CN101347574B - Chinese medicine for treating perineural fibroma disease - Google Patents

Abstract

The invention relates to a traditional Chinese medicine for treating neuroinomatosis, which effectively solves the problem of neurofibroma. The technical scheme of the invention is that: the traditional Chinese medicine is prepared by 72-88g of Chinese ephedra, 108-132g of semen perillae acutae, 108-132g of ballonflower, 135-165g of tansymustard seed, 108-132g of dried orange peel, 90-110g of immature bitter orange, 108-132g of tuckahoe, 90-110g of bulbus fritilariae, 108-132g of tuber pinellia, 90-110g of oarweed, 270-330g of oldenlandia diffusa, and 45-55g of liquorice. Firstly, the Chinese ephedra, the dried orange peel, the tuckahoe, the bulbus fritilariae, the tuber pinellia, the immature bitter orange and the liquorice are pulverized into fine powder, the grain diameter of which is at most 10 mum, and the fine powder is uniformly mixed for spare use; then, water is added in five medicines of the semen perillae acutae, the ballonflower, the tansymustard seed, the oarweed and the oldenlandia diffusa, the mixture is immerged for 30-40 minutes decocted for 1.5h two times; decoction is merged and concentrated into extractum, the relative density of which is 1.20-1.30; the fine powder and the extracted extractum are added in the mixture and mixed together to form medicine lumps; the medicine lumps are placed in a baking box and dried at 70-85 DEG C until the water content is less than 5%. The medicine has the advantages of scientific prescription, good curative effect and great economic and social benefit.

Description

A kind of Chinese medicine for the treatment of neurofibromatosis

One, technical field

The present invention relates to medical domain, particularly a kind of Chinese medicine (claiming micron hard masses softening and resolving ball again) for the treatment of neurofibromatosis.

Two, background technology

Tumor is under various internal and external factor effects, destroying the pathological proliferation reaction of body cell and organizational structure, can occur in any tissue part of body, is the very big disease of hazardness, neurofibroma is a kind of form of expression in the tumor, be that mechanism of qi pent-up forms because a variety of causes causes death, lung governing qi, the table of main the whole body, because insufficiency of primordial QI, lung qi lose in a surname and, inhibited pulmonary QI, respectfully fall dereliction of duty and cause water liquid and be detained, so that stagnation of QI expectorant coagulates, disharmony of nutrient QI with defensive QI, mental disorder cohesion flesh table, the shaping of accumulating in the course of time, sending out is physocele, as depression of liver-QI, qi depression to blood stasis also is to form the main pathogenesis of this disease, so lung qi dispersing is regulated the flow of vital energy, the detumescence of reducing phlegm is only the key of this disease of treatment, neurofibroma mostly is multiple benign tumor, can not perform a surgical operation, adopt Chinese medicine to nurse one's health, treatment by oral administration of medicines leads directly to the gas lung qi dispersing, relieving accumulation of pathogens reduces phlegm, but present medicine for various reasons, can not be from basic solution sufferer, therefore, the development of new drug is imperative.

Three, summary of the invention

At above-mentioned situation, for overcoming the prior art defective, the present invention's purpose just provides a kind of Chinese medicine for the treatment of neurofibromatosis, can effectively solve because of inhibited pulmonary QI, depression of liver-QI, qi depression to blood stasis, the shaping of accumulating in the course of time, send out and be the problem of neurofibroma, the technical scheme of its solution is, this Chinese medicine is by Herba Ephedrae 72-88g, Fructus Perillae 108-132g, Radix Platycodonis 108-132g, Semen Lepidii (Semen Descurainiae) 135-165g, Pericarpium Citri Reticulatae 108-132g, Fructus Aurantii Immaturus 90-110g, Poria 108-132g, Bulbus Fritillariae Cirrhosae 90-110g, Rhizoma Pinelliae 108-132g, Thallus Laminariae (Thallus Eckloniae) 90-110g, Herba Hedyotidis Diffusae 270-330g, Radix Glycyrrhizae 45-55g makes, wherein, earlier with Herba Ephedrae, Pericarpium Citri Reticulatae, Poria, Bulbus Fritillariae Cirrhosae, the Rhizoma Pinelliae, Fructus Aurantii Immaturus, the Radix Glycyrrhizae crushing fine powder, make its grain diameter≤10 μ m (crossing 300 mesh sieves), mixing, standby, again with Fructus Perillae, Radix Platycodonis, Semen Lepidii (Semen Descurainiae), Thallus Laminariae (Thallus Eckloniae), Herba Hedyotidis Diffusae totally 5 flavors was added water to submerge 30-40 minute, decoct secondary, each 1.5 hours, collecting decoction, be concentrated into extractum, relative density is 1.20-1.30, fine powder added with the extractum of extraction mix and patent medicine sticks together, place baking oven 70-85 ℃ to be dried to moisture less than after 5%, take out, can directly take medicine when taking and stick together, also can be processed into capsule, sheet, pill.Prescription science of the present invention, therapeutic effect is good, taking convenience, side's epheday intermedia, Fructus Perillae, Radix Platycodonis dispersing lung-QI and dissipating phlegm are monarch, Semen Lepidii (Semen Descurainiae), Pericarpium Citri Reticulatae, Fructus Aurantii Immaturus, Poria, Bulbus Fritillariae Cirrhosae, the Rhizoma Pinelliae, the dampness removing of regulating the flow of vital energy, reducing phlegm is minister, Thallus Laminariae (Thallus Eckloniae), Herba Hedyotidis Diffusae, and the hot eliminating phlegm of Eradicates, hard masses softening and resolving are assistant, Radix Glycyrrhizae is in harmonious proportion, and drug storage is taken a broad view of full side for making, the little YAOJING in side, merit is concentrated one's efforts grand, the lung qi dispersing that gathers altogether regulate the flow of vital energy, the reduce phlegm merit of detumescence, hard masses softening and resolving, it is succeeded in developing, and is an innovation on the Chinese medicine, and economic and social benefit is huge.

Four, the specific embodiment

Below in conjunction with practical situation the specific embodiment of the present invention is elaborated.

Embodiment 1, the present invention is by Herba Ephedrae 75g, Fructus Perillae 110g, Radix Platycodonis 110g, Semen Lepidii (Semen Descurainiae) 140g, Pericarpium Citri Reticulatae 110g, Fructus Aurantii Immaturus 95g, Poria 110g, Bulbus Fritillariae Cirrhosae 95g, Rhizoma Pinelliae 110g, Thallus Laminariae (Thallus Eckloniae) 95g, Herba Hedyotidis Diffusae 290g, Radix Glycyrrhizae 48g makes, wherein, earlier with Herba Ephedrae, Pericarpium Citri Reticulatae, Poria, Bulbus Fritillariae Cirrhosae, the Rhizoma Pinelliae, Fructus Aurantii Immaturus, the Radix Glycyrrhizae crushing fine powder, make its grain diameter be≤10 μ m (crossing 300 mesh sieves), mixing, standby, again with Fructus Perillae, Radix Platycodonis, Semen Lepidii (Semen Descurainiae), Thallus Laminariae (Thallus Eckloniae), Herba Hedyotidis Diffusae totally 5 flavors was added water to submerge 30 minutes, decoct secondary, each 1.5 hours, collecting decoction was concentrated into extractum, relative density is 1.20, fine powder added with the extractum of extraction mix and patent medicine sticks together, place 80 ℃ in baking oven to be dried to moisture less than after 5%, take out, can be made into ball, or tablet, or capsule;

Embodiment 2, the present invention also can be by Herba Ephedrae 80g, Fructus Perillae 120g, Radix Platycodonis 120g, Semen Lepidii (Semen Descurainiae) 150g, Pericarpium Citri Reticulatae 120g, Fructus Aurantii Immaturus 100g, Poria 120g, Bulbus Fritillariae Cirrhosae 100g, Rhizoma Pinelliae 120g, Thallus Laminariae (Thallus Eckloniae) 100g, Herba Hedyotidis Diffusae 300g, Radix Glycyrrhizae 50g makes, wherein, earlier with Herba Ephedrae, Pericarpium Citri Reticulatae, Poria, Bulbus Fritillariae Cirrhosae, the Rhizoma Pinelliae, Fructus Aurantii Immaturus, the Radix Glycyrrhizae crushing fine powder, making its grain diameter was 300 mesh sieves, mixing, standby, again with Fructus Perillae, Radix Platycodonis, Semen Lepidii (Semen Descurainiae), Thallus Laminariae (Thallus Eckloniae), Herba Hedyotidis Diffusae totally 5 flavors was added water to submerge 40 minutes, decoct secondary, each 1.5 hours, collecting decoction was concentrated into extractum, relative density is 1.25, fine powder added with the extractum of extraction mix and patent medicine sticks together, place baking oven to be dried to moisture 4% for 80 ℃, take out, can be made into ball, or tablet, or capsule;

In said medicine, wherein:

Herba Ephedrae: the removal of impurity and woody stems, clean, cutting is dried respectively, cures mainly anemofrigid cold, cough and asthma, the edema case of a physically strong patient running a high fever and has table disease person that there is curative effect preferably at the acute nephritis initial stage;

Fructus Perillae: the removal of impurity, clean, have the sending down the abnormal ascending QI expectorant, to relieving asthma, the effect of intestine moistening is used for expectorant and stops up QI rising in reverse order, cough and asthma, dryness of the intestine constipation;

Radix Platycodonis: the removal of impurity, clean, dry, have lung qi dispersing, sore-throat relieving eliminates the phlegm, the effect of evacuation of pus;

Semen Lepidii (Semen Descurainiae): the removal of impurity, clean, dry, have eliminating phlegm relieving asthma, the effect of eliminating the pathogens from the lung diuretic;

Pericarpium Citri Reticulatae: clean, dry, have regulating QI and lowering the adverseness, whet the appetite in the accent, the effect of drying dampness to eliminate phlegm is used for the wet resistance of stagnation of QI in spleen and stomach, and chest and diaphragm is full vexed, abdominal distention, anorexia, vomiting hiccup, difficulty in urination and defecation, lung qi retardance, cough with copious phlegm;

Fructus Aurantii Immaturus: clean, dry, have the dispelling the stagnated QI removing food stagnancy, the effect of painful abdominal mass of loosing of reducing phlegm is used for stopping in stagnant, and the feeling of fullness distending pain is heavy behind the dysentery, constipation, the expectorant vapour lock thoracic obstruction that stagnates, blocked-up chest, gastroptosis, proctoptosis, uterine prolapse;

Poria: the removal of impurity, section, drying, have promoting diuresis to eliminate damp pathogen, the effect of spleen invigorating mind calming is used for the edema oliguria, the phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in the loose stool, irritability, palpitation with fear insomnia;

Bulbus Fritillariae Cirrhosae: the removal of impurity, another name Bulbus Fritillariae Cirrhosae, crow flower Bulbus Fritillariae Uninbracteatae have nourishing the lung to arrest cough, the effect of resolving phlegm and relieving asthma;

The Rhizoma Pinelliae: the removal of impurity, clean, section, drying, have drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the effect of dissolving lump and resolving mass is used for the abundant expectoration cough with asthma, the phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, the syncope due to accumulation of phlegm headache, vomiting regurgitation, breast gastral cavity painful abdominal mass is vexed, globus hystericus;

Thallus Laminariae (Thallus Eckloniae): the removal of impurity, clean, dry, have hard masses softening and resolving, expectorant, diuretic is used for goiter, scrofula, painful and swollen testis, phlegm retention edema;

Herba Hedyotidis Diffusae: another name Herba Hedyotidis Diffusae, the removal of impurity, clean, dry, has the clearing up internal heat by using drugs of bitter in taste and cold in nature detoxifcation, the effect of sweet cold eliminating damp-heat, carbuncle, pharyngalgia, snakebite etc. there is stronger removing toxicity for eliminating carbuncles effect, generally be used for the treatment of sore, laryngopharynx swelling and pain, abdominalgia with intestinal abscess, venom, also be used for the puckery pain of pyretic stranguria, dysuria;

Radix Glycyrrhizae: decontamination, clean, dry, have invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, nourishing the lung to arrest cough, coordinating the actions of various ingredients in a prescription is used for stomach, duodenal ulcer, stomach spasm, diarrhea due to hypofunction of the spleen, insufficiency of stomach is thirsty, the cough due to deficiency of the lung.

By last all medicine compatibilities as can be known, the present invention has lung qi dispersing reason, regulating QI, the detumescence of reducing phlegm, and is effective to the treatment of neurofibromatosis, taking convenience, simple, and effective, clinical data has fully to be proved, the concrete relevant relevant clinical data of the present invention is as follows:

One, selects the standard of case

Good sending out in trunk also is common in face and extremity, and tumor is swollen with from skin, poor growth, for multiple, number can not wait from several extremely over thousands of, difference in size is very big, and big to fist greatly from the grain of rice, quality is hard or soft, but most matter are soft, with the depression of finger pressure, can upspring the visible local skin of multiple physocele of part head and neck and extremity portion behind the removal pressure, skin undertissue edema, hyperplasia, thicken, harden and follow the string, the color of the leather of tumor is constant, have or the band pale red, another kind be first generation brown patch not of uniform size, anything superfluous or useless then takes place again, pigmented spots and anything superfluous or useless can also can take place at different parts simultaneously at same position, and sarcoma part lump is born in subcutaneous, matter is soft, similar physocele, but majority is lobulated, no compressibility, and it can not be clamp-oned subcutaneous, the angioma thing softness that swells, indefinite border, touch as spongy, or the lump surface color is scarlet or purple dark, can not fade during pressurization.

Two, diagnostic criteria

1, tcm diagnosis standard: with reference to (the tcm diagnosis efficacy assessment standard) of Society of Internal Medicine of All-China Association of Traditional Chinese Medicine revision in 1986 and " the diagnosis criterion of therapeutical effect of disease of tcm " of national traditional chinese medical science administration issue

(1), primary symptom: whole body many places tumor, soft and not hard, color of the leather as before or disappear or long do not have heat and do not have cold;

(2), onset is slow;

(3), disease is sent out congenital and each age group;

(4), male's adolescence tumor body from shirtfront back to extremity, women's head-ornaments portion mottle, the tumor body increases, increases, female fertility phase whole body tumor body, mottle begin to increase, and increase, and have 20%-50% people may this disease of heredity;

2, Western medicine diagnose standard

Neurofibromatosis is that more rare autosomal dominant inherited disease is a kind of disease of neural skin syndrome, being described in 1849 the earliest and reporting of its clinical symptoms by Smith, VenReeklinghausen passed through pathological research in 1882, set forth in more detail primary disease tissue characteristic and with the relation of nervous tissue, universally acknowledged diagnostic criteria now is:

(1), the coffee with milk speckle, preadolescence has 〉=speckle of 6 diameter 5mm, after the adolescence 〉=speckle of 6 diameter 15mm;

(2), 〉=2 an any kind neurofibroma or a plexiform neurofibroma;

(3), groin or axillary fossa passeris montani saturati speckle;

(4), 〉=2 a Lisech access node saves (iris hamartoma);

(5), clear and definite bone infringement;

(6), first degree relative has NF1, NF1 patient should meet above two at least; The NF2 patient diagnosis should: meet following both one of:

(1), bilateral acoustic neuroma (vestibular nerve sheath tumor);

(2), the neuroma of eavesdropping accompanies by following two kinds of pathological changes: neurofibroma, schwannoma (schwann cell tumor), meningioma, glioma or vitreous opacity, NF2 is the maincenter type of NF, can be divided into amphitypy again according to clinical manifestation: the morbidity in the past in 20 years old of Wishart type, severe symptoms, often with tumor of spinal cord, symptom was lighter with sequela in 20 years old for the Gard-ner type, and focus often is confined to intracranial.

Three, therapeutic scheme

The oral Chinese medicine of the present invention of patient, every day 2 times, each 12g, the child is cut down according to the circumstance, and takes half an hour after meal, takes medicine and stops in 7 days 1 day three months courses of treatment, adds up therapeutic outcome three courses of treatment.

Four, efficacy assessment standard

Cure: mottle, tumor body disappear and are main standard;

Produce effects: the mottle color is thin out, color lump dwindles, the tumor body diminishes;

Effectively: mottle, tumor body reduce;

Invalid: mottle, tumor body do not change.

Five, statistical disposition

Neurofibroma patient through 101 examples being taken Chinese medicine of the present invention in 2 years adds up, in 101 routine patients, and women 58 examples of man's 43 examples, the oldest 53 years old, minimum 5 years old, 26 years old mean age, in the above patient treatment, cure: 41 people, produce effects: 40 people, effectively: 18 people, invalid: 2 people, total effective rate: 98%, in patient's medication, there is no toxicity, show that this medicine is the medicine of treatment neurofibromatosis effective and safe.

Six, conclusion

Shown that by above-mentioned the present invention is the active drug of treatment neurofibromatosis, method is simple, and is effective, and expense is low, and actual clinical meaning is arranged, and for the neurofibroma patient provides the good curing condition, is that one on the Chinese medicine and pharmacy created greatly, makes and benefits society.

Claims (3)

1. Chinese medicine for the treatment of neurofibromatosis, it is characterized in that, by Herba Ephedrae 72-88g, Fructus Perillae 108-132g, Radix Platycodonis 108-132g, Semen Lepidii (Semen Descurainiae) 135-165g, Pericarpium Citri Reticulatae 108-132g, Fructus Aurantii Immaturus 90-110g, Poria 108-132g, Bulbus Fritillariae Cirrhosae 90-110g, Rhizoma Pinelliae 108-132g, Thallus Laminariae (Thallus Eckloniae) 90-110g, Herba Hedyotidis Diffusae 270-330g, Radix Glycyrrhizae 45-55g makes, wherein, earlier with Herba Ephedrae, Pericarpium Citri Reticulatae, Poria, Bulbus Fritillariae Cirrhosae, the Rhizoma Pinelliae, Fructus Aurantii Immaturus, the Radix Glycyrrhizae crushing fine powder, make its grain diameter≤10 μ m, mixing, standby, again with Fructus Perillae, Radix Platycodonis, Semen Lepidii (Semen Descurainiae), Thallus Laminariae (Thallus Eckloniae), Herba Hedyotidis Diffusae totally 5 flavors was added water to submerge 30-40 minute, decoct secondary, each 1.5 hours, collecting decoction, be concentrated into extractum, relative density is 1.20-1.30, fine powder is added with the extractum of extraction mixes, 70-85 ℃ dry to moisture less than 5%.

2. a kind of Chinese medicine for the treatment of neurofibromatosis according to claim 1, it is characterized in that, by Herba Ephedrae 75g, Fructus Perillae 110g, Radix Platycodonis 110g, Semen Lepidii (Semen Descurainiae) 140g, Pericarpium Citri Reticulatae 110g, Fructus Aurantii Immaturus 95g, Poria 110g, Bulbus Fritillariae Cirrhosae 95g, Rhizoma Pinelliae 110g, Thallus Laminariae (Thallus Eckloniae) 95g, Herba Hedyotidis Diffusae 290g, Radix Glycyrrhizae 48g makes, wherein, earlier with Herba Ephedrae, Pericarpium Citri Reticulatae, Poria, Bulbus Fritillariae Cirrhosae, the Rhizoma Pinelliae, Fructus Aurantii Immaturus, the Radix Glycyrrhizae crushing fine powder, making its grain diameter is≤10 μ m, mixing, standby, again with Fructus Perillae, Radix Platycodonis, Semen Lepidii (Semen Descurainiae), Thallus Laminariae (Thallus Eckloniae), Herba Hedyotidis Diffusae totally 5 flavors was added water to submerge 30 minutes, decoct secondary, each 1.5 hours, collecting decoction, be concentrated into extractum, relative density is 1.20, and the extractum adding of fine powder with extraction mixed, and places baking oven to be dried to moisture less than 5% for 80 ℃.

3. a kind of Chinese medicine for the treatment of neurofibromatosis according to claim 1, it is characterized in that, by Herba Ephedrae 80g, Fructus Perillae 120g, Radix Platycodonis 120g, Semen Lepidii (Semen Descurainiae) 150g, Pericarpium Citri Reticulatae 120g, Fructus Aurantii Immaturus 100g, Poria 120g, Bulbus Fritillariae Cirrhosae 100g, Rhizoma Pinelliae 120g, Thallus Laminariae (Thallus Eckloniae) 100g, Herba Hedyotidis Diffusae 300g, Radix Glycyrrhizae 50g makes, wherein, earlier with Herba Ephedrae, Pericarpium Citri Reticulatae, Poria, Bulbus Fritillariae Cirrhosae, the Rhizoma Pinelliae, Fructus Aurantii Immaturus, the Radix Glycyrrhizae crushing fine powder, making its grain diameter was 300 mesh sieves, mixing, standby, again with Fructus Perillae, Radix Platycodonis, Semen Lepidii (Semen Descurainiae), Thallus Laminariae (Thallus Eckloniae), Herba Hedyotidis Diffusae totally 5 flavors was added water to submerge 40 minutes, decoct secondary, each 1.5 hours, collecting decoction, be concentrated into extractum, relative density is 1.25, and the extractum adding of fine powder with extraction mixed, and places baking oven to be dried to moisture 4% for 80 ℃.