CN101199866B - Soluble cotton fiber containing multiple bioactivity and preparing method thereof - Google Patents
Soluble cotton fiber containing multiple bioactivity and preparing method thereof Download PDFInfo
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- CN101199866B CN101199866B CN2007103014275A CN200710301427A CN101199866B CN 101199866 B CN101199866 B CN 101199866B CN 2007103014275 A CN2007103014275 A CN 2007103014275A CN 200710301427 A CN200710301427 A CN 200710301427A CN 101199866 B CN101199866 B CN 101199866B
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- cotton fiber
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- soluble cotton
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Abstract
The invention relates to a soluble cotton fiber, in particular to a soluble cotton fiber with a plurality of biological activities and the preparation method. The preparation method is that by chemical means, in non-aqueous solvent system and under specific condition, the soluble cotton fiber and glycopeptide antibiotics bleomycin A5 with basic group achieves a dynamic and quantitative combination, and then a novel medical soluble cotton fiber is produced. The cotton fiber is provides with not only the hemostasis and debridement functions of the soluble cotton fiber, but also a plurality of external-used medical treatment functions of bleomycinA5, including antibacterial effect, inflammation diminishing, prevention of body surface tumor, lumen tumor and verruca caused by human papillomavirus, condyloma acuminatum and flat wart in particular. The invention is of good curative effect and free of pain and stimulation. Combining bleomycin A5 with the soluble cotton fiber, the invention is a dried product under normal condition, so that the storing stability of the medicine is greatly improved. In addition, the sustained release effect can be exerted in clinic practice.
Description
Technical field
The present invention relates to a kind of solubility cotton fiber, particularly relate to a kind of multiple bioactive solubility cotton fiber and preparation method thereof that has.
Background technology
Solubility gauze in the market mostly is used for the hemostasis of the surgical operation edge of a knife or aseptic wound to be handled.But because of not possessing the wound that antibacterial and anti-inflammation functions is forbidden to be used for suppurative wound or infection is arranged,, occurred antibiotic, antiinflammatory soluble stanching gauze recently again, can play antiinflammatory anti-infective effect simultaneously again in hemostatic for overcoming this shortcoming.But to the skin ulcer face that some diseases causes, do not have the purpose of treatment, do not have effect.As: the condyloma acuminatum that the human papillomavirus causes, verruca plana etc.Especially condyloma acuminatum is the high a kind of sexually transmitted disease (STD) of sickness rate, and the trend that increases is year by year arranged.Clinical Therapeutic Method commonly used generally has two kinds, and a kind of is naturopathy such as freezing, laser, excision etc., patient's misery and weak effect.Another kind is a Drug therapy, and commonly used have a sufficient leaf poison glycoside preparation, and its mesopodium leaf poison glycoside preparation effectively but zest is strong.Another kind is the Yi Kuimote through drugs approved by FDA, is to reach therapeutic purposes by improving immune function of human body, and the course of treatment, long, weak curative effect also had certain stimulation.Also having a kind of is the Bleomycin A5 preparation, and Bleomycin A5 is that Chinese Pharmacopoeia records, and is national essential drugs, is a broad-spectrum antiseptic cancer-resisting substance.For the caused condyloma acuminatum of human papillomavirus very good curative effect is arranged.Though belong to anticarcinogen, local topical can not absorb through skin, and not having general toxicity does not particularly have any stimulation, and is therefore not only safe and effective and accepted by the patient easily, and cure rate can reach 98%.The report of this respect has the Bleomycin A5 cream
[1], the Bleomycin A5 gel preparation is also arranged
[2]These preparations all belong to aqueous compositions, but the Bleomycin A5 chemical compound is the very strong material of water solublity, less stable in aqueous solution, half-life is shorter, even short-term is deposited all tangible degraded can be taken place, therefore this preparation is many as the hospital pharmacy preparation, and short application use can not be applied as the regular preparation that good stability is arranged.
Summary of the invention
The purpose of this invention is to provide a kind of multiple bioactive solubility cotton fiber that has, it can not only hemostasis, antiinflammatory, antibiotic, and condyloma acuminatum that the human papillomavirus is caused, verruca plana etc. have good therapeutical effect, its good stability, non-stimulated, but long-term storage has solved the deficiencies in the prior art part.
An object of the present invention is to provide a kind of multiple bioactive solubility cotton fiber that has.
Another object of the present invention provides described preparation method with multiple bioactive solubility cotton fiber.
The objective of the invention is to be achieved through the following technical solutions:
A kind of have a multiple bioactive solubility cotton fiber, it is characterized in that, is made up of solubility cotton fiber and Bleomycin A5 hydrochloride.;
Solubility cotton fiber of the present invention is: solubility gauze, soluble fiber or soluble fiber powder (CMC-Na).
Preferably, a kind of have a multiple bioactive solubility cotton fiber, and by the finished product gross weight, its composition by following percentage by weight is formed;
Solubility cotton fiber 90-99%
Bleomycin A5 hydrochloride. 0.2-15%
More preferably, a kind of have a multiple bioactive solubility cotton fiber, and by the finished product gross weight, its composition by following percentage by weight is formed;
Solubility cotton fiber 90-95%
Bleomycin A5 hydrochloride. 1-10%
A kind of preparation method with multiple bioactive solubility cotton fiber, it may further comprise the steps;
Take by weighing each raw material, earlier with Bleomycin A5 hydrochloride., be added in the nonaqueous solvent of the dimethyl sulfoxide that contains 10-30% weight, add the solubility cotton fiber again, at temperature 15-40 ℃ of following stirring reaction 0.5-4 hour, take out solubility cotton fiber ethanol flush away dimethyl sulfoxide and unreacted Bleomycin A5 hydrochloride., vacuum drying gets product.
Described nonaqueous solvent is methanol, ethanol, propanol, propylene glycol or its any mixture, is preferably ethanol.
The present invention is a kind of to have multiple bioactive solubility cotton fiber, the principle of foundation is to exchange and reach both and combine having the Bleomycin A5 of the amino glycopeptide class formation of alkalescence and sodium carboxymethyl ion in the fine molecule of solubility cotton in the molecule, this material is owing to meet water soluble, facing the time spent can spread on wound as required or directly fill in tract or humidifying or melt into pasty state, be used for the skin surface affected part and make its performance curative effect, can stop blooding, the antiinflammatory infection, localize cytotoxic, be particularly useful for treating and still do not have desirable medicine and execute the wart kinds of controlling such as condyloma acuminatum, not only curative effect is good and the slow release long-acting effect arranged, non-stimulated, shelf life of products is long, has extraordinary popularizing application prospect.
The specific embodiment
Following examples are in order further to describe the present invention for example, rather than limit the present invention by any way.
Embodiment 1
Get 100 milligrams of Bleomycin A5 hydrochloride .s, dissolve in 100 milliliters of the alcoholic solution that contain 20% dimethyl sulfoxide, add solubility gauze 5 grams, 18 ℃ of following stirring reactions of temperature 2 hours, take out the solubility gauze also with 95% ethanol flush away dimethyl sulfoxide and unreacted Bleomycin A5 hydrochloride., vacuum drying promptly gets product, 15.3 milligrams of the hydrochloric Bleomycin A5s of every gram solubility gauze.
Embodiment 2
Get 50 milligrams of Bleomycin A5 hydrochloride .s, dissolve in 100 milliliters of the methanol solutions that contain 10% dimethyl sulfoxide, add soluble fiber powder 5 grams, 20 ℃ of following stirring reactions of temperature 4 hours, filter, take out the soluble fiber powder also with 95% ethanol flush away dimethyl sulfoxide and unreacted Bleomycin A5 hydrochloride., vacuum drying promptly gets product, 8.7 milligrams of the hydrochloric Bleomycin A5s of every gram soluble fiber powder.
Embodiment 3
Get 100 milligrams of Bleomycin A5 hydrochloride .s, dissolve in 100 milliliters of the propanol solution that contain 30% dimethyl sulfoxide, add soluble fiber 5 grams, 30 ℃ of following stirring reactions of temperature 1 hour, take out soluble fiber also with 95% ethanol flush away dimethyl sulfoxide and unreacted Bleomycin A5 hydrochloride., vacuum drying promptly gets product, 15.6 milligrams of the hydrochloric Bleomycin A5s of every gram soluble fiber.
Embodiment 4
Get 250 milligrams of Bleomycin A5 hydrochloride .s, dissolve in 100 milliliters of the alcoholic solution that contain 15% dimethyl sulfoxide, add solubility gauze 5 grams, 35 ℃ of following stirring reactions of temperature 4 hours, take out the solubility gauze also with 95% ethanol flush away dimethyl sulfoxide and unreacted Bleomycin A5 hydrochloride., vacuum drying promptly gets product, 40 milligrams of the hydrochloric Bleomycin A5s of every gram solubility gauze.
Below have the effect of multiple bioactive solubility cotton fiber by the clinical preliminary test proof embodiment of the invention 1;
Clinical trial unit: Zhongguancun, Beijing City hospital
Test specimen: the solubility gauze of the embodiment of the invention 1
1, health examination:
Press Ministry of Public Health " medicine sanitary standard " regulation, check antibacterial and counting (＜10/gram), do not detect mycete, golden Fructus Vitis viniferae and enterobacteria, standard up to specification.
2, case is selected:
Male 11 examples of sexually transmitted disease (STD) outpatient service condyloma acuminatum example, women 16 examples, age 18-45, suspicious skin lesion is tested judgement in vain with acetic acid.
3, administrated method:
Every gram solubility gauze contains 15.3 milligrams of Bleomycin A5s, is dissolved in 5 milligrams of the sterilized water, and is even, clear and bright, is sticking paste, wipes the affected part every day outward 2 times, 15 days courses of treatment.
4, efficacy evaluation:
Cure and all disappear for the wart body, produce effects is that wart body number or area reduce＞70%, effectively is that wart body number or area reduce 30-70%, and invalid is that wart body number or area reduce＜30%.
5, therapeutic outcome:
25 examples of fully recovering, produce effects 2 examples are 100% more than the produce effects, recovery from illness accounts for 92.59%.
Claims (5)
1. one kind has multiple bioactive solubility cotton fiber, and by the finished product gross weight, its composition by following percentage by weight is formed;
Solubility cotton fiber 90-99%
Bleomycin A5 hydrochloride. 0.2-15%
Wherein said solubility cotton fiber is the cotton fiber that contains sodium carboxymethyl cellulose.
2. a kind of multiple bioactive solubility cotton fiber that has according to claim 1, by the finished product gross weight, its composition by following percentage by weight is formed;
Solubility cotton fiber 90-95%
Bleomycin A5 hydrochloride. 1-10%.
3. a kind of multiple bioactive solubility cotton fiber that has according to claim 1, wherein said solubility cotton fiber is: gauze shape, fibrous or fiber powdery.
4. a kind of preparation method according to claim 1 with multiple bioactive solubility cotton fiber, it may further comprise the steps;
Take by weighing each raw material, earlier with Bleomycin A5 hydrochloride., be added in the nonaqueous solvent of the dimethyl sulfoxide that contains 10-30% weight, add the solubility cotton fiber again, at temperature 15-40 ℃ of following stirring reaction 0.5-4 hour, take out solubility cotton fiber ethanol flush away dimethyl sulfoxide and unreacted Bleomycin A5 hydrochloride., vacuum drying gets product.
5. a kind of preparation method with multiple bioactive solubility cotton fiber according to claim 4, wherein said nonaqueous solvent comprises methanol, ethanol, propanol, propylene glycol or its any mixture.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007103014275A CN101199866B (en) | 2007-12-27 | 2007-12-27 | Soluble cotton fiber containing multiple bioactivity and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007103014275A CN101199866B (en) | 2007-12-27 | 2007-12-27 | Soluble cotton fiber containing multiple bioactivity and preparing method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101199866A CN101199866A (en) | 2008-06-18 |
| CN101199866B true CN101199866B (en) | 2010-09-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007103014275A Expired - Fee Related CN101199866B (en) | 2007-12-27 | 2007-12-27 | Soluble cotton fiber containing multiple bioactivity and preparing method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD289469A5 (en) * | 1989-09-05 | 1991-05-02 | Akademie Der Wissenschaften,De | PROCESS FOR PREPARING LIPOSOME BASED PHARMACEUTICAL PREPARATIONS WITH ANTITUMORO GLYCOPEPTIDES AS ACTIVE COMPONENTS |
| CN1395934A (en) * | 2002-08-26 | 2003-02-12 | 北京昭衍新药研究中心 | Locally applied composite medicine for treating pointed condyloma |
| WO2004046730A2 (en) * | 2002-10-25 | 2004-06-03 | Sense Proteomic Limited | Uses of ble proteins and antibiotics from the bleomycin family |
-
2007
- 2007-12-27 CN CN2007103014275A patent/CN101199866B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD289469A5 (en) * | 1989-09-05 | 1991-05-02 | Akademie Der Wissenschaften,De | PROCESS FOR PREPARING LIPOSOME BASED PHARMACEUTICAL PREPARATIONS WITH ANTITUMORO GLYCOPEPTIDES AS ACTIVE COMPONENTS |
| CN1395934A (en) * | 2002-08-26 | 2003-02-12 | 北京昭衍新药研究中心 | Locally applied composite medicine for treating pointed condyloma |
| WO2004046730A2 (en) * | 2002-10-25 | 2004-06-03 | Sense Proteomic Limited | Uses of ble proteins and antibiotics from the bleomycin family |
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|---|---|
| CN101199866A (en) | 2008-06-18 |
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Granted publication date: 20100922 Termination date: 20161227 |