CN101309677A - Cleaner for precaution against of cow's hoof, manufacturing method thereof, and using method thereof - Google Patents

Cleaner for precaution against of cow's hoof, manufacturing method thereof, and using method thereof Download PDF

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Publication number
CN101309677A
CN101309677A CNA2006800427462A CN200680042746A CN101309677A CN 101309677 A CN101309677 A CN 101309677A CN A2006800427462 A CNA2006800427462 A CN A2006800427462A CN 200680042746 A CN200680042746 A CN 200680042746A CN 101309677 A CN101309677 A CN 101309677A
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China
Prior art keywords
hoof
weight
cow
abluent
cleaning solution
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CNA2006800427462A
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CN101309677B (en
Inventor
白光洙
金载起
金贤燮
朴修奉
朴性在
全炳淳
徐国泫
许太宁
姜锡镇
安秉石
郑善姬
金秉学
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Korea Rural Development Administration
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Republic & Korea Repesented By Rural Development Administration Sk Chemicals Co
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01LSHOEING OF ANIMALS
    • A01L15/00Apparatus or use of substances for the care of hoofs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02Local antiseptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations

Abstract

A hoof cleaning agent for prevention of cow's hoof disorders is provided. Specifically, the present invention provides a hoof cleaning agent for prevention of cow's hoof disorders, and use and preparation thereof, which are capable of simultaneously achieving cleaning and sterilizing effects of cow's hooves, thus allowing for sterilization of animal affected hooves under cleaned conditions of the contaminated area and thereby resulting in early prevention of productivity decrease such as a low milk yield and a low breeding coefficient via prophylaxis of cow's hoof disorders and avoidance of extreme situations such as cow culling, and are also capable of making great contributions to the promotion of cow's health and comfort. For this purpose, the hoof cleaning agent comprises a wash liquid prepared by mixing a solid mixture of tartaric acid, citric acid, zinc sulfate, sodium molybdate and potassium nitrate with water, in order to remove foreign materials from cow's hooves, and a sodium hypochlorite for sterilizing harmful bacteria of cow's hooves from which foreign materials were removed.

Description

The abluent and manufacture method and the using method that are used for precaution against of cow's hoof
Technical field
The present invention relates to a kind of hoof abluent and preparation and application that is used to prevent the Ungula Bovis seu Bubali obstacle.More particularly, the present invention relates to a kind of like this hoof abluent and application and preparation that is used to prevent the Ungula Bovis seu Bubali obstacle, this hoof abluent is used as the raw material of the hoof cleaning solution in the hoof bathroom facilities of Ungula Bovis seu Bubali, and has cleaning and germ-resistant combination function.
Background technology
Usually, there is the domestic animal (for example Korean native cattle (Hanwoo), milch cow etc.) of hoof to suffer or can infects easily because the serious hoof obstacle that intrusion in the space and growth cause of opening that various noxious bacteria and fungus are being limited generously by the hoof base wall.
Because big body of Korean native cattle and milch cow and heavy body weight, thus can they hoof and lower limb on apply heavy weight loading.Therefore, for the cattle that keeps common all day standing, the hoof obstacle can be fatal to the existence of cattle.
Therefore, when not having method to prevent the hoof disease of the animal in the feed lot of Korean native cattle and milch cow, when this disease occurring, the dairy farmer takes measures animal is treated by the following method, a kind of method comprises: to the affected areas coating antibiotic ointment of animal, then it is wrapped up, perhaps another kind of method is to spray copper sulfate (CuSO to ill wound 4) method of solution.In addition, copper-bath or for example the chemical substance of formalin also as the hoof cleaning solution that in hoof bathroom facilities or hoof purge chamber, uses.
Summary of the invention
Technical problem
Yet, above-mentioned the germ-resistant traditional method of animal hooves has been run into the problem that is penetrated into the rare pass of amount of target area with germicidal solution, thereby caused the bactericidal effect deficiency owing to removing pollutant fully the space of opening that can not form from cloot by Korean native cattle and milch cow.
Technical scheme
Therefore, consider that the problems referred to above propose the present invention, an aspect of of the present present invention provides a kind of hoof abluent and application and preparation that is used to prevent the Ungula Bovis seu Bubali obstacle, this hoof abluent can be realized cleaning and the sterilization effects to Ungula Bovis seu Bubali simultaneously, thereby under the condition that allows to be cleaned ill animal hooves is sterilized in contaminated zone, thereby by precaution against of cow's hoof and avoid extreme case (for example, eliminate cattle) come to prevent in early days that productive rate from (for example descending, the rate of giving milk is low and breeding coefficient is low), and also can provide very big help to the health that improves cattle.
Additional aspect of the present invention and/or advantage will partly be mentioned in the description of back, and a part obviously, perhaps can be known by practice of the present invention by describing part.
Beneficial effect
Be used to prevent that according to of the present invention the hoof abluent of Ungula Bovis seu Bubali obstacle from comprising cleaning component and sterilization component simultaneously.
Therefore, when dilution hoof abluent in water is formed on the hoof cleaning solution that uses in the hoof bathroom facilities, and when by the hoof bathroom facilities hoof abluent being applied to Ungula Bovis seu Bubali subsequently, the cleaning component of hoof cleaning solution is at first removed the foreign body on the slit between the cloot that is attached to animal, the noxious bacteria that is attached to simultaneously on the animal hooves is exposed to the hoof cleaning solution fully, in this case, the antibacterial that adheres to is thoroughly sterilized by the sodium hypochlorite that comprises in the hoof cleaning solution.
Therefore, adopt the application of the hoof cleaning solution of hoof abluent of the present invention can prevent and treat the Ungula Bovis seu Bubali obstacle effectively, thereby make and prevent that in early days output from (for example descending, the rate of giving milk is low and breeding coefficient is low), and (for example avoid potential extreme case, eliminate cattle), and realize the health that improves cattle and comfortablely provide very big help.
The specific embodiment
Most preferred embodiment
According to an aspect of the present invention, be used to prevent that by providing a kind of the hoof abluent of Ungula Bovis seu Bubali obstacle from realizing above-mentioned and other purpose, this hoof abluent comprises: washing liquid, mix with water by solid mixture and to prepare, be used to remove the foreign body on the Ungula Bovis seu Bubali tartaric acid, citric acid, zinc sulfate, sodium molybdate and potassium nitrate; Sodium hypochlorite is used for the noxious bacteria on the Ungula Bovis seu Bubali of having removed foreign body is sterilized.
According to a further aspect in the invention, a kind of hoof abluent that is used to prevent the Ungula Bovis seu Bubali obstacle is provided, prepare this hoof abluent by the following method, that is, with 15% to 25% tartaric acid by weight, by weight 15% to 25% citric acid, by weight 15% to 25% zinc sulfate, by weight 15% to 25% sodium molybdate and by weight the solid of 15% to 25% potassium nitrate mix; 50% gained mixture by weight and 50% water by weight mixed and liquefy prepare washing liquid; And 50% washing liquid and 50% sodium hypochlorite mixing by weight by weight.
According to another aspect of the invention, provide a kind of with of the application of hoof abluent as the hoof cleaning solution of the hoof bathroom facilities that is used for Ungula Bovis seu Bubali, wherein, with hoof abluent dilute with water, the concentration of hoof abluent in the hoof cleaning solution is by weight in 5% to 16% scope.
According to another aspect of the invention, a kind of preparation method that is used to prevent the hoof abluent of Ungula Bovis seu Bubali obstacle is provided, and described preparation method comprises: will be by weight 15% to 25% tartaric acid, by weight 15% to 25% citric acid, by weight 15% to 25% zinc sulfate, by weight 15% to 25% sodium molybdate and by weight the solid of 15% to 25% potassium nitrate mix; 50% said mixture by weight and 50% water by weight mixed and liquefy prepare washing liquid; The stock solution of sodium hypochlorite is provided; And 50% washing liquid and 50% sodium hypochlorite stock solution mixing by weight by weight.
Embodiments of the invention
Now, with reference to following example the present invention is described in more detail.It only is for the present invention being shown, limiting the scope of the invention and spirit and should not be construed that these examples are provided.
Be formed on the raw material of the hoof cleaning solution that uses in the hoof bathroom facilities of Ungula Bovis seu Bubali as the process dilute with water according to hoof abluent of the present invention, and provide by the following method according to hoof abluent of the present invention, that is, will by 15% to 25% tartaric acid by weight, by weight 15% to 25% citric acid, by weight 15% to 25% zinc sulfate, by weight 15% to 25% sodium molybdate and by weight the solid mixture of 15% to 25% potassium nitrate mix with the stock solution of sodium hypochlorite with the washing liquid that water is formed.
Prepare the hoof abluent by following technology, that is, with 15% to 25% tartaric acid by weight, by weight 15% to 25% citric acid, by weight 15% to 25% zinc sulfate, by weight 15% to 25% sodium molybdate and by weight the solid of 15% to 25% potassium nitrate mix; 50% gained mixture by weight and 50% water by weight mixed and liquefy prepare washing liquid; And 50% gained washing liquid and 50% sodium hypochlorite stock solution mixing by weight by weight.
When expectation utilizes the hoof abluent of preparation thus to form the hoof cleaning solution, preferably, hoof abluent and water are mixed once more form the hoof cleaning solution (hereinafter will proving) that comprises by weight 5% to 16% hoof abluent by following test value.When the hoof cleaning solution of preparation thus is circulated in the hoof bathroom facilities that Niu Suihou will pass through, during the cattle process, Ungula Bovis seu Bubali is immersed in the hoof cleaning solution, has removed the antibacterial that is present in the Ungula Bovis seu Bubali fully by the cleaning action of washing liquid and the bactericidal action of sodium hypochlorite stock solution.
That is, tartaric acid, citric acid and the zinc sulfate in the component of composition washing liquid is the good material that goes the trowel used for plastering effect of performance, and foreign body and separated from contaminants that their mixture will adhere in the section on the Ungula Bovis seu Bubali in the blink of cattle process hoof bathroom facilities are also removed.At this moment, sodium molybdate and potassium nitrate prevent the interior in the deterioration of going the trowel used for plastering effect of the single component that can occur when tartaric acid, citric acid and zinc sulfate mix mutually.
In case foreign body is removed by the component of washing liquid, the noxious bacteria that adheres on the animal hooves just is exposed to the hoof cleaning solution fully, in this case, by the sodium hypochlorite that comprises in the hoof cleaning solution be used for adherent antibacterial is sterilized completely.The cleaning performance and the bactericidal effect of hoof abluent have been proved by following various clinical trials.
Below show the test result of the bactericidal effect of hoof cleaning solution.Table 1 shows minimal inhibitory concentration (MIC) and the minimal bactericidal concentration (MBC) of hoof abluent to isolate.
[table 1]
Figure A20068004274600061
Promptly, bacteria tested is grown in the broth bouillon test tube of being made by clear glass, this culture medium test tube comprises Muller-Hinton meat soup, and added commercial copper-bath, the dilute solution of the copper-bath of interpolation have be respectively 5.00%, 2.50%, 1.25%, 0.63%, 0.31%, 0.15% with 0.08% different concentration of copper sulfate.The minimal inhibitory concentration (MIC) and the minimal bactericidal concentration (MBC) of copper-bath have been determined.Copper-bath is respectively 0.31% to MIC and the MBC of antibacterial A and antibacterial B.
Yet hoof cleaning solution of the present invention demonstrates 5% MBC to antibacterial A (escherichia coli).What determine is, the hoof cleaning solution demonstrates the MBC higher than copper sulfate, but 5% or higher concentration under, the antibacterial of most of kinds of separating from Ungula Bovis seu Bubali is demonstrated bactericidal effect.
Below, table 2 shows MIC and the MBC of hoof cleaning solution to antibacterial A (escherichia coli).
[table 2]
The concentration of hoof cleaning solution (%)
MIC 1.25
MBC 5.00
In table 2, the concentration of hoof cleaning solution is set to 5.00%, 2.50%, 1.25%, 0.63%, 0.31%, 0.15% and 0.08% respectively.
The hoof cleaning solution is measured as 1.25% and 5.00% respectively to colibacillary MIC and MBC, and is as shown in table 2.
Similar with the result shown in the antibacterial A (escherichia coli) that separates from Ungula Bovis seu Bubali, the hoof cleaning solution also is considered to the escherichia coli of also easily separating from the bottom of cowshed are usually demonstrated enough bactericidal effects.Although not shown, bacillus is also obtained much at one result here.
Be to illustrate below owing to reduce the photo of ratio according to the antibacterial of hoof cleaning solution of the present invention.
[photo 1]
The minimizing ratio of the antibacterial A (escherichia coli) that separates from Ungula Bovis seu Bubali.
(1) with before the processing of hoof cleaning solution
(2) with after 5% the hoof cleaning solution processing
(3) with after 16% the hoof cleaning solution processing
[photo 2]
The minimizing ratio of the antibacterial B (bacillus) that separates from Ungula Bovis seu Bubali
Figure A20068004274600072
(1) with before the processing of hoof cleaning solution
(2) with after 5% the hoof cleaning solution processing
(3) with after 16% the hoof cleaning solution processing
For prove with the similar test condition of condition of the in-situ applications of hoof cleaning solution under the cleaning performance and the bactericidal effect of hoof cleaning solution, the antibacterial kind is gone into aseptic cotton swab, and cotton swab is immersed in the hoof cleaning solution, determine that antibacterial reduces ratio.The result who obtains thus is shown in photo 1 and the photo 2.
In order to check the variation of bacterial number by the colony-forming units (CFU) on the affirmation plate medium, take pictures to finishing cell culture plate medium afterwards, and by calculating cell concentration with red labelling CFU.
Provided the cotton swab test result of hoof cleaning solution in the table 3 below.
[table 3]
Under the MBC concentration and in-situ applications concentration of the hoof abluent of hoof cleaning solution, the minimizing of bacterial number demonstrates 95% or higher height ratio.That is, what determine is, comprises concentration and demonstrates the obvious minimizing of bacterial number for the hoof cleaning solution of 5% to 16% hoof abluent by weight.
Following table 4 shows the comparative result of the bacterial number that exists in the cloot cattle respectively before and after with tap water, copper-bath and hoof cleaning solution of the present invention animal being handled.
[table 4]
Figure A20068004274600082
Confirmablely from the result of table 4 be, when the bacterial number before and after will handling animal compares, as can be seen, compare with handling with tap water or copper-bath, the bacterial number that the cattle of handling with hoof cleaning solution of the present invention shows from animal hooves obviously reduces.
Following table 5 shows the prevalence of the hoof obstacle of the milch cow of raising in common cowshed.
[table 5]
Figure A20068004274600091
Above-mentioned research proceeds in July, 2005 from May, 2005, and the quantity of the cattle that is studied (head) is based on milch cow.Milch cow to 4 places has carried out above-mentioned research.The result of above-mentioned research determined, low walking behavior index (value be 1 be normal) shows the high relatively not serious prevalence of hoof obstacle.
Below table 6 to show after with copper-bath and hoof cleaning solution of the present invention animal being handled respectively cattle be the ratio that 2-3 returns to normal level (value is 1) from the behavior index of walking.
[table 6]
Figure A20068004274600092
Carried out above-mentioned research from year July in May, 2005 to 2005, the phase I is the time period from lasting 30 days of the Start Date of research, and second stage is the time period from lasting 60 days of the Start Date of research.
When in above-mentioned research, using copper-bath and hoof cleaning solution, copper sulfate and hoof abluent are diluted concentration for being 16% by weight respectively.Copper-bath and hoof cleaning solution were changed once in per 7 days.(4 different cowshed) carried out above-mentioned test in 4 places.
Following table 7 shows after with copper-bath and hoof cleaning solution of the present invention animal being handled respectively, and cattle is the ratio that 4-5 returns to normal level (value is 1) from walking behavior index.
[table 7]
Figure A20068004274600093
Carried out above-mentioned research from year July in May, 2005 to 2005, the phase I is the time period from lasting 30 days of the Start Date of research, and second stage is the time period from lasting 60 days of the Start Date of research.
When in above-mentioned research, using copper-bath and hoof cleaning solution, copper sulfate and hoof abluent are diluted concentration for being 16% by weight respectively.Copper-bath and hoof cleaning solution were changed once in per 7 days.
(4 different cowshed) carried out above-mentioned test in 4 places.
Following table 8 shows the hoof obstacle prevalence of milch cow during using the hoof cleaning solution.
[table 8]
Figure A20068004274600101
Here, use hoof cleaning solution of the present invention to study, use copper-bath to study from year November in August, 2005 to 2005 from year July in May, 2005 to 2005.
The quantity of the cattle that is studied (head) is selected based on milch cow.
Although illustrated and described several embodiments of the present invention, but those skilled in the art should understand that, without departing from the principles and spirit of the present invention, can change these embodiments, scope of the present invention is limited in claim and the equivalent thereof.

Claims (4)

1, a kind of hoof abluent that is used to prevent the Ungula Bovis seu Bubali obstacle, described hoof abluent comprises: washing liquid, mix with water by solid mixture and to prepare, thereby remove foreign body from Ungula Bovis seu Bubali with tartaric acid, citric acid, zinc sulfate, sodium molybdate and potassium nitrate; Sodium hypochlorite is used for the noxious bacteria on the Ungula Bovis seu Bubali of having removed foreign body is sterilized.
2, a kind of hoof abluent that is used to prevent the Ungula Bovis seu Bubali obstacle, described hoof abluent prepares by the following method:
With 15% to 25% tartaric acid by weight, by weight 15% to 25% citric acid, by weight 15% to 25% zinc sulfate, by weight 15% to 25% sodium molybdate and by weight the solid of 15% to 25% potassium nitrate mix;
50% said mixture by weight and 50% water by weight mixed and liquefy prepare washing liquid;
With 50% washing liquid and 50% sodium hypochlorite mixing by weight by weight.
3, with the application of hoof abluent as claimed in claim 2 as the hoof cleaning solution of the hoof bathroom facilities that is used for Ungula Bovis seu Bubali, wherein, described hoof abluent dilute with water, the concentration of hoof abluent in the hoof cleaning solution is in 5% to 16% scope by weight.
4, a kind of preparation method that is used to prevent the hoof abluent of Ungula Bovis seu Bubali obstacle, described method comprises:
With 15% to 25% tartaric acid by weight, by weight 15% to 25% citric acid, by weight 15% to 25% zinc sulfate, by weight 15% to 25% sodium molybdate and by weight the solid of 15% to 25% potassium nitrate mix;
50% said mixture by weight and 50% water by weight mixed and liquefy prepare washing liquid;
The stock solution of sodium hypochlorite is provided;
With 50% washing liquid and 50% sodium hypochlorite stock solution mixing by weight by weight.
CN2006800427462A 2005-11-23 2006-11-23 Cleaner for precaution against of cow's hoof, manufacturing method thereof, and using method thereof Expired - Fee Related CN101309677B (en)

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KR10-2005-0112210 2005-11-23
KR20050112210 2005-11-23
PCT/KR2006/004950 WO2007061236A1 (en) 2005-11-23 2006-11-23 Cleaner for precaution against of cow's hoof, manufacturing method thereof, and using method thereof

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US8569373B2 (en) * 2006-09-08 2013-10-29 Delaval Holding Ab Compositions comprising A C2-C14 carboxylic acid and a surfactant for treating hoof diseases
BRPI1105614A2 (en) * 2011-12-06 2013-11-12 I.C.F. S.R.L. Powder Composition for Shell Disinfection Baths
KR101839773B1 (en) 2016-12-07 2018-03-19 (주)대명산업 The herbicide for seaweed
KR101960268B1 (en) * 2017-01-04 2019-03-21 어업회사법인 블루오션(주) The herbicide for chlorophyta

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JPH06206825A (en) * 1992-12-11 1994-07-26 Nippon Rooshiyon Kk Agent for treatment of dermatosis caused by trichophyton, eczema, etc., and agent for skin disinfection and activation
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JP3554749B2 (en) * 2001-02-22 2004-08-18 株式会社アクシス Disinfectant
US20030203027A1 (en) 2002-04-26 2003-10-30 Ethicon, Inc. Coating technique for deposition of drug substance on a substrate

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KR100997709B1 (en) 2010-12-02
WO2007061236A1 (en) 2007-05-31

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