CN101234123A - Application of certain concentration hydrochloric acid water for treating blood vessel disease - Google Patents

Application of certain concentration hydrochloric acid water for treating blood vessel disease Download PDF

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Publication number
CN101234123A
CN101234123A CNA2008100068263A CN200810006826A CN101234123A CN 101234123 A CN101234123 A CN 101234123A CN A2008100068263 A CNA2008100068263 A CN A2008100068263A CN 200810006826 A CN200810006826 A CN 200810006826A CN 101234123 A CN101234123 A CN 101234123A
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CN
China
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hydrochloric acid
medicine
application
blood vessel
aqueous solution
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Pending
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CNA2008100068263A
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Chinese (zh)
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王德寿
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Individual
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Individual
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Priority to CNA2008100068263A priority Critical patent/CN101234123A/en
Priority to PCT/CN2008/000409 priority patent/WO2009100591A1/en
Publication of CN101234123A publication Critical patent/CN101234123A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/20Elemental chlorine; Inorganic compounds releasing chlorine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Abstract

The invention relates to an application of hydrochloric acid in preparing a drug for treating vascular diseases. The drug in the invention is a hydrochloric acid containing water solution, the pH value of the water solution is controlled between 4 and 7; while the drug is used as an oral liquid, the pH value is controlled between 6.5 and 7; the preferred pH value is controlled between 3.5 and 5.5, while for the best, the pH value is 3.5. The drug prepared with hydrochloric acid in the invention is safe and reliable for treating vascular diseases with accurate and obvious effect, and also has remarkable improving effect for the atherosclerotic patients with hypertension and can transform calcium salt that is harmful to human body into calcium required by human body.

Description

The application of certain density salt sour water in the treatment angiopathy
Technical field
The present invention relates to the application of hydrochloric acid in preparation treatment angiopathy medicine, described medicine is in particular and contains aqueous solution of hydrochloric acid, can be used for injecting or drinking.
Background technology
Up to the present the formation of human vas disease, also do not have the method for radical cure.That is to say that in a single day the people got angiopathy (myocardial infarction, hypertension, diabetes, prostatitis, vasculitis etc.), just be difficult to and thoroughly cured, must safeguard throughout one's life by medicine.
Unordered for a long time, the unscientific diet of human body has formed blood capillary and has stopped up and the arterial sclerosis phenomenon.Along with the increase at age, obstruction and hardening phenomenon are more and more serious, destroy the human organ normal function, cause a large amount of appearance in angiopathy ground.
There are many theories in the formation of human vas disease, medical circle, inherited genetic factors, and the endocrine disturbance, diet is bad etc., but is that any theory all is difficult to find a kind of method that can cure angiopathy.
The inventor is in the process of research human digestive system, hypertension and diabetes, the definite gastric acid of father Bao Mang of having found U.S. physiology in 1833 is that the theory of hydrochloric acid is wrong, because the mistake of this theory has hindered the dissection of medical circle to hypertension, diabetes.Then found medical circle according to blood glucose is arranged in the cell, and the blood glucose height in the human blood of some diabetes, the phenomenon that insulin is also high thinks that insulin is a degraded blood glucose, fact proved that it also is wrong.The discovery of inventor's maximum is the calcium bicarbonate instability, and decomposing the calcium carbonate that generates easily has two big character; The one, thin color precipitate, the 2nd, under certain temperature and environmental condition, be binding agent.Just suffice to show that the existence of this character according to stalactitic formation.Up to now, all there is not this character on all textbooks.Because I have found that the calcium carbonate that generates after calcium bicarbonate decomposes has the function of binding agent, has just caused finding the formation mechanism and the radical cure method of a series of diseases such as human hypertension, diabetes.
Think all on all medical science textbooks that gastric acid is hydrochloric acid, why is it wrong so?
1., should and not contain alkaline matters such as calcium carbonate, calcium oxalate, calcium phosphate never in speckle on the blood vessel wall (medical circle claims thrombosis, atheromatous plaque) and the intrinsic calculus of organ so if gastric acid is hydrochloric acid.
2. use the solution contain hydrochloric acid (as long as its content reaches and near the amount of so-called gastric acid in the textbook), all gastropathy all can be fully recovered, since gastric has hydrochloric acid, so humanly just should not get gastropathy.
3. the generation of the gastric hydrochloric acid of setting forth in physiology's textbook is the synthetic hydrochloric acid that generates of chloride ion in the ammonium ion of gastric and the blood plasma.Definitely do not have chloride ion in the blood plasma, have the chloride ion people to be poisoned to death.Chlorine in the sodium chloride can never dissociate out separately and hydrion in conjunction with generating hydrochloric acid.
4.1883 year is definitely not have such equipment can detect in every cubic metre of gastric juice the hydrochloric acid that contains (containing organic acid, hydrion, carbonic acid in the gastric juice) 20-25 mole, does not also have such equipment now.
Human body " three-hypers ", the blood acidification, its old complaint is in blood capillary, cell porch fouling (medical circle claims calcification), makes the nutrition in the blood absorb, to consume institute extremely for cell.To be alkaline binding agent be bonded in metabolite in the blood vessel angiemphraxis (all acidic materials are can be not agglutinating, the occluding vascular that bond must be alkaline matter).Medical circle is controlled the phenomenon of blood acidification when disease, call people edible extremely can agglutinating theophylline, spirulina, propolis come control of diabetes, the blood acidification.When beginning to take, in and the acid in the blood, respite the state of an illness, but quicken the obstruction of blood vessel and blood capillary simultaneously, make the people quicken death.
For example, the hypertension in the human vas disease be formed with following reason:
In the water and the calcium carbonate in the food decompose and can generate sticky object, metabolite (as cholesterol etc.) and solids are bonded on arteries and the blood capillary, increase with the age, the fouling of arteries and blood capillary is more and more thicker, the blood vessel aperture is more and more thinner, thereby it is smooth that blood flow is mended, hypertension.
2. the dirty on the blood vessel wall weakens blood vessel elasticity, the automatic adjusting of restriction blood pressure.
3. the dirty on the blood vessel wall has destroyed blood vessel, is that the elasticity of itself reduces.
At present, hypertensive medicine and therapeutic equipments in the treatment human vas disease all are the expansion artery blood vessels, and blood vessel dilating quickens arterial vascular wearing out repeatedly, and when expanding repeatedly, the deposit of the blood vessel wall occluding vascular that can come off causes diseases such as myocardial infarction.
Summary of the invention
The objective of the invention is to propose to use the application of certain density salt sour water in the treatment angiopathy, take this salt sour water medicine, can calcium oxalate dissolving in adhesive calcium carbonate river separate other agglutinating particulate matters and excrete, to remove the dirty on the blood vessel, make blood vessel recover normal.
The inventor finds that hydrochloric acid is the material of interior calcium carbonate of optimal dissolve body and calcium oxalate, and hydrochloric acid is adsorbed on the inwall by the vascular protection film simultaneously, can repair the blood vessel of damage, makes blood pressure recover normal.
Technical scheme of the present invention is the application of hydrochloric acid in preparation treatment angiopathy medicine.
Described medicine is for containing aqueous solution of hydrochloric acid, and the pH value of described aqueous solution is controlled at 4-7.As oral liquid, the pH value of described aqueous solution is controlled at 6.5-7.More accurate for pH value is controlled at 3.5-5.5, the best is 3.5 for pH value.
Described medicine is oral liquid formulation or injection dosage form.
Described medicine can also add in normal saline or the glucose solution beverage, or adopts mineral water+various vitamin+aminoacid+nutrient of a large amount of trace element of medical hydrochloric acid+contain to form.
Described medicine production comprises following technology:
------------reverse osmosis unit---buffer---mixture generator (adds ferrum to former water-mechanical filter-charcoal filter in middle control cellulosic ultrafiltration system in the 1um secondary filter in the 5um secondary filter, zinc, manganese,, cobalt, strontium, chromium, selenium and other trace elements)------------------------------the import filling machine is canned---to seal---code---packing---UVGI---warehouse-in to ultraviolet sterilization to ozone sterilization to ultrafiltration system to surge tank to aseptic blender to vessel generator (interpolation hydrochloric acid) to mixture generator (interpolation nutrient) to mixture generator (interpolation aminoacid) to mixture generator (interpolation vitamin).
Hydrochloric acid of the present invention prepares the instructions of taking of medicine, and when treatment hypertension, every day, application was no less than 1500ml, was divided into 3-6 time and drank, and 3-6 month is a course of treatment.
Preferably drink 2000ml every day, divide and drink for three times, early Chinese meal was respectively drunk 500ml in last hour, and drink 1000ml before the dinner reduces by half after the general dosage in-year back can reduce 1/4, two year, generally only obeys maintenance dose after 3 years or exempts to obey depressor.Described oral solutions do not allow the heating drink.
Described injection drug form is when injection treatment hypertension, and the recommended amounts of every day is 500ml, injection at twice, and intravenous drip, 2-3 month is a course of treatment continuously.
It is safe and reliable that the present invention invents the hypertension therapy that described hydrochloric acid makes with highly purified hydrochloric acid, definite, obvious effects are arranged, hyperpietic to arterial sclerosis also improves significantly, and can make the calcium salt of harmful to human be converted into the calcium that human body needs.
For therapeutic effect of the present invention is described, use the angiopathy patient of edible salt sour water to carry out clinical observation to 132 examples.Wherein male 97 examples, women 35 examples, 67.5 years old mean age, the range of age 52-84 year.Use is the result show, edible salt sour water or cooperation other drug, as depressor, the patient cures 89 examples, controlling of blood pressure is in 30 examples of normal range, and clothes depressor does not reach normal range and hyperpietic, and the edible salt sour water is after a year and a half, taking same depressor, blood pressure can be controlled at 13 examples of normal range.
The specific embodiment
During medicine, medicine is to contain the aqueous solution of hydrochloric acid pH value to be controlled at 4-7 usually in preparation in the present invention, and pH value can be used as beverage at the solution of 6.5-7 and directly quotes, and can prepare oral liquid and injection and other dosage forms.Use and preferably be no less than 1500ml every day when eating oral liquid treatment hypertension, is divided into 36 times and drinks, and 3-6 month is a course of treatment.When injection treatment hypertension, the recommended amounts of every day is 500ml, at twice injection.Intravenous drip, 2-3 month is a course of treatment continuously, by above-mentioned usage and consumption treatment hypertension, reduces by half after general dosage can reduce 1/4, two year after 1 year, generally only obeys maintenance dose after 3 years or exempts to obey depressor, it is normal that blood pressure recovers.
Artificial preparation oral liquid as follows: hydrochloric acid adds in the drinking water and stirs, and accurately detects pH value before the fill sterilization and is controlled at 4-7; The pH value of edible salt sour water is controlled at 6.5-7.
During the industry preparation, can adopt the pH value control device to carry out continuously, stablize, prepare in large quantity the above-mentioned aqueous solution of hydrochloric acid that contains.
Can prepare injection by usual way pharmaceutically with hydrochloric acid, as long as control injection pH value is at 4-7.
When adopting tap water to prepare the salt sour water, generally should purifier be set and make it reach the sanitary standard of national drinking water at front end.
In order to treat the purpose of angiopathy, hydrochloric acid of the present invention also can be used for other solution, as normal saline, and glucose solution beverage etc., its compound method is the same, and the pH value that need only control oral liquid or injecting gets final product.
Edible salt sour water of the present invention does not allow that generally heating quotes, and makes hydrochloric acid volatilization and loses curative effect because heating, does not drink the beverage and the tea of easy fouling yet, in theophylline and the hydrochloric acid and ineffective.
Best by clinical observation concentration therapeutic effect when the PH=3.5, but because the personalized difference of human body, promoting concentration all is more effective, safe at PH=3.5-5.5.
The certain density salt sour water of PH=3.5-35.5, after entering human body, keep forging ahead in the human vas vessel softening and elimination effectively, dissolving blood vessel blockage and hardening phenomenon by the metabolism decorum, recover the human organ normal function, effectively treat various angiopathys.
In order to be that therapeutic effect is better.A kind of product composition prescription of the present invention is provided:
Medical hydrochloric acid+mineral water (containing a large amount of trace element)+vitamin (AECBD)+aminoacid+compositions such as other nutrient.
Embodiment 1
To stir in the highly purified hydrochloric acid adding drinking water, accurately controlling value 6.5-7 can directly take.
Embodiment 2
Highly purified hydrochloric acid is added drinking water be diluted to 2% hydrochloric acid solution, fill is compared above-mentioned hydrochloric acid solution and drinking water through line-blending with certain flow in the hydrochloric acid solution jar that has flow controller, and described pipe end is provided with the pH value detector; The pH value of control aqueous hydrochloric acid solution makes the pharmaceutical salts sour water at 3.5-5.5.
This product is carried out according to international ISO-9001 quality authentication standard fully.Adopt the scientific compatibility method, the necessary nutrient of human body according to a certain percentage, a certain amount ofly cooperate, produce through 24 road technological processes, its production technology is as follows:
------------reverse osmosis unit---buffer---mixture generator (adds ferrum to former water-mechanical filter-charcoal filter in middle control cellulosic ultrafiltration system in the 1um secondary filter in the 5um secondary filter, zinc, manganese,, cobalt, strontium, chromium, selenium and other trace elements)------------------------------the import filling machine is canned---to seal---code---packing---UVGI---warehouse-in to ultraviolet sterilization to ozone sterilization to ultrafiltration system to surge tank to aseptic blender to vessel generator (interpolation hydrochloric acid) to mixture generator (interpolation nutrient) to mixture generator (interpolation aminoacid) to mixture generator (interpolation vitamin)
Adopt the above-mentioned salt sour water that makes that 17 routine hyperpietics are treated observation, the patient drinks 2000ml every day, divides and drinks for three times, and early Chinese meal was respectively drunk 500ml in last hour, drink 1000ml before the dinner.Its curative effect is as described in Table 1:
Table 1
Patient's numbering Former blood pressure Age The disease treatment situation
1 130/110 65 After taking 2 years, dose reduces by half, withdrawal after 3 years, and blood pressure stabilization is 110/80
2 180/110 62 After taking 3 years, dose reduces by half, and blood pressure stabilization is 130/90
3 180/105 72 Took 2 years, dose reduces 1/4 after 1 year, now refuses to obey blood pressure lowering in 1 year, and blood pressure stabilization is 140/95
4 150/90 74 After taking 2 years, dose reduces by half, withdrawal after 4 years, now-and year disobedience blood pressure lowering, blood pressure stabilization is 110/75
5 200/100 83 After taking 2 years, dose reduces by half, and 2 years half disconnected the taking medicine in back were now refused to obey blood pressure lowering in 1 year, and blood pressure stabilization is 140/85
6 180/90 86 Took 2 years, withdrawal after dose reduces 1/4,3 year after 1 year, blood pressure stabilization is 130/80
7 160/100 63 After taking 1 year, dose reduces by half, withdrawal after 2 years, and blood pressure stabilization is 120/70
8 150/90 82 After taking 2 years, dose reduces by half, and withdrawal after 3 years was now refused to obey blood pressure lowering in 1 year, and blood pressure stabilization is 110/70
9 170/110 75 After taking 1 year half, dose reduces by half, disconnected medicine after 4 years, and blood pressure stabilization is 130/80
10 160/95 56 2000 begin to take, and dose reduces by half after 2 years, and blood pressure stabilization is 125/80
11 140/90 76 Take withdrawal after 3 years, now refused to obey in 2 years and fallen blood
Pressing, blood pressure stabilization is 120/80
12 150/100 58 Took 2 years, 1/4,2 year dose of dose minimizing reduces by half after 1 year, withdrawal after 3 years, and blood pressure stabilization is 130/85
13 190/110 73 After taking 2 years half, dose reduces by half, disconnected medicine after 3 years, and blood pressure stabilization is 140/90
14 160/95 81 After taking 1 year half, dose reduces by half, and withdrawal after 4 years was now refused to obey blood pressure lowering in 1 year, and blood pressure stabilization is 130/85
15 170/100 59 After taking 2 years, dose reduces by half, and blood pressure stabilization is 135/75
16 180/90 67 After taking 2 years, dose reduces by half, and blood pressure stabilization is 140/85
17 160/90 76 After taking 1 year, dose reduces by half, 3 years half disconnected the taking medicine in back, and blood pressure stabilization is 130/80

Claims (14)

1. the application of hydrochloric acid in preparation treatment angiopathy medicine.
2. the application of hydrochloric acid as claimed in claim 1 in preparation treatment blood vessel drug eluting, described medicine is for containing aqueous solution of hydrochloric acid, and the pH value of described aqueous solution is controlled at 4-7.
3. the application of hydrochloric acid as claimed in claim 1 in preparation treatment blood vessel drug eluting is characterized in that described medicine is for containing aqueous solution of hydrochloric acid, and the pH value of described aqueous solution is controlled at 6.5-7.
4. the application of hydrochloric acid as claimed in claim 1 in preparation treatment blood vessel drug eluting is characterized in that described medicine is for containing aqueous solution of hydrochloric acid, and the pH value of described aqueous solution is controlled at 3.5-5.5.
5. the application of hydrochloric acid as claimed in claim 1 in preparation treatment blood vessel drug eluting is characterized in that described medicine is for containing aqueous solution of hydrochloric acid, and the pH value of described aqueous solution is 3.5.
6. the application of hydrochloric acid as claimed in claim 1 in preparation treatment blood vessel drug eluting, described medicine is an oral liquid formulation.
7. the application of hydrochloric acid as claimed in claim 1 in preparation treatment blood vessel drug eluting, described medicine is the injection dosage form.
8. the application in preparation treatment blood vessel drug eluting as claim 6 or 7 described hydrochloric acid, described medicine adds in normal saline or the glucose solution beverage, controls the pH value of oral liquid or injection respectively.
9. as the application in preparation treatment blood vessel drug eluting of claim 6 or 7 described hydrochloric acid, described medicine adopts mineral water+various vitamin+aminoacid+nutrient of a large amount of trace element of medical hydrochloric acid+contain to form.
10. the application of hydrochloric acid as claimed in claim 9 in preparation treatment blood vessel drug eluting, described medicine production comprises following technology:
Former water-mechanical filter-charcoal filter---5um secondary filter---1um secondary filter---middle control cellulosic ultrafiltration system---reverse osmosis unit---buffer---mixture generator, add ferrum, zinc, manganese,, cobalt, strontium, chromium, selenium and other trace elements---mixture generator, add vitamin---mixture generator, add aminoacid---mixture generator,------------------the import filling machine is canned---to seal---code---packing---UVGI---warehouse-in to ultraviolet sterilization to ozone sterilization to ultrafiltration system to surge tank to aseptic blender to add nutrient---vessel generator, interpolation hydrochloric acid.
11. hydrochloric acid as claimed in claim 6 prepares the instructions of taking of medicine, it is characterized in that, described oral liquid formulation medicine is when treatment hypertension, and every day, application was no less than 1500ml, was divided into 3-6 time and drank, and 3-6 month is a course of treatment.
12. hydrochloric acid as claimed in claim 11 prepares the instructions of taking of medicine, it is characterized in that, drink 2000ml every day, divide and drink for three times, early Chinese meal was respectively drunk 500ml in last hour, drink 1000ml before the dinner, and general dosage can reduce 1/4 after 1 year, reduce by half after 2 years, generally only obey maintenance dose after 3 years or exempt to obey depressor.
13. prepare the instructions of taking of medicine, it is characterized in that described oral solutions does not allow that heating drinks as claim 11 or 12 described hydrochloric acid.
14. hydrochloric acid as claimed in claim 7 prepares the using method of medicine, it is characterized in that, described injection drug form is when injection treatment hypertension, and the recommended amounts of every day is 500ml, injection at twice, and intravenous drip, 2-3 month is a course of treatment continuously.
CNA2008100068263A 2008-02-02 2008-02-02 Application of certain concentration hydrochloric acid water for treating blood vessel disease Pending CN101234123A (en)

Priority Applications (2)

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CNA2008100068263A CN101234123A (en) 2008-02-02 2008-02-02 Application of certain concentration hydrochloric acid water for treating blood vessel disease
PCT/CN2008/000409 WO2009100591A1 (en) 2008-02-02 2008-02-28 Use of hydrochloric acid for the manufacture of medicine in treating vascular disease

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CNA2008100068263A CN101234123A (en) 2008-02-02 2008-02-02 Application of certain concentration hydrochloric acid water for treating blood vessel disease

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009100591A1 (en) * 2008-02-02 2009-08-20 Deshou Wang Use of hydrochloric acid for the manufacture of medicine in treating vascular disease
CN105902565A (en) * 2016-05-11 2016-08-31 吴健忠 Method for reversing sclerosis of artery and other soft tissues
CN106038592A (en) * 2016-06-29 2016-10-26 李仁山 Compound for preventing and treating cardiovascular and cerebrovascular diseases and preparation method thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1415308A (en) * 2002-09-30 2003-05-07 安徽大学 Nano selenium of amino acid and its preparation method
CN1640396A (en) * 2004-01-02 2005-07-20 广东奇方药业有限公司 Novel medicinal compositions
CN1830454A (en) * 2005-03-10 2006-09-13 刘智仁 Application of hydrochloric acid in preparation of medicine for treating high blood pressure
CN101234123A (en) * 2008-02-02 2008-08-06 王德寿 Application of certain concentration hydrochloric acid water for treating blood vessel disease

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009100591A1 (en) * 2008-02-02 2009-08-20 Deshou Wang Use of hydrochloric acid for the manufacture of medicine in treating vascular disease
CN105902565A (en) * 2016-05-11 2016-08-31 吴健忠 Method for reversing sclerosis of artery and other soft tissues
CN106038592A (en) * 2016-06-29 2016-10-26 李仁山 Compound for preventing and treating cardiovascular and cerebrovascular diseases and preparation method thereof

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