CN101229230A - Chinese traditional medicine mixture for curing senile dementia - Google Patents
Chinese traditional medicine mixture for curing senile dementia Download PDFInfo
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- CN101229230A CN101229230A CNA2008100566220A CN200810056622A CN101229230A CN 101229230 A CN101229230 A CN 101229230A CN A2008100566220 A CNA2008100566220 A CN A2008100566220A CN 200810056622 A CN200810056622 A CN 200810056622A CN 101229230 A CN101229230 A CN 101229230A
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Abstract
The invention belongs to the technical field for geriatric disease prevention, in particular to a medicine which prevents senile dementia syndrome, and especially prevents vascular dementia effectively without side effects. The invention is characterized in that the medicine is an externally used medical gel and an oral preparation which are prepared from ginkgo leaves, barrenwort, salvia, schisandra chinensis, platyciad semen and camphor (oral administrations are borneol).
Description
Technical field
The invention belongs to control Senile disease technical field, specifically a kind of medicine that is used to prevent and treat senile dementia, especially can be effectively and have no side effect to the control of vascular dementia.
Background technology
Senile dementia is a kind of performance of elderly brain functional disorder, is a kind of symptom that is changed to feature with intellectual deterioration and behavior and personality.Clinical classical symptom has the obstacle of memory, abstract thinking, orientation force, simultaneously going down with the social activity ability.Can be divided into 4 types:
(1) alzheimer disease.
(2) vascular dementia.
(3) Combination dementia, promptly alzheimer disease and vascular dementia exist simultaneously.
(4) dementia of other type, the dementia that causes as cerebral trauma, carbon monoxide poisoning, vitamin B complex shortage etc.
Dementia syndrome is meant with headache, dizziness, insomnia, anxiety, depression, dysmnesia, bradykinesia, the forced smile of crying by force, hallucination, vain hope are the clinical syndrome of its characteristics.Learn investigation according to world pop is sick, serious dementia accounts for over-65s old man's 5%, still has 10% for slightly to moderate dementia.Dementia mainly is divided into senile (Alaheimer) type dementia at present; Vascular dementia; Combination is dull-witted and other four kinds.
Vascular dementia accounts for the 8%-39% of whole dementias.Account for 37% at Japanese vascular dementia, mixed type accounts for 50%.Dull-witted generation is relevant with following factors: (1) dull-witted people's cerebral blood flow reduces, and allly is the dement, may just have cerebral blood flow to reduce before 1-2, and the while reduces with CMRO2.(2) neurotransmitter is unusual, neurotransmitter is relevant with memory, elderly patients' cholinesterase increases in cerebrospinal fluid, acetylcholine is few, thereby dysmnesia take place, and the noradrenaline cellulose content reduces in cerebrospinal fluid simultaneously, 5-Hydroxyalkyl tryptamines activity also reduces, because the minimizing of these neurotransmitteies influences old people's intelligence, so occurs dull-witted.(3) alcoholism may be to cause dull-witted risk factor, alcoholism can increase packed cell volume, reduce erythrocyte deformability, cause dysfunction of platelet, promote blood coagulation, reduce cerebral blood flow, also can bring out hormonal balance imbalance and lipid metabolism changes, make hypertension, arrhythmia impels apoplexy to take place.Long-term chronic drink spills, and can make degeneration such as cortex, callosity guanidine body, thereby remembers, directed attention disorders.At present, sell on the market to be used for the treatment of having of above-mentioned disease multiple, but be function singleness mostly, control it and mark not Zhi Qiben.
Summary of the invention
The objective of the invention is provides a kind of medicine of preventing and treating senile dementia and preparation method thereof according to the risk factor and the pathogeny of senile dementia, the object of the present invention is achieved like this, it is characterized in that it is made by the following weight proportion raw material:
Folium Ginkgo 100g, Herba Epimedii 100g, Radix Salviae Miltiorrhizae 100g, Fructus Schisandrae Chinensis 100g, Semen Platycladi 100g, Camphora 1g (Oral preparation is Borneolum Syntheticum 1g), the external of ten amounts; The former medicine of Chinese herbal medicine all adopts circumfluence method to be condensed into flowing soaking paste with the one all after-filtration slagging-off of 95% soak with ethanol again; All genus Western medicine of various medicament or the equal grind into fine powder of Chinese herbal medicine refining product down extract medicine with other in room temperature and fully mix afterwards standby.
Medicament of the present invention can be made into dosage form for oral administration and exterior-applied formulation.Its preparation form of Oral preparation has water preparation, fluid extract, tablet, pill, capsule.Exterior-applied formulation mainly is to deliver medicine to patient part by external application, and its preparation form has ointment, liquor, plaster etc.In these preparation forms, make external application to medicament and dosage form for oral administration by conventional process with normally used auxiliary agent, additive, spreader-sticker etc.
The present invention is processed into through modern scientific method Shi Xuan in traditional theory of Chinese medical science.Have refreshment spasmolytic, causing resuscitation with aromatic drugs, promotion cytoactive in the side, improve the medicine of cerebral cortex biology, have thrombolytic to promote blood circulation again, suppressing the hyperactive liver and subsiding YANG reduces blood viscosity, strengthens vessel wall elasticity, promotes the medicine of cerebral circulation metabolism.Through clinical observation, all medicines share can prevent and treat brain atrophy, and the wordizations brain cell improves local microcirculation, dwindles infarct, strengthens corticocerebral irritability, promotes dopamine synthetic.The present invention cures mainly brain atrophy, cerebral arteriosclerosis, cerebral malacia, subcortical arteriosclerotic encephalopathy.The present invention has the cell ageing of energy prevention of brain, promotes the effect of brain cell regeneration.The present invention has also that preparation technology is simple, cost is low, the feature of no any poison effect of paying, determined curative effect, below will the invention will be further described by example:
The specific embodiment
Example 1: Folium Ginkgo 100g, Herba Epimedii 100g, Radix Salviae Miltiorrhizae 100g, Fructus Schisandrae Chinensis 100g, Semen Platycladi 100g, Camphora 1g, ten amounts; The former medicine of Chinese herbal medicine all adopts circumfluence method to be condensed into flowing soaking paste with the one all after-filtration slagging-off of 95% soak with ethanol again, to go up the ratio that the amount mixture concentrates fluid extract (10: 2) acrylic compounds water-dispersion type pressure sensitive adhesive during molding and fully mix, then according to the paster of preparation technology's production (film～storage storehouse control release type transdermal delivery system is the multiple structure that has more than 5 layers) of known film～storage storehouse control release type transdermal delivery system.
Employing has the acrylic compounds water-dispersion type pressure sensitive adhesive of viscosity.This water-dispersion type pressure sensitive adhesive is all very stable to heat and ultraviolet, the good oxidative resistance of tool, as adjusting each monomeric proportioning in the polymer in process of production, change its vitrification point, select suitable molecular weight distribution, polarity, the degree of cross linking or branched structure can obtain to be fit to the different pressure sensitive adhesives that require of pasting.In emulsion, generally no longer add other additives such as viscosifier, antioxidant, light stability agent, can reduce the risk factor that produces skin irritation and pasting the interference of performance.Increase the carbon number of lateral chain of ester group in the copolymer, help improving unordered degree, reduction degree of crystallinity and vitrification point, increase viscosity, the flexibility of improving pressure sensitive adhesive and the shearing strength of polymer.Add polarity and the water permeability that a small amount of acrylic acid increases latex in the reaction, help the adhesion of polar substrates and breathability and the poisture-penetrability that is beneficial to skin.
Disposable medicine glue reaches medicine in the time of can guaranteeing to treat at every turn and effectively treats concentration.Medicine glue cures mainly dementia syndrome, and is especially effective to diseases such as alzheimer disease, vascular dementia, Combination dementias.Can this plaster be affixed on the treating correlative diseases position according to the Chinese medicine meridian principle during use gets final product.
Example 2: Folium Ginkgo 100g, Herba Epimedii 100g, Radix Salviae Miltiorrhizae 100g, Fructus Schisandrae Chinensis 100g, Semen Platycladi 100g, Borneolum Syntheticum 1g, ten amounts; The former medicine of Chinese herbal medicine all adopts circumfluence method to be condensed into flowing soaking paste with all after-filtration slagging-off of 95% soak with ethanol one again, will go up the amount mixture during molding and concentrate fluid extract (1: 10) and add pure water and make water preparation, and every day, secondary was oral.
The present invention has easy to use, rapid-action as externally applied drug glue and formulation product for oral administration, The characteristics of determined curative effect because main active ingredient is extracted from plant, have no side effect, Safe and reliable, the long-term use reaches the purpose of control senile dementia.
Through clinical observation significant curative effect is arranged, its social benefit is remarkable, raw material required for the present invention And medicament sources to enrich valency low, the very high ratio of performance to price is arranged, its application also has high Economic benefit.
Claims (3)
1. prevent and treat medicine of senile dementia and preparation method thereof for one kind, it is characterized in that it is made by the following weight proportion raw material, comprise Folium Ginkgo 100g, Herba Epimedii 100g, Radix Salviae Miltiorrhizae 100g, Fructus Schisandrae Chinensis 100g, Semen Platycladi 100g, Camphora 1g (Oral preparation is Borneolum Syntheticum 1g), the external of ten amounts, the former medicine of Chinese herbal medicine all adopt circumfluence method to be condensed into flowing soaking paste with the one all after-filtration slagging-off of 95% soak with ethanol again, and medicament of the present invention can be made into dosage form for oral administration and exterior-applied formulation, its preparation form of Oral preparation has water preparation, fluid extract, tablet, pill, capsule, its preparation form of exterior-applied formulation has ointment, liquor, plaster etc.
2. described according to claim 1, it is characterized in that Folium Ginkgo 100g, Herba Epimedii 100g, Radix Salviae Miltiorrhizae 100g, Fructus Schisandrae Chinensis 100g, Semen Platycladi 100g, Camphora 1g (Oral preparation is Borneolum Syntheticum 1g), the external of ten amounts, the former medicine of Chinese herbal medicine all adopts circumfluence method to be condensed into flowing soaking paste with the one all after-filtration slagging-off of 95% soak with ethanol again, down fully to mix the back standby with other medicines in room temperature, and the ratio that will go up concentrated fluid extract (10: 2) the acrylic compounds water-dispersion type pressure sensitive adhesive of amount mixture during molding fully mixes, and the preparation technology according to known film～storage storehouse control release type transdermal delivery system produces paster then.
3. described according to claim 1, it is characterized in that Folium Ginkgo 100g, Herba Epimedii 100g, Radix Salviae Miltiorrhizae 100g, Fructus Schisandrae Chinensis 100g, Semen Platycladi 100g, Borneolum Syntheticum 1g, ten times amount is taken, and the former medicine of Chinese herbal medicine all adopts circumfluence method to be condensed into flowing soaking paste with the one all after-filtration slagging-off of 95% soak with ethanol again, down fully to mix the back standby with other medicines in room temperature, will go up the concentrated fluid extract (1: 10) of amount mixture during molding and add pure water and make water preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100566220A CN101229230A (en) | 2008-01-23 | 2008-01-23 | Chinese traditional medicine mixture for curing senile dementia |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100566220A CN101229230A (en) | 2008-01-23 | 2008-01-23 | Chinese traditional medicine mixture for curing senile dementia |
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| CN101229230A true CN101229230A (en) | 2008-07-30 |
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| CNA2008100566220A Pending CN101229230A (en) | 2008-01-23 | 2008-01-23 | Chinese traditional medicine mixture for curing senile dementia |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103055014A (en) * | 2012-12-31 | 2013-04-24 | 青岛华仁信息技术开发有限公司 | Folium ginkgo health product for preventing senile dementia and preparation method thereof |
| CN108272949A (en) * | 2012-05-12 | 2018-07-13 | 石家庄以岭药业股份有限公司 | A kind of application of Chinese medicine composition in preparing the dull-witted drug for the treatment of |
-
2008
- 2008-01-23 CN CNA2008100566220A patent/CN101229230A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108272949A (en) * | 2012-05-12 | 2018-07-13 | 石家庄以岭药业股份有限公司 | A kind of application of Chinese medicine composition in preparing the dull-witted drug for the treatment of |
| CN108272949B (en) * | 2012-05-12 | 2021-01-01 | 石家庄以岭药业股份有限公司 | Application of traditional Chinese medicine composition in preparation of medicine for treating dementia |
| CN103055014A (en) * | 2012-12-31 | 2013-04-24 | 青岛华仁信息技术开发有限公司 | Folium ginkgo health product for preventing senile dementia and preparation method thereof |
| CN103055014B (en) * | 2012-12-31 | 2014-09-17 | 青岛华仁技术孵化器有限公司 | Folium ginkgo health product for preventing senile dementia and preparation method thereof |
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Open date: 20080730 |