CN101229219A - Technology of processing astragalus root decoction pieces - Google Patents
Technology of processing astragalus root decoction pieces Download PDFInfo
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- CN101229219A CN101229219A CNA2007100367152A CN200710036715A CN101229219A CN 101229219 A CN101229219 A CN 101229219A CN A2007100367152 A CNA2007100367152 A CN A2007100367152A CN 200710036715 A CN200710036715 A CN 200710036715A CN 101229219 A CN101229219 A CN 101229219A
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Abstract
The invention discloses a processing technique of astragalus decoction pieces; the invention is characterized by comprising the following steps: cleaning and selecting step, smoothing and softening step by 2 to 24 hours, slicing step, and drying step under the temperature of 20 to 85 DEG C. By being proved by experiment and being unified in standard and parameter, the technique of the invention is steady and the processing quality is accordant, so the technique improves the content of astragaloside and strengthens the medical efficacy of astragalus.
Description
Technical field
The present invention relates to a kind of technology of processing astragalus root decoction pieces.
Background technology
The prepared slices of Chinese crude drugs are that the traditional Chinese medical science is faced the element of examining prescription, also are the base stocks of Chinese patent medicine, and the quality of its quality will directly have influence on the embodiment of tcm clinical curative effect, thereby concern people health.Although the prepared slices of Chinese crude drugs are in the existing very long processing of China and use historically, comprehensive research of Chinese medicine is often lacked systematic perspective and globality, be unfavorable for the prepared slices of Chinese crude drugs and the announcement of concocting inherent law.The low-level production and the application that has influence on the prepared slices of Chinese crude drugs of prepared slices of Chinese crude drugs quality research.The present ubiquity of prepared slices of Chinese crude drugs manufacturing enterprise that production form is extensive, processing technique is simple; The quality control method poorness, quality index is coarse and crude and single; , problem such as automaticity low, the production scale little prepared slice quality that cause uneven and production and marketing level low backward because of production equipment.The existence of these problems has badly influenced the traditional Chinese medical science faces and examines stabilizing and increasing of prescription and Chinese patent medicine clinical efficacy, has also seriously restricted motherland's medicine and pharmacology treasure-house is further excavated.
The Radix Astragali is given birth to product and is longer than benefiting QI for strengthening the superficies, promoting pus discharge and tissue regeneration strengthening, and the diuresis detumescent, the spontaneous perspiration or the body void that often are applied to failure of superficial QI to protect the body against disease are easy to flu, and deficiency of vital energy edema, carbuncle are not burst or are burst for a long time and do not hold back.Therefore, Radix Astragali decoction pieces is the main component in the qi-invigorating herb compatibility always.
The process of preparing Chinese medicine for the Radix Astragali, there is reed method (" gold is deficient ") Han dynasty, there is steaming method (" Thunder God ") in Liu Song of Northern and Southern Dynasties epoch, there is processed with honey (" medicine card ") Song dynasty, salt soup soaks and irons, fries that (" total record " j, wine boil (" delivering a letter "), salt is processed concocting methods such as (" variola sides "), the Ming Dynasty has increased stir-frying with ginger juice (" kindness "), water from washing rice stirs methods such as (" criterions "), the Qing Dynasty has increased human milk system concocting methods such as (" picking up any lost article from the road "), and the concocting method that existing 2000 version pharmacopeia are recorded the Radix Astragali is: the Radix Astragali is removed impurity, sheet, drying are separated, cleaned, run through, cut to size.Though can reach the effect of concocting the Radix Astragali, owing to there is not unified standard, therefore, the quality of the process of preparing Chinese medicine is inconsistent, can not get a desired effect.
Summary of the invention
The present invention is in order to overcome the shortcoming that existing Chinese medicine industry exists in Radix Astragali concocting method, and provide a kind of make concoct step standard, parameter and standard unified, improve Radix Astragali quality Radix Astragali processing procedure.
The technical measures that the present invention takes are: technology of processing astragalus root decoction pieces, be characterized in, and may further comprise the steps:
A, clean step;
B, moisten soft step: moistened soft 2～24 hours;
C, slicing step;
D, drying steps: dry under the temperature of 20～85 degree.
Above-mentioned technology of processing astragalus root decoction pieces, wherein, the described Radix Astragali is the dry root of leguminous plant Radix Astragali.
Above-mentioned technology of processing astragalus root decoction pieces, wherein, described profit soft time optimal is 4 hours.
Above-mentioned technology of processing astragalus root decoction pieces, wherein, described baking temperature the best is 75 ± 5 ℃.
Above-mentioned technology of processing astragalus root decoction pieces wherein, in the described slicing step, is cut to circular the described Radix Astragali or oval-shaped, thick 0.1～0.4cm.
The present invention is owing to adopted above technical scheme, to clean, to moisten 4 hours, section, as optimised process, make the processing procedure of Radix Astragali decoction pieces that unified standard arranged the Radix Astragali 75 ± 5 ℃ of oven dry, thereby make steady quality, measure important function guaranteeing tragacanthin.
Description of drawings
Concrete feature of the present invention, performance are further described by following embodiment and accompanying drawing thereof.
Fig. 1 is a process chart of the present invention.
The specific embodiment
See also Fig. 1, Fig. 1 is a process flow diagram of the present invention.The Radix Astragali of the present invention is meant the dry root of leguminous plant Radix Astragali.The processing procedure of the Radix Astragali of the present invention is: the dry root (two seasons of spring and autumn excavate) of getting crude drug Radix Astragali Astragalusmembranaceus (Fisch) Bge earlier is up to the standards by standards of pharmacopoeia, then operation according to the following steps:
A, clean step 1, comprise remove fibrous root and root head, remove impurity, size separately, the preorder arrangement such as clean;
B, the soft step 2 of profit: moistened soft 2～24 hours;
C, slicing step 3; The root of the Radix Astragali directly is cut into astragalus mongholicus tablet, and the present invention is cut to circular described astragalus mongholicus tablet or oval-shaped, and thick 0.2～0.4cm is for well.
D, drying steps 4: dry under the temperature of 20～85 degree; Can be under natural temperature dry, also can be in dehydrator bake drying.
Be up to the standards at last and carry out packing 5.
The method according to this invention is concocted Radix Astragali decoction pieces, shows that through optimizing test result and analysis result best process of preparing Chinese medicine condition is: soaked 0 hour, and moistened 75 ± 5 ℃ of baking temperatures soft 4 hours.Astragaloside content can be the highest under this best process of preparing Chinese medicine condition.
The present invention also finds by research, the Radix Astragali main product in the Inner Mongol, ground such as Gansu, Shanxi, Shandong, Jilin, Heilungkiang, Shanxi, Gansu be mainly to cultivate the product places of production.Tradition thinks that Radix Astragali spring and autumn gathers, and experimental result shows, the first salidroside content is minimum seedling stage at the beginning of 5 months, and is along with the plant growing contents increased, the highest to JIUYUE.And the detection index by different places of production Radix Astragali medical material, for example: total ash content (%), sour insoluble the ash content of coal (%), moisture (%), astragaloside content (%), extract content indexs such as (%), and with reference to GB/T5009-1996 check weighing metal, press GB/T5009.22 (2)-1996 and survey aflatoxin B1, press 2000 editions one appendix IX Q of Chinese Pharmacopoeia and survey organochlorine residue, find: the west of Gansu Province, the Gansu every index of Radix Astragali raw material all complies with relevant regulations.Therefore select the Radix Astragali in the west of Gansu Province, Gansu as optimum feed stock.
The present invention has worked out indexs such as moisture, ash, extractum, content limit by to Radix Astragali decoction pieces every index determining result of sample repeatedly, and test result is as follows:
1, character:
Exocuticle sundown or shallow sepia, as seen vertical wrinkle or longitudinal furrow, tangent plane skin zone yellow-white, woody part is faint yellow, and radial texture and crack are arranged, and the center idol that has has dry and decayed shape, pitchy or be the cavity, feeble QI, it is little sweet to distinguish the flavor of, and that chews littlely has a beany flavor.
2, differentiate:
(1) astragalus mongholicus tablet powder yellow-white, the pale brown color of Radix Astragali Preparata powder, fiber bunchy or loose from, diameter 8～30um, wall thickness, there is longitudinal crack on the surface, and primary wall often separates with secondary wall, and the two ends normal off is cleaved into must shape, or more truncate.Bordered pit vessel is colourless or orange-yellow, and bordered pit is arranged closely.Stone cell is rare, circle, Long Circle or out-of-shape, and wall is thicker.
(2) get astragalus mongholicus tablet need testing solution and astragaloside reference substance solution under the assay item, test according to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2000), draw above-mentioned two kinds of each 2ul of solution, put respectively on same silica gel g thin-layer plate, with chloroform: methanol: lower floor's solution of water (13: 7: 2) is developing solvent, launches, take out, dry, spray is with 10% ethanol solution of sulfuric acid, and it is clear to be heated to speckle colour developing at 105 ℃.In the astragalus mongholicus tablet test sample chromatograph, with the corresponding position of reference substance chromatograph on, sharing the same light all shows down identical sepia speckle; All show identical orange-yellow fluorescence speckle under the ultra-violet lamp (365nm).
3, check:
Total ash must not surpass 5.0%;
Acid-insoluble ash must not surpass 1.0%;
Residual Levels of Organochlorine Pesticides Gamma Hexaochlorocyclohexane (total BHC) all must not surpass 2/10000000ths;
Clofenotane (total DDT) all must not surpass 2/10000000ths:
Pentachloronitrobenzene (PCNB) all must not surpass 1/10000000th
4, extractum:
Measure according to the cold-maceration under the water-soluble extractives algoscopy item, astragalus mongholicus tablet must not be less than 17.0%.
5, assay:
Get each about 1.5g of astragalus mongholicus tablet, it is fixed to get the accurate respectively title of this product coarse powder mensuration moisture simultaneously in addition, puts in the apparatus,Soxhlet's, adds methanol 40ml, merceration spends the night, and it is an amount of to add methanol again, refluxes 4 hours, extracting solution reclaims methanol and is concentrated into driedly, and residue adds water 10ml, and slight fever makes dissolving, extract 3 times with water saturated n-butyl alcohol jolting, each 20ml merges n-butanol extracting liquid, extract 2 each 20ml with the nitrogen test solution, discard ammoniacal liquor, n-butyl alcohol liquid evaporate to dryness, residue adds water 3～5ml makes dissolving, puts coldly, passes through D
LolType macroporous adsorptive resins (internal diameter 1.5cm, long 12cm) is with water 50ml eluting, discard water liquid, reuse 40% ethanol 30ml eluting discards 40% ethanol elution, continues with 70% ethanol 50ml eluting, collect eluent, evaporate to dryness with dissolve with methanol and be transferred in the 2ml volumetric flask, adds methanol to scale, shake up, as need testing solution.Precision takes by weighing the astragaloside reference substance in addition, adds methanol and makes the solution that every 1ml contains 1mg, in contrast product solution.Test according to thin layer chromatography, accurate need testing solution 2ul and 6ul, reference substance solution 2ul and the 4ul of drawing, the cross point is on same silica gel G book laminate respectively, with chloroform: methanol: water (13: 6: 2) is placed the lower floor's solution that spends the night below 10 ℃ be developing solvent, launch, take out, dry, spray is with 10% ethanol solution of sulfuric acid, and it is clear to be heated to speckle colour developing at 100 ℃, take out, on lamellae, cover onesize glass plate, use immobilization with adhesive tape on every side, scan according to thin layer chromatography, wavelength: go into s=530nm, go into
R=700nm measures test sample trap integrated value and reference substance trap integrated value, calculates, promptly.
Astragalus mongholicus tablet is pressed dry product and is calculated, and contains astragaloside (C
41H
68O
14) Radix Astragali must not be less than 0.040%.
The present invention has extracted three batch samples, presses quality standard and detects as follows:
| Kind | Lot number | Moisture content (%) | Total ash (%) | Acid-insoluble ash (%) | Extractum (%) | Astragaloside (%) |
| 1 | 01 | 7.43 | 3.78 | 0.42 | 32.8 | 0.044 |
| 2 | 02 | 8.18 | 4.06 | 0.38 | 39，6 | 0.047 |
| 3 | 03 | 6.23 | 3.82 | 0.47 | 34.5 | 0.049 |
These parameters substantially exceeds prescription.
6, nature and flavor and return through:
Sweet, temperature is returned lung, spleen channel.
7, function and curing mainly:
The astragalus mongholicus tablet invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation; It is weak to be used for the deficiency of vital energy, anorexia and loose stool, and sinking of QI of middle-JIAO, the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle is burst, and burst for a long time and do not hold back, the blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
8, usage and consumption:
9～30g。
Replica test is the result show, the repeatability of sample is good.
The present invention makes process stabilizing owing to unified standard and parameter, the uniform quality of the process of preparing Chinese medicine, thus improved the content of astragaloside, strengthened the medical effect of the Radix Astragali.
Claims (5)
1. technology of processing astragalus root decoction pieces is characterized in that, may further comprise the steps:
A, clean step;
B, moisten soft step: moistened soft 2～24 hours;
C, slicing step;
D, drying steps: dry under the temperature of 20～85 degree.
2. technology of processing astragalus root decoction pieces according to claim 1 is characterized in that, the described Radix Astragali is the dry root of leguminous plant Radix Astragali.
3. technology of processing astragalus root decoction pieces according to claim 1 is characterized in that, described profit soft time optimal is 4 hours.
4. technology of processing astragalus root decoction pieces according to claim 1 is characterized in that, described baking temperature the best is 75 ± 5 ℃.
5. technology of processing astragalus root decoction pieces according to claim 1 is characterized in that, in the described slicing step, is cut to circular the described Radix Astragali or oval-shaped, thick 0.2～0.4cm.
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| CNA2007100367152A CN101229219A (en) | 2007-01-23 | 2007-01-23 | Technology of processing astragalus root decoction pieces |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102813169A (en) * | 2012-08-28 | 2012-12-12 | 刘俊希 | Radix Astragali processing method |
| CN102885877A (en) * | 2011-07-22 | 2013-01-23 | 岷县顺兴和中药材有限责任公司 | Hand cutting processing method for astragalus decoction pieces |
| CN104173421A (en) * | 2014-08-19 | 2014-12-03 | 浙江尖峰健康科技有限公司 | Radix astragali decoction piece and preparation method thereof |
| CN104622944A (en) * | 2013-11-12 | 2015-05-20 | 呼和浩特市通瑞科技有限责任公司 | Method for processing Radix Astragali decoction pieces in producing area |
| CN105193907A (en) * | 2015-10-09 | 2015-12-30 | 江苏健生源中药材有限公司 | Method for preparing astragalus membranaceus decoction pieces |
| CN106706634A (en) * | 2016-05-21 | 2017-05-24 | 广州今典精方药业有限公司 | Quality standard and preparation process of qualitative and quantitative Chinese herbal astragali radix decoction slice |
| CN107582612A (en) * | 2017-09-12 | 2018-01-16 | 福建省尤溪仙锦药业有限公司 | A kind of concocting method of the Radix Astragali |
| CN108210552A (en) * | 2018-03-08 | 2018-06-29 | 蔺君 | A kind of production method of the Radix Astragali prepared slices of Chinese crude drugs |
| CN110367363A (en) * | 2019-08-28 | 2019-10-25 | 甘肃国丽康中药材研发有限责任公司 | Radix Astragali bubble boils dedicated medicine materical crude slice and preparation method thereof |
| CN110496151A (en) * | 2019-10-15 | 2019-11-26 | 安徽协和成药业饮片有限公司 | A kind of preparation method of Radix Astragali medicine materical crude slice |
| CN110833571A (en) * | 2019-12-13 | 2020-02-25 | 宁夏隆德县六盘山中药资源开发有限公司 | Preparation method of astragalus membranaceus decoction piece finished product |
-
2007
- 2007-01-23 CN CNA2007100367152A patent/CN101229219A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102885877A (en) * | 2011-07-22 | 2013-01-23 | 岷县顺兴和中药材有限责任公司 | Hand cutting processing method for astragalus decoction pieces |
| CN102813169A (en) * | 2012-08-28 | 2012-12-12 | 刘俊希 | Radix Astragali processing method |
| CN104622944A (en) * | 2013-11-12 | 2015-05-20 | 呼和浩特市通瑞科技有限责任公司 | Method for processing Radix Astragali decoction pieces in producing area |
| CN104173421A (en) * | 2014-08-19 | 2014-12-03 | 浙江尖峰健康科技有限公司 | Radix astragali decoction piece and preparation method thereof |
| CN105193907A (en) * | 2015-10-09 | 2015-12-30 | 江苏健生源中药材有限公司 | Method for preparing astragalus membranaceus decoction pieces |
| CN106706634A (en) * | 2016-05-21 | 2017-05-24 | 广州今典精方药业有限公司 | Quality standard and preparation process of qualitative and quantitative Chinese herbal astragali radix decoction slice |
| CN107582612A (en) * | 2017-09-12 | 2018-01-16 | 福建省尤溪仙锦药业有限公司 | A kind of concocting method of the Radix Astragali |
| CN108210552A (en) * | 2018-03-08 | 2018-06-29 | 蔺君 | A kind of production method of the Radix Astragali prepared slices of Chinese crude drugs |
| CN110367363A (en) * | 2019-08-28 | 2019-10-25 | 甘肃国丽康中药材研发有限责任公司 | Radix Astragali bubble boils dedicated medicine materical crude slice and preparation method thereof |
| CN110496151A (en) * | 2019-10-15 | 2019-11-26 | 安徽协和成药业饮片有限公司 | A kind of preparation method of Radix Astragali medicine materical crude slice |
| CN110833571A (en) * | 2019-12-13 | 2020-02-25 | 宁夏隆德县六盘山中药资源开发有限公司 | Preparation method of astragalus membranaceus decoction piece finished product |
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