2478693B1 (es) | 2012-12-21 | 2015-04-29 | Universidad Complutense De Madrid | Elemento bloqueante de longitudes de onda corta en fuentes de iluminación de tipo led |
| US9798163B2 (en) | 2013-05-05 | 2017-10-24 | High Performance Optics, Inc. | Selective wavelength filtering with reduced overall light transmission |
| ES1094781Y (es) | 2013-06-03 | 2014-02-24 | Univ Complutense De Madrid (100 0%) | Dioptrio configurado para restringir las radiaciones electromagnéticas que dañan el sistema visual |
| US9683102B2 (en) | 2014-05-05 | 2017-06-20 | Frontier Scientific, Inc. | Photo-stable and thermally-stable dye compounds for selective blue light filtered optic |
| US10901125B2 (en) | 2014-05-23 | 2021-01-26 | Eyesafe, Llc | Light emission reducing compounds for electronic devices |
| US10642087B2 (en) | 2014-05-23 | 2020-05-05 | Eyesafe, Llc | Light emission reducing compounds for electronic devices |
| EP3125005A1 (en) | 2015-07-29 | 2017-02-01 | Tecnología Sostenible y Responsable SL | Optical product comprising two pigments |
| EP3419966B1 (en) | 2016-02-22 | 2020-03-25 | Alcon Inc. | Uv-absorbing vinylic monomers and uses thereof |
| WO2017145022A1 (en) | 2016-02-22 | 2017-08-31 | Novartis Ag | Uv/visible-absorbing vinylic monomers and uses thereof |
| EP3214483A1 (en) * | 2016-03-04 | 2017-09-06 | ESSILOR INTERNATIONAL (Compagnie Générale d'Optique) | Method for determining a value quantifying the effect of an optical filter on a parameter linked to an eye |
| WO2019017975A1 (en) | 2017-07-21 | 2019-01-24 | Xinova, LLC | SYSTEMS AND METHODS FOR RADIATION DOSIMETRY |
| US11439536B2 (en) | 2017-11-22 | 2022-09-13 | Lutronic Vision Inc. | Optical filter on contact lens surface |
| US11347099B2 (en) | 2018-11-28 | 2022-05-31 | Eyesafe Inc. | Light management filter and related software |
| US11810532B2 (en) | 2018-11-28 | 2023-11-07 | Eyesafe Inc. | Systems for monitoring and regulating harmful blue light exposure from digital devices |
| US11592701B2 (en) | 2018-11-28 | 2023-02-28 | Eyesafe Inc. | Backlight unit with emission modification |
| US11126033B2 (en) | 2018-11-28 | 2021-09-21 | Eyesafe Inc. | Backlight unit with emission modification |
| US10971660B2 (en) | 2019-08-09 | 2021-04-06 | Eyesafe Inc. | White LED light source and method of making same |
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| SU1533689A1 (ru) * | 1985-11-12 | 1990-01-07 | Stolyarenko Georgij E | Способ защиты сетчатой оболочки от фототоксического действи видимого света |
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| US4952046A (en) * | 1982-02-26 | 1990-08-28 | Stephens James B | Optical lenses with selective transmissivity functions |
| US4961640A (en) * | 1982-08-20 | 1990-10-09 | Irlen Helen L | Method and apparatus of treatment of symptoms of the Irlen syndrom |
| DE3520346A1 (de) * | 1985-06-07 | 1986-12-11 | Fa. Carl Zeiss, 7920 Heidenheim | Bereichsweise gefaerbte kontaktlinse |
| JPH0824694B2 (ja) * | 1988-02-09 | 1996-03-13 | ホーヤ株式会社 | 青視症補正用コンタクトレンズ |
| JP2724012B2 (ja) * | 1988-03-03 | 1998-03-09 | ホーヤ株式会社 | 青視症補正用眼内レンズの製造方法 |
| AU611786B2 (en) * | 1988-03-03 | 1991-06-20 | Hoya Corporation | Process for producing intraocular lens for correcting cyanopia |
| AU6604890A (en) * | 1989-09-28 | 1991-04-28 | John D. Gottsch | Armd-related vision impairment treatment |
| PT95736B (pt) | 1989-11-01 | 1998-07-31 | Schering Corp | Lente de contacto colorida que tem uma aparencia muito natural |
| US5470932A (en) * | 1993-10-18 | 1995-11-28 | Alcon Laboratories, Inc. | Polymerizable yellow dyes and their use in opthalmic lenses |
| JP3069498B2 (ja) | 1994-09-01 | 2000-07-24 | 富士通株式会社 | 充放電装置および電子機器 |
| US5846457A (en) * | 1994-10-28 | 1998-12-08 | Hoffman; William C. | Light filtering contact lens method |
| FR2761785B3 (fr) | 1997-04-07 | 1999-05-14 | Dan Ruben Isaac Haiun | Lentille de contact correctrice et therapeutique contre les myopies et les strabismes |
| JPH11253480A (ja) * | 1998-03-16 | 1999-09-21 | Haruo Nomura | 白内障用カラーコンタクトレンズ |
| US6948815B2 (en) | 2003-07-28 | 2005-09-27 | Ceramoptec Industries, Inc. | Laser safety contact lenses |
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2005
- 2005-04-19 ES ES200500937A patent/ES2247946B2/es active Active
- 2005-07-28 AU AU2005330628A patent/AU2005330628B2/en not_active Expired - Fee Related
- 2005-07-28 CA CA002605940A patent/CA2605940A1/en not_active Abandoned
- 2005-07-28 JP JP2008507098A patent/JP2008538711A/ja active Pending
- 2005-07-28 MX MX2007012981A patent/MX2007012981A/es not_active Application Discontinuation
- 2005-07-28 BR BRPI0520229-9A patent/BRPI0520229A2/pt not_active Application Discontinuation
- 2005-07-28 EP EP05786112A patent/EP1878411A1/en not_active Ceased
- 2005-07-28 EA EA200702267A patent/EA011798B1/ru not_active IP Right Cessation
- 2005-07-28 CN CN2005800500016A patent/CN101193611B/zh not_active Expired - Fee Related
- 2005-07-28 WO PCT/ES2005/000431 patent/WO2006111588A1/es active Application Filing
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2006
- 2006-04-10 US US11/401,440 patent/US7524060B2/en active Active
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- 2007-10-21 EG EGNA2007001121 patent/EG24768A/xx active
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1533689A1 (ru) * | 1985-11-12 | 1990-01-07 | Stolyarenko Georgij E | Способ защиты сетчатой оболочки от фототоксического действи видимого света |
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| JP平1-204668A 1989.08.17 |
| JP特开平11-253480A 1999.09.21 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1878411A1 (en) | 2008-01-16 |
| BRPI0520229A2 (pt) | 2010-01-26 |
| US7524060B2 (en) | 2009-04-28 |
| AU2005330628B2 (en) | 2012-02-02 |
| ES2247946B2 (es) | 2006-10-01 |
| CN101193611A (zh) | 2008-06-04 |
| EG24768A (en) | 2010-08-04 |
| JP2008538711A (ja) | 2008-11-06 |
| MX2007012981A (es) | 2008-03-18 |
| ES2247946A1 (es) | 2006-03-01 |
| WO2006111588A1 (es) | 2006-10-26 |
| HK1123966A1 (en) | 2009-07-03 |
| CA2605940A1 (en) | 2006-10-26 |
| EA011798B1 (ru) | 2009-06-30 |
| AU2005330628A1 (en) | 2006-10-26 |
| EA200702267A1 (ru) | 2008-04-28 |
| US20060238703A1 (en) | 2006-10-26 |
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