CN101277698B - 作为抗菌剂的喹啉衍生物 - Google Patents

作为抗菌剂的喹啉衍生物 Download PDF

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Publication number
CN101277698B
CN101277698B CN2006800367813A CN200680036781A CN101277698B CN 101277698 B CN101277698 B CN 101277698B CN 2006800367813 A CN2006800367813 A CN 2006800367813A CN 200680036781 A CN200680036781 A CN 200680036781A CN 101277698 B CN101277698 B CN 101277698B
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alkyl
formula
purposes
compound
compounds
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CN2006800367813A
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English (en)
Chinese (zh)
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CN101277698A (zh
Inventor
K·J·L·M·安德里斯
A·考尔
J·E·G·吉尔蒙特
E·T·J·帕斯奎尔
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN2006800367813A 2005-08-03 2006-07-31 作为抗菌剂的喹啉衍生物 Active CN101277698B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05107155 2005-08-03
EP05107155.3 2005-08-03
PCT/EP2006/064847 WO2007014934A2 (en) 2005-08-03 2006-07-31 Quinoline derivatives as antibacterial agents

Publications (2)

Publication Number Publication Date
CN101277698A CN101277698A (zh) 2008-10-01
CN101277698B true CN101277698B (zh) 2011-06-22

Family

ID=35768115

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800367813A Active CN101277698B (zh) 2005-08-03 2006-07-31 作为抗菌剂的喹啉衍生物

Country Status (30)

Country Link
US (1) US8691800B2 (enExample)
EP (1) EP1912649B1 (enExample)
JP (1) JP5208739B2 (enExample)
KR (1) KR101413094B1 (enExample)
CN (1) CN101277698B (enExample)
AP (1) AP2483A (enExample)
AR (1) AR054888A1 (enExample)
AU (1) AU2006274873B2 (enExample)
BR (1) BRPI0614099B8 (enExample)
CA (1) CA2615900C (enExample)
CY (1) CY1113535T1 (enExample)
DK (1) DK1912649T3 (enExample)
EA (1) EA014834B1 (enExample)
ES (1) ES2397358T3 (enExample)
HR (1) HRP20120910T1 (enExample)
IL (1) IL189140A (enExample)
JO (1) JO2837B1 (enExample)
ME (1) ME01485B (enExample)
MX (1) MX2008001601A (enExample)
MY (1) MY147637A (enExample)
NO (1) NO342328B1 (enExample)
NZ (1) NZ566012A (enExample)
PL (1) PL1912649T3 (enExample)
PT (1) PT1912649E (enExample)
RS (1) RS52606B (enExample)
SI (1) SI1912649T1 (enExample)
TW (1) TWI385168B (enExample)
UA (1) UA95911C2 (enExample)
WO (1) WO2007014934A2 (enExample)
ZA (1) ZA200801106B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2837B1 (en) 2005-08-03 2014-09-15 جانسن فارمسيتكا ان في Quinoline derivatives acting as antibacterial agents
JO2683B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JO3271B1 (ar) * 2006-12-06 2018-09-16 Janssen Pharmaceutica Nv مشتقات الكوينولين المضادة للجراثيم
JP5246715B2 (ja) * 2009-01-27 2013-07-24 独立行政法人科学技術振興機構 蛋白質架橋阻害剤およびその用途
DK2841426T3 (en) 2012-04-27 2017-01-09 Janssen Pharmaceutica Nv ANTIBACTERIAL QUINOLIN DERIVATIVES
EA035443B1 (ru) 2012-04-27 2020-06-17 Янссен Фармацевтика Нв Антибактериальные хинолиновые производные
KR102355154B1 (ko) * 2016-03-07 2022-01-26 더 글로벌 얼라이언스 포 티비 드러그 디벨롭먼트, 잉크. 항박테리아 화합물 및 그의 용도

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004011436A1 (en) * 2002-07-25 2004-02-05 Janssen Pharmaceutica N.V. Quinoline derivatives and their use as mycobacterial inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0936866A4 (en) * 1996-10-28 2001-04-11 Dept Of The Army Us Government Compounds, compositions and methods for treating antibiotic-resistant infections
US6103905A (en) * 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
GB0101577D0 (en) * 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
TW200409637A (en) * 2002-06-26 2004-06-16 Glaxo Group Ltd Compounds
AP2188A (en) * 2004-01-23 2010-12-14 Janssen Pharmaceutica Nv Substituted quinolines and their use as mycobacterial inhibitors.
JO2837B1 (en) 2005-08-03 2014-09-15 جانسن فارمسيتكا ان في Quinoline derivatives acting as antibacterial agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004011436A1 (en) * 2002-07-25 2004-02-05 Janssen Pharmaceutica N.V. Quinoline derivatives and their use as mycobacterial inhibitors

Also Published As

Publication number Publication date
AU2006274873A1 (en) 2007-02-08
SI1912649T1 (sl) 2013-01-31
CA2615900C (en) 2014-12-09
AR054888A1 (es) 2007-07-25
BRPI0614099B1 (pt) 2019-11-12
ES2397358T3 (es) 2013-03-06
HK1124232A1 (zh) 2009-07-10
EA200800513A1 (ru) 2008-06-30
UA95911C2 (ru) 2011-09-26
US20080227775A1 (en) 2008-09-18
ZA200801106B (en) 2009-09-30
KR101413094B1 (ko) 2014-07-01
MX2008001601A (es) 2008-02-19
IL189140A0 (en) 2008-08-07
IL189140A (en) 2014-07-31
CN101277698A (zh) 2008-10-01
PL1912649T3 (pl) 2013-03-29
BRPI0614099A2 (pt) 2011-03-09
TW200800971A (en) 2008-01-01
WO2007014934A8 (en) 2007-05-18
CA2615900A1 (en) 2007-02-08
EA014834B1 (ru) 2011-02-28
WO2007014934A3 (en) 2007-04-05
AU2006274873B2 (en) 2012-12-13
NO342328B1 (no) 2018-05-07
BRPI0614099B8 (pt) 2021-05-25
HRP20120910T1 (hr) 2012-12-31
ME01485B (me) 2014-04-20
AP2483A (en) 2012-10-01
WO2007014934A2 (en) 2007-02-08
JO2837B1 (en) 2014-09-15
US8691800B2 (en) 2014-04-08
JP2009503021A (ja) 2009-01-29
MY147637A (en) 2012-12-31
TWI385168B (zh) 2013-02-11
NO20081068L (no) 2008-02-29
EP1912649B1 (en) 2012-10-10
RS52606B (sr) 2013-04-30
CY1113535T1 (el) 2016-06-22
PT1912649E (pt) 2013-01-14
KR20080039961A (ko) 2008-05-07
NZ566012A (en) 2011-02-25
EP1912649A2 (en) 2008-04-23
JP5208739B2 (ja) 2013-06-12
DK1912649T3 (da) 2013-01-21

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