CN1788730B - Gel containing centella general glycoside and sodium hyaluronate for preparing drop and spray agent - Google Patents
Gel containing centella general glycoside and sodium hyaluronate for preparing drop and spray agent Download PDFInfo
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- CN1788730B CN1788730B CN 200410089456 CN200410089456A CN1788730B CN 1788730 B CN1788730 B CN 1788730B CN 200410089456 CN200410089456 CN 200410089456 CN 200410089456 A CN200410089456 A CN 200410089456A CN 1788730 B CN1788730 B CN 1788730B
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- Prior art keywords
- sodium
- gel
- hyaluronic acid
- herba centellae
- total glycosides
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Abstract
The present invention belongs to the field of medicine preparation technology, and is one kind of gel dripping preparation and aerosol containing asiaticoside and sodium hyaluronate. The gel dripping preparation and aerosol is different from gel preparation in that it can form one film on the surface of wound. The gel dripping preparation and aerosol is relatively thin, easy to form film on wound, and suitable for wound of patient incapable of being painted with gel directly. The present invention also provides the preparation process.
Description
Technical field:
The invention belongs to the medicament field.Be specifically related to be used to prepare the gel that contains Herba Centellae total glycosides and hyaluronic acid sodium of drop or spray.
Background technology:
Herba Centellae total glycosides is to extract purified pentacyclic triterpenoid from Herba Centellae, mainly contains asiaticoside (Asiaticoside) and asiaticoside (Madecassoside).Asiaticoside is applied to all kinds of wounds and can the accelerated in wounds granulation tissue forms, and promotes wound healing, and can be suppressed to the unordered hypertrophy of fibrocyte, minimizing cicatrix.The asiaticoside cream can only use after the wound face reparation, and significant feature is to prevent scar hyperplasia.
Hyaluronic acid sodium is a macromolecule polysaccharidase, is made up of a part acetylglucosamine and glucuronic acid.Because of its three-dimensional spatial structure has better elastic, lubricity and biocompatibility, can form smooth, gas-pervious thin film at skin surface, hyaluronic acid sodium also can promote wound healing simultaneously.But the wound face of some wounded patient should not directly be smeared colloid.
Summary of the invention:
Technical problem to be solved by this invention is to overcome above-mentioned weak point, and design can directly be applied in the dosage form on the wound face.
The invention provides a kind of gel drop and spray that contains Herba Centellae total glycosides and hyaluronic acid sodium.This gel drop or spray are to comprise as the Herba Centellae total glycosides of active ingredient and hyaluronic acid sodium and pharmaceutic adjuvant forming, be 1: 1～8: 1 as the Herba Centellae total glycosides of active component and the content proportioning of hyaluronic acid sodium wherein, every ml gel drop or spray contain Herba Centellae total glycosides 1～50mg, contain hyaluronic acid sodium 1～30mg.
Used pharmaceutic adjuvant is osmotic pressure regulator, pH buffer agent, antiseptic, freshener and stabilizing agent in gel drop of the present invention and the spray.
Gel-type vehicle of the present invention is carbomer, sodium carboxymethylcellulose pyce, sodium carboxymethyl cellulose or calcium, hydroxyethylmethyl-cellulose, hydroxypropyl emthylcellulose, polyvinyl alcohol, tragacanth gum or alginic acid and its esters; Osmotic pressure regulator is sodium chloride, sodium hydrogen phosphate, sodium dihydrogen phosphate, Borax or boric acid electrolyte or is glycerol or glucose non-electrolyte; The pH buffer agent is a sodium dihydrogen phosphate---sodium hydrogen phosphate buffer, borate buffer, Borax---borate buffer and hydrochloric acid, sodium hydroxide or sodium carbonate alkaline matter; Antiseptic is parabens, quaternary ammonium salt, alcohols, organic mercury class, benzoic acid or sorbic acid; Every 100ml gel drop or spray contain 0.001～0.5 gram antiseptic; Freshener is Borneolum Syntheticum or Mentholum; Stabilizing agent is disodiumedetate, tween 80, ethanol, glycerol, propylene glycol or Polyethylene Glycol.
The main pharmacodynamics of asiaticoside of the present invention-sodium hyaluronate gel drop is to be studied by Ruijin Hospital Attached to Shanghai Medical Univ No.2 Shanghai digestion institute of Surgical Research, and result of study is as follows:
1. test objective:
Trauma model with rabbit carries out asiaticoside gel and asiaticoside drop pharmacodynamic study.
2. test material:
1). test drug:
(1). asiaticoside gel Shanghai Institute of Pharmaceutical Industry
Lot number: 020528
(2). asiaticoside drop Shanghai Institute of Pharmaceutical Industry
Lot number: 020819
(3). Yadong Pharma Inc. of skin Kang Shuan Shanghai Institute of Pharmaceutical Industry
The Golconda pharmaceutical factory
Lot number: 020102
2). experimental animal: Female rabbits
Body weight: 2.2kg-3.0kg
3. test method:
1). numbering and grouping:
A: rabbit number: 1,2,3,4,5
B: rabbit number: 1,2,3,4,5
C: rabbit number: 1,2,3,4,5
2). Animal Anesthesia:
The intravenous injection pentobarbital sodium
3). shave hair
4). trauma model:
With the mercurochrome telltale mark, cut respectively, wipe out the holostrome (on fascia) of circular skin, the about 1.0-2.0cm of diameter with the disinfectant minor operation.Every rabbit has six place's wounds, and the left side is the matched group without medicine, and the right is the administration group.
5). administration:
A: asiaticoside drop
B: asiaticoside colloid
C: skin Kang Shuan
Operation was administration the same day, and this be that later every morning is administered once for the first time, at every turn about the about 0.2ml of dosage, and successive administration eight days.
6). observe and record:
Measure wound area every day with slide gauge (0-15cm), promptly write down major diameter (2a), minor axis (2b), reference area in view of the above.
7). the evaluation criteria of curative effect:
With measured major diameter (2a), minor axis (2b), press following formula reference area percent:
Area=π ab
The result is carried out statistics relatively (because of the accurate surname of wound incrustation influence measurement in the 8th day, so calculate by the 7th day area).
4. result of the test
The asiaticoside gel of Shanghai Institute of Pharmaceutical Industry and drop are after the rabbit wound face is used, through making comparisons with not medication group (matched group), the result shows that the pharmacodynamics test that carries out compares in the trauma model of rabbit, shown that the asiaticoside drop has identical curative effect with skin Kang Shuan on the treatment repair in trauma.
5. discuss
Show that in the trauma model test of pesticide effectiveness of rabbit asiaticoside gel and asiaticoside drop have the function of tangible promotion wound healing.
Asiaticoside-hyaluronic acid sodium drop does not have any stimulation and anaphylaxis.
Another object of the present invention has provided gel drop or the spray preparing process that contains Herba Centellae total glycosides and hyaluronic acid sodium, this method is to take by weighing the asiaticoside grass total glycosides of formula ratio and hyaluronic acid sodium to be dissolved in the solution that contains additives such as antiseptic respectively and to dissolve, stir, be sub-packed in the interior or quantitative spray bottle of the drop bottle that contains dosing pump.
With drop and the spray that asiaticoside (Asiaticoside) and hyaluronic acid sodium (Sodium hyaluronate) are formed, its major function is that the accelerated in wounds granulation tissue forms, and promotes the healing of wound tissue, can suppress unordered scar hyperplasia again in the wound later stage.And because of glass acid sodium is macromolecule polysaccharide, have slow releasing function, can progressively discharge asiaticoside, thereby prolonged the action time of medicine at wound face.Again because of hyaluronic acid sodium has good film property, colloid agent can form transparent, gas-pervious thin film at wound surface simultaneously, protection wound tissue.
Drop and spray are different from gel, are the gelling performances of using hyaluronic acid sodium itself, form thin film in wound surface.Colloid is thinner, is easy to drop in wound surface, with its free-flow or be sprayed at and form thin film on the wound surface, is suitable for some patients that should not directly smear gel on wound surface and uses.
Asiaticoside hyaluronic acid sodium drop and spray can be widely used in all kinds of wounds, thereby the market demand is big, and preparation technology is simple, and the cost of raw material is low, is suitable for suitability for industrialized production.
The specific embodiment:
Embodiment 1 asiaticoside-sodium hyaluronate gel drop:
Prescription:
Herba Centellae total glycosides 1.5g
Hyaluronic acid sodium 0.3g
Sodium chloride 0.5g
Essence of Niobe 0.1g
Propyl benzoate 0.01g
Propylene glycol 0.1g
AMSP 0.7g
Disodium hydrogen phosphate,anhydrous 0.1g
Borneolum Syntheticum 0.02g
Distilled water 100ml
Collocation method:
1, takes by weighing asiaticoside by prescription, be dissolved in right amount in the buffer that contains stabilizing agent, freshener, treat that it dissolves fully.
2, take by weighing hyaluronic acid sodium by prescription, be dissolved in the solution that contains antiseptic, osmotic pressure regulator, placement is spent the night, and treats to dissolve fully.
3, under slowly stirring, asiaticoside solution is slowly added in the hyaluronic acid sodium solution to full and uniform.
4, be sub-packed in the drop bottle that contains dosing pump.
Embodiment 2 asiaticosides-sodium hyaluronate gel spray:
Prescription:
Herba Centellae total glycosides 2.4g
Hyaluronic acid sodium 0.6g
Sodium chloride 1.5g
Benzalkonium chloride 0.01g
Polyethylene Glycol 1.0g
Boric acid 1.2g
Borax 0.06g
Mentholum 0.01g
Distilled water: 100ml
Collocation method: 1-3 is with embodiment 1
4. be sub-packed in the quantitative spray bottle.
Embodiment 3
Prescription: other component and collocation method be all with example 2, but
Herba Centellae total glycosides 4.0g
Hyaluronic acid sodium 0.5g
Embodiment 4
Prescription:
Herba Centellae total glycosides 0.1g
Hyaluronic acid sodium 0.1g
Glycerol 2.2g
Chlorobutanol 0.5g
Propylene glycol 1.0g
AMSP 0.68g
Disodium hydrogen phosphate,anhydrous 0.1g
Borneolum Syntheticum 0.1g
Distilled water 100ml
Collocation method: with embodiment 2
Embodiment 5
Prescription:
Herba Centellae total glycosides 1.0g
Hyaluronic acid sodium 0.5g
Thimerosal 0.01g
Propylene glycol 5.0g
AMSP 0.72g
Disodium hydrogen phosphate,anhydrous 0.15g
Borneolum Syntheticum 0.1g
Collocation method: with embodiment 2
Embodiment 6
Prescription:
Herba Centellae total glycosides 3.0g
Hyaluronic acid sodium 3.0g
Sorbic acid 0.15g
Tween-80 0.2g
Disodium edetate 0.05g
AMSP 0.7g
Disodium hydrogen phosphate,anhydrous 0.1g
Borneolum Syntheticum 0.05g
Distilled water 100ml
Collocation method: with embodiment 1
Embodiment 7
Prescription:
Herba Centellae total glycosides 5.0g
Hyaluronic acid sodium 2.0g
Benzoic acid 0.05g
Disodium edetate 0.05g
AMSP 0.72g
Disodium hydrogen phosphate,anhydrous 0.15g
Ethanol 0.8g
Borneolum Syntheticum 0.1g
Distilled water: 100ml
Collocation method: with embodiment 1
Embodiment 8
Prescription:
Herba Centellae total glycosides 2.5g
Hyaluronic acid sodium 1.0g
Sorbic acid 0.15g
Disodium edetate 0.05g
AMSP 0.72g
Disodium hydrogen phosphate,anhydrous 0.15g
Ethanol 1.0g
Borneolum Syntheticum 0.1g
Distilled water 100ml
Collocation method: with embodiment 1
Embodiment 9
Prescription:
Herba Centellae total glycosides 1.5g
Hyaluronic acid sodium 0.5g
Benzyl alcohol 0.25g
Propylene glycol 0.1g
Boric acid 1.2g
Borax 0.06g
Mentholum 0.01g
Distilled water 100ml
Collocation method: with embodiment 2
Claims (2)
1. gel that contains Herba Centellae total glycosides and hyaluronic acid sodium that is used to prepare drop or spray, it is characterized in that this gel comprises Herba Centellae total glycosides and hyaluronic acid sodium and the pharmaceutic adjuvant as active ingredient, be 1: 1～8: 1 as the Herba Centellae total glycosides of active component and the content proportioning of hyaluronic acid sodium wherein, every ml gel contains Herba Centellae total glycosides 1～50mg, contains hyaluronic acid sodium 1～30mg; Described pharmaceutic adjuvant is gel-type vehicle, osmotic pressure regulator, pH buffer agent, antiseptic, freshener and stabilizing agent; Described gel-type vehicle is a carbomer, sodium carboxymethylcellulose pyce, sodium carboxymethyl cellulose or calcium, hydroxyethylmethyl-cellulose, hydroxypropyl emthylcellulose, polyvinyl alcohol, tragacanth gum or alginic acid and salt thereof, described osmotic pressure regulator is a sodium chloride, sodium hydrogen phosphate, sodium dihydrogen phosphate, the electrolyte of Borax or boric acid or be the non-electrolyte of glycerol or glucose, described pH buffer agent is a sodium dihydrogen phosphate---the sodium hydrogen phosphate buffer, borate buffer or Borax---borate buffer, described antiseptic are p-Hydroxybenzoate, benzalkonium chloride, benzyl alcohol, chlorobutanol, thimerosal, benzoic acid or sorbic acid; Described freshener is Borneolum Syntheticum or Mentholum, and described stabilizing agent is disodiumedetate, tween 80, ethanol, glycerol, propylene glycol or Polyethylene Glycol.
2. a kind of gel that contains Herba Centellae total glycosides and hyaluronic acid sodium that is used to prepare drop or spray according to claim 1 is characterized in that every 100ml gel drop or spray contain 0.001-0.5 gram antiseptic.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410089456 CN1788730B (en) | 2004-12-13 | 2004-12-13 | Gel containing centella general glycoside and sodium hyaluronate for preparing drop and spray agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410089456 CN1788730B (en) | 2004-12-13 | 2004-12-13 | Gel containing centella general glycoside and sodium hyaluronate for preparing drop and spray agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1788730A CN1788730A (en) | 2006-06-21 |
| CN1788730B true CN1788730B (en) | 2010-05-05 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410089456 Expired - Fee Related CN1788730B (en) | 2004-12-13 | 2004-12-13 | Gel containing centella general glycoside and sodium hyaluronate for preparing drop and spray agent |
Country Status (1)
| Country | Link |
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| CN (1) | CN1788730B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101138543B (en) * | 2006-09-06 | 2012-01-04 | 上海医药工业研究院 | Centella asiatica partial film forming gel composition and uses thereof |
| CN103191163B (en) * | 2013-04-29 | 2014-07-09 | 崔新明 | Skin wound repairing pharmaceutical composition |
| CN103356693A (en) * | 2013-06-19 | 2013-10-23 | 深圳市海普瑞药业股份有限公司 | Compound low-molecular heparin sodium liposome gel and preparation method and application thereof |
| CN107670099A (en) * | 2017-11-28 | 2018-02-09 | 苏州汇涵医用科技发展有限公司 | A kind of liquid dressing and preparation method thereof |
| CN112891615B (en) * | 2021-01-14 | 2022-06-10 | 广州贝奥吉因生物科技股份有限公司 | Liquid adhesive bandage and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1353972A (en) * | 2000-11-21 | 2002-06-19 | 国家医药管理局上海医药工业研究院 | Asiaticoside antisticking film and its preparation method |
| CN1406633A (en) * | 2001-08-23 | 2003-04-02 | 王哲 | Scarless composite biological material containing hyaluronic acid |
-
2004
- 2004-12-13 CN CN 200410089456 patent/CN1788730B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1353972A (en) * | 2000-11-21 | 2002-06-19 | 国家医药管理局上海医药工业研究院 | Asiaticoside antisticking film and its preparation method |
| CN1406633A (en) * | 2001-08-23 | 2003-04-02 | 王哲 | Scarless composite biological material containing hyaluronic acid |
Non-Patent Citations (2)
| Title |
|---|
| 王瑞国等.积雪草甙对成纤细胞DNA合成与胶原蛋白合成的影响.福建中医学院学报11 2.2001,11(2),全文. |
| 王瑞国等.积雪草甙对成纤细胞DNA合成与胶原蛋白合成的影响.福建中医学院学报11 2.2001,11(2),全文. * |
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| Publication number | Publication date |
|---|---|
| CN1788730A (en) | 2006-06-21 |
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Granted publication date: 20100505 Termination date: 20111213 |