CN100998581A - Injection liquid containing sodium decanoy acetaldehyde and sodium chloride - Google Patents
Injection liquid containing sodium decanoy acetaldehyde and sodium chloride Download PDFInfo
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- CN100998581A CN100998581A CN 200610032713 CN200610032713A CN100998581A CN 100998581 A CN100998581 A CN 100998581A CN 200610032713 CN200610032713 CN 200610032713 CN 200610032713 A CN200610032713 A CN 200610032713A CN 100998581 A CN100998581 A CN 100998581A
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Abstract
An injection of sodium neohouttuyfonate-sodium chloride is proportionally prepared from sodium neohouttuyfonate, polyethanediol-400, polysorbide-80, sodium chloride and the water for injection. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of injection liquid containing sodium decanoy acetaldehyde and sodium chloride and preparation method thereof.
Background technology
Neo-houttuyninum is the synthetics of a kind of aldehydes composition in the saururaceae plant houttuynia cordata Herb volatile oil, chemistry dodecoic acid acetaldehyde sodium sulfite by name, with effective ingredient houttuynine sodium bisulfite in the natural houttuynine sodium bisulfite be isonomic sodium sulfite addition product.Both pharmacological actions are similar substantially with curative effect, are antibiosis anti-inflammatory drug, and it has the obvious suppression effect to Diplococcus pneumoniae, Bacillus typhi, staphylococcus aureus, colibacillus and sporothrix etc.But human body immunity improving power strengthens the leukocytic phagocytic function of patient, improves serum properdin level, improves the body non-specific immunity.Intramuscular injection or intravenous drip during use need be diluted in the 5-10% glucose injection during owing to intravenous drip temporarily, are prone to pollution, influence medicinal safety; Simultaneously, make up a prescription makes process loaded down with trivial details temporarily, inefficiency.
Summary of the invention
The invention provides a kind of injection liquid containing sodium decanoy acetaldehyde and sodium chloride and preparation method thereof.Described injection liquid containing sodium decanoy acetaldehyde and sodium chloride, its main component is neo-houttuyninum, sodium chloride, Polyethylene Glycol-400 and Tween-80, contain neo-houttuyninum 16mg in per 100 milliliters of injection, Polyethylene Glycol-400 50mg, Tween-80 100mg, sodium chloride 0.9g, surplus is a water for injection.The preparation method of injection liquid containing sodium decanoy acetaldehyde and sodium chloride: measure Tween-80 by prescription, Polyethylene Glycol-400 and sodium chloride join in 30% water for injection of recipe quantity, in 60 ℃ of stirring and dissolving, add 0.05% needle-use activated carbon, boil 15min, filtering decarbonization, get concentrated wiring liquid, add injection water to 80%, be heated to 60 ℃, add the neo-houttuyninum of recipe quantity, stirring makes it dissolving, regulate pH value to 4.5-6.5 with the sodium carbonate liquor of 1mol/L, add to the full amount of water for injection, add the needle-use activated carbon of total amount 0.03%, stirred 20 minutes about 60 ℃, charcoal is taken off in filtration, product in the middle of getting, product in the middle of detecting, filtering with microporous membrane with 0.45 μ m, cannedly roll lid in the 100mL infusion bottle, 115 ℃ of pressure sterilizing 30min, quality inspection, packing promptly.This product can be used for treating all kinds of inflammation of gynecological such as adnexitis, pelvic inflammatory disease, chronic cervicitis, and is used for upper respiratory tract infection, chronic bronchitis, pneumonia etc.
This product has the following advantages: 1, on the basis of original new houttuynine sodium bisulfite injection, add a certain proportion of sodium chloride and make injection liquid containing sodium decanoy acetaldehyde and sodium chloride, promptly simplified process, need not to be dissolved in the 5-10% glucose injection, stopped to make up a prescription the hidden danger of pollution occurs temporarily, guarantees drug safety temporarily again, improved efficient, make things convenient for medication, reduce medical expense, satisfied clinical growing needs.2, the neo-houttuyninum sodium raw materials is white flakey or acicular crystal powder, and slightly soluble in water and ethanol in order to increase its dissolubility in water, should add the cosolvent of appropriate amount.Present existing neo-houttuyninum product for improving liquor strength, has added the cosolvent tween 80 in the prescription, not only easily produce haemolysis, and certain toxic and side effects is arranged.This product adds a certain proportion of Tween-80 and Polyethylene Glycol-400 as cosolvent in the process of preparation, solved the water solublity problem of neo-houttuyninum, has increased liquor strength, has improved curative effect, and has had no side effect.
The injection liquid containing sodium decanoy acetaldehyde and sodium chloride of above-mentioned preparation carries out following safety test: 1, in the experiment white mice of 20 groups of 18-20g (5 every group), this product of tail vein injection 0.3ml, or lumbar injection 1ml, in 24 hours, do not see any poisoning symptom and the phenomena of mortality.2, the Cavia porcellus experiment is 40, does control experiment for 20, presses consumption per day 8mg/kg, divides 2 times lumbar injection, and successive administration was put to death after 30 days, and tissues such as the administration animal heart, liver, kidney, lung there is no specificity pathology pathological changes.
The specific embodiment
Injection liquid containing sodium decanoy acetaldehyde and sodium chloride is got Tween-80 100g, Polyethylene Glycol-400 50g and sodium chloride 900g, join in 30% water for injection, 60 ℃ of stirring and dissolving add 0.05% needle-use activated carbon, boil 15min, filtering decarbonization gets concentrated wiring liquid, adds injection water to 80%, be heated to 60 ℃, add neo-houttuyninum 16g, stir and make it dissolving, transfer pH value to 4.5-6.5 with the 1mol/L sodium carbonate liquor, add the injection water to 100L, add 0.03% needle-use activated carbon, stirred 20 minutes filtering decarbonization about 60 ℃, get intermediate, product in the middle of detecting, 0.45 μ m filtering with microporous membrane, canned in the 100ml infusion bottle, roll lid, 115 ℃ of pressure sterilizing 30min, quality inspection, packing promptly gets this product.
Claims (3)
1, a kind of injection liquid containing sodium decanoy acetaldehyde and sodium chloride and preparation method thereof is characterized in that: this product main component is neo-houttuyninum, sodium chloride, Polyethylene Glycol-400 and Tween-80.
2, injection liquid containing sodium decanoy acetaldehyde and sodium chloride according to claim 1 and preparation method thereof, it is characterized in that: contain neo-houttuyninum 16mg in per 100 milliliters of injection, Polyethylene Glycol-400 50mg, Tween-80 100mg, sodium chloride 0.9g, surplus is a water for injection.
3, injection liquid containing sodium decanoy acetaldehyde and sodium chloride according to claim 1 and preparation method thereof, it is characterized in that: preparation process is: measure Tween-80 by prescription, Polyethylene Glycol-400 and sodium chloride join in 30% water for injection of recipe quantity, in 60 ℃ of stirring and dissolving, add 0.05% needle-use activated carbon, boil 15min, filtering decarbonization gets concentrated wiring liquid, adds injection water to 80%, be heated to 60 ℃, the neo-houttuyninum that adds recipe quantity stirs and makes it dissolving, regulates pH value to 4.5-6.5 with the sodium carbonate liquor of 1mol/L, add to the full amount of water for injection, the needle-use activated carbon that adds total amount 0.03% stirred 20 minutes about 60 ℃, filtered and took off charcoal, product in the middle of getting, product in the middle of detecting, with the filtering with microporous membrane of 0.45 μ m, canned in the 100mL infusion bottle, roll lid, 115 ℃ of pressure sterilizing 30min, quality inspection, packing is promptly.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN 200610032713 CN100998581A (en) | 2006-01-09 | 2006-01-09 | Injection liquid containing sodium decanoy acetaldehyde and sodium chloride |
Applications Claiming Priority (1)
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CN 200610032713 CN100998581A (en) | 2006-01-09 | 2006-01-09 | Injection liquid containing sodium decanoy acetaldehyde and sodium chloride |
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CN100998581A true CN100998581A (en) | 2007-07-18 |
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CN 200610032713 Pending CN100998581A (en) | 2006-01-09 | 2006-01-09 | Injection liquid containing sodium decanoy acetaldehyde and sodium chloride |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103265459A (en) * | 2013-06-03 | 2013-08-28 | 四川省惠达药业有限公司 | Novel sodium houttuyfonate compound as well as preparation method and pharmaceutical composition thereof |
CN106806360A (en) * | 2015-12-01 | 2017-06-09 | 北京盈科瑞药物研究院有限公司 | A kind of Sodium New Houttuyfonate Neulized inhalation pharmaceutical solutions and preparation method thereof |
CN112791074A (en) * | 2021-03-17 | 2021-05-14 | 中山大学 | Application of houttuynin and/or sodium new houttuyfonate in preparing NDM-1 inhibitor |
-
2006
- 2006-01-09 CN CN 200610032713 patent/CN100998581A/en active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103265459A (en) * | 2013-06-03 | 2013-08-28 | 四川省惠达药业有限公司 | Novel sodium houttuyfonate compound as well as preparation method and pharmaceutical composition thereof |
CN103265459B (en) * | 2013-06-03 | 2015-09-09 | 四川省惠达药业有限公司 | A kind of novel sodium houttuyfonate compound, its preparation method and pharmaceutical composition thereof |
CN106806360A (en) * | 2015-12-01 | 2017-06-09 | 北京盈科瑞药物研究院有限公司 | A kind of Sodium New Houttuyfonate Neulized inhalation pharmaceutical solutions and preparation method thereof |
CN112791074A (en) * | 2021-03-17 | 2021-05-14 | 中山大学 | Application of houttuynin and/or sodium new houttuyfonate in preparing NDM-1 inhibitor |
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Open date: 20070718 |