CN101190322B

CN101190322B - Traditional Chinese medicine for treating zoster post herpetic neuralgia

Info

Publication number: CN101190322B
Application number: CN200610131664A
Authority: CN
Inventors: 李洋; 李有田
Original assignee: Individual
Current assignee: Individual
Priority date: 2006-11-24
Filing date: 2006-11-24
Publication date: 2010-05-26
Anticipated expiration: 2026-11-24
Also published as: CN101190322A

Abstract

The invention relates to a Chinese traditional medicine used for treating postherpetic neuralgia, which aims at developing a Chinese traditional medicine used for treating postherpetic neuralgia by adopting the theory of Chinese traditional medicine. The formula of the invention includes magnet, turmeric, dyers woad leaf, radix isatidis, cape jasmine fruit, radix scutellariae, Chinese thorowax root, rehmanniae praeparatum, semen plantaginis, liquoric root, angelica and white paeony root. The invention has the advantages of low price, good curative effect, being not easy to recur and extremelygood social and economic benefits. The total effective rate of the medicine of the invention can reach more than 94.70%.

Description

A kind of Chinese medicine for the treatment of post-herpetic neuralgia

Technical field:

The invention belongs to the field of Chinese medicines, particularly relate to a kind of Chinese medicine for the treatment of post-herpetic neuralgia.

Background technology

Post-herpetic neuralgia is commonly encountered diseases, the frequently-occurring disease of department of dermatologry and the department of neurology and the department of Chinese medicine, and it is funny by water---herpesvirus causes.Because the primary disease toxin can be hidden in dorsal ganglion for a long time, so still left over neuralgia after the herpes incrustation, some even delay difficulty are more given patient's life, study, work and are brought greatly painful mentally.At present, this disease still there is not specific treatment both at home and abroad.America and Europe and Japan and other countries are to the treatment of post-herpetic neuralgia, adopt cut off root of sympathetic nerve more, ethanol sealing or with treatments such as hormone, vitamin B group, analgesics, though pain is alleviated, but side effect is many, and cost an arm and a leg, treatment time longer relapse rate height and patient nearly shortcoming such as should not accept.

Summary of the invention:

The objective of the invention is to adopt theory of Chinese medical science, develop a kind of Chinese medicine for the treatment of post-herpetic neuralgia.

The present invention makes the raw materials of effective components weight portion and consists of:

Magnetitum 8～15 Radix Curcumaes 1～2 Folium Isatidis 5～10

Radix Isatidis 5～10 Fructus Gardeniaes 1～1.5 Radix Scutellariae 1.5～2.5

Radix Bupleuri 1～1.5 Radix Rehmanniae 1.5～2.5 Semen Plantaginiss 1～2

Radix Glycyrrhizae 0.5～1.5 Radix Angelicae Sinensis 1.5～2 Radix Paeoniae Albas 1.5～3

The present invention is cheap, good effect, and treatment time is short, should not recur, and social benefit, economic benefit are splendid.Medicine total effective rate of the present invention reaches more than 94.70%.

The specific embodiment:

Magnetitum 8～15 Radix Curcumaes 1～2 Folium Isatidis 5～10

Radix Isatidis 5～10 Fructus Gardeniaes 1～1.5 Radix Scutellariae 1.5～2.5

Radix Bupleuri 1～1.5 Radix Rehmanniae 1.5～2.5 Semen Plantaginiss 1～2

Preparation method is:

1. said medicine is placed one and reinstate cold water immersion 30 minutes;

2. boiled 30 minutes with big fire;

3. use slow fire boiling instead;

4. use health gauze three layer filtration;

5. repeat above-mentioned steps, the herb liquid of obtaining for twice is placed in one glass, divide two parts;

6. press secondary every day, each 200ml one after each meal.

Embodiment 1:

Magnetitum 8 Radix Curcumaes 1 Folium Isatidis 5

Radix Isatidis 5 Fructus Gardeniaes 1 Radix Scutellariae 1.5

Radix Bupleuri 1 Radix Rehmanniae 1.5 Semen Plantaginiss 1

Radix Glycyrrhizae 0.5 Radix Angelicae Sinensis 1.5 Radix Paeoniae Albas 1.5

Preparation method is:

1. said medicine is placed one and reinstate cold water 500ml immersion 30 minutes;

2. boiled 30 minutes with big fire;

3. use slow fire boiling instead, medicinal liquid is surplus to be 100ml;

4. use health gauze three layer filtration;

6. every part of 100ml, every day secondary, each 100ml one after each meal.

Embodiment 2:

Magnetitum 11.5 Radix Curcumaes 1.5 Folium Isatidiss 7.5

Radix Isatidis 7.5 Fructus Gardeniaes 1.25 Radix Scutellariaes 2

Radix Bupleuri 1.25 Radix Rehmanniae 2 Semen Plantaginiss 1.5

Radix Glycyrrhizae 1 Radix Angelicae Sinensis 1.75 Radix Paeoniae Albas 2.25

Preparation method is:

1. said medicine is placed one and reinstate cold water 1000ml immersion 30 minutes;

2. boiled 30 minutes with big fire;

3. use slow fire boiling instead, medicinal liquid is surplus to be 200ml;

4. use health gauze three layer filtration;

6. every part of 200ml, every day secondary, each 200ml one after each meal.

Embodiment 3:

Magnetitum 15 Radix Curcumaes 2 Folium Isatidiss 10

Radix Isatidis 10 Fructus Gardeniaes 1.5 Radix Scutellariaes 2.5

Radix Bupleuri 1.5 Radix Rehmanniae 2.5 Semen Plantaginiss 2

Radix Glycyrrhizae 1.5 Radix Angelicae Sinensis 2 Radix Paeoniae Albas 3

Preparation method is:

1. said medicine is placed one and reinstate cold water 1500ml immersion 30 minutes;

2. boiled 30 minutes with big fire;

3. use slow fire boiling instead, medicinal liquid is surplus to be 200ml;

4. use health gauze three layer filtration;

6. every part of 200ml, every day secondary, each 200ml one after each meal.

Clinical experiment of the present invention:

Drug therapy herpes neuralgia 315 examples of the present invention, matched group somedon treatment herpes neuralgia 79 examples, all cases all are diagnosed as the out-patient of post-herpetic neuralgia through No.1 Hospital of Jilin Univ.'s department of dermatologry or Neurology Department.

According to document post herpetic neuralgia is divided into III degree (Huang Yanshou chief editor, pain, Xi'an: People's Education Publishing House, Shaanxi, 1993.74): slight (+): patient tells pain, does not influence rest, no attitude movement response; Moderate (++): it is obvious that patient tells pain, but can stand, and no attitude movement response is had a rest in influence slightly; Severe (+++): patient tells sharp ache, is difficult to tolerance, and influence is had a rest, and can not fall asleep, and action (affected part nude) occurs escaping.

2 groups of patients' general clinical data and state of an illness contrast see Table 1:

Table 1:

Tcm syndrome differentiation and typing (Cheng Shiqi chief editor, Chinese medicine. Beijing: People's Health Publisher, 1994.178) 1. liver and gall fire Sheng type (or claiming excessive heat type, fire-toxin type): Pi Fu inflammation is red, as seen the vesicle of pimple and tonic vesicle wall, conscious scorching hot severe pain, companion's dry throat with bitter taste, the yellow urine constipation, red tongue, yellow fur, wiry and frequent pulse.2. spleen and stomach damp-heat type (damp-heat type, noxious dampness type): the patient has tangible pale vesicle, collection bunch in groups, bleb liquid muddiness, diabrosis is oozed out or is rotten to the corn, companion's pain, indigestion and loss of appetite abdominal distention, pale tongue, tongue is greasy in vain or yellow greasy, soft and rapid pulse or sliding number.3. qi stagnation and blood stasis type: deflorescence, but still gnawing pains take no rest, and it is not peaceful to sleep night, and body of the tongue is dark violet, white and thin fur, thready and stringy pulse.Treatment is organized in 315 examples, liver and gall fire Sheng type 203 examples, spleen and stomach damp-heat type 7 examples, qi stagnation and blood stasis type 105 examples.

Medicine and Therapeutic Method:

Treatment group decoct 200ml of the present invention, 2 times on the 1st, make every 200ml by the Drug Manufacturing Room of No.1 Hospital of Jilin Univ. by prescription of the present invention and contain 11.5 parts of Magnetitums, 1.5 parts of Radix Curcumaes, 7.5 parts of Folium Isatidiss, 7.5 parts of Radix Isatidiss, 1.25 parts of Fructus Gardeniaes, 2 parts of Radix Scutellariaes, 1.25 parts of Radix Bupleuri, 2 parts in the Radix Rehmanniae, 1.5 parts of Semen Plantaginiss, 1 part in Radix Glycyrrhizae, 1.75 parts of Radix Angelicae Sinensis, 2.25 parts of the Radix Paeoniae Albas.The oral somedon 0.5g of matched group (Ji Rui pharmaceutcal corporation, Ltd in Changchun produces, the date of manufacture: on November 8th, 1996), each 1,2 times on the 1st.Two groups was 1 course of treatment with 10 days all, the period in a medicine other drug of stopping using.

The result:

Criterion of therapeutical effect is cured: affected part post herpetic neuralgia symptom complete obiteration, after clinical observation half a year, there is not the recidivist.Take a turn for the better: affected part post herpetic neuralgia sx, intermittently prolong, the recidivist appears again after discontinuing medication.Invalid: through 3 more than the course of treatment treatment after, the post herpetic neuralgia symptom does not have the improver.

2 groups of efficacy results see Table 2, table 3

Table 2:

Table 3:

Treatment group curative effect and tcm syndrome differentiation and typing curative effect with liver and gall fire Sheng type and qi stagnation and blood stasis type for well.Liver and gall fire Sheng type is totally 203 examples, wherein cures 153 examples, accounts for 75.4%, and 45 examples that take a turn for the better account for 22.1%; Qi stagnation and blood stasis type is totally 105 examples, wherein cures 69 examples, accounts for 65.7%, and 32 examples that take a turn for the better account for 30.5%.

After half a year, follow up a case by regular visits to curing case, the treatment group is followed up a case by regular visits to 223 examples, recurrence 8 examples (accounting for 3.6%) after the drug withdrawal; Matched group is followed up a case by regular visits to recurrence 11 examples (accounting for 68.8%) in 16 examples, and relapse rate is with of the present invention group obviously low (P＜0.01).In addition, the matched group period in a medicine has 9 examples vomiting to occur, and erythra appears in 4 examples, amount to 13 examples (accounting for 16.5%), and the treatment group is not seen and other untoward reaction similar.

Discuss and cognition:

Motherland's medical science is thought: primary disease is many because of due to the factor affecting hepatobiliary catharsis functions such as gas, blood, wet, heat.315 routine post-herpetic neuralgia patients of clinical research of the present invention, for seeing, and spleen and stomach damp-heat type is more rare more with liver and gall fire Sheng type and qi stagnation and blood stasis type for differential diagnosis in tcm.Think that post herpetic neuralgia is that liver and gall fire is contained, due to waste heat (poison) is clear, so the present invention adopts the liver heat removing function of gallbladder promoting, eliminating fire and detoxication, removing waste heat (poison), blood circulation promoting and blood stasis dispelling, dredge the meridian passage, promoting the circulation of QI to relieve pain, general rule are bitterly method not.Magnetitum, Radix Curcumae, Folium Isatidis are monarch drug in the prescription, and Radix Isatidis, Fructus Gardeniae, Radix Scutellariae are ministerial drug, and Radix Bupleuri, the Radix Rehmanniae, Semen Plantaginis are adjuvant drug, and Radix Glycyrrhizae, Radix Angelicae Sinensis, the Radix Paeoniae Alba are messenger drug.All medicines share, and play removing fire from the liver altogether, dampness removing heat, and yin nourishing blood, depressed liver-energy dispersing and QI regulating, blood circulation promoting and blood stasis dispelling is removed waste heat (poison), to reach not bitterly merit of general rule.

Also finding in the treatment, take medicine of the present invention, can obviously shorten the course of treatment, is excellent than traditional western medicine, and medicine source abundance, and inexpensive, taking convenience is not seen toxic and side effects, is the comparatively ideal medicine of treatment primary disease.

Claims

1. Chinese medicine for the treatment of post-herpetic neuralgia, wherein make the raw materials of effective components weight portion and consist of:

Magnetitum 8～15 Radix Curcumaes 1～2 Folium Isatidis 5～10

Radix Isatidis 5～10 Fructus Gardeniaes 1～1.5 Radix Scutellariae 1.5～2.5

Radix Bupleuri 1～1.5 Radix Rehmanniae 1.5～2.5 Semen Plantaginiss 1～2

Radix Glycyrrhizae 0.5～1.5 Radix Angelicae Sinensis 1.5～2 Radix Paeoniae Albas 1.5～3.