CN101337022A - Oral preparation capable of reducing blood fat and blood pressure, nourishing the heart and protecting brain and preparation method thereof - Google Patents
Oral preparation capable of reducing blood fat and blood pressure, nourishing the heart and protecting brain and preparation method thereof Download PDFInfo
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- CN101337022A CN101337022A CNA2008100458353A CN200810045835A CN101337022A CN 101337022 A CN101337022 A CN 101337022A CN A2008100458353 A CNA2008100458353 A CN A2008100458353A CN 200810045835 A CN200810045835 A CN 200810045835A CN 101337022 A CN101337022 A CN 101337022A
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Abstract
The invention provides a preparation for oral administration, which has the effects of reducing blood lipid and blood pressures, nourishing heart and protecting brain, and has no toxic or side effect, and the preparation method thereof, and belongs to the natural health-care food, in particular to the plant-based health-care food and the preparation method thereof. The raw material mainly comprises rhodiola sachalinensis, kudzu vine root, hawthorn, sea backthern and bulbus lilii. The preparation method comprises the following steps: extracting, filtering, drying, etc., and the preparation can be prepared into capsules, tablets, granules or oral solutions. The product has the effects of reducing blood lipid and blood pressures, nourishing heart, protecting brain, promoting blood circulation and relieving pain.
Description
(1) technical field:
A kind of blood fat-reducing blood pressure-decreasing, nourishing heart and protect brain oral formulations and preparation method thereof, belong to natural health care, have no side effect, particularly is the health food of raw material with the plant, and its preparation method.
(2) background technology:
After the people had arrived person in middle and old age, because the endocrine disturbance appears in physiology and psychology easily, weak and sickly and cardiovascular and cerebrovascular disease caused blood fat, hypertension, the phenomenon of angina pectoris, dizziness headache occurs, influences people's healthy and quality of life.The medicine that is used at present blood fat-reducing blood pressure-decreasing on the market mostly is Western medicine, and side effect is big, and in case takes and will take medicine throughout one's life.
(3) summary of the invention:
The problem to be solved in the present invention is exactly that to provide a kind of at above deficiency be the health food of raw material with the plant, and its preparation method.This product has blood fat reducing, blood pressure lowering, nourishes heart and protect the effect of brain, promoting blood circulation and stopping pain.Its technical scheme is as follows:
It mainly comprises the raw material of following weight parts:
Radix Rhodiolae 650-750, Radix Puerariae 330-380, Fructus Crataegi 180-220, Fructus Hippophae 90-110, Bulbus Lilii 60--80.
In order to reach better effect, raw material of the present invention also comprises Flos Carthami 40--60 part.
Preparation method of the present invention may further comprise the steps:
1) Radix Rhodiolae, Radix Puerariae, Fructus Crataegi, Fructus Hippophae are extracted twice, add crude drug 6-8 times of water gaging for the first time and extracted 1.5--2.5 hour, filter, get filtrate; Added water extraction 1--2 hour that crude drug 6--8 doubly measures for the second time, filter, get filtrate; Merge filtrate twice, filter, get filtrate, perhaps concentrate, drying gets extract;
2) with the Bulbus Lilii drying, be ground into fine powder;
3) with extract or filtrate and Bulbus Lilii fine powder mix homogeneously, capsule, tablet, dissolved granule or oral liquid are made in sterilization.
If also with the Flos Carthami combination, its preparation method is:
1) Radix Rhodiolae, Radix Puerariae, Fructus Crataegi, Fructus Hippophae, Flos Carthami are extracted twice, add crude drug 6-8 times of water gaging for the first time and extracted 1.5--2.5 hour, filter, get filtrate; Added water extraction 1--2 hour that crude drug 6--8 doubly measures for the second time, filter, get filtrate; Merge filtrate twice, filter, get filtrate, perhaps concentrate, drying gets extract;
2) with the Bulbus Lilii drying, be ground into fine powder;
3) with extract or filtrate and Bulbus Lilii fine powder mix homogeneously, capsule, tablet, dissolved granule or oral liquid are made in sterilization.
Being used for characteristic and function that raw material of the present invention has is:
Radix Rhodiolae: be the dry root and rhizome of Crassulaceae plant Radix Rhodiolae, hide name " Suo Luomabao ", sweet in the mouth, little hardship, cool in nature.Function boosting qi and nourishing yin, heart tonifying Fructus Alpiniae Oxyphyllae.Modern pharmacological research shows, Radix Rhodiolae has has fabulous conditioning and repair to human central nervous system, hormonal system and metabolic system, can strengthen the irritability of reticular formation of brain stem, activate the spontaneous potential activity of primary structure under cortex sensorimotor area, vision area and the cortex, strengthen the respond of sign stimulus to external world.Radix Rhodiolae has significant anti-hypoxia function, increases body blood supply oxygen delivery capacity, reduces myocardial oxygen consumption.
Flos Carthami: be the dried floral of feverfew Flos Carthami, hide name " Gou Ri Gou Mu ", acrid in the mouth, warm in nature.The function promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing.Scientific experiments proves that Flos Carthami can make coronary flow increase, and myocardial cell is had significant protective effect; Flos Carthami extract can significantly improve the mice hypoxia-bearing capability, and the animal model of acute ischemia hypoxic ischemic encephalopathy is had good protective effect; Effectively blood fat reducing of safflower oil, but the serum total cholesterol of cholesterol reducing mass formed by blood stasis rabbit, total fat, triacylglycerol and non-esterified fatty acid level.
Radix Puerariae: be the dry root of legume pueraria lobata or Radix Puerariae rattan, sweet in the mouth, suffering, property is flat.The function flesh that induces sweat, promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal.Modern pharmacological research proves that Radix Puerariae extract has remarkable myocardial ischemia and the arrhythmia improved, and reduces myocardial oxygen consumption, especially cerebral hypoxia ischemia is had significant protective effect.The Radix Puerariae isoflavone constituents can reduce serum cholesterol, triacylglycerol, and puerarin also has the effect of obvious reduction serum cholesterol.
Fructus Hippophae: be the dry mature fruit of Elaeangnaceae plant Fructus Hippophae, hide name " Da Erbu ", sour in the mouth, little sweet, property is flat.Function lung moistening nourishing the stomach, promoting the production of body fluid to quench thirst, antidiarrheal helps digestion.Pharmacological evaluation proves that Fructus Hippophae total flavones has the arteria coronaria of increasing and myocardial nutritional flow amount, reduces effects such as myocardium keto consumption and anticoagulant.Oleum Hippophae has the effect of the exogenous high fat experimental rat serum total cholesterol of obvious reduction, compares with matched group, and the decline of last serum total cholesterol all around is about 68.63%.According to the study, Fructus Hippophae is kept fit and anti-aging effects.
Fructus Crataegi: be the dry mature fruit of rosaceous plant Fructus Pyri Pashiae or Fructus Crataegi, hide name and " occupy as draw ", sweet in the mouth, acid, slightly warm in nature.Function promoting digestion and invigorating the stomach, blood circulation promoting and blood stasis dispelling.Confirmed that Fructus Crataegi can reduce the serum cholesterol and the beta Lipoprotein of rabbit experiment hyperlipidemia.Extractum has the cholesterol reducing effect to the young rat of breast.The Semen Crataegi alcohol extract can significantly reduce the Carnis Coturnicis japonicae serum total cholesterol, reduces cholesterol and the deposition of cholesteryl ester in arterial wall.Fructus Crataegi has cardiac stimulant effect, increases coronary flow, reduces myocardial oxygen consumption and coefficient of oxygen utilization.In addition, Fructus Crataegi can suppress collagen-induced platelet aggregation, blood viscosity lowering very significantly external.
Bulbus Lilii: be the dry meat scale leaf of liliaceous plant tiger lily, Bulbus Lilii or Lilium tenuifolium, hide name " reach as prunus mume (sieb.) sieb.et zucc. piece ", sweet in the mouth, little hardship, cool in nature.Function nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.Clinical lung moistening, the clearing away heart-fire for tranquillization of being used for.The clinical nourishing the lung to arrest cough that is used for, replenishing YIN and removing heat, vexed insomnia, insufficiency of vital energy and blood etc." book on Chinese herbal medicine is stated ": " merit of Bulbus Lilii, in QI invigorating and furthermore promoting the circulation of QI, in that support just and more can be eliminating evil, thus Li Shi call its for ooze profit with in U.S. medicine also." Shennong's Herbal: " sweet in the mouth, flat.Bloated, pained, the sharp defecation of eliminating evil pneumoperitoneum, invigorating the spleen and replenishing QI ".
Advantage compared with prior art of the present invention is: above each material combination, produce good synergism, the product of making has blood fat reducing, blood pressure lowering, nourishes heart and protect the effect of brain, promoting blood circulation and stopping pain, is applicable to crowds such as hyperlipidemia, hypertension, coronary heart disease, angina pectoris, dizziness headache.The raw materials used plant material that is, the product of making has no side effect, and is safe.
For showing the effect of product of the present invention to blood fat reducing, blood pressure lowering, the present invention has done the clinical observation of system to 100 routine hypertension, hyperlipemic patients:
Experimenter group: be diagnosed as the patient of hypertension, hyperlipidemia through disease, the age is between 45-70 year, serious primary disease such as no cardiovascular, liver, kidney and psychosis.Hypertension is meant not to be used under the antihypertensive situation, and systolic pressure 〉=139mmHg and/or diastolic pressure 〉=89mmHg are divided into 1,2 by blood pressure level with hypertension, 3 grades.Systolic pressure 〉=140mmHg and diastolic pressure＜90mmHg are single-row to be isolated systolic hypertension.The patient previously has history of hypertension, is using antihypertensive at present, though blood pressure is lower than 140/90mmHg, also should be diagnosed as hypertension.Hyperlipidemia is meant cholesterol in the blood plasma, triglyceride, phospholipid and the lipid compositions such as fat acid of fatization a kind of disease disease of increasing not.
Dosage regimen: oral capsule of the present invention, each 2 (being equivalent to crude drug amount 5.4g), every day 2 times.The consumption per day of being grown up is equivalent to 1/50th of safe dose.If take other dosage form, also should follow this dosage generally speaking.Viewing duration, the experimenter need keep reasonable diet structure and work rest program, forbids the other drug of non-observation.
The course of treatment: 30 days
Took product of the present invention 30 days after rough estimates are 92% to blood fat reducing, the total obvious effective rate of blood pressure lowering, effective percentage is 88%.Do not find that in the outpatient service process of clinical application this medicine has obvious adverse reaction, takes safety.
Because the present invention is to be the health food of raw material with the plant, also can take for blood fat, normotensive crowd, plays the effect of prevention and health care.
(4) description of drawings:
Accompanying drawing is technological process of production figure of the present invention.
(5) specific embodiment:
Embodiment one:
Take by weighing each raw material by following weight proportion:
Radix Rhodiolae 650, Radix Puerariae 380, Fructus Crataegi 180, Fructus Hippophae 110, Bulbus Lilii 60.
Its preparation method may further comprise the steps:
1) Radix Rhodiolae, Radix Puerariae, Fructus Crataegi, Fructus Hippophae are extracted twice, add 6 times of water gagings of crude drug for the first time and extracted 1.5 hours, filter, get filtrate; Add for the second time the water extraction 1 hour of 6 times of amounts of crude drug, filter, filtrate; Merge filtrate twice, 150 orders filter, and adopting vacuum decompression to be concentrated into relative density is 1.1, uses the spray dryer spray drying, 175 ℃ of spray dryer inlet temperature, and 115 ℃ of leaving air temps get extract;
2) Bulbus Lilii is cleaned with drinking water, be dried to water content 7%, be ground into fine powder and cross 100 mesh sieves at 70 ℃;
3), be sterilization 30 minutes under the 0.068mPa at 115 ℃, air pressure with autoclaving with extract and Bulbus Lilii fine powder mix homogeneously.
4) to select 85% ethanol for use with facility for granulating be that binding agent is made powdery granule to the mixture after will sterilizing, and is dried to water content 4% with drying equipment at 65 ℃, and granule is crossed 40 mesh sieves, uses the mixer mixing, and is encapsulated, makes 1000 altogether, the 0.3g/ grain.
Embodiment two:
Take by weighing each raw material by following weight proportion:
Radix Rhodiolae 750, Radix Puerariae 330, Fructus Crataegi 220, Fructus Hippophae 90, Bulbus Lilii 80.
Its preparation method may further comprise the steps:
1) Radix Rhodiolae, Radix Puerariae, Fructus Crataegi, Fructus Hippophae are extracted twice, add 8 times of water gagings of crude drug for the first time and extracted 2 hours, filter, get filtrate; Add for the second time the water extraction 1 hour of 8 times of amounts of crude drug, filter, filtrate; Merge filtrate twice, 150 orders filter, and adopting vacuum decompression to be concentrated into relative density is 1.15, uses the spray dryer spray drying, 180 ℃ of spray dryer inlet temperature, and 120 ℃ of leaving air temps get extract.
2) Bulbus Lilii is cleaned with drinking water, be dried to water content 8%, be ground into fine powder and cross 100 mesh sieves at 80 ℃.
3), be sterilization 30 minutes under the 0.068mPa at 115 ℃, air pressure with autoclaving with extract and Bulbus Lilii fine powder mix homogeneously.
4) to select starch slurry for use with facility for granulating be that binding agent is made powdery granule to the mixture after will sterilizing, and is dried to water content 5% with drying equipment at 70 ℃, and compacting is made 1000, the 0.3g/ sheet in flakes altogether then.
Embodiment three:
Take by weighing each raw material by following weight proportion:
Radix Rhodiolae 700, Radix Puerariae 350, Fructus Crataegi 200, Fructus Hippophae 100, Bulbus Lilii 70.
Its preparation method may further comprise the steps:
1) Radix Rhodiolae, Radix Puerariae, Fructus Crataegi, Fructus Hippophae, Bulbus Lilii are extracted twice, add the water extraction 2.5 hours of 7 times of amounts of crude drug for the first time, filter, filtrate; Add for the second time the water extraction 2 hours of 7 times of amounts of crude drug, filter, filtrate; Merge filtrate twice, 150 orders filter, and adopting vacuum decompression to be concentrated into relative density is 1.2, uses the spray dryer spray drying, 185 ℃ of spray dryer inlet temperature, and 125 ℃ of leaving air temps get extract.
2) Bulbus Lilii is cleaned with drinking water, be dried to water content 9%, be ground into fine powder and cross 100 mesh sieves at 80 ℃.
3), be sterilization 30 minutes under the 0.068mPa at 115 ℃, air pressure with autoclaving with extract and Bulbus Lilii fine powder mix homogeneously.
4) to select starch slurry for use be binding agent to the mixture after will sterilizing and add dextrin and make granule in right amount with facility for granulating, is dried to water content 5% with drying equipment at 75 ℃, and granule is crossed 20 mesh sieves, use the mixer mixing, dissolved granule is made in pack, makes 1000 bags altogether, the 2g/ bag.
Embodiment four:
Take by weighing each raw material by following weight proportion:
Radix Rhodiolae 650, Radix Puerariae 380, Fructus Crataegi 180, Fructus Hippophae 110, Bulbus Lilii 60, Flos Carthami 60.
Its preparation method may further comprise the steps:
1) Radix Rhodiolae, Radix Puerariae, Fructus Crataegi, Fructus Hippophae, Flos Carthami are extracted twice, add 6 times of water gagings of crude drug for the first time and extracted 1.5 hours, filter, get filtrate; Add for the second time the water extraction 1 hour of 6 times of amounts of crude drug, filter, filtrate; Merge filtrate twice, 150 orders filter, and adopting vacuum decompression to be concentrated into relative density is 1.1, uses the spray dryer spray drying, 175 ℃ of spray dryer inlet temperature, and 115 ℃ of leaving air temps get extract;
2) Bulbus Lilii is cleaned with drinking water, be dried to water content 7%, be ground into fine powder and cross 100 mesh sieves at 70 ℃;
3), be sterilization 30 minutes under the 0.068mPa at 115 ℃, air pressure with autoclaving with extract and Bulbus Lilii fine powder mix homogeneously.
4) to select 85% ethanol for use with facility for granulating be that binding agent is made powdery granule to the mixture after will sterilizing, and is dried to water content 4% with drying equipment at 65 ℃, and granule is crossed 40 mesh sieves, uses the mixer mixing, and is encapsulated, makes 1000 altogether, the 0.3g/ grain.
Embodiment five:
Take by weighing each raw material by following weight proportion:
Radix Rhodiolae 750, Radix Puerariae 330, Fructus Crataegi 220, Fructus Hippophae 90, Bulbus Lilii 80, Flos Carthami 40.
Its preparation method may further comprise the steps:
1) Radix Rhodiolae, Radix Puerariae, Fructus Crataegi, Fructus Hippophae, Flos Carthami are extracted twice, add 8 times of water gagings of crude drug for the first time and extracted 2 hours, filter, get filtrate; Add for the second time the water extraction 1 hour of 8 times of amounts of crude drug, filter, filtrate; Merge filtrate twice, 150 orders filter, and adopting vacuum decompression to be concentrated into relative density is 1.15, uses the spray dryer spray drying, 180 ℃ of spray dryer inlet temperature, and 120 ℃ of leaving air temps get extract.
2) Bulbus Lilii is cleaned with drinking water, be dried to water content 8%, be ground into fine powder and cross 100 mesh sieves at 80 ℃.
3), be sterilization 30 minutes under the 0.068mPa at 115 ℃, air pressure with autoclaving with extract and Bulbus Lilii fine powder mix homogeneously.
4) to select starch slurry for use with facility for granulating be that binding agent is made powdery granule to the mixture after will sterilizing, and is dried to water content 5% with drying equipment at 70 ℃, and compacting is made 1000, the 0.3g/ sheet in flakes altogether then.
Embodiment six:
Take by weighing each raw material by following weight proportion:
Radix Rhodiolae 700, Radix Puerariae 350, Fructus Crataegi 200, Fructus Hippophae 100, Bulbus Lilii 70, Flos Carthami 50.
Its preparation method may further comprise the steps:
1) Radix Rhodiolae, Radix Puerariae, Fructus Crataegi, Fructus Hippophae, Bulbus Lilii, Flos Carthami are extracted twice, add the water extraction 2.5 hours of 7 times of amounts of crude drug for the first time, filter, filtrate; Add for the second time the water extraction 2 hours of 7 times of amounts of crude drug, filter, filtrate; Merge filtrate twice, 150 orders filter, and get filtrate.
2) Bulbus Lilii is cleaned with drinking water, be dried to water content 9%, be ground into fine powder and cross 100 mesh sieves at 80 ℃.
3) the Bulbus Lilii fine powder is put into filtrate and fully mix, 180 orders filter, and add purified water and make oral liquid to 10000ml and bottling, be to sterilize 30 minutes under the 0.068mPa with autoclaving at 115 ℃, air pressure, make 1000 bottles altogether, the 10ml/ bottle.
Claims (4)
1, a kind of blood fat-reducing blood pressure-decreasing, nourish heart and protect the brain oral formulations, it is characterized in that preparing the raw material that its active component raw material comprises following weight portion:
Radix Rhodiolae 650-750, Radix Puerariae 330-380, Fructus Crataegi 180-220, Fructus Hippophae 90-110, Bulbus Lilii 60--80.
2, the described blood fat-reducing blood pressure-decreasing of claim 1, nourish heart and protect the preparation method of brain oral formulations, it is characterized in that may further comprise the steps:
1) Radix Rhodiolae, Radix Puerariae, Fructus Crataegi, Fructus Hippophae are extracted twice, add crude drug 6-8 times of water gaging for the first time and extracted 1.5--2.5 hour, filter, get filtrate; Added water extraction 1--2 hour that crude drug 6--8 doubly measures for the second time, filter, get filtrate; Merge filtrate twice, filter, get filtrate, perhaps concentrate drying gets extract;
2) with the Bulbus Lilii drying, be ground into fine powder;
3) with extract or filtrate and Bulbus Lilii fine powder mix homogeneously, capsule, tablet, dissolved granule or oral liquid are made in sterilization.
3, according to the described blood fat-reducing blood pressure-decreasing of claim 1, nourish heart and protect the brain oral formulations, it is characterized in that wherein raw material also has Flos Carthami 40--60 part.
4, according to the described blood fat-reducing blood pressure-decreasing of claim 3, nourish heart and protect the preparation method of brain oral formulations, it is characterized in that may further comprise the steps:
1) Radix Rhodiolae, Radix Puerariae, Fructus Crataegi, Fructus Hippophae, Flos Carthami are extracted twice, add crude drug 6-8 times of water gaging for the first time and extracted 1.5--2.5 hour, filter, get filtrate; Added water extraction 1--2 hour that crude drug 6--8 doubly measures for the second time, filter, get filtrate; Merge filtrate twice, filter, get filtrate, perhaps concentrate, drying gets extract;
2) with the Bulbus Lilii drying, be ground into fine powder;
3) with extract or filtrate and Bulbus Lilii fine powder mix homogeneously, capsule, tablet, dissolved granule or oral liquid are made in sterilization.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100458353A CN101337022A (en) | 2008-08-18 | 2008-08-18 | Oral preparation capable of reducing blood fat and blood pressure, nourishing the heart and protecting brain and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100458353A CN101337022A (en) | 2008-08-18 | 2008-08-18 | Oral preparation capable of reducing blood fat and blood pressure, nourishing the heart and protecting brain and preparation method thereof |
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| CN101337022A true CN101337022A (en) | 2009-01-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNA2008100458353A Pending CN101337022A (en) | 2008-08-18 | 2008-08-18 | Oral preparation capable of reducing blood fat and blood pressure, nourishing the heart and protecting brain and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102919435A (en) * | 2012-07-26 | 2013-02-13 | 安军 | Aging-retarding blood-lipid-regulating health-care tea |
| CN103598580A (en) * | 2013-11-13 | 2014-02-26 | 王玉清 | Health-care food for reducing blood sugar and blood fat, and preparation method thereof |
| CN103652156A (en) * | 2013-10-18 | 2014-03-26 | 梅州广通制药有限公司 | Instant molecular health-care tea |
-
2008
- 2008-08-18 CN CNA2008100458353A patent/CN101337022A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102919435A (en) * | 2012-07-26 | 2013-02-13 | 安军 | Aging-retarding blood-lipid-regulating health-care tea |
| CN103652156A (en) * | 2013-10-18 | 2014-03-26 | 梅州广通制药有限公司 | Instant molecular health-care tea |
| CN103652156B (en) * | 2013-10-18 | 2015-09-16 | 广东正源分子中药有限公司 | A kind of instant molecular health-care tea |
| CN103598580A (en) * | 2013-11-13 | 2014-02-26 | 王玉清 | Health-care food for reducing blood sugar and blood fat, and preparation method thereof |
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Application publication date: 20090107 |