CN101306010A - Function food for reducing the blood sugar and preventing diabetes complicating disease - Google Patents
Function food for reducing the blood sugar and preventing diabetes complicating disease Download PDFInfo
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- CN101306010A CN101306010A CNA2008100286198A CN200810028619A CN101306010A CN 101306010 A CN101306010 A CN 101306010A CN A2008100286198 A CNA2008100286198 A CN A2008100286198A CN 200810028619 A CN200810028619 A CN 200810028619A CN 101306010 A CN101306010 A CN 101306010A
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- blood sugar
- taurine
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Abstract
The invention discloses a functional food used for reducing blood sugar and preventing diabetes mellitus complications, which comprises the active ingredients by the weight percentages as follows: 10 to 70 percent of alginate, 15 to 75 percent of taurine, 10 to 70 percent of L-arginine and 0.01 to 5 percent of nutrient chromium. In the active ingredients of the functional food, the alginate has the function of improving the glucose tolerance, the nutrient chromium is the nutrients for a patient, the taurine has the antioxidation function, and the L-arginine has the function of improving the blood vessels. The functional food combines the functions of the alginate, the taurine, the L-arginine, and the nutrient chromium according to a certain rule, and manufactures the functional food according to a certain component proportion, thereby leading the alginate, the taurine, the L-arginine, and the nutrient chromium to be put into full-play during the process of reducing blood sugar and preventing diabetes mellitus complications.
Description
Technical field
The present invention relates to a kind of hypoglycemic functional food that is used for, relating in particular to a kind of is the functional food that is used for blood sugar lowering and prevent diabetes complication of main material preparation with aminoacid, trace element and Sargassum extract.
Background technology
Diabetes are because insulin deficit or can not normally bring into play a kind of syndrome that carbohydrate metabolism disturbance that physiological action causes causes multiple substance metabolism disorders such as protein, fat, water, electrolyte then in the body is one of modal chronic disease.Along with the raising of people's living standard, the increase of aged tendency of population and fat incidence rate, the sickness rate of diabetes is ascendant trend year by year.Diabetes reach 2% at the sickness rate of China, and according to statistics, the diabetics made a definite diagnosis of China reaches 4,000 ten thousand, and with annual 1000000 speed increase.Diabetes are second killers in the modern disease, and its harm to human body is only second to cancer.In China's diabetics, the complicated hypertension person reaches 1,200 ten thousand, apoplexy person 5,000,000, and coronary disease patient 6,000,000, the person of losing the sight of both eyes 450,000, the person of uremia 500,000.Hyperglycemia is the cardinal symptom of diabetes, life threatening be the complication of diabetes, the harm that diabetes are brought is nearly all from its complication.Blood sugar lowering, the prevent diabetes complication, maimed person that the reduction chronic complicating diseases of diabetes causes and premature death are the effective ways of prevent diabetes development, this purpose also of the present invention just.
It is at present domestic that to have a hypoglycemic health food more, major part is that the Chinese herbal medicine with medicine-food two-purpose is the primary raw material preparation, also there are some to prepare with plant extracts such as Fructus Cucurbitae moschatae, Fructus Momordicae charantiaes, also have some to prepare with propolis, nutrition chromium primary raw material, selected raw material function mainly is to be used for blood sugar lowering.With aminoacid, trace element and Sargassum extract is raw material, is that the functional food of purpose is still seen at the end with blood sugar lowering and prevent diabetes complication.
Summary of the invention
The object of the present invention is to provide a kind of functional food that is used for blood sugar lowering and prevent diabetes complication, this functional food effect of lowering blood sugar composition is clear and definite, and steady quality has no side effect.
Solution of the present invention is based on understanding and the principle to blood sugar lowering and prevent diabetes complication, and to the understanding of aminoacid, trace element and Sargassum extract active function, with reference to modern medicine and pharmacological research achievement, comform to filter out in amino acids, trace element and the Sargassum extract and have blood sugar lowering and the active raw material of prevent diabetes complication, scientific composition makes the effect of the anti-sugar of its performance improvement, the effect that replenishes diabetes patient's nutrient, antioxidation and improve blood vessel.
Active component and the weight content thereof of forming functional food of the present invention are:
Alginate 10～70%
Taurine 15～75%
L-arginine 10～70%
Nutrition chromium 0.01～5%.
The preferred weight content of forming the active component of functional food of the present invention is:
Alginate 15～50%
Taurine 20～55%
L-arginase 12 5～60%
Nutrition chromium 0.1～2%.
In the above-mentioned active component, described alginate is meant employed alginic acid zinc, calcium alginate, sodium alginate, potassium alginate or alginic acid magnesium in drug additive, food additive and health food nutrient; Described taurine is meant the taurine that extracts or the taurine of synthetic from biology; Described nutrition chromium is meant at employed chromium trichloride, nicotinic acid chromium, chromium picolinate or chromium yeast in drug additive, food additive and health food nutrient.
The above-mentioned functional food that is used for blood sugar lowering and prevent diabetes complication by common process, can be made said multiple dosage form on the pharmaceutics, as capsule, tablet, powder, electuary, unguentum or granule.
An important feature of the present invention is the mechanism of action that alginate improves anti-sugar, at first be that food paste rises because of viscosity after taking in alginate, thereby secondly the food and extend paste is the diffusion velocity that has reduced glucose in the small intestinal in the holdup time of gastric.Delayed the process of digesting and assimilating of sugar, increased the sensitivity of tissue, impelled blood glucose to descend insulin.In addition, alginate is the very high dietary fiber of purity, is the macromolecule block compound that manna alditol and manna guluronic acid are formed, and has the not available physicochemical property of general cellulose, and the effect that stops lipid to absorb is arranged.In addition, can make free movement of the bowels, thereby reduce sodium, water retention, thereby receive that edema alleviates, the effect of weight loss.
Another important feature of the present invention is a taurine antioxidative mechanism of action.Taurine has important function such as the crystalloid osmotic pressure of adjusting and antioxidation; take place in the process of development in cataract; sorbitol content increases in the crystalline lens; crystalloid osmotic pressure increases; then obviously reduce as the content of taurine of regulating the osmotic pressure important substance; antioxidation weakens, the albumen generation over oxidation in the crystal, thus cause or increase the weight of cataractous the development.Taurine can suppress the lipid peroxidation that galactose causes, and it is muddy to prevent that crystal from taking place, and supplementation of taurine can suppress developing of diabetic cataract.Taurine is regulated basic roles such as body osmotic pressure and antioxidation by it, diabetics is played protection β cell, blood sugar lowering and prevents and treats diabetes and the effect of complication.
Another characteristics of the present invention are mechanism of action that the L-arginine improves blood vessel.The L-arginine is the synthetic nitric oxide production precursor of blood vessel endothelium, synthetic endogenous nitric oxide under the effect of nitric oxide synthetase.Nitric oxide has lax vascular smooth muscle, and vasodilator is regulated Peripheral resistance and other biological effect.The diastolic function that diabetic vascular complications ubiquity blood vessel endothelium relies on reduces, and the endothelium-derived relaxing factor nitric oxide generates and reduces.Nitric oxide has blood vessel dilating, suppresses vascular smooth muscle cell proliferation, alleviates atherosclerosis and thrombosis, suppresses biological effect widely such as platelet adhesion and gathering.Except that vascular endothelial cell, vascular smooth muscle cell, platelet etc. can both produce nitric oxide, keeps the stable of cardiovascular system jointly, and participates in its adjusting, thereby reduces the generation and the development of diabetic vascular complications.
Non-insulin-dependent diabetes mellitus (NIDDM) patient exists tissue that insulin sensitivity is reduced, i.e. insulin resistant.Scarce chromium then is one of important pathogenesis of NIDDM, by additional chromium element, thereby a kind of complex one carbohydrate tolerance factor (GTF) that contains that lacks in NIDDM patient's body is replenished, and then plays the effect of blood sugar lowering.
Diabetes are that multiple factor causes, and the present invention is that the wherein main pathogeny of basis adopts multiple function raw material to carry out the science compatibility.Alginate has the effect that improves anti-sugar; Nutrition chromium is diabetes patient's nutrient; Taurine can play the antioxidative effect; The L-arginine has the effect that improves blood vessel, the effect that they can play is made up by certain law, and by certain component proportion, make functional food, makes four kinds of raw materials give full play to each self-applying in the process of blood sugar lowering and prevent diabetes complication.The present invention proves to have obvious hypoglycemic function through the animal function test.
In addition, functional food effective component of the present invention is clear and definite, and steady quality is easy to control.The raw material components that the present invention selects for use is few, flat flavor, and instant has no side effect.
The present invention is further illustrated below in conjunction with the specific embodiment and contractile studies.
The specific embodiment
The present invention will be described below to enumerate specific embodiment.It is pointed out that embodiment only is used for that the invention will be further described, do not represent protection scope of the present invention, nonessential modification and adjustment that other people prompting according to the present invention is made still belong to protection scope of the present invention.
Embodiment 1
Active component and the weight content thereof of forming functional food of the present invention are:
Potassium alginate 70%
Taurine 20%
L-arginine 9.9%
Chromium yeast 0.1%.
Embodiment 2
Active component and the weight content thereof of forming functional food of the present invention are:
Alginic acid magnesium 50%
Taurine 29.5%
L-arginase 12 0%
Nicotinic acid chromium 0.5%.
Embodiment 3
Active component and the weight content thereof of forming functional food of the present invention are:
Sodium alginate 45%
Taurine 35%
L-arginine 19.5%
Chromium trichloride 0.5%.
Embodiment 4
Active component and the weight content thereof of forming functional food of the present invention are:
Alginic acid zinc 50%
Taurine 20%
L-arginase 12 8%
Chromium picolinate 2%.
Embodiment 5
Active component and the weight content thereof of forming functional food of the present invention are:
Calcium alginate 30%
Taurine 35%
L-arginine 30%
Chromium picolinate 5%.
The functional food that is used for blood sugar lowering and prevent diabetes complication of the foregoing description by common process, can be made said multiple dosage form on the pharmaceutics, as capsule, tablet, powder, electuary, unguentum or granule.
The animal function test
The capsule that adopts the foregoing description 1 prescription to make carries out the animal function test according to Ministry of Public Health " health food check and assessment technique standard (2003 editions) " regulation, and content of the test is: make hyperglycemia model; Reduce the fasting glucose experiment; To intact animal's fasting glucose influence test; Date processing.
1 result of the test:
1.1 the influence of fasting blood sugar falls in capsule of the present invention to alloxan hyperglycemia mice:
As seen from Table 1, blood glucose rate before and after middle dosage group (0.30g/kg) experiment back blood glucose and the experiment [before (before the experiment-experiment back)/experiment * 100%] and hyperglycemia matched group relatively, difference has highly significant meaning (P＜0.01); High dose group (0.60g/kg) is tested back blood glucose and experiment front and back blood glucose rate and hyperglycemia matched group and is compared, and difference has significance meaning (P＜0.05).The result shows that capsule of the present invention has the effect that reduces fasting glucose to alloxan hyperglycemia mice, and experimental result is positive.
Table 1 capsule of the present invention is to the influence of hyperglycemia mice fasting glucose (x ± S)
Annotate: compare with the hyperglycemia matched group,
*Be P＜0.01
*Be P＜0.05 (q check)
1.2 capsule of the present invention is to the influence of normal mouse fasting glucose:
By table 2 as seen, high dose group experiment back blood glucose and blank group compare, and difference does not have the significance meaning, shows that capsule of the present invention does not have obvious influence to the normal mouse fasting glucose.
Table 2 capsule of the present invention is to the influence of normal mouse fasting glucose (x ± s)
1.3 capsule of the present invention is to the influence of the forward and backward body weight of alloxan hyperglycemia mouse experiment:
By table 4 as seen, body weight and hyperglycemia matched group compare before and after each dosage group mouse experiment, and difference does not have the significance meaning, shows that capsule of the present invention is to the positive result of the influence of hyperglycemia animal body weight.
Table 3 capsule of the present invention is to the influence of alloxan hyperglycemia mice body weight (x ± s)
2. conclusion:
Give the present invention that various dose (0.30,0.60,1.20g/kg b.w.) and normal mouse give 1.20g/kg b.w. continuous every day after 30 days to alloxan hyperglycemia mice, can reduce hyperglycemia mice fasting blood sugar; Not obviously influence of fasting blood sugar to normal mouse.
Criterion according to Ministry of Public Health " health food check and assessment technique standard (2003 editions) " judges that capsule of the present invention has the effect of blood sugar lowering and prevent diabetes complication.
Claims (6)
1, a kind of functional food that is used for blood sugar lowering and prevent diabetes complication is characterized in that active component and the weight content thereof of forming this functional food are:
Alginate 10～70%
Taurine 15～75%
L-arginine 10～70%
Nutrition chromium 0.01～5%.
2, the functional food that is used for blood sugar lowering and prevent diabetes complication according to claim 1 is characterized in that the weight content of each active component is:
Alginate 15～50%
Taurine 20～55%
L-arginase 12 5～60%
Nutrition chromium 0.1～2%.
3, the functional food that is used for blood sugar lowering and prevent diabetes according to claim 1 and 2 is characterized in that described alginate is meant employed alginic acid zinc, calcium alginate, sodium alginate, potassium alginate or alginic acid magnesium in drug additive, food additive and health food nutrient.
4, the functional food that is used for blood sugar lowering and prevent diabetes according to claim 1 and 2 is characterized in that described taurine is meant the taurine that extracts or the taurine of synthetic from biology.
5, the functional food that is used for blood sugar lowering and prevent diabetes according to claim 1 and 2 is characterized in that described nutrition chromium is meant at employed chromium trichloride, nicotinic acid chromium, chromium picolinate or chromium yeast in drug additive, food additive and health food nutrient.
6, the functional food of blood sugar lowering according to claim 1 and 2 and prevent diabetes complication is characterized in that said dosage form is capsule, tablet, powder, electuary, unguentum or granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100286198A CN101306010B (en) | 2008-06-06 | 2008-06-06 | Function food for reducing the blood sugar and preventing diabetes complicating disease |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100286198A CN101306010B (en) | 2008-06-06 | 2008-06-06 | Function food for reducing the blood sugar and preventing diabetes complicating disease |
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| Publication Number | Publication Date |
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| CN101306010A true CN101306010A (en) | 2008-11-19 |
| CN101306010B CN101306010B (en) | 2010-06-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2008100286198A Expired - Fee Related CN101306010B (en) | 2008-06-06 | 2008-06-06 | Function food for reducing the blood sugar and preventing diabetes complicating disease |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973589A (en) * | 2012-11-26 | 2013-03-20 | 合肥博太医药生物技术发展有限公司 | Application of alginic acid in preparing medicament for treating diabetes mellitus |
| CN104000865A (en) * | 2014-06-13 | 2014-08-27 | 沈阳农业大学 | Taurine compound preparation with blood fat reducing function and blood sugar reducing function |
-
2008
- 2008-06-06 CN CN2008100286198A patent/CN101306010B/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973589A (en) * | 2012-11-26 | 2013-03-20 | 合肥博太医药生物技术发展有限公司 | Application of alginic acid in preparing medicament for treating diabetes mellitus |
| CN104000865A (en) * | 2014-06-13 | 2014-08-27 | 沈阳农业大学 | Taurine compound preparation with blood fat reducing function and blood sugar reducing function |
| CN104000865B (en) * | 2014-06-13 | 2017-08-04 | 沈阳农业大学 | It is a kind of that there is reducing blood lipid, the Taurine of function of blood sugar reduction |
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| Publication number | Publication date |
|---|---|
| CN101306010B (en) | 2010-06-02 |
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Granted publication date: 20100602 Termination date: 20200606 |