CN101333483B - Red rice yellow wine with antihypertensive function - Google Patents
Red rice yellow wine with antihypertensive function Download PDFInfo
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Abstract
The present invention relates to a red yeast yellow wine having the blood pressure lowering function; and the red yeast yellow wine is prepared by the following processes of: taking glutinous rice as a raw material, steaming and boiling the glutinous rice, and then adding distillers yeast made of red yeast and supplementary materials as well as functional red yeast wine lees with the weight percent of 10 percent to 20 percent of the raw material for undergoing initial fermentation and secondary fermentation, then pressing the mixture to make the red yeast yellow wine having the blood pressure lowering function, and recovering the red yeast wine lees. The invention fully utilizes the supplementary material of red yeast wine lees for producing the red yeast wine, thereby increasing the added value and preparing the red yeast yellow wine with high GABA content and blood pressure lowering function; and the red yeast yellow wine has an unexpected effect to the treatment and prevention of hypertension, and also has the auxiliary blood pressure lowering function.
Description
Technical field
The present invention relates to a kind of red colouring agent for food, also used as a Chinese medicine metabolism product, relate to a kind of red rice yellow wine in particular with antihypertensive function.
Background technology
Hypertension be a kind of be the common disease of main clinical manifestation with the systemic blood pressure rising, often involve blood vessel, especially important devices such as thin, the arteriole of whole body and the heart, kidney, brain are dirty, usually can cause generations such as complication such as cerebral apoplexy, chronic cardiac insufficiency, renal failure, existing antihypertensive drug can be divided into: (one) hydragog(ue), hydrochlorothiazide etc., but untoward reactions such as hyperlipidemia, reduction sugar tolerance can appear aggravating in the use of these medicines; (2) tonin Depressant and angiotensin-ii receptor blocking agent, captopril, losartan etc., but untoward reactions such as ypotension, cough, hyperkalemia can appear in the use of these medicines; (3) beta receptor blocking agent, Proprasylyte etc.; (4) calcium antagonists, the low equality of nifedipine, ammonia chlorine, but untoward reactions such as the use of these medicines headache, oedema, palpitaition can occur, feels sick, stomachache, old friends increase day by day for the demand with hypotensive heath food.
Since ancient times, since ancient times, monascus product is crossed the history of existing more than one thousand years at me.One of " four big doctors are tame for gold dollar " Mr. Zhu Danxi has put down in writing red colouring agent for food, also used as a Chinese medicine in " Amplification on Materia Medica addendum ": sweet, warm, nontoxic.Cure mainly: help digestion and invigorate blood circulation, stomach is warmed up in invigorating the spleen, controls dysentery with red and white feces, Xia Shuigu, Chen Jiuzhe are good.The Teng Zhang professor far away of Japanese agriculture university in 1979 to the enlightenment that red colouring agent for food, also used as a Chinese medicine has the effect of invigorating blood circulation, discovers that the product that utilizes behind the red koji fermentation has reducing blood-fat, hypotensive, effect in reducing blood glucose to human body according to Mr.'s Zhu Danxi theory of traditional Chinese medical science record; People such as Kohama in 1987 isolate GABA from red colouring agent for food, also used as a Chinese medicine and vagusstoff has hypotensive effect, Chinese patent application (02158370.6) monascus mutant strain and in the purposes of preparation hypotensive activity tunning, though it has screened the monascus mutant strain that GABA content is higher, citrinin content is lower and has related to its cultural method and pharmaceutical composition and foodstuff additive, but this bacterial screening is difficulty relatively, and sudden change back surviving rate is low, and random factor is higher; From this patent application document, can't learn whether inactivation of influence that GABA in monascus or its tunning is subjected to factors such as temperature, pH value in addition, thus the hypertensive property of medicine of forfeiture treatment.
Summary of the invention
The object of the present invention is to provide a kind of red rice yellow wine with antihypertensive function, this red rice yellow wine is prepared by following method: be raw material with glutinous rice, after boiling, adding red colouring agent for food, also used as a Chinese medicine, auxiliary material and accounting for raw material weight per-cent is that 10%～20% functional Monascus vinasse are through fermentation just earlier, fermentation again, squeezing is made the red rice yellow wine with antihypertensive function and is reclaimed Monas cuspurpureus Went distiller grains then.The GABA that contains high level in this red rice yellow wine, two kinds of acceptors of GABAa and GABAb are arranged on the neuronal cell of human body, wherein the GABAa acceptor can suppress adrenaline secretion youngster naphthols amine after receiving the GABA stimulation, thereby weaken orthosympathetic effect blood pressure is reduced, the GABA function that also has an activation renal function promotes blood pressure to reduce in addition.
As preferably, described functional Monascus vinasse are prepared by following method: adopt the fermentation of early rice and monascus specie to make red colouring agent for food, also used as a Chinese medicine, get Monas cuspurpureus Went distiller grains, the rice skin adds red colouring agent for food, also used as a Chinese medicine, adds the entry mixing then, ferment and made the functional Monascus vinasse in 40～200 hours.The GABA that also has high level in this Monas cuspurpureus Went distiller grains, thereby reach the purpose of making red rice yellow wine with antihypertensive function, the raw material that the present invention makes the functional Monascus vinasse is attached material-Monas cuspurpureus Went distiller grains of producing wine of rice fermented with red yeast, the acid anhydrides that contains pyrroles's carboxylic acid-bran acid in the Monas cuspurpureus Went distiller grains, monascus specie product GABA ability is strong, contains active stronger GAD in the rice skin, and the two acting in conjunction is in Monas cuspurpureus Went distiller grains, make it through Secondary Fermentation, improved the content of GABA.
As preferably, described monascus specie is a kind of in red monascus strain Dan Xi-No. 1, monascus strain Dan Xi-No. 3; Wherein red monascus strain Dan Xi-No. 1 on 06 10th, 2005 in China Committee for Culture Collection of Microorganisms's preservation, deposit number CGMCC No.1405; The applicant applies for a patent separately, and application number is: 200510061479.0; Monascus strain Dan Xi-No. 3 on 06 10th, 2005 in China Committee for Culture Collection of Microorganisms's preservation, deposit number CGMCCNo.1407; The applicant applies for a patent separately, and application number is: 200510061481.8.Wherein these two kinds of monascus species can produce high-load GABA after by fermentation, reach 4000～8500mg/kg.
As preferably, the weight ratio of described Monas cuspurpureus Went distiller grains, Mi Pi and red colouring agent for food, also used as a Chinese medicine is: 1.0～2.0:0.5～1.5:0.08～0.15; The weight ratio of wherein above-mentioned three kinds of raw materials and water is 100:75～150.Under identical condition, Monas cuspurpureus Went distiller grains of the present invention/rice skin/red colouring agent for food, also used as a Chinese medicine can obtain the higher GABA of content with above-mentioned weight proportion, reaches more than the 4000mg/kg; And the concentration that how much relates to substrate of moisture content and the concentration of red colouring agent for food, also used as a Chinese medicine, in general, concentration one timing when Monascus ruber, concentration of substrate is determining the speed of Monascus ruber reaction, along with the concentration of substrate increases and increases, after concentration of substrate reached certain value, speed of response just can not increase again, and at this moment the concentration of substrate is almost irrelevant with speed of response.And when concentration of substrate was sufficient, if other condition is constant, then enzyme reaction rate was to increase along with the increase of enzyme concn within the specific limits, can obtain the GABA of high level in material water weight ratio scope of the present invention.
As preferably, leavening temperature is 30 ℃～50 ℃ in the described functional Monascus vinasse preparation process, and the fermentation pH value is 4.0～6.0.Because the meta-bolites that GABA is bran acid to be formed through the L-Glutamic decarboxylase decarboxylation, so red colouring agent for food, also used as a Chinese medicine is 30 ℃～50 ℃ in temperature and is fermented into the functional Monascus vinasse, the katalysis maximum of enzyme, vigor is the strongest, enzymatic reaction is the fastest, and can sex change and inactivation, thereby generates GABA content height; And red colouring agent for food, also used as a Chinese medicine is 4.0～6.0 to be fermented into the functional Monascus vinasse at pH value, and the GABA generating rate is very fast, and pH value is too high or too low all can to influence the GABA yield.
As preferably, the content of GABA is 1～2mg/ml in the described red rice yellow wine.
Indulge the above: the present invention has the following advantages:
1, the present invention has made full use of attached material-Monas cuspurpureus Went distiller grains of producing wine of rice fermented with red yeast, thereby improves its added value, prepare GABA content higher red rice yellow wine with antihypertensive function;
2, this red rice yellow wine not only can be obtained beyond thought effect to treatment and preventing hypertension, and has the aided blood pressure-lowering function, and the result is as follows in the record experimentation on animals:
1 material and method
1.1 sample preparation: for test agent is 10 times of concentrated solutions of product, and Vandyke brown is a solvent with common yellow rice wine during experiment, and sample ligand is made each dosage, transfers about pH to 5.5 solvent control (common yellow rice wine) same treatment with sodium bicarbonate.
1.2 laboratory animal and testing conditions: experiment is with spontaneous hypertension rat (SHR), and is male, cleaning level, 10-12 week in age week, body weight 180-220 grams; The SD rat is used in experiment, and is male, the cleaning level, and body weight 180-220 grams provide by Chinese Academy of Sciences's Shanghai Experimental Animal Center, and the laboratory animal production licence number is SCXK (Shanghai) 2002-0010.Laboratory animal occupancy permit number: SYXK (Zhejiang) 2005-0059.Animal-feed is provided by Zhejiang Province's Experimental Animal Center, operative norm GB14924-2001.Sense environmental conditions, temperature range 20-23 ℃, relative humidity scope 40-70%.In the Animal House environment, adapt to 7 days before the rat test.
1.3 method
1.3.1 dosage design and preparation: experiment divides spontaneous hypertension rat (SHR) and normal SD rats test, the SHR rat is established basic, normal, high three dosage groups, be respectively 0.50,1.00 and the 3.00ml/kg body weight, be equivalent to 5 times, 10 times, 30 times (people's recommended amounts is 6ml/ day) of people's recommended amounts, other establishes a negative control group (H
2O) and solvent (common yellow rice wine) control group.Amount supplies to try sample thief 12.0ml respectively before the experiment, 24.0ml, 72.0ml add common yellow rice wine to 240mL, transfers about pH to 5.5 for examination with sodium bicarbonate.Normal rat is established given the test agent high dose group and negative control group (H
2O).Irritate stomach and give sample, irritate gastric capacity and press the 1ml/100g batheroom scale.
1.3.2 experimental technique: experiment adopts the tail pulses method to carry out repeatedly blood pressure measurement to animal subject the last week, makes it adapt to the pressure measurement environment.Be divided into 3 dosage groups and negative control group and solvent control group, 10 every group at random according to the basic blood pressure value of spontaneous hypertension rat; Basic blood pressure value according to normal SD rats is divided into 3.00ml/kg body weight dosage group and a negative control group at random, every group 10, the dosage group gives different amounts every day and is tried thing, negative control group gives water, the solvent control group gives common yellow rice wine, per os gave for 4 weeks, measured blood pressure, heart rate weekly and weighed 1 time.
1.4 experimental data statistics: adopt the SPSS/PC11.5 software package to analyze.
2. result
2.1 red rice yellow wine is to the influence of spontaneous hypertension rat body weight
Table 1. red rice yellow wine to the influence of spontaneous hypertension rat body weight (x ± SD, g)
In entire test, each treated animal well-grown is movable normal.The results are shown in Table 1, raw data meets homoscedasticity and requires (P〉0.05), tests each dosage group body weight of each observation period and negative control group (H
2O), there are no significant for the control group comparing difference (variance analysis, P〉0.05) for solvent (common yellow rice wine).
2.2 red rice yellow wine is to the influence of spontaneous hypertension rat blood pressure
Table 2. red rice yellow wine to the influence of spontaneous hypertension rat blood pressure (x ± SD, mmHg)
Q check: compare #P＜0.05 with negative control group; Compare with the solvent control group:
△P＜0.05
The results are shown in Table 2, raw data meets homoscedasticity and requires (P〉0.05), with negative control group (H
2O) and solvent (common yellow rice wine) control group relatively, the blood pressure of the 3rd all high dose group is lower than negative control group and solvent (common yellow rice wine) control group, difference all has significance (q check, P＜0.05); The blood pressure of the 4th all middle and high dosage groups all is starkly lower than negative control group and solvent (common yellow rice wine) control group, and difference all has significance (q check, P＜0.05).
2.3 red rice yellow wine is to the influence of spontaneous hypertension rat heart rate
Table 3. red rice yellow wine is to the influence of spontaneous hypertension rat heart rate (x ± SD, inferior/minute)
The results are shown in Table 3, raw data meets homoscedasticity and requires (P〉0.05), tests each dosage group spontaneous hypertension rat heart rate and negative control group (H of each observation period
2O), solvent (common yellow rice wine) control group is compared difference there are no significant (variance analysis, P〉0.05).
2.4 red rice yellow wine is to the influence of normal SD rat body weight
Table 4. red rice yellow wine to the influence of normal SD rat body weight (x ± SD, g)
In entire test, growth of animal is good, and is movable normal.The results are shown in Table 4, raw data meets homoscedasticity and requires (P〉0.05), tests each observation period 3.00ml/kg dosage group rat body weight and negative control group (H
2O) there are no significant (t check, P〉0.05) for comparing difference.
2.5 red rice yellow wine is to the influence of normal SD rat blood pressure
Table 5. red rice yellow wine to the influence of normal SD rat blood pressure (x ± SD, mmHg)
The results are shown in Table 5, raw data meets homoscedasticity and requires (P〉0.05), tests each observation period 3.00ml/kg body weight dosage group rat blood pressure and negative control group (H
2O) there are no significant (t check, P〉0.05) for comparing difference.
2.6 red rice yellow wine is to the influence of normal SD rats heart rate
Table 6. red rice yellow wine is to the influence of normal SD rats heart rate (x ± SD, inferior/minute)
The results are shown in Table 6, raw data meets homoscedasticity and requires (P〉0.05), tests each observation period 3.00ml/kg body weight dosage group rat heart rate and negative control group (H
2O) there are no significant (t check, P〉0.05) for comparing difference.
Embodiment
Below by specific embodiment, technical scheme of the present invention is described in further detail; But the present invention is not limited to these embodiment
Production Example 1
Get (red monascus strain Dan Xi-No. 1) bacterial classification Dan Xi-No. 1, under aseptic condition (sterilisable chamber or Bechtop), with a little bacterial classification of inoculation picking, transfer in sterilized solid maltose nutrient agar culture dish, placed interior 25 ℃ ± 1 ℃ activation culture of incubator 96 hours.Take out 96 hours bacterial classification of activation, under aseptic condition, insert the good bacterial classification of activation in one-level solid maltose nutrient agar, cultivated 96 hours, be Dan Xi-No. 1 first order seed at 25 ℃ ± 1 ℃ with sterilization with the same manner.
Adopt 500 milliliters of glass triangle bottles, 100 milliliters of the liquid maltose substratum that prepare of packing into, 15 pounds of sterilizations 30 minutes are standby.Get Dan Xi-No. 1 first order seed, under aseptic condition, be inoculated in and be equipped with in 500 milliliters of glass triangle bottles of 100 milliliters of liquid maltose substratum, the first order seed inoculum size connects five triangular flasks for each culture dish, after cultivating 96 hours to 25 ℃ ± 1 ℃ shaking table, as the red koji fermentation secondary seed solution.
Production Example 2
Get (monascus strain Dan Xi-No. 3) bacterial classification Dan Xi-No. 3, under aseptic condition (sterilisable chamber or Bechtop), with a little bacterial classification of inoculation picking, transfer in sterilized solid maltose nutrient agar culture dish, placed interior 25 ℃ ± 1 ℃ activation culture of incubator 168 hours.Take out 168 hours bacterial classification of activation, under aseptic condition, insert the good bacterial classification of activation in one-level solid maltose nutrient agar, cultivated 168 hours, be Dan Xi-No. 3 first order seed at 25 ℃ ± 1 ℃ with sterilization with the same manner.
Adopt 500 milliliters of glass triangle bottles, 100 milliliters of the liquid maltose substratum that prepare of packing into, 15 pounds of sterilizations 30 minutes are standby.Get Dan Xi-No. 3 first order seed, under aseptic condition, be inoculated in and be equipped with in 500 milliliters of glass triangle bottles of 100 milliliters of liquid maltose substratum, the first order seed inoculum size connects five triangular flasks for each culture dish, after cultivating 168 hours to 25 ℃ ± 1 ℃ shaking table, as the red koji fermentation secondary seed solution.
Embodiment 1
The early rice immersion that koji is used cooks, and then stirring in No. 1 adding of the red small stream early rice meal as secondary seed solution in the above-mentioned Production Example 1 fermentation is made red colouring agent for food, also used as a Chinese medicine in 5 days, dries above-mentioned red colouring agent for food, also used as a Chinese medicine standby; Get Monas cuspurpureus Went distiller grains, the rice skin adds red colouring agent for food, also used as a Chinese medicine, adds the entry mixing then,, be 25 ℃ in temperature, pH value is that 6.0 condition bottom fermentation was made the functional Monascus vinasse in 200 hours; The weight ratio of wherein said Monas cuspurpureus Went distiller grains, Mi Pi and red colouring agent for food, also used as a Chinese medicine is: 2.0:1.0:0.11; The weight ratio of stating three kinds of raw materials and water is 100:150; Selected organic glutinous rice is raw material, adds pure water and soaks into 30 hours, and raw material is fully absorbed water, evenly steamed 10 minutes the back soaking into good raw material, in above-mentioned raw materials, add above-mentioned make account for raw material weight than the functional Monascus vinasse that are 20%; Account for raw material weight and just ferment earlier with wheaten distiller's yeast with the juice that Herba polygoni hydropiperis presses than the red colouring agent for food, also used as a Chinese medicine that is 7%, ferment again to filter in 2 months and make wine of rice fermented with red yeast and Monas cuspurpureus Went distiller grains, wherein Monas cuspurpureus Went distiller grains is recycled, the wine of rice fermented with red yeast clarification, a continuous instantaneous heating is passed through in the clarification back, rapidly the heat exchanger cooling of cooling; Just obtain red rice yellow wine after the sterilization; The content of γ-An Jidingsuan in the red rice yellow wine (GABA) is 1～2mg/ml.
Embodiment 2
The early rice immersion that koji is used cooks, and then makes red colouring agent for food, also used as a Chinese medicine in 5 days with adding the fermentation that stirs of early rice meal for No. 3 as the red small stream of secondary seed solution in the above-mentioned Production Example 2, dries above-mentioned red colouring agent for food, also used as a Chinese medicine standby; Get Monas cuspurpureus Went distiller grains, the rice skin adds red colouring agent for food, also used as a Chinese medicine, adds the entry mixing then,, be 35 ℃ in temperature, pH value is that 5.0 condition bottom fermentation was made the functional Monascus vinasse in 150 hours; The weight ratio of wherein said Monas cuspurpureus Went distiller grains, Mi Pi and red colouring agent for food, also used as a Chinese medicine is: 1.5:0.7:0.10; The weight ratio of stating three kinds of raw materials and water is 100:128; Selected organic glutinous rice is raw material, adding pure water soaked into 30 hours, raw material is fully absorbed water, evenly steamed 10 minutes the back soaking into good raw material, add above-mentioned make account for raw material weight than the functional Monascus vinasse that are 15%, account for raw material weight and just ferment earlier with wheaten distiller's yeast with the juice that Herba polygoni hydropiperis presses than the red colouring agent for food, also used as a Chinese medicine that is 5%, ferment again to make in 2 months and filter wine of rice fermented with red yeast and Monas cuspurpureus Went distiller grains, wherein Monas cuspurpureus Went distiller grains is recycled, the wine of rice fermented with red yeast clarification, a continuous instantaneous heating is passed through in the clarification back, rapidly the heat exchanger cooling of cooling; Just obtain red rice yellow wine after the sterilization; The content of γ-An Jidingsuan in the red rice yellow wine (GABA) is 1～2mg/ml.
Embodiment 3
The early rice immersion that koji is used cooks, and then makes red colouring agent for food, also used as a Chinese medicine in 5 days with adding the fermentation that stirs of early rice meal for No. 1 as the red small stream of secondary seed solution in the above-mentioned Production Example 1, dries above-mentioned red colouring agent for food, also used as a Chinese medicine standby; Get Monas cuspurpureus Went distiller grains, the rice skin adds red colouring agent for food, also used as a Chinese medicine, adds the entry mixing then,, be 45 ℃ in temperature, pH value is that 3.8 condition bottom fermentation was made the functional Monascus vinasse in 80 hours; The weight ratio of wherein said Monas cuspurpureus Went distiller grains, Mi Pi and red colouring agent for food, also used as a Chinese medicine is: 1.0:1.2:0.08; The weight ratio of stating three kinds of raw materials and water is 100:100; Selected organic glutinous rice is raw material, adds pure water and soaks into 30 hours, and raw material is fully absorbed water, and evenly steams 10 minutes the back soaking into good raw material, and adding the above-mentioned raw material weight ratio of making that accounts for is 10% functional Monascus vinasse; Account for raw material weight and just ferment earlier with wheaten distiller's yeast with the juice that Herba polygoni hydropiperis presses than the red colouring agent for food, also used as a Chinese medicine that is 3%, ferment and made wine of rice fermented with red yeast and Monas cuspurpureus Went distiller grains in 2 months, wherein Monas cuspurpureus Went distiller grains is recycled, the wine of rice fermented with red yeast clarification, a continuous instantaneous heating is passed through in the clarification back, rapidly the heat exchanger cooling of cooling; Just obtain red rice yellow wine after the sterilization; The content of γ-An Jidingsuan in the red rice yellow wine (GABA) is 1～2mg/ml.
Specific embodiment described in the present invention only is that the present invention is illustrated.The technician of the technical field of the invention can make various modifications or replenishes or adopt similar mode to substitute described specific embodiment, but can't depart from the defined scope of appended claims of the present invention.
Although the present invention has been made detailed explanation and has quoted some specific exampless as proof, to those skilled in the art, only otherwise leave that scope of the present invention can be done various variations or correction is obvious.
Claims (4)
1. red rice yellow wine with antihypertensive function, it is characterized in that: this red rice yellow wine is prepared by following method: be raw material with glutinous rice, after boiling, the juice that adds red colouring agent for food, also used as a Chinese medicine and Herba polygoni hydropiperis is with wheaten distiller's yeast and to account for raw material weight per-cent be that 10%～20% functional Monascus vinasse are through fermentation just earlier, fermentation again, squeezing is made the red rice yellow wine with antihypertensive function and is reclaimed Monas cuspurpureus Went distiller grains then; Described functional Monascus vinasse are prepared by following method: adopt the fermentation of early rice and monascus specie to make red colouring agent for food, also used as a Chinese medicine, get Monas cuspurpureus Went distiller grains, rice skin adding red colouring agent for food, also used as a Chinese medicine, add the entry mixing then, ferment and made the functional Monascus vinasse in 40～200 hours, the weight ratio of described Monas cuspurpureus Went distiller grains, Mi Pi and red colouring agent for food, also used as a Chinese medicine is: 1.0～2.0: 0.5～1.5: 0.08～0.15; The weight ratio of wherein above-mentioned three kinds of raw materials and water is 100: 75～150.
2. a kind of red rice yellow wine with antihypertensive function according to claim 1 is characterized in that: described monascus specie is a kind of in red monascus strain Dan Xi-No. 1, monascus strain Dan Xi-No. 3.
3. a kind of red rice yellow wine with antihypertensive function according to claim 1 is characterized in that: leavening temperature is 25 ℃～45 ℃ in the described functional Monascus vinasse preparation process, and the fermentation pH value is 3.8～6.0.
4. according to each described a kind of red rice yellow wine with antihypertensive function of claim 1～3, it is characterized in that: the content of GABA is 1～2mg/ml in this red rice yellow wine.
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| CN102408966A (en) * | 2011-10-13 | 2012-04-11 | 江苏恒顺醋业股份有限公司 | Monascus rice wine and preparation method thereof |
| CN102690741B (en) * | 2012-06-18 | 2013-05-22 | 福建师范大学 | Brewing method of dry type red rice yellow millet wine |
| CN103131582B (en) * | 2012-12-18 | 2014-03-19 | 山东中惠食品有限公司 | Preparing method of brown rice function red rice health care wine |
| CN103740541A (en) * | 2014-02-15 | 2014-04-23 | 福建永春顺德堂食品有限公司 | Red koji wine and production process thereof |
| CN104164333A (en) * | 2014-08-04 | 2014-11-26 | 西藏自治区农牧科学院 | Highland barley red rice wine and brewing method thereof |
| CN104225272B (en) * | 2014-09-03 | 2018-08-21 | 崔俊英 | A kind of external application Chinese medicine, external application fermented medical wine and preparation method thereof |
| CN105524792B (en) * | 2016-02-03 | 2018-09-18 | 浙江红石梁集团济公家酒坊有限公司 | A kind of preparation method of mixed culture |
| CN107988024A (en) * | 2018-01-15 | 2018-05-04 | 浙江素瑞生物科技有限公司 | Health care Noni fruit wine |
| CN112210455A (en) * | 2020-10-16 | 2021-01-12 | 蒋亥风 | Health-care strong-flavor liquor and preparation method and application thereof |
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