CN101347581A - Chinese medicine preparation for treating anypnia induced by nervous prostration - Google Patents

Abstract

The invention relates to a traditional Chinese medicine preparation for treating neurasthenic insomnia, which is prepared by traditional Chinese medicine according to the following parts by weight: 12-18 parts of epimedium, 12-18 parts of milkvetch seed, 12-18 parts of fructus corni, 12-18 parts of wolfberry fruit, 12-18 parts of shizandra, 12-18 parts of babchi seed, 12-18 parts of English walnut seed, 12- 18 parts of curculigo orchioides, 12-18 parts of broomrape, 10-15 parts of polygala, 10-15 parts of calamus, 17-23 parts of dangshen, 17-23 parts of prepared rehmannia root, 17- 23 parts of fleece-flower root, 12-18 parts of longan pulp, 12-18 parts of mulberry fruit, 1.2-1.8 parts of cinnabar, 4-6 parts of amber, and 17-23 parts of spiranthes sinensis. Compared with sleeping pills containing chemical components, the medicine for treating insomnia has high recovery rate and low recurernce rate. By nourishing the blood, regulating qi, relieving depression, reducing pathogenic fire, relieving uneasiness and tranquilizing, the mind, the yin qi and the yang qi of a human body are harmonizied and the sleep conditions are obviously improved. In addition, the drug dependence and the toxicity and side effect, which are caused by western medicines, are avoided.

Description

The Chinese medicine preparation of treatment anypnia induced by nervous prostration

Technical field

The invention belongs to the pharmaceutical product technical field, particularly is the Chinese medicine preparation of raw material with the natural Chinese medicinal herb.

Background technology

The neurasthenia belongs to a kind of of mental illness, is that class spirit is excited easily and mentality is tired easily, the neurosis disorder of often be in a bad mood worry and psychological physiological signs.Along with rhythm of life is accelerated and the social pressure increase, more and more people's emotion worries, anxiety, easily angry; Sensation is mental, muscle power is tired, absent minded easily, poor memory; Also have more people's sleeping problems serious, the performance difficulty of sleeping of behaving, dreaming often and waking easily is felt not recover from fatigue after waking up, and the sleeplessness at night often occurs, and daytime is listless or doze off.Though insomnia does not belong to critical illness, often hinders people's orthobiosis, work, study and health, and can increase the weight of or bring out cardiopalmus, the thoracic obstruction, dizzy, headache, apoplexy etc.

Use sleeping pill and control insomnia and not only medicine is produced and rely on, take for a long time and can cause iatrogenic disease.

Summary of the invention

The object of the invention provides a kind of Chinese medicine preparation for the treatment of anypnia induced by nervous prostration.

Technical scheme: insomnia claims " unable to close the eyes ", " insomnia ", " must not crouch " in " interior warp ".Difficult Classic claims " being insomnia ".Zhang Jingyue is divided into insomnia in " Jing Yue's complete work is insomnia " heresy, two types of naivetes, think naivete be " pondering over the terrified melancholy of overstrain doubts; and not have tire out and the person that is insomnia more; always belong to the deficiency of Kidney-Yin essence and blood; negative and positive are not handed over; and god has the ear of being discontented with one's home ", point out " naivete and the person of being insomnia ... should be ... have promptly that little expectorant low baking temperature is neither must to be turned round and look at; only should cultivate QI and blood; the then all again diseases of vim and vigour are from moving back ... " in view of the above in " Jing Yue's complete work be insomnia opinion control " to support nutrition gas for curing mainly, " heresy is arranged and the person of sleeping, eliminating the pathogen and refreshing pacify certainly as ".

Institute of the present invention Cure for insomnia is that neurasthenia in the western medicine, climacteric syndrome are main person with insomnia, the cause of disease by feelings will hindered, deficiency of vital energy insufficiency of blood, innate deficiency, pathogenesis is the imbalance of heart and gallbladder spleen kidney yin sun, qi-blood disharmony lack of preservation of spirit or the irritability of causing, the fooled elimnation for excess and tonification for deficiency of treatment, tranquilizing the mind on the basis of resolving depression pathogenic fire reducing, nourishing blood and invigorating qi, QI and blood regulating negative and positive.

Specifically, a kind of Chinese medicine preparation for the treatment of anypnia induced by nervous prostration, it is to make with the following weight parts raw material of Chinese medicine:

Herba Epimedii 12-18, Semen Astragali Complanati 12-18, Fructus Corni 12-18, Fructus Lycii 12-18, Fructus Schisandrae Chinensis 12-18, Fructus Psoraleae 12-18, semen juglandis 12-18, Rhizoma Curculiginis 12-18, Herba Cistanches 12-18, Radix Polygalae 10-15, Rhizoma Acori Graminei 10-15, Radix Codonopsis 17-23, Radix Rehmanniae Preparata 17-23, Radix Polygoni Multiflori 17-23, Arillus Longan 12-18, Fructus Mori 12-18, Cinnabaris 1.2-1.8, succinum 4-6 Radix seu Herba Spiranthis Lanceae 17-23.

The following prescription of special recommendation of the present invention:

Herba Epimedii 15, Semen Astragali Complanati 15, Fructus Corni 15, Fructus Lycii 15, Fructus Schisandrae Chinensis 15, Fructus Psoraleae 15, semen juglandis 20, Rhizoma Curculiginis 15, Herba Cistanches 20, Radix Polygalae 13, Rhizoma Acori Graminei 13, Radix Codonopsis 20, Radix Rehmanniae Preparata 20, Radix Polygoni Multiflori 20, Arillus Longan 15, Fructus Mori 15, Cinnabaris 1.5, succinum 5, Radix seu Herba Spiranthis Lanceae 20.

The Analysis on Mechanism of the used medicine of the present invention, wherein:

Herba Epimedii-kidney invigorating and YANG supporting, expelling wind and removing dampness, blood pressure lowering, antitussive is eliminated the phlegm, and relievings asthma;

The solid sugar of Semen Astragali Complanati-the kidney invigorating, nourishing the liver to improve visual acuity;

Fructus Corni-liver and kidney tonifying, puckery sugared reducing urination, consolidating channel for hemostasis, arresting sweating takes off admittedly;

Fructus Lycii-nourishing the liver and kidney, nourishing the liver to improve visual acuity;

Fructus Schisandrae Chinensis-astringing lung-QI and relieving cough, consolidating superficial resistance arresting sweating, puckery sugared antidiarrheal, promoting the production of body fluid to quench thirst;

Fructus Psoraleae-kidney invigorating and YANG supporting is Gu sugared reducing urination is warming spleen and stopping diarrha;

The strong spleen of Semen Juglandis-the kidney invigorating, astringing lung QI for relieving asthma;

Rhizoma Curculiginis-warming the kidney to invigorate YANG, dispelling cold and dampness, bone and muscle strengthening;

Radix seu Herba Spiranthis Lanceae-removing heat from blood toxin expelling, the YIN nourishing tonify deficiency;

Herba Cistanches-kidney invigorating and YANG supporting, loosening bowel to relieve constipation;

Radix Polygalae-tranquilizing by nourishing the heart, expelling phlegm for arresting cough;

Rhizoma Acori Graminei-the expectorant of having one's ideas straightened out, the refreshment brain-strengthening is opened the eliminating cold for resuscitation stomach;

Radix Codonopsis-invigorating the spleen and replenishing QI, nourishing blood to promote the production of body fluid;

Radix Rehmanniae Preparata-tonifying blood and regulating menstruation, sun is educated in nourishing kidney;

Radix Polygoni Multiflori-the kidney invigorating liver, benefiting essence-blood;

Cinnabaris-tranquilizing mind, toxin expelling doctor skin ulcer;

Arillus Longan-nourishing blood to tranquillize the mind;

Fructus Mori-nourishing YIN and supplementing blood;

Succinum-tranquillizing and allaying excitement, inducing diuresis for treating stranguria syndrome, blood circulation promoting and blood stasis dispelling;

The all medicines of the present invention share, and by adjusting viscera QI and blood function, often can significantly improve sleep state, and not cause drug dependence and iatrogenic disease.

The specific embodiment

Prescription 1 (unit: gram, down together): Herba Epimedii 12, Semen Astragali Complanati 18, Fructus Corni 12, Fructus Lycii 18, Fructus Schisandrae Chinensis 12, Fructus Psoraleae 18, semen juglandis 12, Rhizoma Curculiginis 18, Herba Cistanches 12, Radix Polygalae 15, Rhizoma Acori Graminei 10, Radix Codonopsis 23, Radix Rehmanniae Preparata 17, Radix Polygoni Multiflori 23, Arillus Longan 12, Fructus Mori 18, Cinnabaris 1.2, succinum 6, Radix seu Herba Spiranthis Lanceae 17.

Prescription 2: Herba Epimedii 15, Semen Astragali Complanati 15, Fructus Corni 15, Fructus Lycii 15, Fructus Schisandrae Chinensis 15, Fructus Psoraleae 15, semen juglandis 20, Rhizoma Curculiginis 15, Herba Cistanches 20, Radix Polygalae 13, Rhizoma Acori Graminei 13, Radix Codonopsis 20, Radix Rehmanniae Preparata 20, Radix Polygoni Multiflori 20, Arillus Longan 15, Fructus Mori 15, Cinnabaris 1.5, succinum 5, Radix seu Herba Spiranthis Lanceae 20.

Prescription 3: Herba Epimedii 18, Semen Astragali Complanati 12, Fructus Corni 18, Fructus Lycii 12, Fructus Schisandrae Chinensis 18, Fructus Psoraleae 12, semen juglandis 18, Rhizoma Curculiginis 12, Herba Cistanches 18, Radix Polygalae 10, Rhizoma Acori Graminei 15, Radix Codonopsis 17, Radix Rehmanniae Preparata 23, Radix Polygoni Multiflori 17, Arillus Longan 18, Fructus Mori 12, Cinnabaris 1.8, succinum 4, Radix seu Herba Spiranthis Lanceae 23.

Making the watered pill after each medicine of above-mentioned prescription mixes gets final product.

It is as follows that the present invention treats the insomnia clinical report that neurasthenia and climacteric syndrome etc. cause:

1 data and method

1.1 the physical data treatment is organized 96 examples and is out-patient and the department of Chinese medicine, doctor trained in Western medicine internal medicine inpatient, being mainly Western medicine diagnose is main person for neurasthenia and climacteric syndrome with insomnia.96 examples are organized in treatment, male 31 examples, women 65 examples; 17～65 years old age, the course of disease 2 months～4 years; With climacteric syndrome 47 examples.

1.2 diagnostic criteria is drafted with reference to " tcm clinical practice disease diagnosis criterion of therapeutical effect " [the 6th edition " Chinese Internal Medicine "].(1) classical symptom: difficulty falling asleep or sleep and easily wake up, sleep and unstable or wake up after can not sleep; Wake up morning too early; Or lie awake all night, 5h does not have enough sleep.(2) simultaneous phenomenon: the dizzy headache of normal companion, palpitation and amnesia, spiritlessness and weakness, malaise, dreaminess etc.(3) history of repeated attack is arranged.(4), find no nypnapagogic other organic diseases through each system and lab testing.

1.3 TCM Syndrome Type is with reference to " new drug treatment by Chinese herbs insomnia clinical research guideline " typing standard.

1.4 insomnia weight grade scale is with reference to " new drug treatment by Chinese herbs insomnia clinical research guideline ".Treatment group: slight 10 examples, moderate 55 examples, severe 31 examples.

1.5 treatment and observational technique

All patients take the watered pill of formulation of the present invention, take for three times according to restraining to divide every days 30; First three sky of severe patient adds speed peace 15mg, takes before sleeping; Oryzanol 10mg 3 times/d, stops Western medicine after three days.Treatment cycle was an observation period with 7 days, statistical result after all patient's drug withdrawals.

2 results

2.1 curative effect determinate standard is with reference to " tcm clinical practice disease diagnosis criterion of therapeutical effect ".

Clinical recovery: recover normal the length of one's sleep, or nighttime sleep is more than 6h, sleep is dull, and the back of waking up is hale and hearty, follows up a case by regular visits to and does not have recurrence in 2 years.

Produce effects: sleep is clearly better, and increases the length of one's sleep more than the 3h, and Depth of sleep increases, and wakes up back spirit better, follows up a case by regular visits to not recurrence in 2 years; Or slight recurrence is arranged, symptom after taking medicine disappears.

Effectively: sx, the length of one's sleep more preceding increase＜3h, simultaneous phenomenon alleviates.

Invalid: the insomnia of treatment back does not have obvious the improvement.

2.4 therapeutic outcome:

Result after (1) 7 day:

Clinical recovery 11 people; Produce effects 21 people; Effective 47 people; Invalid 17 people;

Result after (2) 14 days:

Clinical recovery 41 people; Produce effects 35 people; Effective 13 people; Invalid 7 people;

(3) the present invention is 92.7% to insomniac's effective percentage, invalid 7.3%.Wherein invalid patient 7 people all are 50 years old left and right sides women, and main cause is that self mood regulation curative effect that causes out of control is not good enough.

Use Cure for insomnia of the present invention, relatively cure rate height, recurrence are lacked with the chemical constituent sleeping pill.Full square tube is crossed the regulating QI of nourishing blood, resolving depression pathogenic fire reducing, tranquilizing the mind, and the human body yang blood and qi is in harmonious proportion, and sleep state significantly improves, and avoids caused drug dependence of Western medicine and toxic and side effects, but longer the course of treatment to the severe insomniac.

Claims (2)

1, a kind of Chinese medicine preparation for the treatment of anypnia induced by nervous prostration is characterized in that making with the following weight parts raw material of Chinese medicine:

Herba Epimedii 12-18, Semen Astragali Complanati 12-18, Fructus Corni 12-18, Fructus Lycii 12-18, Fructus Schisandrae Chinensis 12-18, Fructus Psoraleae 12-18, semen juglandis 12-18, Rhizoma Curculiginis 12-18, Herba Cistanches 12-18, Radix Polygalae 10-15, Rhizoma Acori Graminei 10-15, Radix Codonopsis 17-23, Radix Rehmanniae Preparata 17-23, Radix Polygoni Multiflori 17-23, Arillus Longan 12-18, Fructus Mori 12-18, Cinnabaris 1.2-1.8, succinum 4-6, Radix seu Herba Spiranthis Lanceae 17-23.

2, a kind of Chinese medicine preparation for the treatment of anypnia induced by nervous prostration according to claim 1 is characterized in that making with the following weight parts raw material of Chinese medicine:

Herba Epimedii 15, Semen Astragali Complanati 15, Fructus Corni 15, Fructus Lycii 15, Fructus Schisandrae Chinensis 15, Fructus Psoraleae 15, semen juglandis 20, Rhizoma Curculiginis 15, Herba Cistanches 20, Radix Polygalae 13, Rhizoma Acori Graminei 13, Radix Codonopsis 20, Radix Rehmanniae Preparata 20, Radix Polygoni Multiflori 20, Arillus Longan 15, Fructus Mori 15, Cinnabaris 1.5, succinum 5, Radix seu Herba Spiranthis Lanceae 20.