CN101327288A - Method for preparing Liaoyuanqili super fine powder - Google Patents
Method for preparing Liaoyuanqili super fine powder Download PDFInfo
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- CN101327288A CN101327288A CNA2008100456305A CN200810045630A CN101327288A CN 101327288 A CN101327288 A CN 101327288A CN A2008100456305 A CNA2008100456305 A CN A2008100456305A CN 200810045630 A CN200810045630 A CN 200810045630A CN 101327288 A CN101327288 A CN 101327288A
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Abstract
The invention discloses a Liaoyuan Qili ultrafine powder and a preparation method thereof. The Liaoyuan Qili ultrafine powder with the grain size that D90 is less than or equal to 12 Mu m can be smoothly made by using the processing steps of drying in low temperature, adequately mixing, coarse crushing, ultrafine crushing and so on. The effective components can be absorbed by human body rapidly. High efficacy can be obtained with small dosage. The power has the characteristics of rapid efficacy and high efficiency. Furthermore, most of eggs, bacteria and viruses are all killed in the process of ultrafine crushing, which has higher hygiene quality than traditional power, and is much more favorable for controlling quality and prolonging shelf life. Additionally, because the effective dosage of the Liaoyuan Qili ultrafine powder is reduced after being processed by ultrafine crushing, the medicine with the same effect can be made by consuming much less raw materials, namely the raw materials consumption can be reduced.
Description
Technical field
The invention belongs to technical field of medicine, particularly a kind of preparation method of Liaoyuanqili super fine powder.
Background technology
Liaoyuanqili super contains 13 flavor medical materials (Sanguis Draxonis, Flos Carthami, Borneolum Syntheticum, Olibanum, Myrrha, catechu, Radix Angelicae Sinensis, Eupolyphaga Seu Steleophaga, Radix Notoginseng, Rhizoma Drynariae, Radix Et Rhizoma Rhei, Fang Hai, Lignum Dalbergiae Odoriferae); Has relaxing muscles and tendons to promote blood circulation, the effect of eliminating stasis to stop pain; Be usually used in treating traumatic injury, stop in the blood stasis, sway one's hips and feel a pain in the chest when breathing, redness is had a pain etc.The Liaoyuanqili super of tradition breaking method preparation, its particle size range is 75-150 μ m (a 200-100 order).Because its powder granularity is bigger, cell is breaking cellular wall not, so onset is slower, and the performance of curative effect also is restricted; And the efficient of traditional mechanical method pulverization process is very low, also causes great deal of raw materials to expend.In order to improve its curative effect and to reach quick-acting purposes, need improve the preparation method of Liaoyuanqili super, as each medical material being carried out technical finesses such as cell wall breaking.But, because Olibanum and Myrrha in the Liaoyuanqili super belong to the resinae medicine, heating easily in the crushing process, and its viscosity of back of being heated increases, and therefore is difficult to pulverize; In addition, medical materials such as Radix Angelicae Sinensis wherein, Radix Notoginseng, Rhizoma Drynariae and Lignum Dalbergiae Odoriferae because fiber content is very high, adopt routine techniques also to be difficult to reach the effect of superfine grinding.Though above-mentioned medical material also can adopt the liquid nitrogen freezing crushing technology to handle, the cost of liquid nitrogen freezing crushing technology is too high, thereby has limited its development and use.
Summary of the invention
Purpose of the present invention is exactly the above-mentioned defective at prior art, a kind of preparation method of Liaoyuanqili super fine powder is provided, can make the Liaoyuanqili super fine powder that granularity is D90≤12 μ m by this method, can reduce consumption of raw materials simultaneously, improve curative effect and reach quick-acting purposes.
The technical solution adopted for the present invention to solve the technical problems is:
A kind of preparation method of Liaoyuanqili super fine powder is that (the cumulative particle sizes distribution number of a sample reaches 90% o'clock pairing particle diameter to D90 by the method prepared sizes that comprise the steps; To be particle diameter account for 90% smaller or equal to its granule to its physical significance)≤Liaoyuanqili super fine powder of 12 μ m:
(1) drying: except that Olibanum, Myrrha and Borneolum Syntheticum do not need the drying, to other raw medicinal material (comprising Sanguis Draxonis, Flos Carthami, catechu, Radix Angelicae Sinensis, Eupolyphaga Seu Steleophaga, Radix Notoginseng, Rhizoma Drynariae, Radix Et Rhizoma Rhei, Fang Hai, Lignum Dalbergiae Odoriferae), adopt low temperature drying method, use common equipment of crop drying, at 30-65 ℃ of dry 4-10h, to avoid causing loss of active ingredients and destruction in the crude drug;
(2) coarse pulverization: prepare each raw medicinal material in the pharmaceutical formulation ratio, select at least a in Sanguis Draxonis, Flos Carthami, the Radix Notoginseng, mix with Olibanum, Myrrha, common disintegrating apparatus such as employing impact crusher, shearing pulverizer, crystal pulverizer carry out coarse pulverization, are that the 50-80 purpose is mixed coarse powder I to granularity; The common disintegrating apparatus of same employing carries out coarse pulverization to other raw medicinal material in the Liaoyuanqili super, carry out coarse pulverization after each raw medicinal material can being mixed, also each raw medicinal material can be carried out coarse pulverization separately one by one, getting granularity is that the 50-80 purpose is mixed coarse powder II or each raw medicinal material coarse powder;
(3) superfine grinding: get above-mentioned (2) mixing coarse powder II or each raw medicinal material coarse powder in step, with mix coarse powder I and mix, join then in the superfine grinding equipment such as vibromill, mechanical impact crusher, ball mill, stirring mill, jet mill, pulverization process 30-60min, can obtain granularity is the Liaoyuanqili super fine powder of D90≤12 μ m.
In (1) step of above-mentioned preparation method, described low temperature drying method, preferably dry 4-8h under 50-58 ℃ of temperature.
In (2) step of above-mentioned preparation method, described pharmaceutical formulation ratio, can also can suitably adjust according to actual needs with reference to each pharmaceutical formulation ratio (its part by weight is: Sanguis Draxonis 50, Flos Carthami 450, Borneolum Syntheticum 16, Olibanum 240, Myrrha 200, catechu 160, Radix Angelicae Sinensis 90, Eupolyphaga Seu Steleophaga 80, Radix Notoginseng 50, Rhizoma Drynariae 240, Radix Et Rhizoma Rhei 240, sea, side 240, Lignum Dalbergiae Odoriferae 240) of traditional compound recipe Liaoyuanqili super; Each pharmaceutical formulation ratio with traditional compound recipe Liaoyuanqili super is good.
Compared with prior art, the invention has the beneficial effects as follows:
The inventive method adopts suitable hybrid mode to different raw medicinal material, and by cold drying, suitably mix back coarse pulverization, branch step process such as superfine grinding again, can make granularity is the Liaoyuanqili super fine powder of D90≤12 μ m.Its effective ingredient is absorbed by the body easily fast; Low dose of use can obtain higher curative effect, has quick-acting, characteristics of high efficiency.And, in the superfine grinding process,, most of worm's ovum, antibacterial and virus can be killed by mechanical force in the superfine grinding process and mechanical force and chemical effect, higher than traditional powder hygienic quality, more help quality control and extend the shelf life.In addition, because the Liaoyuanqili super effective dose after the superfine grinding reduces,, can reduce consumption of raw materials so the raw medicinal material that only needs to consume less amount can make the medicine that can reach effect same.
The specific embodiment
The present invention is described in further detail below in conjunction with the specific embodiment.
But this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following embodiment.
Embodiment 1
Present embodiment is for to prepare Liaoyuanqili super fine powder by the method that comprises the steps:
(1) drying: except that Olibanum, Myrrha and Borneolum Syntheticum do not need the drying, with other raw medicinal material (comprising Sanguis Draxonis, Flos Carthami, catechu, Radix Angelicae Sinensis, Eupolyphaga Seu Steleophaga, Radix Notoginseng, Rhizoma Drynariae, Radix Et Rhizoma Rhei, Fang Hai, Lignum Dalbergiae Odoriferae) dry 8h in drying baker, baking temperature is about 50 ℃;
(2) coarse pulverization: prepare each raw medicinal material (Sanguis Draxonis 50g, Flos Carthami 450g, Borneolum Syntheticum 16g, Olibanum 240g, Myrrha 200g, catechu 160g, Radix Angelicae Sinensis 90g, Eupolyphaga Seu Steleophaga 80g, Radix Notoginseng 50g, Rhizoma Drynariae 240g, Radix Et Rhizoma Rhei 240g, side extra large 240g, Lignum Dalbergiae Odoriferae 240g) in the pharmaceutical formulation ratio, Sanguis Draxonis is mixed with Olibanum, Myrrha, adopting impact crusher to carry out coarse pulverization, is that 50～60 purposes are mixed coarse powder I to granularity; The then same impact crusher that adopts carries out coarse pulverization separately one by one to other raw medicinal material in the Liaoyuanqili super, and getting granularity is each raw medicinal material coarse powder of 50～60 purposes;
(3) superfine grinding: get above-mentioned (2) each raw medicinal material coarse powder in step, and mixes coarse powder I mixing, join pulverization process 30min in the vibromill then, the granularity D90 that obtains the Liaoyuanqili super fine powder mixture is 12 μ m.
Embodiment 2
Present embodiment is for to prepare Liaoyuanqili super fine powder by the method that comprises the steps:
(1) drying: except that Olibanum, Myrrha and Borneolum Syntheticum do not need the drying, with other raw medicinal material (comprising Sanguis Draxonis, Flos Carthami, catechu, Radix Angelicae Sinensis, Eupolyphaga Seu Steleophaga, Radix Notoginseng, Rhizoma Drynariae, Radix Et Rhizoma Rhei, Fang Hai, Lignum Dalbergiae Odoriferae) dry 4h in drying baker, baking temperature is about 65 ℃;
(2) coarse pulverization: prepare each raw medicinal material (Sanguis Draxonis 50g, Flos Carthami 450g, Borneolum Syntheticum 16g, Olibanum 240g, Myrrha 200g, catechu 160g, Radix Angelicae Sinensis 90g, Eupolyphaga Seu Steleophaga 80g, Radix Notoginseng 50g, Rhizoma Drynariae 240g, Radix Et Rhizoma Rhei 240g, side extra large 240g, Lignum Dalbergiae Odoriferae 240g) in the pharmaceutical formulation ratio, Sanguis Draxonis, Flos Carthami are mixed with Olibanum, Myrrha, adopting shear crusher to carry out coarse pulverization, is that 70～80 purposes are mixed coarse powder I to granularity; The then same shear crusher that adopts carries out coarse pulverization separately one by one to other raw medicinal material in the Liaoyuanqili super, and getting granularity is each raw medicinal material coarse powder of 70～80 purposes;
(3) superfine grinding: get above-mentioned (2) each raw medicinal material coarse powder in step, and mix coarse powder I and mix, join then stir grind in pulverization process 60min, the granularity D90 that obtains the Liaoyuanqili super fine powder mixture is 11 μ m.
Embodiment 3
Present embodiment is for to prepare Liaoyuanqili super fine powder by the method that comprises the steps:
(1) drying: except that Olibanum, Myrrha and Borneolum Syntheticum do not need the drying, with other raw medicinal material (comprising Sanguis Draxonis, Flos Carthami, catechu, Radix Angelicae Sinensis, Eupolyphaga Seu Steleophaga, Radix Notoginseng, Rhizoma Drynariae, Radix Et Rhizoma Rhei, Fang Hai, Lignum Dalbergiae Odoriferae) dry 10h in drying baker, baking temperature is about 30 ℃;
(2) coarse pulverization: prepare each raw medicinal material (Sanguis Draxonis 50g, Flos Carthami 450g, Borneolum Syntheticum 16g, Olibanum 240g, Myrrha 200g, catechu 160g, Radix Angelicae Sinensis 90g, Eupolyphaga Seu Steleophaga 80g, Radix Notoginseng 50g, Rhizoma Drynariae 240g, Radix Et Rhizoma Rhei 240g, side extra large 240g, Lignum Dalbergiae Odoriferae 240g) in the pharmaceutical formulation ratio, Flos Carthami, Radix Notoginseng are mixed with Olibanum, Myrrha, adopting the crystal fracture machine to carry out coarse pulverization, is that 60～70 purposes are mixed coarse powder I to granularity; The then same crystal fracture machine that adopts will carry out coarse pulverization after other raw medicinal material mixing in the Liaoyuanqili super, and getting granularity is that 60～70 purposes are mixed coarse powder II;
(3) superfine grinding: get above-mentioned (2) the mixing coarse powder II in step, and mixes coarse powder I mixing, join pulverization process 40min in the ball mill then, the granularity D90 that obtains the Liaoyuanqili super fine powder mixture is 10 μ m.
Embodiment 4
Present embodiment is for to prepare Liaoyuanqili super fine powder by the method that comprises the steps:
(1) drying: except that Olibanum, Myrrha and Borneolum Syntheticum do not need the drying, with other raw medicinal material (comprising Sanguis Draxonis, Flos Carthami, catechu, Radix Angelicae Sinensis, Eupolyphaga Seu Steleophaga, Radix Notoginseng, Rhizoma Drynariae, Radix Et Rhizoma Rhei, Fang Hai, Lignum Dalbergiae Odoriferae) dry 5h in drying baker, baking temperature is about 58 ℃;
(2) coarse pulverization: prepare each raw medicinal material (Sanguis Draxonis 50g, Flos Carthami 450g, Borneolum Syntheticum 16g, Olibanum 240g, Myrrha 200g, catechu 160g, Radix Angelicae Sinensis 90g, Eupolyphaga Seu Steleophaga 80g, Radix Notoginseng 50g, Rhizoma Drynariae 240g, Radix Et Rhizoma Rhei 240g, side extra large 240g, Lignum Dalbergiae Odoriferae 240g) in the pharmaceutical formulation ratio, Sanguis Draxonis, Flos Carthami, Radix Notoginseng are mixed with Olibanum, Myrrha, adopting impact crusher to carry out coarse pulverization, is that 70～80 purposes are mixed coarse powder I to granularity; The then same impact crusher that adopts will carry out coarse pulverization after other raw medicinal material mixing in the Liaoyuanqili super, and getting granularity is that 70～80 purposes are mixed coarse powder II;
(3) superfine grinding: get above-mentioned (2) the mixing coarse powder II in step, and mixes coarse powder I mixing, join pulverization process 60min in the vibromill then, the granularity D90 that obtains the Liaoyuanqili super fine powder mixture is 8 μ m.
The inventor is by following " to the therapeutical effect of rabbit acute soft tissue injury " and other multinomial pharmacology pharmacodynamic experimental study, the result shows: compare with traditional Liaoyuanqili super, the Liaoyuanqili super fine powder that the inventive method makes has that drug effect is more excellent, onset characteristics faster.
The test method of " to the therapeutical effect of rabbit acute soft tissue injury " and result etc. are as follows:
1, impacts the foundation of dampening model
Get male Japan large ear rabbit, after the forelimb depilation rabbit is fixed, use the self-control beating device, cause triceps brachii belly of muscle place, outside soft tissue contusion (not having fracture) behind the rabbit forelimb upper arm.The animal of modeling success is made the local swelling of membranous part position, palor, and the skin relaxing the bowels with purgatives of warm nature falls, disorder of limb ' s activity.
2, experiment grouping and medication
Get 48 of the animals of modeling success, be divided into 6 groups at random, every group 8, be respectively model group (not administration), matched group (giving traditional Liaoyuanqili super), 1 group, 2 groups, 3 groups, 4 groups of trial drugs (giving the Liaoyuanqili super fine powder of the foregoing description 1,2,3,4 gained respectively).Each treated animal 2 h after modeling begin coating, and except that model group, all the other are respectively organized medicine and are applied to rabbit modeling position by 3.6g/kg every day, and dosage divides to be applied to the affected part 3 times every day, continuously 4d.
3, observation index and result of the test
(1) swelling: before measuring modeling, after the modeling before the administration, and administration after the trouble limb place perimeter change situation of 1～4d.The results are shown in following table 1:
The influence of table 1 pair rabbit acute soft tissue injury swelling (X ± SD, n=8)
Compare with model group
*P＜0.05
*P＜0.01
Table 1 is the result show, each superfine powder of the Liaoyuanqili super that traditional Liaoyuanqili super and the inventive method make all can obviously reduce the swelling degree that rabbit suffers from limb; And each superfine powder of the Liaoyuanqili super that the inventive method makes is respectively organized effect and all is better than traditional Liaoyuanqili super group slightly.
(2) tenderness: pin modeling centre (the about 1cm2 of contact area) with manometric pressure plate, be forced into animal gradually and pain reaction (rabbit struggle) occurs, record pressure at this moment is tenderness value (kg).The tenderness value of the animal soft tissue injury region of 1～4d before measuring modeling respectively, before the administration and after the administration.The results are shown in following table 2:
The influence of table 2 pair rabbit acute soft tissue injury tenderness (X ± SD, n=8)
Compare with model group
*P＜0.05
*P＜0.01
Table 2 is the result show, each superfine powder of the Liaoyuanqili super that traditional Liaoyuanqili super and the inventive method make is the pain of the rapid emergency damage rabbit of energy all; And each superfine powder of the Liaoyuanqili super that the inventive method makes is respectively organized effect and all obviously is better than traditional Liaoyuanqili super group.
(3) subcutaneous tissue blood stasis area and muscular death percentage rate (%): put to death animal on the 4th day after the administration, measure muscular death percentage rate in subcutaneous tissue blood stasis area and the same position muscular tissue.The results are shown in following table 3:
Table 3 pair rabbit acute soft tissue injury subcutaneous tissue blood stasis area and the percentile influence of muscular death (X ± SD, n=8)
Compare with model group
*P＜0.05
*P＜0.01
Table 3 is the result show, each superfine powder of the Liaoyuanqili super that traditional Liaoyuanqili super and the inventive method make all can significantly reduce muscular death percentage rate in damage rabbit undertissue's blood stasis area and the muscular tissue; And each superfine powder of the Liaoyuanqili super that the inventive method makes is respectively organized effect and all significantly is better than traditional Liaoyuanqili super group.
Claims (3)
1. the preparation method of a Liaoyuanqili super fine powder is the Liaoyuanqili super fine powder of D90≤12 μ m by the method prepared sizes that comprise the steps:
(1) cold drying: except that Olibanum, Myrrha and Borneolum Syntheticum do not need the drying,, adopt low temperature drying method, use common equipment of crop drying, at 30-65 ℃ of dry 4-10h to other raw medicinal material;
(2) coarse pulverization: prepare each raw medicinal material in the pharmaceutical formulation ratio, select at least a in Sanguis Draxonis, Flos Carthami, the Radix Notoginseng, mixes, adopt common pulverizer to carry out coarse pulverization with Olibanum, Myrrha, to granularity be 50-80 purpose mixing coarse powder I; Adopt common disintegrating apparatus that other raw medicinal material in the Liaoyuanqili super is carried out coarse pulverization, method is: carry out coarse pulverization after each raw medicinal material is mixed, perhaps each raw medicinal material is carried out coarse pulverization separately one by one, getting granularity is that the 50-80 purpose is mixed coarse powder II or each raw medicinal material coarse powder;
(3) superfine grinding: get above-mentioned (2) mixing coarse powder II or each raw medicinal material coarse powder in step, and mixes coarse powder I mixing, join pulverization process 30-60min in the superfine grinding equipment then, promptly obtaining granularity is the Liaoyuanqili super fine powder of D90≤12 μ m.
2. the preparation method of Liaoyuanqili super fine powder according to claim 1 is characterized in that: the low temperature drying method described in (1) step is at 30-65 ℃ of dry 4-10h.
3. the preparation method of Liaoyuanqili super fine powder according to claim 1 is characterized in that: the pharmaceutical formulation ratio described in (2) step, each pharmaceutical formulation ratio of the traditional compound recipe Liaoyuanqili super of reference, or suitably adjustment according to actual needs.
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| CN103127390A (en) * | 2012-12-26 | 2013-06-05 | 福建省金草生物集团有限公司 | Compound blood sugar reducing jewel orchid submicron powder and preparation method thereof |
| CN103127389A (en) * | 2012-12-26 | 2013-06-05 | 福建省金草生物集团有限公司 | Compound liver protection jewel orchid submicron powder and preparation method thereof |
| CN103127390B (en) * | 2012-12-26 | 2014-12-17 | 福建省龙岩市梁野山种业有限公司 | Compound blood sugar reducing jewel orchid submicron powder and preparation method thereof |
| CN103127389B (en) * | 2012-12-26 | 2014-12-17 | 福建省龙岩市梁野山种业有限公司 | Compound liver protection jewel orchid submicron powder and preparation method thereof |
| CN104055859A (en) * | 2014-06-26 | 2014-09-24 | 蔡合 | Medicine for treating acute waist injury and preparation method thereof |
| CN104055859B (en) * | 2014-06-26 | 2016-05-04 | 张怀胜 | A kind of medicine for the treatment of acute waist wound and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN101327288B (en) | 2012-02-29 |
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