CN101306080B - Elsholtzia spray - Google Patents
Elsholtzia spray Download PDFInfo
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- CN101306080B CN101306080B CN2007100089867A CN200710008986A CN101306080B CN 101306080 B CN101306080 B CN 101306080B CN 2007100089867 A CN2007100089867 A CN 2007100089867A CN 200710008986 A CN200710008986 A CN 200710008986A CN 101306080 B CN101306080 B CN 101306080B
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- herba moslae
- nebula
- elsholtzia
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Abstract
The utility model provides Elsholtzia ciliata nebula, which is prepared from Elsholtzia ciliata oil or other plant extracts which can be combined, and auxiliary materials. The Elsholtzia ciliata comprises 1 to 99 parts of Elsholtzia ciliata oil, 10 to 50 parts of vegetable oil, 10 to 40 parts of carrier oil, 10 to 30 parts of a flavoring agent, 2 to 15 parts of a surfactant and 100 to 1000 parts of purified water. The components are fully and uniformly mixed to prepare the nebula. The medicinal nebula can be directly sprayed to the nasal cavity or the pharyngeal portion. The nebula can reach the diseased parts directly without being absorbed by gastrointestinal tracts, and act on mucous membrane so that the medicine can directly play a local role. The Elsholtzia ciliata nebula is used safely and carried conveniently.
Description
Technical field
The present invention relates to a kind of preparation of quintessence oil extract, specifically be meant Elsholtzia spray.
Background technology
Herba Moslae volatile oil has stronger broad-spectrum antibacterial action, and its effective antimicrobial component is thymol, carvacrol and to P-cymene etc.Contain a large amount of active antibacterial compositions in the Herba Moslae volatile oil, the growth of escherichia coli, gold-coloured staphylococci is had obvious inhibitory action.This class antipathogenic composition content is up to 83.20% in the Herba Moslae volatile oil.1: 2000 ratio of Herba Moslae oil complex has akin sterilization ability with disposing of sewage with 75% ethanol when sterilizing, and the 6min sterilization rate is respectively 99.2%, 99.36%.In addition, Herba Moslae volatile oil or water decoction all have remarkable antibacterial action to escherichia coli, staphylococcus epidermidis, group B streptococcus, Bacillus paratyphosus B, bacillus typhi murium, dysentery bacterium, diphtheria corynebacterium, pneumobacillus, Bacillus proteus, anthrax bacillus, bacillus pyocyaneus and meningococcus etc.
Herba Moslae oil concentration can effectively suppress Vero cell CPE due to the influenza A3 virus during greater than 4.9mg/L.Concentration is 500mg/L in instar chicken embryo on the 9th, and the Herba Moslae oil of 250mg/L and 50mg/L can make influenza A3 viral hemoagglutination tire to drop to 1: 20 respectively, 1: 40 and 1: 16 by 1: 1280.. dosage has the obvious treatment effect to mice influenza virus property pneumonia when 100 μ g/ (g*d) are above.The result shows that Herba Moslae oil has influenza A3 virus function.
The Herba Moslae oil complex has remarkable inhibitory action external to Asia influenza A virus and Orphan virus.In vivo, administration can delay pathological changes appearance 72～96h when Orphan virus (E-CHO11) infects or after infecting.And finding the effect that the Herba Moslae oil complex has influenza A3 type virus, every kg body weight administration 100mg is above to have the obvious treatment effect to mice influenza virus property pneumonia.
By enclosing with the Herba Moslae oil complex in the dog root canal to infecting and non-infection periapical tissue and rabbit osseous tissue medicine bury the irritant test confirmation, this medicine has good antiinflammation to infecting periapical tissue, to non-infection periapical tissue and rabbit osseous tissue nonirritant, good biocompatibility, anti-infection ability is good.
In existing Herba Moslae and the Herba Moslae oil goods, with oral in the majority, as Herba Moslae oil drop pill, Herba Moslae oil granule, Herba Moslae beverage etc., often composition is single for these Herba Moslaes and Herba Moslae oil goods, effects such as prevention and treatment influenza, rhinitis are not obvious, and the oral focus of going directly that also is not easy to influences the performance of its useful effect.
Summary of the invention
Main purpose of the present invention is to overcome the deficiency of Herba Moslae and Herba Moslae oil goods in the prior art, provides a kind of and is used to prevent and treats influenza, rhinitis etc. and have the preferable prevention and the Elsholtzia spray of therapeutic effect.
The present invention adopts following technical scheme: Elsholtzia spray, and by Herba Moslae oil or add other plant extract of can compatibility using and spray that adjuvant is made.
The described plant extract that other can compatibility be used is selected from eucalyptus oil, Camellia sinensis wet goods other plant oil.
Described adjuvant comprises substrate oil, deodorant tune, surfactant, purified water.
Aforesaid Elsholtzia spray, the weight proportion of each component is as follows: 1～99 part of Herba Moslae oil, 10～50 parts of vegetable oil, 10～40 parts of substrate oil, 10～30 parts of deodorant tunes, 2～15 parts in surfactant, add purified water to 100～1000 part,, make spray the abundant mixing of each component.
Aforesaid Elsholtzia spray, the preferred weight proportion of each component is as follows: 8～10 parts of Herba Moslae oils, 10～20 parts of vegetable oil, 15～20 parts of substrate oil, 18～22 parts of deodorant tunes, 8～10 parts in surfactant, add purified water to 100～1000 part,, make spray the abundant mixing of each component.
Described substrate grease separation is from the Fructus Canarii albi wet goods.
Described deodorant tune is selected from aromatic such as Borneolum Syntheticum, Mentholum.
Described surfactant is tween～80.
By the above-mentioned description of this invention as can be known, compare with prior art, the present invention has following advantage:
1) spray of goods of the present invention can directly be sprayed on nasal cavity or pharyngeal with medicine, acts on mucosa, and medicine is directly played a role in the part, without gastrointestinal absorption, has avoided first pass effect, improves bioavailability of medicament.This product is safe in utilization, and is easy to carry.Through clinical use proof prevention and treatment influenza, rhinitis there are better curative effect, are free from side effects.
2) add the zest that other plant oil, substrate oil can be alleviated Herba Moslae oil in the component of the present invention, also can play Synergistic antimicrobial, antiviral, antiinflammatory, enhance immunity effect simultaneously;
3) add the Absorption that deodorant tune Borneolum Syntheticum, Mentholum etc. have refrigerant sense and strengthen bronchia mucosal in the component of the present invention;
4) the present invention adds the effect that cosolvent is played in tween～80, makes effective ingredient emulsifying of the present invention, becomes fine emulsion droplet, is easier to absorb.
The specific embodiment
Embodiment one:
Adopt technology such as water vapour distillation, supercritical fluid extraction to make Herba Moslae oil Mosla chinensis Maxim.cv.Jiangxiangru or Mosla chinensis Maxim. raw material, press following weight portion proportioning: 8 parts of Herba Moslae oils, 10 parts of eucalyptus oils, 10 parts of tea tree oil, 10 parts in olive oil, 10 parts of Borneolum Syntheticums, 10 parts of Mentholums, 10 parts of tween 80s add water to 1000 parts, with the abundant mixing of each component, make spray.
The present invention is through showing clinical trial 396 cases of viral influenza with headache, nasal obstruction, pharyngalgia: treat 285 examples with spray of the present invention, clinical recovery 92 examples (32.28%) wherein, produce effects 139 examples (48.77%), effective 35 examples (12.28%), total obvious effective rate 81.05%; Total effective rate 93.33%.Matched group is treated 101 examples with the oral formulations that contains Herba Moslae, clinical recovery 20 examples (19.8%), produce effects 24 examples (23.76%), effective 41 examples (40.59%), total obvious effective rate 43.56%, total effective rate 84.15%.Two groups of above case contrasts of produce effects, there is significant difference P＜0.01.
Tool is effective aspect nasal obstruction, pharyngalgia, healing time short in the present invention, especially allergic rhinitis is had more unique therapeutical effect.Data shows: the routine number of mediation nasal obstruction is removed pharyngalgia onset time and healing time and is significantly shorter than matched group (P＜0.01) obviously more than matched group (P＜0.01), and to the allergic rhinitis produce effects, and matched group is invalid.
Embodiment two:
Adopt technology such as water vapour distillation, supercritical fluid extraction to make Herba Moslae oil Mosla chinensis Maxim.cv.Jiangxiangru or Mosla chinensis Maxim. raw material, press following weight portion proportioning: 10 parts of Herba Moslae oils, 10 parts of eucalyptus oils, 10 parts of tea tree oil, 5 parts in olive oil, 10 parts of Borneolum Syntheticums, 8 parts of Mentholums, tween～80 8 part add water to 200 parts, with the abundant mixing of each component, make spray.
Embodiment three:
Adopt technology such as water vapour distillation, supercritical fluid extraction to make Herba Moslae oil Mosla chinensis Maxim.cv.Jiangxiangru or Mosla chinensis Maxim. raw material, press following weight portion proportioning: 5 parts of Herba Moslae oils, 10 parts in olive oil, 10 parts of Borneolum Syntheticums, tween～80 5 part add water to 100 parts, with the abundant mixing of each component, make spray.
Embodiment four:
Adopt technology such as organic solvent extraction, supercritical fluid extraction to make Herba Moslae oil Mosla chinensis Maxim.cv.Jiangxiangru or Mosla chinensis Maxim. raw material, press following weight portion proportioning: 30 parts of Herba Moslae oils, 30 parts of eucalyptus oils, 25 parts in olive oil, 20 parts of Mentholums, 10 parts of tween 80s add water to 500 parts, with the abundant mixing of each component, make spray.
Embodiment five:
Adopt technology such as organic solvent extraction, supercritical fluid extraction to make Herba Moslae oil Mosla chinensis Maxim.cv.Jiangxiangru or Mosla chinensis Maxim. raw material, press following weight portion proportioning: 60 parts of Herba Moslae oils, 20 parts of eucalyptus oils, 20 parts of tea tree oil, 30 parts in olive oil, 15 parts of Borneolum Syntheticums, 15 parts of Mentholums, 15 parts of tween 80s add water to 1000 parts, with the abundant mixing of each component, make spray.
Embodiment six:
Adopt technology such as organic solvent extraction, supercritical fluid extraction to make Herba Moslae oil Mosla chinensis Maxim.cv.Jiangxiangru or Mosla chinensis Maxim. raw material, press following weight portion proportioning: 80 parts of Herba Moslae oils, 10 parts of eucalyptus oils, 10 parts of tea tree oil, 10 parts in olive oil, 10 parts of Borneolum Syntheticums, 10 parts of Mentholums, 10 parts of tween 80s add water to 800 parts, with the abundant mixing of each component, make spray.
Above-mentioned only is several specific embodiment of the present invention, but design concept of the present invention is not limited thereto, and allly utilizes this design that the present invention is carried out the change of unsubstantiality, all should belong to the behavior of invading protection domain of the present invention.
Claims (2)
1. Elsholtzia spray, the weight proportion that it is characterized in that each component is as follows: 1～99 part of Herba Moslae oil, 10～50 parts of eucalyptus oil and/or tea tree oil, 10～40 parts in olive oil, 10～30 parts of Borneolum Syntheticum and/or Mentholums, 2～15 parts of tween 80s add purified water to 100～1000 part, with the abundant mixing of each component, make spray.
2. Elsholtzia spray as claimed in claim 1, it is characterized in that the preferred weight proportion of each component is as follows: 8～10 parts of Herba Moslae oils, 10～20 parts of eucalyptus oil and/or tea tree oil, 15～20 parts in olive oil, 18～22 parts of Borneolum Syntheticum and/or Mentholums, 8～10 parts of tween 80s add purified water to 100～1000 part, with the abundant mixing of each component, make spray.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100089867A CN101306080B (en) | 2007-05-17 | 2007-05-17 | Elsholtzia spray |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100089867A CN101306080B (en) | 2007-05-17 | 2007-05-17 | Elsholtzia spray |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101306080A CN101306080A (en) | 2008-11-19 |
| CN101306080B true CN101306080B (en) | 2011-09-21 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007100089867A Active CN101306080B (en) | 2007-05-17 | 2007-05-17 | Elsholtzia spray |
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| CN (1) | CN101306080B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111110574B (en) * | 2020-01-19 | 2022-10-25 | 江西中医药大学 | Wet tissue with three-in-one functions of cleaning, sterilizing and moisturizing and preparation method thereof |
| CN111297949A (en) * | 2020-03-19 | 2020-06-19 | 王鹏 | Essential oil mask and preparation method thereof |
| CN112386628A (en) * | 2020-12-08 | 2021-02-23 | 武汉萃绿科技有限公司 | Elsholtzia volatile oil nanoemulsion and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1628757A (en) * | 2004-08-27 | 2005-06-22 | 山东华旗生物工程有限公司 | Externally applied healthy medicinal formulation |
| CN1879701A (en) * | 2006-05-08 | 2006-12-20 | 广州中医药大学 | Cold-treating medicine and preparation method thereof |
-
2007
- 2007-05-17 CN CN2007100089867A patent/CN101306080B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1628757A (en) * | 2004-08-27 | 2005-06-22 | 山东华旗生物工程有限公司 | Externally applied healthy medicinal formulation |
| CN1879701A (en) * | 2006-05-08 | 2006-12-20 | 广州中医药大学 | Cold-treating medicine and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 广州铁路局长沙分局卫生防疫站.香薷油膏涂鼻剂和香薷油喷雾剂对流行性脑脊髓膜炎带菌者防治效果初步观察.《医学研究通讯》.1977,17-18. * |
| 贾一江等.香薷喷雾剂.《当代中药外治临床大全》.1991,611. * |
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| Publication number | Publication date |
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| CN101306080A (en) | 2008-11-19 |
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| C06 | Publication | ||
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| C14 | Grant of patent or utility model | ||
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Owner name: GOLDEN SUN PHARMACEUTICAL (CHINA) CO., LTD. Free format text: FORMER NAME: XIAMEN JINRI PHARMACEUTICAL CO., LTD. |
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| CP03 | Change of name, title or address |
Address after: 361100 Jinri industrial village, Jinri Road, Tong'an District, Xiamen City, Fujian Province (production and operation address: No.88 Rongyuan Road, Chengdong Industrial Zone, Tong'an District, Xiamen City) Patentee after: Golden day Pharmaceutical (China) Co., Ltd. Address before: Tong'an District Xiamen city Fujian province 361100 golden sun Road No. 1 Patentee before: Xiamen Jinri Pharmaceutical Co., Ltd. |