CN101342223A - Jade butterfly beauty treatment speckle removing plaster and preparation method thereof - Google Patents
Jade butterfly beauty treatment speckle removing plaster and preparation method thereof Download PDFInfo
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- CN101342223A CN101342223A CNA2008100634020A CN200810063402A CN101342223A CN 101342223 A CN101342223 A CN 101342223A CN A2008100634020 A CNA2008100634020 A CN A2008100634020A CN 200810063402 A CN200810063402 A CN 200810063402A CN 101342223 A CN101342223 A CN 101342223A
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Abstract
The present invention relates to a jade butterfly beautifying and ecchymoses removing cream and a preparation method thereof. The cream contains a pharmaceutical product and a cream matrix; the pharmaceutical product is extracted from persimmon leaf, India trumpetflower and Chinese dodder; India trumpetflower, persimmon leaf and Chinese dodder are respectively decocted with water and the decoction is mixed, filtered and condensed to obtain a supernatant fluid; the supernatant fluid (medicinal components) is added into the cream matrix and the proportion between the pharmaceutical product and the cream matrix is 5:1 to 5:5. The jade butterfly beautifying and ecchymoses removing cream prepared by the present invention has the effects of nourishing qi and tonifying kidney-yin; nourishing skin and removing ecchymoses, especially suitable for chloasma on face caused by blood stasis; having no stimulus to skin and efficacy of beautifying, protection skin and removing ecchymoses, which is a beautifying medicinal product.
Description
(1) technical field:
The present invention relates to a kind of facial area that is used for the treatment of and jade butterfly beauty treatment speckle removing plaster of yellowish-brown patch and preparation method thereof occurs.
(2) background technology:
Chloasma, the traditional Chinese medical science are referred to as " chloasma ", also are referred to as " dusty face " person, are that the yellowish-brown patch appears in a kind of facial area, have the chronic pigment anomaly dermatoses that decreases capacitive.Pregnancy women is more common in its morbidity, menoxenia person and some other gynecological diseases, also have some chronic diseases as: hepatopathy, the tuberculosis primary disease that often occurred together, male and many unmarried women also often have trouble simultaneously.And nearly 20-30 comes the generation increasing day by day of this disease, and is superficial though primary disease does not have obvious subjective symptoms, and whole body health is had not big harm, the infringement of its appearance to the patient cause mentally, psychological injury is very big.And to this disease at present clinically, Chinese and western medicine and medical cosmetology circle all still do not have ideal Drug therapy, particularly medicine for external application lack especially as.In order better to develop and excavate pools of traditional Chinese medicine, allow the Chinese medicine be that human beings'health and good days are made bigger contribution, so it is very necessary to develop a kind of medicine for external use for the treatment of chloasma.
(3) summary of the invention:
Task of the present invention is according to traditional Chinese medical science principle, a kind of jade butterfly beauty treatment speckle removing plaster agent that is used for the treatment of chloasma, senile plaque that can suitability for industrialized production is provided, effect with skin care, skin protection, speckle dispelling, and be unguentum, guarantee fully to contact, give skin suitable oils and fats, can guarantee that the composition in the medicine discharges very fast simultaneously with skin, select the oil-in-water ointment, bring into play curative effect of medication to greatest extent.
Another task of the present invention has provided the preparation method of jade butterfly beauty treatment speckle removing plaster of the present invention.
The preparation of the present invention's development, used medicine are based on Folium Kaki, but this property of medicine is distinguished the flavor of, function rarely has record especially for the treatment chloasma in ancient books, modern doctor and herbal medicine.Therefore the use value of developing Folium Kaki is undoubtedly a kind of very significant work.Research and development of the present invention have following advantage: 1. the deficiency that has remedied current treatment chloasma Chinese medicine medicine for external use (preparation) from clinical practice.2. Folium Kaki is used seldom clinically, and medicine source electrode horn of plenty, and is cheap, preparation is easy, and by clinical verification, satisfactory effect is convenient to be extensive use of and can obtain good social benefit and economic benefit.The income that particularly improves hill farmer also is considerable.
The etiology and pathogenesis more complicated of chloasma, all internal injury caused by excess of seven emotions, stagnation of QI due to depression of the liver, improper diet and overtiredness, women's irregular menstruation or the like all can cause the generation of primary disease.The normal physiological activity of skin is to rely on the four stages in the course of an epidemic febrile disease body fluid that internal organs produce, and keeps by the defeated cloth of passages through which vital energy circulates.As: " Ling Shu Miraculous Pivot or Divine Axis. pathogen is hidden the sick shape piece of writing in mansion ": " twelve regular channels, 365 networks, its vim and vigour all go up in face, and walk the sky key ".Again " element is asked. six joints are hidden and are resembled opinion ": " heart ... its China is at face, and it fills at blood vessels ".Therefore, the face colour of skin is even, and the bright profit of gloss guarantees by honor on the defeated cloth of blood vessels operation by the five internal organs vital essence.If function of five internal organs imbalance disharmony between QI and blood, vital essence is weak, can not go up flourish in the then full of stains or spots and sick change of the face colour of skin of face.Dialectical according to diagnosis according to the five colors, yellow main spleen, blue or green main liver, black main kidney and blood stasis.Main and liver,spleen,kidney Threefold Canon pathological changes of the generation of primary disease and qi depression to blood stasis are in close relations.Blood stored in the liver, main catharsis, if feelings will is unsuccessful, the rage impairing the liver, depression of liver-QI, the catharsis imbalance, QI and blood is contrary, can not go up flourish in face SHENGHUANG brown patch sheet then; The spleen being in charge of dampness, if main fortuneization is intemperance of taking food, have a liking for the five tastes or melancholy impairing the spleen partially, deficiency of spleen-QI, fortuneization is inconsiderate, QI and bloodization is given birth to and is not filled, and accumulate in water is wet, so that QI and blood is few flourish in face, and general in face also SHENGHUANG brown patch sheet on the gas that water wets: the kidney being a ZANG-organ containing both water and fire, prolonged illness is impairment of the kidney or excess of sexual intercourse, and the damage kidney essense makes insufficiency of water leading to hyperactivity of fire, it is SHENGHUANG brown patch sheet that hyperactivity of deficient fire, pent-up do not loose.So the genesis mechanism of primary disease mainly is because liver,spleen,kidney three dirty functional disorders cause.Blood stasis due to qi deficiency, disharmony between QI and blood, special recent studies is illustrated and is emphasized " blood stasis " important function in chloasma forms, so the viewpoint of " the no stasis of blood does not become speckle " is arranged.
The treatment of chloasma should be based on treatment by oral administration of medicines, and external treatment is the principle of assisting.According to the performance of its morbidity, carry out determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, belong to the stagnation of QI due to depression of the liver person, suitable liver-smoothing, qi-regulating, it is main invigorating blood circulation, and belongs to the insufficiency of the spleen wet person of accumulateing, suitable invigorating the spleen and benefiting QI, damp eliminating is main, belongs to the deficiency of kidney-YIN person, suitable enriching yin and nourishing kidney, its external treatment should be taken all factors into consideration the cause of disease, syndrome, treating both the principal and secondary aspects of a disease, by the QI invigorating replenishing essence, change the silt speckle removing, so external treatment is also occupied crucial status in the treatment of primary disease.It can not only cooperate the internal treatment to improve curative effect, and single with external treatment also may command, mitigate the disease so that reach the healing purpose.What should propose especially is the primary disease rising day by day of sickness rate in the last few years, and a lot of patients there is no with other sufferer, the simple facial yellowish-brown patch that occurs.As have plenty of with use cosmetics inferior or be subjected to Exposure to Sunlight, contact chemical substance and environment, due to the weather, pollution variation.Also also have many agnogenio, the patient that whole body is all right, the suitable external treatment that adopts of this type of morbidity crowd, more because external treatment is easy to use, simply this also is the treatment that the patient is easy to accept.
Medicinal composition is Folium Kaki, Semen Cuscutae, Semen Oroxyli three flavor medicines in the jade butterfly beauty treatment speckle removing plaster of the present invention.The Folium Kaki bitter in the mouth, cold in nature, nontoxic, specially go into lung meridian, cure mainly cough with asthma, lung qi expands, various internal hemorrhages.(" Chinese medicine dictionary ") all do not find the record of relevant Folium Kaki treatment chloasma in numerous medical books.Do not seen relevant report yet.Only the function of relevant " Fructus kaki Siccus " has in curing mainly in supplement to the Herbal: " polyphagia removes face, removes stagnated blood in the abdomen." this selects and can illustrate that also Fructus kaki Siccus has the effect of disappear mottle and elimination blood stasis.In addition do not find relevant therewith record.By clinical practice for many years, use single Folium Kaki levigation, be configured to external-applied ointment, be applied to the fact that the chloasma part can make mottle go down, can prove that Folium Kaki has the effect of speckle removing.Dosage is big in the prescription, plays a leading role, so be monarch drug.With butterfly be ministerial drug, its nature and flavor bitter cold has lung heat clearing function such as regulate the flow of vital energy.The record of external is arranged, as " the treating the liver pain due to disorder of QI pastes carbuncle, the argumentation that the bottom is damp and hot " in the Compendium of Material Medica.Be minister with it in this prescription, real assistant monarch drug surplusly stagnantly also can play good effectiveness for damp and hot except that the mottle of dispelling.(the blue or green middle age of this disease is for seeing more, and often can see trace after the acne).Semen Cuscutae, its nature and flavor suffering, sweet, flat is gone into the Liver and kidney warp, is for mending the key medicine of liver,spleen,kidney three warps.(" book on Chinese herbal medicine is dredged warp ").Be product on the yin nourishing collateral dredging, its little suffering of distinguishing the flavor of has sun in the moon, keeps and can walk.Among the five tastes, suffering can be led to four gas " warp " Yan Xin to moisten it, and the genus of Semen Cuscutae is also ..., the function of also soft and moist skin." book on Chinese herbal medicine justice ", so Semen Cuscutae can be transferred tonifying liver spleen kidney, beneficial menses reach the adjusting function, the purpose of skin moistening is adjuvant drug.
According to traditional Chinese medical science principle, the present inventor's long-felt is summed up the jade butterfly beauty treatment speckle removing plaster agent that draws, and its medicinal ingredient extracts from Folium Kaki, Semen Oroxyli, Semen Cuscutae three flavor medicines, and component (by weight) scope of three flavor medicines is: Folium Kaki 10～30, Semen Oroxyli 5～25, Semen Cuscutae 1～5.
The jade butterfly beauty treatment speckle removing plaster agent that the present invention relates to, its medicinal ingredient extracts from Folium Kaki, Semen Oroxyli, Semen Cuscutae three flavor medicines, and preferred component (by weight) scope of three flavor medicines is to be unit with the weight portion: Folium Kaki 20, Semen Oroxyli 15, Semen Cuscutae 2.
The preparation method of the jade butterfly beauty treatment speckle removing plaster that contains the said medicine component that the present invention relates to comprises the steps:
A) preparation medicament: get Semen Oroxyli by prescription, decoct with water secondary, each 1～4 hour, decoct with water for the first time 10～30 times the water yield that the added water yield is a medical material weight, the water yield that adds for the second time is 5～25 times of medical material weight, collecting decoction, filter, get Semen Oroxyli filtrate A; After getting Folium Kaki, Semen Cuscutae medical material and mix by prescription, decoct with water secondary, each 0.3～2 hour, decoct 10～30 times the water yield that adds the medical material gross weight for the first time, decoct 5～25 times the water yield that adds the medical material gross weight, collecting decoction for the second time, filter, get Folium Kaki, Semen Cuscutae liquor B; Merging filtrate A and liquor B are concentrated into 400～900ml (relative density is 1.00～1.20) under 50～60 ℃ condition, centrifugal filtration obtains supernatant C, and is standby;
B) preparation jade butterfly beauty treatment speckle removing plaster: the supernatant C medicament that above-mentioned processing is extracted adds in the mastic substrate, and mix homogeneously promptly obtains jade butterfly beauty treatment speckle removing plaster, and the ratio of medicament and mastic substrate is 5: 1～5: 5.
The jade butterfly beauty treatment speckle removing plaster that the present invention relates to is that the supernatant C medicament with above-mentioned preparation is to follow these steps to add in the mastic substrate:
(1) gets 15～25 parts of stearic acid, 15～25 parts of glyceryl monostearates, 15～25 parts of octadecanol, 5～15 parts of hexadecanol, 10～20 parts of light liquid petrolatums, 30～80 parts of MCT Oil, 0.5～2 part of butylated hydroxytoluene by weight, mix, be heated to 85 ℃ while stirring, dissolve oil phase, be incubated standby;
(2) get 20～70 parts of glycerol, 20～40 parts of propylene glycol, 15～25 parts of polyoxyl stearate, 5～15 parts of sucrose stearate S-15,1～5 part of potassium sorbate by weight, mix, add an amount of distilled water (addition of distilled water, be as the criterion to supply mastic substrate umber), the medicament supernatant C that adds above-mentioned preparation then, be heated to 85 ℃ while stirring, be incubated water;
(3) water is slowly added in the standby oil phase of insulation, constantly stir, speed 50～4000r/min, emulsifying 10-40 minute, continue stirring and be cooled to about 40 ℃, stir, make mastic.In water and the oil phase mixing process, can add an amount of essence seasoning.
Jade butterfly beauty treatment speckle removing plaster of the present invention be yellowish-brown to the sepia emulsifiable paste, feeble QI perfume (or spice).Can differentiate in the following manner by the jade butterfly beauty treatment speckle removing plaster agent that the present invention obtains:
(1) gets product 20g of the present invention, add 0.4%NaOH solution 50ml, 30 minutes (power 250W of supersound process, frequency 40kHz), extracts secondary, each 30ml with the petroleum ether jolting, discard petroleum ether liquid, the NaOH extracting solution extracts with water-saturated n-butanol 30ml jolting, discards n-butyl alcohol liquid, and the NaOH extracting solution adds concentrated hydrochloric acid and transfers pH about 2, put in the water-bath and refluxed 30 minutes, put coldly, extract secondary with the ethyl acetate jolting, each 30ml, combined ethyl acetate liquid, evaporate to dryness, residue add ethyl acetate 1ml dissolving, as need testing solution.Respectively get Folium Kaki medical material 0.5g and Semen Cuscutae medical material 0.2g, add 0.4%NaOH solution 50ml, make Folium Kaki medical material solution and Semen Cuscutae medical material solution with method.Other gets the Quercetin reference substance, adds ethyl acetate and makes the solution that every 1ml contains 0.1mg, in contrast product solution.Test according to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2005), each draws need testing solution 12 μ l (need testing solution comprises three kinds: need testing solution of the present invention, Folium Kaki medical material solution and Semen Cuscutae medical material solution), reference substance solution 5 μ l, put respectively on same silica gel g thin-layer plate, launch with petroleum ether (60-90 ℃) earlier, dry, be developing solvent with chloroform-ethyl acetate-formic acid (5: 3: 1) again, launch, take out, dry, spray is inspected under ultra-violet lamp (365nm) with 5% aluminum chloride alcoholic solution.In the test sample chromatograph, with Folium Kaki medical material, Semen Cuscutae medical material chromatograph and reference substance chromatograph relevant position on, show the fluorescence speckle of same color.Show that the present invention contains Folium Kaki medical material and Semen Cuscutae medical material.
(2) product of the present invention should meet relevant every regulation (appendix IR of Chinese Pharmacopoeia version in 2005) of ointment under the ointment item.
(3) content of baicalin is measured: measure according to high performance liquid chromatography (appendix VID of Chinese Pharmacopoeia version in 2005).
Chromatographic condition and system suitability test: with octadecylsilane chemically bonded silica is filler; Methanol-0.4% phosphoric acid solution (40: 60) is a mobile phase; The detection wavelength is 278nm.Number of theoretical plate calculates by the baicalin peak should be not less than 2500.
The preparation of reference substance solution: precision takes by weighing at 4 hours baicalin reference substance of 60 ℃ of drying under reduced pressure an amount of, adds ethanol and makes the solution that every 1ml contains 10 μ g.
The preparation of need testing solution: get the about 3g of product of the present invention, the accurate title, decide, and puts in the conical flask, the accurate ethanol 50ml that adds, claim to decide weight, supersound process 30 minutes (power 250W, frequency 40kHz) is put cold, supply the weight that subtracts mistake with ethanol, shake up, filter with microporous filter membrane (0.45 μ m), promptly.
Algoscopy: accurate respectively reference substance solution 10 μ l and each 10 μ l of need testing solution of drawing, inject chromatograph of liquid, measure, promptly.The every 1g of this product contains Semen Oroxyli in baicalin, must not be lower than 0.1mg.Show that the present invention contains the Semen Oroxyli medical material.
The jade butterfly beauty treatment speckle removing plaster that the present invention makes, the flesh speckle removing is supported in the QI invigorating replenishing essence, is applicable to the chloasma faciei due to the QI and blood stasis asthenia of essence and blood.Effect with skin care, skin protection, speckle dispelling is the beauty and skin care medicine.
The present invention is an ointment, guarantees fully to contact with skin, gives skin suitable oils and fats, can guarantee that the composition in the medicine discharges comparatively fast simultaneously, selects the oil-in-water ointment, brings into play curative effect of medication to greatest extent.
The jade butterfly beauty treatment speckle removing plaster that the present invention makes is the external agent, cleans facial before using, get and embrocate in right amount in the facial colour spot place, every day 2～3 times, it is one month that general chloasma is treated the course of treatment, after the use, the facial colour spot area reduces or disappears, and skin pigment is thin out or disappear.Through clinic trial, do not see apparent side effect.
The dermatologic irritant experiment of product of the present invention
1) respectively guinea pig skin is carried out sensitization by product of the present invention and contact, do not cause the anaphylactic reaction of Cavia porcellus with excitability.
2) by product of the present invention to the test of the skin irritation of rabbit, confirm: accept the rabbit of jade butterfly beauty treatment speckle removing plaster, at whole viewing duration, spirit, activity, hair, ingest, feces etc. there is no unusual performance; Intact skin group and damaged skin treated animal and arranged on left and right sides skin, do not see hyperemia is arranged, local excitation such as edema reaction.
Conclusion: product of the present invention is to the skin nonirritant.
All do not cause the animal general toxic reaction by acute toxicity test and long term toxicity test (rabbit three months) to this product, the rabbit body weight there is not obvious influence, 15 biochemical indicators such as peripheral hemogram regulating liver-QI, renal function all fluctuate in normal range, also do not see have through pathological study, local skin is not had the obvious stimulation effect yet because of the caused pathological change of medicine.Illustrating that product of the present invention does not have obvious toxicity in institute's amount of reagent scope, is comparison safety.
In the prescription of the present invention, be to obtain active ingredient through the modern Chinese medicine extractive technique, be aided with the ointment that the substrate of unguentum is made, because of not containing heavy metal and hormone like substance by natural Folium Kaki, Semen Oroxyli, Semen Cuscutae three flavor medical materials, skin is had no stimulation, thereby can guarantee safe medication.In clinical preliminary test, compare the observation of system, after the patient used, the symptom of chloasma can disappear or alleviate, and obvious effective rate is 68%, and total effective rate is more than 99.6%, determined curative effect.
(4) specific embodiments:
Below, with reference to subsidiary embodiment the present invention being described in more detail, these embodiment are limitation of the present invention anything but.
Embodiment 1 preparation 1000kg jade butterfly beauty treatment speckle removing plaster, medicament: mastic substrate=5: 5
(1) the medicinal ingredient prescription (kg) in the jade butterfly beauty treatment speckle removing plaster of the present invention: Folium Kaki 20, Semen Oroxyli 15, Semen Cuscutae 2;
(2) extraction of medicinal ingredient obtains 500kg supernatant C (medicament);
A) get Semen Oroxyli by prescription, decoct with water secondary, each 1～4 hour, decoct with water 10～30 times the water yield that the added water yield is a medical material weight for the first time, the water yield that adds for the second time is 5～25 times of medical material weight, collecting decoction filters, and gets Semen Oroxyli filtrate A;
B) get Folium Kaki, Semen Cuscutae medical material and mix by prescription after, decoct with water secondary, each 0.3～2 hour, decoct 10～30 times the water yield that adds the medical material gross weight for the first time, decoct 5～25 times the water yield that adds the medical material gross weight, collecting decoction for the second time, filter, get Folium Kaki, Semen Cuscutae liquor B;
C) merge above-mentioned filtrate A and liquor B, be concentrated into relative density and be 1.00～1.20 concentrated solution (the about 500kg of concentrated solution) under 50～60 ℃ condition, centrifugal filtration obtains about 500kg supernatant C (medicament), and is standby;
(3) preparation 1000kg jade butterfly beauty treatment speckle removing plaster, wherein mastic substrate is 500kg:
A) get stearic acid 15～25kg, glyceryl monostearate 15～25kg, octadecanol 15～25kg, hexadecanol 5～15kg, light liquid petrolatum 10～20kg, MCT Oil 30～80kg, butylated hydroxytoluene 0.5～2kg, mix, be heated to 85 ℃ while stirring, dissolve oil phase, be incubated standby;
B) get glycerol 20～70kg, propylene glycol 20～40kg, polyoxyl stearate 15～25kg, sucrose stearate S-15 5～15kg, potassium sorbate 1～5kg by weight, mix, adding distil water (the amount of distilled water, be advisable to 500kg to supply mastic substrate), the medicament supernatant C (about 500kg) that adds above-mentioned preparation then, be heated to 85 ℃ while stirring, be incubated water;
C) water is slowly added in the standby oil phase of insulation, constantly stir speed 50～4000r/min, emulsifying 10～40 minutes continues stirring and is cooled to about 40 ℃, stirs, can add an amount of essence,, make the 1000kg ointment to improve the fragrance of ointment.
Embodiment 2 preparation 1000kg jade butterfly beauty treatment speckle removing plasters, medicament: mastic substrate=5: 4
(1) the medicinal ingredient prescription (kg) in the jade butterfly beauty treatment speckle removing plaster of the present invention: get Folium Kaki 15: Semen Oroxyli 18: Semen Cuscutae 5;
(2) extracting method of medicinal ingredient obtains 556kg supernatant C (medicament) with embodiment 1;
(3) preparation method of 1000kg jade butterfly beauty treatment speckle removing plaster is with embodiment 1, and wherein mastic substrate is 444kg.
Embodiment 3 preparation 1000kg jade butterfly beauty treatment speckle removing plasters, medicament: mastic substrate=5: 3
(1) the medicinal ingredient prescription (kg) in the jade butterfly beauty treatment speckle removing plaster of the present invention: get Folium Kaki 10: Semen Oroxyli 25: Semen Cuscutae 1;
(2) extracting method of medicinal ingredient obtains 625kg supernatant C (medicament) with embodiment 1;
(3) preparation method of jade butterfly beauty treatment speckle removing plaster is with embodiment 1, and wherein mastic substrate is 375kg.
Embodiment 4 preparation 1000kg jade butterfly beauty treatment speckle removing plasters, medicament: mastic substrate=5: 2
(1) the medicinal ingredient prescription (kg) in the jade butterfly beauty treatment speckle removing plaster of the present invention: get Folium Kaki 30: Semen Oroxyli 5: Semen Cuscutae 5;
(2) extracting method of medicinal ingredient obtains 714kg supernatant C (medicament) with embodiment 1;
(3) preparation method of jade butterfly beauty treatment speckle removing plaster is with embodiment 1, and wherein mastic substrate is 286kg.
Embodiment 5 preparation 1000kg jade butterfly beauty treatment speckle removing plasters, medicament: mastic substrate=5: 1
(1) the medicinal ingredient prescription (kg) in the jade butterfly beauty treatment speckle removing plaster of the present invention: get Folium Kaki 30: Semen Oroxyli 10: Semen Cuscutae 3;
(2) extracting method of medicinal ingredient obtains 833kg supernatant C (medicament) with embodiment 1;
(3) preparation method of jade butterfly beauty treatment speckle removing plaster is with embodiment 1, and wherein mastic substrate is 167kg.
Embodiment 6 preparation 1000kg jade butterfly beauty treatment speckle removing plasters, medicament: mastic substrate=5: 2
(1) the medicinal ingredient prescription (kg) in the jade butterfly beauty treatment speckle removing plaster of the present invention: get Folium Kaki 20: Semen Oroxyli 16: Semen Cuscutae 5;
(2) extracting method of medicinal ingredient obtains 715kg supernatant C (medicament) with embodiment 1;
(3) preparation method of jade butterfly beauty treatment speckle removing plaster is with embodiment 1, and wherein mastic substrate is 285kg.
Embodiment 7 preparation 1000kg jade butterfly beauty treatment speckle removing plasters, medicament: mastic substrate=5: 1
(1) the medicinal ingredient prescription (kg) in the jade butterfly beauty treatment speckle removing plaster of the present invention: get Folium Kaki 20: Semen Oroxyli 20: Semen Cuscutae 4;
(2) extracting method of medicinal ingredient obtains 834kg supernatant C (medicament) with embodiment 1;
(3) preparation method of jade butterfly beauty treatment speckle removing plaster is with embodiment 1, and wherein mastic substrate is 166kg.
Embodiment 8 preparation 1000kg jade butterfly beauty treatment speckle removing plasters, medicament: mastic substrate=5: 1
(1) the medicinal ingredient prescription (kg) in the jade butterfly beauty treatment speckle removing plaster of the present invention: get Folium Kaki 25: Semen Oroxyli 15: Semen Cuscutae 2;
(2) extracting method of medicinal ingredient obtains 834kg supernatant C (medicament) with embodiment 1;
(3) preparation method of jade butterfly beauty treatment speckle removing plaster is with embodiment 1, and wherein mastic substrate is 166kg.
Claims (4)
1. a jade butterfly beauty treatment speckle removing plaster is characterized in that: contain the medicament that the following weight parts raw material is made in the mastic substrate of jade butterfly beauty treatment speckle removing plaster: Folium Kaki 10～30, Semen Oroxyli 5～25, Semen Cuscutae 1～5.
2. jade butterfly beauty treatment speckle removing plaster according to claim 1 is in its feature: contain the medicament that the following weight parts raw material is made in the mastic substrate of jade butterfly beauty treatment speckle removing plaster: Folium Kaki 20, Semen Oroxyli 15, Semen Cuscutae 2.
3. the preparation method of jade butterfly beauty treatment speckle removing plaster according to claim 1 and 2 is characterized in that comprising the following steps:
A) preparation medicament: get Semen Oroxyli by prescription, decoct with water secondary, each 1～4 hour, decoct with water for the first time 10～30 times the water yield that the added water yield is a medical material weight, the water yield that adds for the second time is 5～25 times of medical material weight, collecting decoction, filter, get Semen Oroxyli filtrate A; After getting Folium Kaki, Semen Cuscutae medical material and mix by prescription, decoct with water secondary, each 0.3～2 hour, decoct 10～30 times the water yield that adds the medical material gross weight for the first time, decoct 5～25 times the water yield that adds the medical material gross weight, collecting decoction for the second time, filter, get Folium Kaki, Semen Cuscutae liquor B; Merging filtrate A and liquor B are concentrated into relative density and are 1.00～1.20 concentrated solution under 50～60 ℃ condition, about 400～900ml, and centrifugal filtration obtains supernatant C, and is standby;
B) preparation jade butterfly beauty treatment speckle removing plaster: the supernatant C medicament that above-mentioned processing is extracted adds in the mastic substrate, and mix homogeneously promptly obtains jade butterfly beauty treatment speckle removing plaster, and the ratio of medicament and mastic substrate is 5: 1～5: 5.
4. the preparation method of jade butterfly beauty treatment speckle removing plaster according to claim 3 is characterized in that: the medicament of above-mentioned preparation is followed these steps to add in the mastic substrate:
(1) gets 15～25 parts of stearic acid, 15～25 parts of glyceryl monostearates, 15～25 parts of octadecanol, 5～15 parts of hexadecanol, 10～20 parts of light liquid petrolatums, 30～80 parts of MCT Oil, 0.5～2 part of butylated hydroxytoluene by weight, mix, be heated to 85 ℃ while stirring, dissolve oil phase, be incubated standby;
(2) get 1～5 part of 20～70 parts of glycerol, 20～40 parts of propylene glycol, 15～25 parts of polyoxyl stearate, sucrose stearate S-155～15 part, potassium sorbate by weight, mix, add distilled water to supply mastic substrate umber, and then add the medicament supernatant C of above-mentioned preparation, be heated to 85 ℃ while stirring, be incubated water;
(3) water is slowly added in the standby oil phase of insulation, constantly stir, speed 50～4000r/min, emulsifying 10-40 minute, continue stirring and be cooled to about 40 ℃, stir, make mastic.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104383369A (en) * | 2014-12-06 | 2015-03-04 | 范旭升 | Pharmaceutical composition for treating gynecological chloasma |
| CN107543893A (en) * | 2017-08-24 | 2018-01-05 | 重庆市畜牧科学院 | The discrimination method of Semen Cuscutae in a kind of female's Huang Zheng oral liquid |
| CN113693974A (en) * | 2020-09-26 | 2021-11-26 | 北京御本堂控股集团有限公司 | Persimmon leaf clear paste and preparation method thereof, freckle removing composition and application thereof, freckle removing preparation and preparation method of freckle removing paste |
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| CN1054976C (en) * | 1993-01-03 | 2000-08-02 | 周至譓 | Freckle removing agent |
| CN100542564C (en) * | 2004-08-17 | 2009-09-23 | 江苏中康药物科技有限公司 | A kind of extracting method for the treatment of the combined plant medicine of chloasma |
| CN1264528C (en) * | 2004-12-31 | 2006-07-19 | 北京国仁堂医药科技发展有限公司 | Spot dispelling capsule and its preparation method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104383369A (en) * | 2014-12-06 | 2015-03-04 | 范旭升 | Pharmaceutical composition for treating gynecological chloasma |
| CN107543893A (en) * | 2017-08-24 | 2018-01-05 | 重庆市畜牧科学院 | The discrimination method of Semen Cuscutae in a kind of female's Huang Zheng oral liquid |
| CN113693974A (en) * | 2020-09-26 | 2021-11-26 | 北京御本堂控股集团有限公司 | Persimmon leaf clear paste and preparation method thereof, freckle removing composition and application thereof, freckle removing preparation and preparation method of freckle removing paste |
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