CN101356165A - 吉西他滨的制备方法和相关的中间体 - Google Patents

吉西他滨的制备方法和相关的中间体 Download PDF

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Publication number
CN101356165A
CN101356165A CNA2006800471287A CN200680047128A CN101356165A CN 101356165 A CN101356165 A CN 101356165A CN A2006800471287 A CNA2006800471287 A CN A2006800471287A CN 200680047128 A CN200680047128 A CN 200680047128A CN 101356165 A CN101356165 A CN 101356165A
Authority
CN
China
Prior art keywords
general formula
chloro
erythro
mixture
fluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2006800471287A
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English (en)
Chinese (zh)
Inventor
V·纳达卡
E·克罗普弗
S·萨伊德
D·蒙特维利斯基
O·阿拉德
J·卡斯皮
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wavelength Pharmaceuticals Ltd
Original Assignee
Chemagis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemagis Ltd filed Critical Chemagis Ltd
Publication of CN101356165A publication Critical patent/CN101356165A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
CNA2006800471287A 2005-12-13 2006-12-12 吉西他滨的制备方法和相关的中间体 Pending CN101356165A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74968905P 2005-12-13 2005-12-13
US60/749,689 2005-12-13

Publications (1)

Publication Number Publication Date
CN101356165A true CN101356165A (zh) 2009-01-28

Family

ID=38163614

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2006800471287A Pending CN101356165A (zh) 2005-12-13 2006-12-12 吉西他滨的制备方法和相关的中间体

Country Status (3)

Country Link
KR (1) KR20080094890A (ko)
CN (1) CN101356165A (ko)
WO (1) WO2007070804A2 (ko)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109651459A (zh) * 2019-01-24 2019-04-19 江苏八巨药业有限公司 一种吉西他滨中间体甲磺酰酯的制备方法
CN111393546A (zh) * 2020-03-31 2020-07-10 浙江康特生物科技有限公司 一种螯合树脂的制备及去除试剂盒纯化水中钴离子的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223608A (en) * 1987-08-28 1993-06-29 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
US5521294A (en) * 1995-01-18 1996-05-28 Eli Lilly And Company 2,2-difluoro-3-carbamoyl ribose sulfonate compounds and process for the preparation of beta nucleosides

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109651459A (zh) * 2019-01-24 2019-04-19 江苏八巨药业有限公司 一种吉西他滨中间体甲磺酰酯的制备方法
CN109651459B (zh) * 2019-01-24 2020-09-08 江苏八巨药业有限公司 一种吉西他滨中间体甲磺酰酯的制备方法
CN111393546A (zh) * 2020-03-31 2020-07-10 浙江康特生物科技有限公司 一种螯合树脂的制备及去除试剂盒纯化水中钴离子的应用

Also Published As

Publication number Publication date
KR20080094890A (ko) 2008-10-27
WO2007070804A3 (en) 2008-01-03
WO2007070804A2 (en) 2007-06-21

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Open date: 20090128