CN101254248A - Applications of Chinese medicinal composition for preparing medicament for curing chronic fatigue syndrome medicament - Google Patents
Applications of Chinese medicinal composition for preparing medicament for curing chronic fatigue syndrome medicament Download PDFInfo
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Abstract
The invention discloses an application of a Chinese medicinal composition in preparing medicines for treating chronic fatigue syndrome as well as sub-health fatigue and sports fatigue belonging to chronic fatigue syndrome. The inventive Chinese medicinal composition improves the activity of endogenous antioxidant system of human bodies, regulates the vasomotor factors and the steady state of the correlative factors thereof, takes action against vascular endothelial damage, effectively improves vascular endothelial dysfunction caused by the chronic fatigue syndrome, and improves and treats diseases resulting from the vascular endothelial dysfunction, especially hypertension, hyperlipidemia, atherosclerosis, heart failure and diabetes that are easy to cause vascular pathological changes.
Description
Technical field
The present invention relates to a kind of new purposes of Chinese medicine composition, particularly, relate to the application of a kind of Chinese medicine composition in preparation treatment chronic fatigue syndrome medicament, belong to the Chinese medicine application.
Background technology
In busy work, studying and living, some people is felt persistence fatigue and weak, lethargy, hypomnesis, confusion of thinking, dizziness and blurred vision, soreness of the waist and knees, shortness of breath and palpitation is vexedly slept hands and feet being not warm less, the abdominal distention poor appetite, hectic fever night sweat etc. medically be can not check tangible positive pathological changes again, so call " chronic fatigue syndrome " this between the healthy performance of asking with disease.As if untimely treatment, the possibility of the corresponding solid lesion of secondary will be arranged.Subhealth state due to overworked, sports fatigue also belong to this category, are the forms of expression [research of the Sun Guizhi Chinese medicine chronic fatigue syndrome traditional Chinese medical science, 1996 02 phase: 50-51] of chronic fatigue syndrome.
1987, U.S. disease prevention and control center was by expert testimony, with one group be the syndrome of principal character with mentality and physical fatigue lastingly chronic or outbreak repeatedly, definite designation is chronic fatigue syndrome (CFS).And drafted the clinical diagnosis standard of CFS.The people of chronic fatigue syndrome state exists unusually at important life control such as immune system, nervous system, hormonal system maincenter, and as not drawing attention, consequence will be serious.Disease that modern society threatens human health is as malignant tumor.Hypertensive diabetes, Peptic Ulcers, hepatitis and the obesity of bringing all miseries to the mankind, excessively become thin, hyperlipidemia, insomnia, menoxenia, sexual dysfunction, muscular soreness, sterility and infertility, depression, anxiety neurosis, schizophrenia etc., can say with chronic fatigue syndrome very confidential relation is arranged, hypertension wherein, hyperlipemia, atherosclerosis, heart failure, cardiovascular and cerebrovascular diseases such as diabetes and metabolic disease are and the more closely-related several frequently seen disease of CFS, vascular endothelium dysfunction very easily takes place, it also is several big killer's disease that threatens human health, be the most critical factor [Li Min that CFS finally causes overworking death, the diagnosis and treatment of Wei Meng field .CFS and the application of exercise prescription thereof. Journal of Beijing University of Physical Education, 2006, (05): 637-639].
Sports fatigue is meant " the organism physiology process can not continue its function can not keep a certain predetermined exercise intensity at a certain specified level or each organ ", during extreme sport, the body oxygen consumption increases by 10～20 times, and myofibrillar oxygen consumption 100 times when being peace and quiet, wherein most oxygen is oxidized to water in the myocardial mitochondria respiratory chain, but there is 2%～5% oxygen to be reduced into free radical, can be used as chronic fatigue syndrome model [Zhai Liwu. contain power oral liquid resisting kinetic fatigue The Animal Model Study [J]. Chinese TCM basis medical journal, 2006,12 (7): 515～516.].
Blood vessel endothelium is the mechanical barrier between blood circulation and vascular smooth muscle, have functions such as acceptance, transmission information and secretion vaso-active substance simultaneously, keep normally unobstructed significant for the smooth and blood flow of guaranteeing blood vessel wall of the complete sum function of blood vessel endothelium.Vascular endothelial injury causes vascular endothelium dysfunction.The generation development of cardiovascular and cerebrovascular disease such as vascular endothelium dysfunction and hypertension, hyperlipemia, atherosclerosis, heart failure, diabetes and metabolic disease is closely related, what should highly cause concern is, endothelial function disturbance due to the vessel endothelium and induced endothelial is one of the important constituent of metabolism syndrome [Xue Jianfeng, Zhao Chengjun, Jia Ruyi. vascular endothelial injury mark [J] medical science summary, 2006, (08) .].The obstacle of endothelial function is that vascular endothelial cell is under effects such as pathological factor (as hyperlipidemia, oxygen-derived free radicals, smoking, high blood flow shearing stress), losing the pathological process of normal function, is the latent dangerous factor and the key link of the generation development of various cardiovascular and cerebrovascular diseases and metabolic disease.Anti-angiogenic endothelial injury, the protection endothelial function has become one of important goal of treatment cardiovascular disease and metabolic disease.
The present invention is the improvement invention of carrying out on the basis of No. 01131203.3 Chinese patent and No. 200410048292.2 patent application, quotes in full the content of this two patent documents record at this.The invention provides the application of a kind of Chinese medicine composition in preparation treatment chronic fatigue syndrome medicament.Chinese medicine composition of the present invention improves the activity of body endogenous antioxidant system, multi-angle is regulated the stable state between the vasomotion factor and the correlative factor thereof, bring into play the effect that it improves vascular endothelial function, can effectively treat chronic fatigue syndrome, sports fatigue, overworked due to subhealth state and the chronic fatigue syndrome hypertension, hyperlipemia, atherosclerosis, heart failure, the diabetes that cause.
Summary of the invention
The object of the invention provides the application of a kind of Chinese medicine composition in preparation treatment chronic fatigue syndrome medicament.
During the present invention uses, the application due to Chinese medicine composition preparation treatment of the present invention is overworked in the medicine of subhealth state, sports fatigue.
Chinese medicine composition of the present invention suppresses the excessive generation of free radical in the chronic fatigue syndrome patient arterial tissue, improves the activity of body endogenous antioxidant system, and multi-angle is regulated the stable state between the vasomotion factor and the correlative factor thereof.
The present invention also provides the application of this Chinese medicine composition in the medicine of the vascular endothelium dysfunction disease that preparation treatment chronic fatigue syndrome causes.
During the present invention used, the vascular endothelium dysfunction disease that Chinese medicine composition of the present invention is treated was hypertension, hyperlipemia, atherosclerosis, heart failure, the diabetes that chronic fatigue syndrome causes.
Another object of the present invention provides the active component in the application of this Chinese medicine composition in preparation treatment chronic fatigue syndrome medicament.
During the present invention used, described Chinese medicine composition was made by following bulk drugs:
Radix Ginseng 3-10 Hirudo 3-11 Eupolyphaga Seu Steleophaga 5-10 Olibanum (system) 1-5 Radix Paeoniae Rubra 3-9 Lignum Dalbergiae Odoriferae 1-5
Lignum Santali Albi 1-5 Scorpio 3-9 Periostracum Cicadae 3-12 Scolopendra 1-3 Borneolum Syntheticum 1-7 Semen Ziziphi Spinosae (stir-fry) 3-10;
Preferably, this Chinese medicine composition is made by following bulk drugs:
Radix Ginseng 6 Hirudo 10 Eupolyphaga Seu Steleophagas, 7 Olibanums (system) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpios 7 Periostracum Cicadaes 7 Scolopendra 1 Borneolum Syntheticum, 5 Semen Ziziphi Spinosaes (stir-fry) 5; Or:
Radix Ginseng 10 Hirudo 8 Eupolyphaga Seu Steleophagas, 7 Olibanums (system) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpios 9 Periostracum Cicadaes 7 Scolopendra 1 Borneolum Syntheticum, 5 Semen Ziziphi Spinosaes (stir-fry) 5; Or:
Radix Ginseng 6 Hirudo 11 Eupolyphaga Seu Steleophagas, 7 Olibanums (system) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpios 3 Periostracum Cicadaes 7 Scolopendra 1 Borneolum Syntheticum, 5 Semen Ziziphi Spinosaes (stir-fry) 5;
In the Chinese medicine composition of the present invention, the latin name of raw medicinal material and processing method thereof are from " Chinese medicine voluminous dictionary " (in July, 1977, front page, Shanghai science tech publishing house) and " Chinese pharmacopoeia (version in 2005, Chemical Industry Press).
In the application of the present invention, one or more in each raw material of described Chinese medicine composition can be replaced by the raw material of Chinese medicine medicine of the identical property of medicine, effect individually or simultaneously, and after the replacement, composite preparation and effect do not change.
In the application of the present invention, the active component of this Chinese medicine composition is made up of following ingredients:
The a mean diameter is less than Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga, Periostracum Cicadae and the Olibanum (processed) medicated powder of 100 μ m;
B Borneolum Syntheticum medicated powder;
The volatile oil that c is extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi;
The alcohol-extracted extract of the alcohol extract of d Radix Ginseng after after concentrating with ethanol extraction;
The water extracted immersing paste that is condensed into behind the water extract after the Lignum Dalbergiae Odoriferae behind the e extraction composition c and water extract, Radix Paeoniae Rubra and the Semen Ziziphi Spinosae (parched) of Lignum Santali Albi medicinal residues decoct with water and the water extract filtration of the medicine residues of Radix Ginseng after the extraction ingredient d, the mixing.
In the application of the present invention, described Chinese medicine composition dosage form is capsule, tablet, pill, oral liquid, soft capsule or drop pill.
Chinese medicinal composition preparation of the present invention can also be routinely preparation process, for example, the preparation technology of Fan Biting " pharmacy of Chinese materia medica " (Shanghai Science Press 1997 December the 1st edition) record, make the acceptable any conventional dosage form of pharmaceutics, for example capsule, tablet, pill, oral liquid, soft capsule, drop pill etc.
In the application of the present invention, described Chinese medicine composition is a kind of in capsule, tablet, pill, oral liquid, soft capsule, the dropping pill formulation, for above-mentioned dosage form can be realized, need when these dosage forms of preparation, to add the pharmacy acceptable auxiliary, for example: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, fixed, the Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods of acetic acid chloroethene; Substrate comprises: PEG6000, PEG4000, insect wax etc.For making above-mentioned dosage form can realize pharmacy of Chinese materia medica, need when these dosage forms of preparation, to add acceptable other adjuvant of pharmacy (adjuvant of each dosage form record among the Fan Biting " pharmacy of Chinese materia medica ", Shanghai Science Press December in 1997 the 1st edition).
Preparation of the present invention is preferably made by following preparation method: five kinds of Chinese medicine such as the Hirudo of said ratio, Scorpio, Periostracum Cicadae, Eupolyphaga Seu Steleophaga, Scolopendra cleaned, and oven drying at low temperature, standby; Lignum Santali Albi, Lignum Dalbergiae Odoriferae extract volatile oil, and medicinal residues and aqueous solution are standby; Radix Ginseng extracts secondary with 70% alcohol heating reflux, and 3 hours for the first time, 2 hours for the second time, merge extractive liquid, reclaimed ethanol to there not being the alcohol flavor; The medicinal residues of medicine residues of Radix Ginseng and Lignum Santali Albi, Lignum Dalbergiae Odoriferae merge with aqueous solution, add Radix Paeoniae Rubra, Semen Ziziphi Spinosae (stir-fry), decoct with water secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction filters, and filtrate is concentrated into the clear paste that relative density is 1.20-1.25 (60 ℃), add above-mentioned panaxynol extract, mixing, cold drying is ground into fine powder; The five tastes such as Olibanum (system) and Hirudo are ground into fine powder altogether; The Borneolum Syntheticum porphyrize, with above-mentioned fine powder facing-up, mixing sprays into volatile oil respectively, and mixing incapsulates, promptly.
Perhaps, preparation of the present invention is preferably made by following preparation method:
A) weight ratio of crude drug is: Radix Ginseng 3-10 part, Hirudo 3-11 part, Eupolyphaga Seu Steleophaga 5-10 part, Olibanum (processed) 1-5 part, Radix Paeoniae Rubra 3-9 part, Lignum Dalbergiae Odoriferae 1-5 part, Lignum Santali Albi 1-5 part, Scorpio 3-9 part, Periostracum Cicadae 3-12 part, Scolopendra 1-3 part, Borneolum Syntheticum 1-7 part, Semen Ziziphi Spinosae (parched) 3-10 part;
B) pulverizing medicinal materials technology:
Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and five kinds of worm medicines of Periostracum Cicadae are prepared burden by prescription through the Olibanum (processed) that cleans, washes after handling the back and cleaning the process of preparing Chinese medicine, pulverized by pulverizer, the medicated powder fineness reaches more than 80 orders; Medicated powder behind the coarse powder carries out micronizing through various superfine communication techniques, makes the medicated powder mean diameter less than 100 μ m; Medical material to be pulverized is prepared burden after the cleaning, drying sterilization;
C) extract concentrated and drying process:
Reuse water extraction behind Lignum Dalbergiae Odoriferae and the Lignum Santali Albi elder generation extracting in water volatile oil, Radix Paeoniae Rubra and Semen Ziziphi Spinosae decoct with water, after the water extract filters, extractum to be condensed into; Radix Ginseng with ethanol extraction after, reuse water extraction, alcohol extract are condensed into alcohol-extracted extract after reclaiming ethanol, the water extract filter with all water extract mixings after be condensed into the water extracted immersing paste;
D) preparation process:
In Fluidbedgranulatingdrier, add the superfine powder flour, again the step c) gained is extracted extractum and spray into granulation; The granule made through granulate, is added the Borneolum Syntheticum fine powder, spray into the volatile oil that extracts by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by the capsule filler filling, make capsule behind the mixing.
Perhaps, preparation of the present invention is preferably made by following preparation method:
A) weight ratio of crude drug is: Radix Ginseng 3-10 part, Hirudo 3-11 part, Eupolyphaga Seu Steleophaga 5-10 part, Olibanum (system) 1-5 part, Radix Paeoniae Rubra 3-9 part, Lignum Dalbergiae Odoriferae 1-5 part, Lignum Santali Albi 1-5 part, Scorpio 3-9 part, Periostracum Cicadae 3-12 part, Scolopendra 1-3 part, Borneolum Syntheticum 1-7 part, Semen Ziziphi Spinosae (parched) 3-10 part;
B) pulverizing medicinal materials technology:
Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and five kinds of worm medicines of Periostracum Cicadae are prepared burden by prescription through the Olibanum (processed) that cleans, washes after handling the back and cleaning the process of preparing Chinese medicine, pulverized by pulverizer, the medicated powder fineness reaches more than 80 orders; Medicated powder behind the coarse powder carries out micronizing through various superfine communication techniques, makes the medicated powder mean diameter less than 100 μ m; Medical material to be pulverized is prepared burden after the cleaning, drying sterilization;
C) extract concentrated and drying process:
Reuse water extraction behind Lignum Dalbergiae Odoriferae and the Lignum Santali Albi elder generation extracting in water volatile oil, Radix Paeoniae Rubra and Semen Ziziphi Spinosae decoct with water, after the water extract filters, extractum to be condensed into; Radix Ginseng with ethanol extraction after, reuse water extraction, alcohol extract are condensed into alcohol-extracted extract after reclaiming ethanol, the water extract filter with all water extract mixings after be condensed into the water extracted immersing paste, extractum directly is spray dried to spray powder;
D) preparation process:
The superfine powder flour is added in the Fluidbedgranulatingdrier with step c) gained spray drying powder, sprays solvent again and make granule; The granule made through granulate, is added the Borneolum Syntheticum fine powder, spray into the volatile oil that extracts by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by the capsule filler filling, make capsule behind the mixing.
During the present invention used, this Chinese medicine composition suppressed the excessive generation of free radical in the chronic fatigue syndrome patient arterial tissue, improved the activity of body endogenous antioxidant system, and multi-angle is regulated the stable state between the vasomotion factor and the correlative factor thereof.
During the present invention used, the consumption of the present composition by the crude drug gross weight, was each 0.8-3 gram, and take 2-4 every day, is preferably each 1.11-2.22 gram, takes every day three times.
For illustrating the activity of traditional Chinese medicine composition for treating myocardial infarction of the present invention, use the capsule 's content dry powder (to call medicine of the present invention in the following text) that makes by embodiment 1 method to carry out following animal experiment.
1, materials and methods
1.1 main medicine and reagent
Medicine of the present invention (Hebei Yiling Medicine Inst. Co., Ltd provides); SOD, MDA, NO test kit (Nanjing is built up biological reagent company and provided); ET, Ang II radioimmunological kit (Chinese People's Liberation Army General Hospital put in East Asia exempt from institute provide).
1.2 grouping of method animal and administration:
Method: " forcing swimming with a load attached to the body " method of employing is set up rat motor fatigue model, detects superoxide dismutase in the rat blood serum (SOD) activity, malonaldehyde (MDA), nitric oxide (NO) content and endothelin level (ET), Angiotensin II (AngII) level respectively organized; Electron microscopic observation thoracic aorta histopathology morphological change.
Grouping: healthy Wistar male rat, 100, body weight 180-220g, Beijing dimension tonneau China Experimental Animal Center provides the (quality certification number: SCXK (capital) 2002-0003), be divided into matched group, model group, medicine low dose group of the present invention, medicine high dose group of the present invention at random, each is organized in experiment and finishes the back collecting blood sample, and the blood of gathering is divided into three parts, part blood injects the test tube that contains 10%EDTA-2Na30 μ L and aprotinin 40 μ L, 4 ℃, the centrifugal 10min of 3000rpm, separated plasma ,-20 ℃ of preservations; Another part blood injects ice-cooled aprotinin anticoagulant tube rapidly, shakes up the centrifugal 10min of 1000rpm, separated plasma ,-20 ℃ of preservations; In the direct injecting tube of third part blood, after waiting to solidify, separation of serum ,-20 ℃ of preservations, routine is left and taken the thoracic aorta electron microscope specimen in order to detecting simultaneously.
Administration: medicine low dose group of the present invention, give 4 times of clinical consumption, count 0.03g/kg by crude drug weight, before the administration, be mixed with the suspension of concentration with 0.5% carboxymethylcellulose sodium solution (CMC-Na), irritate stomach for (by crude drug weight) 0.03g/ml; Medicine high dose group of the present invention gives 16 times of clinical consumption, counts 0.12g/kg by crude drug weight, is mixed with the suspension of concentration for (by crude drug weight) 0.12g/ml with 0.5% carboxymethylcellulose sodium solution (CMC-Na), irritates stomach; Matched group and model group wait dosage 0.5%CMC-Na to irritate stomach respectively.
1.3 statistical procedures
Experimental data mean ± standard deviation (x ± s) expression.Adopt the SPSS11.0 statistical software to carry out one factor analysis of variance (one-way ANOVA), there were significant differences, and the person compares in twos with least significant difference (LSD), is that there were significant differences with P＜0.05.
2, result
Exhaust the comparison that swimming time changes 2.1 respectively organize rat body weight and power
The body weight of model group rat obviously descends, and swimming time obviously shortens [seeing accompanying drawing 1, accompanying drawing 2 for details].
2.2 respectively organize rat blood serum MDA, NO content and the active variation of SOD
Each is organized serum NO, MDA content, the active mensuration of SOD and sees Table 1, compare with matched group as seen from Table 1 that NO content obviously reduces (P＜0.01) in the model group animal serum, MDA content obviously raise (P＜0.01) in the blood plasma, active significantly reduce (p＜0.01) of SOD, medicine of the present invention can make NO content obviously raise, MDA content is reduction in various degree, and SOD is active obviously to raise.
The comparison of MDA, NO content and SOD activity change in each treated animal serum of table 1 (x ± s, n=20).
Annotate: compare with matched group
*Compare with model group p＜0.01
#P＜0.05
2.3 respectively organize the variation of rat blood serum ET, Ang II content
Each is organized, and the mensuration of Ang II and ET level sees Table 2 in the blood plasma, compares with matched group as seen from Table 2 that Ang II and ET level significantly raise (p＜0.01) in the model group animal blood, and medicine of the present invention can make Ang II and ET level obviously reduce (p＜0.05).
The comparison that nervous plain II of each treated animal blood plasma medium vessels of table 2 and level of ET change (x ± s, n=20).
Annotate: compare with matched group
*P＜0.01, vs and model group are relatively
#P＜0.05,
##P＜0.01
2.4 respectively organize the Ultrastructural variation of rat chest aorta endotheliocyte under the transmission electron microscope
See under the transmission electron microscope that the normal endothelial cell ultrastructure is complete, no abnormality seen, and the model group microvillus obviously reduces, Cytoplasm is treating serious edema caused, the part membranolysis, and kytoplasm is excessive, dilatation of rough endoplasmic reticula is the pond shape, and the granule of taking off phenomenon is arranged, and the most of ridge of mitochondrion merges or disappears, and gulps down the drink vesicle and reduces; The above-mentioned pathological change of medicine group of the present invention of variant dosage obviously alleviates [seeing accompanying drawing 3].
3, conclusion:
The foundation of the method success of this research and utilization " basal diet+swimming with a load attached to the body " rat motor fatigue model, found that the body weight of model group rat obviously descends, swimming time obviously shortens; See under the transmission electron microscope that aortic blood endothelial cell microvillus obviously reduces, Cytoplasm is treating serious edema caused, the part membranolysis, kytoplasm is excessive, dilatation of rough endoplasmic reticula is the pond shape, and the granule of taking off phenomenon is arranged, and the most of ridge of mitochondrion merges or disappears, gulp down the drink vesicle and reduce, the above-mentioned pathological change of medicine group of the present invention of variant dosage obviously alleviates; The model group serum NO levels significantly descends, obviously then extremely significantly decline of rising SOD activity of MDA content simultaneously, and medicine group NO content of the present invention obviously raises, and MDA content is reduction in various degree, the active obviously rising of SOD; Ang II and ET level significantly raise in the model group animal blood, and medicine of the present invention can make Ang II and ET level obviously reduce.
For every index of sports fatigue in various degree improvement is arranged all by the visible Chinese medicine composition of the present invention of result, thereby can effectively treat chronic fatigue syndrome, sports fatigue and the overworked subhealth state that causes.Chinese medicine composition of the present invention can effectively improve the activity of body endogenous antioxidant system, and multi-angle is regulated the stable state between the vasomotion factor and the correlative factor thereof; Thereby can effectively treat the vascular endothelium dysfunction disease that chronic fatigue syndrome causes; The vascular endothelium dysfunction disease that chronic fatigue syndrome causes comprises: hypertension, hyperlipemia, atherosclerosis, heart failure, diabetes; Chinese medicine composition of the present invention can have treatment and improve the vascular endothelium dysfunction disease and comprise: hypertension, hyperlipemia, atherosclerosis, heart failure, diabetes.
Description of drawings
The comparison of each treated animal body weight change of Fig. 1.
Each group power of Fig. 2 exhausts the variation of swimming time.
Fig. 3 respectively organizes the Ultrastructural variation of rat aorta endotheliocyte; A: matched group (8.0k *); B: matched group (20.0k *); C: model group (12.0.k *); D: medicine group of the present invention (20.0k *).
The specific embodiment
Embodiment 1: the preparation of medicine of the present invention
A) the crude drug prescription is:
Radix Ginseng 39.6g Hirudo 72.6g Eupolyphaga Seu Steleophaga 46.2g Olibanum (system) 13.2g
Radix Paeoniae Rubra 33g Lignum Dalbergiae Odoriferae 13.2g Lignum Santali Albi 13.2g Scorpio 19.8g
Periostracum Cicadae 46.2g Scolopendra 6.6g Borneolum Syntheticum 33g Semen Ziziphi Spinosae (stir-fry) 33g;
B) pulverizing medicinal materials technology:
Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and five kinds of worm medicines of Periostracum Cicadae are prepared burden by prescription through the Olibanum (processed) that cleans, washes after handling the back and cleaning the process of preparing Chinese medicine, pulverized by pulverizer, the medicated powder fineness reaches more than 80 orders; Medicated powder behind the coarse powder carries out micronizing through various superfine communication techniques, makes the medicated powder mean diameter less than 30-40 μ m; Medical material to be pulverized is prepared burden after the cleaning, drying sterilization;
C) extract concentrated and drying process:
Reuse water extraction behind Lignum Dalbergiae Odoriferae and the Lignum Santali Albi elder generation extracting in water volatile oil, Radix Paeoniae Rubra and Semen Ziziphi Spinosae add suitable quantity of water and decoct secondary, and each 3 hours, merge decocting liquid, after the water extract filters, extractum to be condensed into; Radix Ginseng is with an amount of 70% ethanol extraction secondary, each 3 hours, merge extractive liquid,, reclaim ethanol to there not being the alcohol flavor, the reuse water extraction, it is 0.9～1.1 (60 ℃) alcohol-extracted extract that alcohol extract is condensed into relative density, is concentrated into the clear paste that relative density is 0.9～1.1 (60 ℃) behind the filtration of water extract and above-mentioned all water extract mixings, standby;
D) preparation process:
In Fluidbedgranulatingdrier, add the superfine powder flour, again the step c) gained is extracted extractum and spray into granulation; The granule made through granulate, is added the Borneolum Syntheticum fine powder, spray into the volatile oil that extracts by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by the capsule filler filling, make 1000 capsules behind the mixing.
Indication: be used for the vascular endothelial function protection, hyperlipidemia.
Usage and consumption: oral.One time 2～4,3 times on the one.
Claims (9)
1. the Chinese medicine composition application in preparation treatment chronic fatigue syndrome medicament is characterized in that described Chinese medicine composition made by following bulk drugs:
Radix Ginseng 3-10 Hirudo 3-11 Eupolyphaga Seu Steleophaga 5-10 Olibanum (system) 1-5 Radix Paeoniae Rubra 3-9 Lignum Dalbergiae Odoriferae 1-5
Lignum Santali Albi 1-5 Scorpio 3-9 Periostracum Cicadae 3-12 Scolopendra 1-3 Borneolum Syntheticum 1-7 Semen Ziziphi Spinosae (stir-fry) 3-10.
2. application as claimed in claim 1 is characterized in that described Chinese medicine composition made by following bulk drugs:
Radix Ginseng 6 Hirudo 10 Eupolyphaga Seu Steleophagas, 7 Olibanums (system) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpios 7 Periostracum Cicadaes 7 Scolopendra 1 Borneolum Syntheticum, 5 Semen Ziziphi Spinosaes (stir-fry) 5.
3. application as claimed in claim 1 is characterized in that described Chinese medicine composition made by following bulk drugs:
Radix Ginseng 6 Hirudo 11 Eupolyphaga Seu Steleophagas, 7 Olibanums (system) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpios 3 Periostracum Cicadaes 7 Scolopendra 1 Borneolum Syntheticum, 5 Semen Ziziphi Spinosaes (stir-fry) 5.
4. as each described application among the claim 1-3, it is characterized in that the active component of described Chinese medicine composition is made up of following ingredients:
The a mean diameter is less than Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga, Periostracum Cicadae and the Olibanum (processed) medicated powder of 100 μ m;
B Borneolum Syntheticum medicated powder;
The volatile oil that c is extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi;
The alcohol-extracted extract of the alcohol extract of d Radix Ginseng after after concentrating with ethanol extraction;
The water extracted immersing paste that is condensed into behind the water extract after the Lignum Dalbergiae Odoriferae behind the e extraction composition c and water extract, Radix Paeoniae Rubra and the Semen Ziziphi Spinosae (parched) of Lignum Santali Albi medicinal residues decoct with water and the water extract filtration of the medicine residues of Radix Ginseng after the extraction ingredient d, the mixing.
5. as each described application among the claim 1-3, it is characterized in that described Chinese medicine composition dosage form is capsule, tablet, pill, oral liquid, soft capsule or drop pill.
6. as the described application of claim 1-3, it is characterized in that the application of described Chinese medicine composition in the medicine of subhealth state, sports fatigue due to the preparation treatment is overworked.
7. as each described application among the claim 1-3, it is characterized in that described Chinese medicine composition suppresses the excessive generation of free radical in the chronic fatigue syndrome patient arterial tissue, improve the activity of body endogenous antioxidant system, multi-angle is regulated the stable state between the vasomotion factor and the correlative factor thereof.
8. application as claimed in claim 7 is characterized in that, the application of described Chinese medicine composition in the medicine of the vascular endothelium dysfunction disease that preparation treatment chronic fatigue syndrome causes.
9. application as claimed in claim 8 is characterized in that, described vascular endothelium dysfunction disease is hypertension, hyperlipemia, atherosclerosis, heart failure, the diabetes that chronic fatigue syndrome causes.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102091139A (en) * | 2009-12-15 | 2011-06-15 | 河北以岭医药研究院有限公司 | Application of traditional Chinese medicinal composition to preparation of medicaments for improving hypercholesterolemia-induced cardiac dysfunction |
| CN102210761A (en) * | 2010-04-08 | 2011-10-12 | 河北以岭医药研究院有限公司 | Application of Chinese medicinal component in preparation of medicament for treating chronic mesenteric ischemia |
| CN101744917B (en) * | 2008-12-01 | 2013-05-08 | 河北以岭医药研究院有限公司 | Applications of Chinese medicinal composition to preparation of medicament for improving hypertension nervous symptoms |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1124153C (en) * | 2001-08-31 | 2003-10-15 | 石家庄以岭药业股份有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
| CN1305490C (en) * | 2004-06-18 | 2007-03-21 | 河北以岭医药研究院有限公司 | Supermicro heart-meridians-activating Chinese medicine composition and its preparing method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101744917B (en) * | 2008-12-01 | 2013-05-08 | 河北以岭医药研究院有限公司 | Applications of Chinese medicinal composition to preparation of medicament for improving hypertension nervous symptoms |
| CN102091139A (en) * | 2009-12-15 | 2011-06-15 | 河北以岭医药研究院有限公司 | Application of traditional Chinese medicinal composition to preparation of medicaments for improving hypercholesterolemia-induced cardiac dysfunction |
| CN102210761A (en) * | 2010-04-08 | 2011-10-12 | 河北以岭医药研究院有限公司 | Application of Chinese medicinal component in preparation of medicament for treating chronic mesenteric ischemia |
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