CN101264222A - Chinese medicinal composition for treating breast cancer - Google Patents
Chinese medicinal composition for treating breast cancer Download PDFInfo
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- CN101264222A CN101264222A CN 200810106123 CN200810106123A CN101264222A CN 101264222 A CN101264222 A CN 101264222A CN 200810106123 CN200810106123 CN 200810106123 CN 200810106123 A CN200810106123 A CN 200810106123A CN 101264222 A CN101264222 A CN 101264222A
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Abstract
The invention relates to a Chinese herbal medicine composition for curing breast cancer, comprising bupleurum, Largehead Atractylodes Rhizome, common curculigo rhizome, angelica sinensis, phellodendron bark, root of herbaceous peony, mint, poria cocos, anemarrhena, radix glycyrrhizae, morinda officinalis, milettia reticulate, lanceolata, prepared rhizome of rehmanniae, Nutgrass Galingale Rhizome and/or medically acceptable carrier. The invention also relates to the preparation method of the Chinese herbal medicine composition. The Chinese herbal medicine composition has the functions of smoothing liver, dispelling melancholy, regulating thoroughfare and controlling vessels, complementing qi and blood, regulating the flow of vital energy and removing phlegm, and can be used for curing breast cancer caused by qi and blood stagnation, liver and spleen deficiency and toxic pathogens accumulation.
Description
Technical field
The invention belongs to technical field of Chinese medicines, specifically, relate to a kind of Chinese medicine composition for the treatment of breast carcinoma, the invention still further relates to the preparation method of its Chinese medicine composition.
Background technology
Breast carcinoma is meant the malignant tumor that originates from breast duct epithelium and lobules of mammary gland, is common malignancy the most among the whole world women.Worldwide, some developed countries of west are as North America and most of European countries, district occurred frequently for women with breast cancer, the highest sickness rate sees the white man of Hawaiian white man and British Columbia, Canada, and sickness rate is up to 80,/10 ten thousand, and only is 12,/10 ten thousand at Japanese sickness rate.In same country, white man's sickness rate is higher than Black people.Minimum sickness rate sees the crowd in Africa and Asia, is 10～15,/10 ten thousand.Chinese and Japanese in the U.S. though the sickness rate of its women with breast cancer is not high like that from the people, exceed 3 times than the Chinese of Singapore and people in Japan.China belongs to that breast carcinoma is low sends out the district, but its sickness rate rises just year by year in recent years, and the city is higher than the rural area, and the coastal area is higher than interiorly.Shanghai, Beijing, Tianjin and coastal area are the hotspots of Chinese breast carcinoma.Especially with Shanghai for the highest, leapt to the first place of women's malignant tumor.
The cause of disease of breast carcinoma still can not be clear fully, and certified some pathogenic factors also still exists many disputes.Menopause is preceding to be to stimulate the obvious factor that breast carcinoma takes place with postmenopausal estrogen.In addition, inherited genetic factors, dietary factor, extraneous chemical factors and some breast benign disease and breast carcinoma has certain relation.Known several principal element of bringing out breast carcinoma:
1, the age: in the women, sickness rate rises with advancing age, and is rare before menarche, also rare before 20 years old, but sickness rate rises rapidly after 20 years old, and 45～50 years old is higher, but be relative smooth, menopause sequela rate continues to rise, and reaches summit by about 70 years old.Mortality rate also rises with the age, and mortality rate progressively rises after 25 years old, remains ascendant trend when old age.
2, inherited genetic factors: the women of family has the breast carcinoma history person of the straight relative by marriage of first order family, and the danger of its breast carcinoma is 2～3 times of normal population.
3, the menarche age: age of menarche is age 2.2 times greater than 17 years old person early than the danger of person's morbidity in 13 years old.
4, age of meuopause: age of meuopause increases than the danger less than 45 years old greater than 55 years old person.
5, for the first time conceived age: danger increases gradually along with the postponement at primiparity age, and the primiparity age is higher than atoke history person the 35 years old danger with the latter.
6, complementing estrogen after the menopause: take the danger that estrogen may increase breast carcinoma for a long time climacteric.
7, oral contraceptive.
8, food: fat diet especially can increase the danger of breast carcinoma.
9, drink.
10, weight increase: may be the important risk factor that breast carcinoma takes place the women after menopause.
Breast carcinoma performance the earliest be suffer from breast occur single-shot, painless property and be the little lump of carrying out property growth.Lump is positioned at the outer quadrant of going up to be seen at most, secondly is nipple, mammary areola district and UIQ.Because of many no conscious symptons, lump often is that patient is in (as having a bath, changing one's clothes) discovery unintentionally.A few patients can have tenderness or stimulation and nipple discharge in various degree.The speed of growth of lump is very fast, invades and surrounding tissue can cause and the change of breast profile a series of signs occur.As: the tumor surface skin depressions; The cancerous protuberance of contiguous nipple can be led nipple to the cancerous protuberance direction; Retracted nipple etc.Cancerous protuberance the greater can make whole breast tissue shrink, and lump obviously protrudes.Cancerous protuberance continues to increase, and forms so-called " Pericarpium Citri Reticulatae sample " and changes.These all are the vital sign of breast carcinoma.
The traditional Chinese medical science thinks that breast carcinoma belongs to categories such as " mammary calculus carbuncle ", " breast carcinoma ", " Shi breast ", " breast carcinoma ".Chinese medicine starts from the description of Shanxi Ge Hong handbook of Prescription for Emergency to primary disease to the understanding of breast carcinoma, generation and diseases caused by exogenous pathogenic factor six climate exopathogens, evil poison that it is generally acknowledged primary disease pent up, or feelings will is not smooth, and liver spleen two injures Chong and Ren channel disorder, coagulation of QI-blood is relevant, pathological changes and liver spleen kidney and the closest towards the relation of appointing.The heresy of diseases caused by exogenous pathogenic factor six climate exopathogens, evil poison pents up, and the visitor falls ill in newborn network; The relation of the generation of breast carcinoma and feelings will is very close, the smooth and depression of liver-QI of feelings will, and dysfunction of the spleen in transportation is then given birth in the phlegm-damp, and stagnation of QI expectorant coagulates, and the meridians painful abdominal mass is puckery, causes into primary disease; Dash to appoint to be under the jurisdiction of Liver and kidney, be the sea of QI and blood, deficiency of the liver and kindey, Chong and Ren channel disorder then QI-blood circulation are not smooth, and qi stagnation hemagglutination hinders to send out in newborn network and is primary disease.Breast carcinoma patient's cause of disease mainly is the yin-yang and five elements imbalance that " worried think of anger " is brought.When patient just with language, irriate in the action, just fire of moxibustion begins to rise, and causes the conflict of sufficient Yangming Channel and meridian of Hand-YANG MING, with conflicting of meridian of Hand-TAI YIN and meridian of Foot-TAI YIN, heat in the gas and heat disaccord and turn to poison; Poison is repeated multiple times on meridians, and the red blood in its position is ruined, condense enlargement and canceration.
The traditional Chinese medical science is divided into three types with this disease:
1) liver energy depression and phlegm stagnation type: depressed emotion, or irascible temperament, feeling of oppression over the chest and distention of hypochondrium, or companion's breast premenstruum is done to expand or few abdomen expands, and breast portion lump color of the leather is constant.Thin fur, stringy pulse.
2) Chong and Ren channel disorder type: through the thing disorder, premenstruum distending pain of the breast, or fertility never after marriage, or the history of repeatedly miscarrying.Pale tongue, thin fur, stringy pulse are low.
3) the vehement type of weakened body resistance poison: lump enlarges, and the back of bursting is harder, seepage flow blood and slime, not bitterly or severe pain, and lethargy, complexion is silent or pale, and diet advances less, palpitation and insomnia.Purplish tongue or have ecchymosis, yellow fur, weak pulse unable.
The traditional Chinese medical science adopts this disease of decoction for the treatment of dispersing the stagnated live-QI to relieve the stagnation of QI, regulating thoroughfare and controlling vessel, compensate qi and blood, activating QI to eliminate phlegm.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of breast carcinoma.
The present invention also aims to provide a kind of preparation method of this Chinese medicine composition.
In order to realize purpose of the present invention, the invention provides a kind of Chinese medicine composition for the treatment of breast carcinoma, be to make by effective ingredient and/or pharmaceutically acceptable carrier, described effective ingredient is made by weight by following raw materials according:
Radix Bupleuri 10-20 part Rhizoma Atractylodis Macrocephalae 5-10 part Rhizoma Curculiginis 15-20 part
Radix Angelicae Sinensis 10-15 part Cortex Phellodendri 15-25 part Radix Paeoniae Alba 5-15 part
Herba Menthae 10-20 part Poria 10-15 part Rhizoma Anemarrhenae 10-25 part
Radix Glycyrrhizae 10-20 part Radix Morindae Officinalis 15-25 part Caulis Spatholobi 5-10 part
Radix Codonopsis 15-25 part Radix Rehmanniae Preparata 10-20 part Rhizoma Cyperi 10-15 part
Effective ingredient is preferably made by weight by following raw materials according:
18 parts of 8 portions of Rhizoma Curculiginises of 16 parts of Rhizoma Atractylodis Macrocephalaes of Radix Bupleuri
11 parts of 21 portions of Radix Paeoniae Albas of 13 portions of Cortex Phellodendris of Radix Angelicae Sinensis
18 parts of 13 parts of Rhizoma Anemarrhenaes of 16 parts of Poria of Herba Menthae
8 parts of 21 portions of Caulis Spatholobis of 16 parts of Radix Morindae Officinaliss of Radix Glycyrrhizae
13 parts of 16 portions of Rhizoma Cyperis of 21 parts of Radix Rehmanniaes Preparata of Radix Codonopsis
The present invention also provides a kind of preparation method of this Chinese medicine composition, comprises the steps:
(1) Radix Glycyrrhizae powder is broken into impalpable powder, and is standby;
(2) Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Codonopsis are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(3) Radix Bupleuri, the Rhizoma Atractylodis Macrocephalae, Rhizoma Curculiginis, Cortex Phellodendri, Herba Menthae, Poria, the Rhizoma Anemarrhenae, Radix Morindae Officinalis, Caulis Spatholobi, Radix Rehmanniae Preparata, Rhizoma Cyperi decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, make granule, capsule and tablet with pharmaceutically acceptable carrier.
Chinese medicine composition of the present invention can with receivable carrier pharmaceutically, for example: filler such as starch, microcrystalline Cellulose etc.; Binding agent such as vitamin derivative, starch etc.; Mode by granule, capsule, tablet oral administration is used.
Chinese medicine composition of the present invention has effects such as dispersing the stagnated live-QI to relieve the stagnation of QI, regulating thoroughfare and controlling vessel, compensate qi and blood, activating QI to eliminate phlegm, is used for that evil poison pents up, liver spleen two is hindered, coagulation of QI-blood institute is to diseases such as breast carcinoma.
The specific embodiment
Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.
Embodiment 1: Chinese medicinal composition granules of the present invention
(1) Radix Glycyrrhizae 160g is ground into impalpable powder, and is standby;
(2) Radix Angelicae Sinensis 130g, Radix Paeoniae Alba 110g, Radix Codonopsis 210g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(3) Radix Bupleuri 160g, Rhizoma Atractylodis Macrocephalae 80g, Rhizoma Curculiginis 180g, Cortex Phellodendri 210g, Herba Menthae 160g, Poria 130g, Rhizoma Anemarrhenae 180g, Radix Morindae Officinalis 210g, Caulis Spatholobi 80g, Radix Rehmanniae Preparata 160g, Rhizoma Cyperi 130g decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, and got supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned fine powder and clear paste, drying is ground into fine powder, adds lactose 400g, dextrin 500g, mixing sieves, with 74% ethanol wet granulation, drying, pack promptly.
Embodiment 2: Chinese medicinal composition capsules agent of the present invention
(1) Radix Glycyrrhizae 160g is ground into impalpable powder, and is standby;
(2) Radix Angelicae Sinensis 130g, Radix Paeoniae Alba 110g, Radix Codonopsis 210g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(3) Radix Bupleuri 160g, Rhizoma Atractylodis Macrocephalae 80g, Rhizoma Curculiginis 180g, Cortex Phellodendri 210g, Herba Menthae 160g, Poria 130g, Rhizoma Anemarrhenae 180g, Radix Morindae Officinalis 210g, Caulis Spatholobi 80g, Radix Rehmanniae Preparata 160g, Rhizoma Cyperi 130g decoct with water secondary, each 2 hours, filter merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, dry, be ground into fine powder, add dextrin 400g mixing, in the capsulae vacuus of packing into promptly.
Embodiment 3: Chinese medicine composition tablet of the present invention
(1) Radix Glycyrrhizae 160g is ground into impalpable powder, and is standby;
(2) Radix Angelicae Sinensis 130g, Radix Paeoniae Alba 110g, Radix Codonopsis 210g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(3) Radix Bupleuri 160g, Rhizoma Atractylodis Macrocephalae 80g, Rhizoma Curculiginis 180g, Cortex Phellodendri 210g, Herba Menthae 160g, Poria 130g, Rhizoma Anemarrhenae 180g, Radix Morindae Officinalis 210g, Caulis Spatholobi 80g, Radix Rehmanniae Preparata 160g, Rhizoma Cyperi 130g decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, add starch 300g, carboxymethylstach sodium 20g is with 70% ethanol wet granulation, tabletting, coating are promptly.
Claims (4)
1, a kind of Chinese medicine composition for the treatment of breast carcinoma is to be made by effective ingredient and/or pharmaceutically acceptable carrier, it is characterized in that described effective ingredient is made by weight by following raw materials according:
Radix Bupleuri 10-20 part Rhizoma Atractylodis Macrocephalae 5-10 part Rhizoma Curculiginis 15-20 part
Radix Angelicae Sinensis 10-15 part Cortex Phellodendri 15-25 part Radix Paeoniae Alba 5-15 part
Herba Menthae 10-20 part Poria 10-15 part Rhizoma Anemarrhenae 10-25 part
Radix Glycyrrhizae 10-20 part Radix Morindae Officinalis 15-25 part Caulis Spatholobi 5-10 part
Radix Codonopsis 15-25 part Radix Rehmanniae Preparata 10-20 part Rhizoma Cyperi 10-15 part.
2, Chinese medicine composition as claimed in claim 1 is characterized in that described effective ingredient made by weight by following raw materials according:
18 parts of 8 portions of Rhizoma Curculiginises of 16 parts of Rhizoma Atractylodis Macrocephalaes of Radix Bupleuri
11 parts of 21 portions of Radix Paeoniae Albas of 13 portions of Cortex Phellodendris of Radix Angelicae Sinensis
18 parts of 13 parts of Rhizoma Anemarrhenaes of 16 parts of Poria of Herba Menthae
8 parts of 21 portions of Caulis Spatholobis of 16 parts of Radix Morindae Officinaliss of Radix Glycyrrhizae
13 parts of 16 portions of Rhizoma Cyperis of 21 parts of Radix Rehmanniaes Preparata of Radix Codonopsis.
3,, it is characterized in that described Chinese medicine composition can be made into granule, capsule and tablet as the arbitrary described Chinese medicine composition of claim 1-2.
4, a kind of preparation method as the arbitrary described Chinese medicine composition of claim 1-3 comprises the steps:
(1) Radix Glycyrrhizae is broken into impalpable powder, and is standby;
(2) Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Codonopsis are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(3) Radix Bupleuri, the Rhizoma Atractylodis Macrocephalae, Rhizoma Curculiginis, Cortex Phellodendri, Herba Menthae, Poria, the Rhizoma Anemarrhenae, Radix Morindae Officinalis, Caulis Spatholobi, Radix Rehmanniae Preparata, Rhizoma Cyperi decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, make granule, capsule and tablet with pharmaceutically acceptable carrier.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200810106123 CN101264222A (en) | 2008-05-08 | 2008-05-08 | Chinese medicinal composition for treating breast cancer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200810106123 CN101264222A (en) | 2008-05-08 | 2008-05-08 | Chinese medicinal composition for treating breast cancer |
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| CN101264222A true CN101264222A (en) | 2008-09-17 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102727832A (en) * | 2012-07-09 | 2012-10-17 | 王焕江 | Chinese medicinal preparation for treating breast diseases and uterine fibroid and preparation method thereof |
| CN104107313A (en) * | 2013-07-27 | 2014-10-22 | 成都绿迪科技有限公司 | Traditional Chinese medicine composition used for treating kidney-deficiency liver-depression type breast distention before menstruation |
| CN105749187A (en) * | 2016-05-05 | 2016-07-13 | 王爱华 | Traditional Chinese medicine preparation for treating breast cancer |
-
2008
- 2008-05-08 CN CN 200810106123 patent/CN101264222A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102727832A (en) * | 2012-07-09 | 2012-10-17 | 王焕江 | Chinese medicinal preparation for treating breast diseases and uterine fibroid and preparation method thereof |
| CN102727832B (en) * | 2012-07-09 | 2014-09-10 | 王焕江 | Chinese medicinal preparation for treating breast diseases and uterine fibroid and preparation method thereof |
| CN104107313A (en) * | 2013-07-27 | 2014-10-22 | 成都绿迪科技有限公司 | Traditional Chinese medicine composition used for treating kidney-deficiency liver-depression type breast distention before menstruation |
| CN105749187A (en) * | 2016-05-05 | 2016-07-13 | 王爱华 | Traditional Chinese medicine preparation for treating breast cancer |
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Open date: 20080917 |