CN101252845B - 胶囊化活性成分、制备方法及其用途 - Google Patents

胶囊化活性成分、制备方法及其用途 Download PDF

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Publication number
CN101252845B
CN101252845B CN2006800319167A CN200680031916A CN101252845B CN 101252845 B CN101252845 B CN 101252845B CN 2006800319167 A CN2006800319167 A CN 2006800319167A CN 200680031916 A CN200680031916 A CN 200680031916A CN 101252845 B CN101252845 B CN 101252845B
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CN
China
Prior art keywords
starch
active ingredient
particle
capsules
glassy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2006800319167A
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English (en)
Chinese (zh)
Other versions
CN101252845A (zh
Inventor
皮埃尔-艾蒂安·布克朗
格雷戈里·达尔代勒
塞巴斯蒂安·古安
比吉特·施莱芬鲍姆
吉尔·特罗法迪
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Firmenich SA
Original Assignee
Firmenich SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by Firmenich SA filed Critical Firmenich SA
Publication of CN101252845A publication Critical patent/CN101252845A/zh
Application granted granted Critical
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Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/70—Fixation, conservation, or encapsulation of flavouring agents
    • A23L27/72—Encapsulation
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A61K9/5057—Gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Cosmetics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2006800319167A 2005-08-30 2006-08-29 胶囊化活性成分、制备方法及其用途 Expired - Fee Related CN101252845B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP05107932.5 2005-08-30
EP05107932 2005-08-30
US71490905P 2005-09-06 2005-09-06
US60/714,909 2005-09-06
PCT/IB2006/052995 WO2007026307A2 (en) 2005-08-30 2006-08-29 Encapsulated active ingredients, methods of preparation and their use

Publications (2)

Publication Number Publication Date
CN101252845A CN101252845A (zh) 2008-08-27
CN101252845B true CN101252845B (zh) 2012-03-28

Family

ID=37809262

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800319167A Expired - Fee Related CN101252845B (zh) 2005-08-30 2006-08-29 胶囊化活性成分、制备方法及其用途

Country Status (10)

Country Link
US (1) US20080206325A1 (enExample)
EP (1) EP1924156B1 (enExample)
JP (1) JP5322643B2 (enExample)
CN (1) CN101252845B (enExample)
AT (1) ATE430488T1 (enExample)
CA (1) CA2620507C (enExample)
DE (1) DE602006006695D1 (enExample)
ES (1) ES2325039T3 (enExample)
RU (1) RU2008112212A (enExample)
WO (1) WO2007026307A2 (enExample)

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WO2008142637A1 (en) * 2007-05-21 2008-11-27 Firmenich Sa Large coacervated capsules
US20100272859A1 (en) * 2007-08-28 2010-10-28 Pepsico, Inc. Delivery and controlled release of encapsulated water-insoluble flavorants
US9186640B2 (en) 2007-08-28 2015-11-17 Pepsico, Inc. Delivery and controlled release of encapsulated lipophilic nutrients
CA2742367A1 (en) * 2008-11-10 2010-05-14 Colgate-Palmolive Company Shelf stable capsules
WO2010143141A1 (en) * 2009-06-10 2010-12-16 Firmenich Sa Spray-dried delivery system
BR112012029473A8 (pt) * 2010-05-17 2017-11-21 Abbott Lab Método para produzir emulsões nutricionais contendo óleos encapsulados
US20130274225A1 (en) * 2010-07-19 2013-10-17 Actamax Surgical Materials, Llc Method for making a polysaccharide dialdehyde having high purity
WO2012107095A1 (en) 2011-02-10 2012-08-16 Alfa Biogene International B.V. Plant hsp70 for use in the treatment of food allergy
WO2012106777A1 (en) 2011-02-11 2012-08-16 Clover Corporation Limited Nutritional compositions and uses thereof
US20130004617A1 (en) * 2011-07-01 2013-01-03 Pepsico, Inc. Coacervate complexes, methods and food products
US9687010B2 (en) 2012-03-14 2017-06-27 Mccormick & Company, Incorporated Extrusion encapsulation of actives at an increased load, using surface active plant extracts
GB201206859D0 (en) * 2012-04-19 2012-05-30 Givaudan Sa Method and composition
FR2996418B1 (fr) * 2012-10-09 2015-05-29 Seppic Sa Compositions alimentaires comprenant des capsules obtenues par coacervation ne mettant pas en œuvre de reticulant toxique
CN103876104A (zh) * 2014-01-21 2014-06-25 四川亿生元科技有限公司 益生元低钠盐和益生元低钠盐复合调味料及其制备方法
CN103876103A (zh) * 2014-01-21 2014-06-25 四川亿生元科技有限公司 益生元食用盐及其制备方法
WO2015127537A1 (en) * 2014-02-27 2015-09-03 B-Organic Films Corp. Bioactive agents included in functionalized starch having a single helix v-structure
CA3176674A1 (en) 2015-05-18 2016-11-24 5071, Inc. Homogenous cannabis compositions and methods of making the same
CN118807630A (zh) 2016-02-02 2024-10-22 弗门尼舍有限公司 在室温下干燥悬浮液的方法
US10508185B2 (en) 2016-06-21 2019-12-17 Baker Hughes, A Ge Company, Llc Controlled release of activation chemicals for the deployment of shape memory polymers
US20210093578A1 (en) * 2017-04-27 2021-04-01 Clover Corporation Limited Encapsulated nutritional and pharmaceutical compositions
US20190015383A1 (en) * 2017-07-14 2019-01-17 5071, Inc. Cannabinoid compositions and methods of preparation thereof
WO2019020642A1 (en) * 2017-07-27 2019-01-31 Firmenich Sa METHOD FOR DRYING A SUSPENSION OF HYDROGEL MICROCAPSULES
JP7004968B2 (ja) * 2017-10-06 2022-01-21 青葉化成株式会社 食用の徐放性機能材の製造方法
TW201943410A (zh) * 2018-04-10 2019-11-16 荷蘭商帝斯曼知識產權資產管理有限公司 具有彈性結構之多顆粒固體劑型
WO2019206984A1 (en) * 2018-04-27 2019-10-31 Dsm Ip Assets B.V. Powderous composition comprising carotenoid and/or derivative thereof, d-glycose oligomers and modified polysaccharide as well as food, feed or personal care formulation comprising the composition
CN111971371A (zh) 2018-06-21 2020-11-20 弗门尼舍有限公司 提供持久草莓气味的化合物
TR201810669A2 (tr) * 2018-07-25 2018-08-27 Bursa Teknik Ueniversitesi Enkapsüle edi̇lmi̇ş bi̇r ari sütü ve i̇lgi̇li̇ üreti̇m yöntemi̇
WO2020182792A1 (en) * 2019-03-12 2020-09-17 Dsm Ip Assets B.V. Coated coacervate capsules
US10945953B1 (en) 2019-09-12 2021-03-16 Nulixir Inc. Controlled release core-shell particles and suspensions including the same
US12291689B2 (en) 2019-12-19 2025-05-06 Firmenich Sa Compounds for providing a long-lasting floral and fruity odor
JP2021115287A (ja) * 2020-01-28 2021-08-10 青葉化成株式会社 液状医療材料
JP2021115285A (ja) * 2020-01-28 2021-08-10 青葉化成株式会社 液状高分子化合物組成物
US12030680B2 (en) * 2020-05-22 2024-07-09 Protocol Lab, LLC Systems and methods for oxygen free packaging
CN112494453B (zh) * 2020-12-30 2022-03-04 山东农业大学 一种琼脂/麦芽糊精缓释胶囊及其制备方法
CA3233972A1 (en) * 2021-10-21 2023-04-27 Eline Marion BOTH Powdered compositions containing an edible oil and their use in food products
US12378950B2 (en) 2023-07-11 2025-08-05 Baker Hughes Oilfield Operations Llc Controlled deployment of shape-memory articles
WO2025015337A2 (en) * 2023-07-13 2025-01-16 Dsm Ip Assets B.V. Pufa-containing edible product comprising shell and center filling

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WO1997013416A1 (en) * 1995-10-12 1997-04-17 Mccormick & Company, Inc. Double encapsulation process and flavorant compositions prepared thereby
US20020044968A1 (en) * 1996-10-28 2002-04-18 General Mills, Inc. Embedding and encapsulation of sensitive components into a matrix to obtain discrete controlled release particles
US20040017017A1 (en) * 2002-07-24 2004-01-29 Van Lengerich Bernhard H. Encapsulation of sensitive components using pre-emulsification
US20040037890A1 (en) * 2000-12-15 2004-02-26 Jack Burger Moisture and oxygen stable composition and a process for obtaining said composition

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US20020044968A1 (en) * 1996-10-28 2002-04-18 General Mills, Inc. Embedding and encapsulation of sensitive components into a matrix to obtain discrete controlled release particles
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US20040017017A1 (en) * 2002-07-24 2004-01-29 Van Lengerich Bernhard H. Encapsulation of sensitive components using pre-emulsification

Also Published As

Publication number Publication date
CA2620507C (en) 2011-07-19
JP5322643B2 (ja) 2013-10-23
EP1924156B1 (en) 2009-05-06
CN101252845A (zh) 2008-08-27
US20080206325A1 (en) 2008-08-28
ES2325039T3 (es) 2009-08-24
ATE430488T1 (de) 2009-05-15
EP1924156A2 (en) 2008-05-28
WO2007026307A2 (en) 2007-03-08
DE602006006695D1 (de) 2009-06-18
WO2007026307A3 (en) 2007-07-12
CA2620507A1 (en) 2007-03-08
JP2009506106A (ja) 2009-02-12
RU2008112212A (ru) 2009-10-10

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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20120328

Termination date: 20140829

EXPY Termination of patent right or utility model