CN101190181B - Monomer nano silver sanitary tampon and preparation method thereof - Google Patents
Monomer nano silver sanitary tampon and preparation method thereof Download PDFInfo
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- CN101190181B CN101190181B CN200610157172A CN200610157172A CN101190181B CN 101190181 B CN101190181 B CN 101190181B CN 200610157172 A CN200610157172 A CN 200610157172A CN 200610157172 A CN200610157172 A CN 200610157172A CN 101190181 B CN101190181 B CN 101190181B
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- nano silver
- monomer
- monomer nano
- silver
- sanitary tampon
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Abstract
The invention relates to a monocase nano-silver sanitary suppository and a manufacturing method of the suppository. The invention comprises nano-silver content and basic component. The nano-silver content is the monocase nano-silver, i.e. pure silver monocase of nano size, and the basic component is water solubility component. The weight of the monocase nano-silver accounts to 1 to 2000 ppm of the total weight of the suppository. The sanitary suppository of the invention can be used for treating various dermatosis, gynecological diseases and prostate diseases, etc. Compared with the prior art, the sanitary suppository of the invention has the advantages that the sterilization effect is high; after the sterilization, no matter which is harmful for people is generated; the medicine effect is moderate and durable. The manufacturing method of the monocase nano-silver sanitary suppository of the invention is that monocase nano-silver water solution is prepared first; then the monocase nano-silver water solution is dispersed to the water solubility component. And the solution can be dispersed evenly just by stirring, with a simple manufacturing process.
Description
Technical field the present invention relates to be shaped as with specific physical the pharmaceutical product of feature, particularly relates to the suppository that effective ingredient is a nanometer silver.
The background technology nanometer silver can sterilize at the subcutaneous 2mm of rapid permeability place, and human body is woven with good therapeutical effect than the depths infected group, can be used to treat various dermatosiss, gynaecopathia and prostatosis etc.A kind of gynopathic bactericidal nano-silver women's medical sanitary tampon and preparation method thereof that is used for the treatment of is disclosed as Chinese patent CN1202868C, this medicated tampon comprises that nanometer silver is antibiotic powder and bolt substrate, and wherein bolt substrate is cocos nucifera oil fat, cocoa butter, mixing-in fat acid glyceride, palmitic acid lipid, propylene glycol stearate etc.This medicated tampon and preparation method thereof has the following disadvantages: 1. bolt is oil-soluble with substrate, and after oil-soluble substrate melts in human body, is difficult to be absorbed by the body, and the active ingredient nanometer silver is difficult to infiltrate through under the epidermis equally, thereby influences bactericidal effect; 2. because the tampon that oil-soluble substrate is made, after putting into body, be it to be melted by body temperature, so tampon is placed in pharmacy, hospital, the family or carries at ordinary times, if temperature surpass 37 ℃ will deliquescing, could use after must putting into the refrigerator sclerosis, but key is out of shape after the deliquescing, sclerosis back shape is also inevitable irregular, puts into tract like this and has sticky feeling, and wait the people who does not have refrigerator use very inconvenient concerning going on business; 3. nanometer silver powder joins in the oleaginous base, is difficult to be uniformly dispersed production technology and quality control complexity.
The summary of the invention the technical problem to be solved in the present invention is to avoid above-mentioned the deficiencies in the prior art part and proposes a kind of bactericidal action monomer nano silver sanitary tampon strong, easy to use and make simple monomer nano silver sanitary tampon method.
The present invention determines described technical problem can be by realizing by the following technical solutions:
Monomer nano silver sanitary tampon of the present invention comprises nanometer silver composition and substrate, and described nanometer silver composition is a monomer nano silver, i.e. the fine silver monomer of nano-scale, and substrate is water-soluble base; Described monomer nano silver accounts for the 1ppm～2000ppm of suppository gross weight.。Described monomer nano silver is meant that the effective ingredient of tampon has only a kind of silver that exists with monomeric form, not the silver that exists with other forms such as ionic state, oxide, complex.
The manufacture method of monomer nano silver sanitary tampon of the present invention may further comprise the steps successively,
1. prepare the monomer nano silver aqueous solution, wherein monomer nano silver accounts for the 10ppm～20000ppm of total solution weight;
2. prepare suppository, be about to the above-mentioned monomer nano silver aqueous solution for preparing and join in the water-soluble base, be stirred to and be uniformly dispersed, described monomer nano silver accounts for the 1ppm～2000ppm of suppository gross weight;
3. described suppository is poured into molding rear demoulding in the bolt film, obtained monomer nano silver sanitary tampon.
Compare with prior art, technique effect of the present invention is:
1. because monomer nano silver sanitary tampon of the present invention adopts water-soluble base, be easy to be absorbed by the body, after substrate was absorbed, the active ingredient nanometer silver of the inside can be gone into subcutaneous sterilization by rapid permeability, and bactericidal action is strong;
2. after the sterilization of effective ingredient monomer nano silver is finished, can not produce chemical change, can not produce any harmful material, and after the silver that non-monomer nano silver of the prior art promptly exists with other forms such as ionic state, oxide, complex sterilization finishes, may produce harmful material;
3. water-soluble base is it to be dissolved by body fluid, so tampon gently is dissolved in the secretions after filling in tract, drug effect relaxes and lasting; And substrate is not melting below 40 ℃, and tampon is not easy distortion;
4. the tampon made of water-soluble base is flexible, not frangibility;
5. the manufacture method of monomer nano silver sanitary tampon of the present invention is to dispose the monomer nano silver aqueous solution earlier, the monomer nano silver aqueous solution is scattered in the water-soluble base again, only needs to stir just can be uniformly dispersed, and processing technology is simple.
The specific embodiment is following to be described in further detail most preferred embodiment.
Monomer nano silver sanitary tampon of the present invention comprises nanometer silver composition and substrate, and described nanometer silver composition is a monomer nano silver, i.e. the fine silver monomer of nano-scale, and substrate is water-soluble base; Described monomer nano silver accounts for the 1ppm～2000ppm of suppository gross weight.
The manufacture method of monomer nano silver sanitary tampon of the present invention may further comprise the steps successively:
1. prepare the monomer nano silver aqueous solution, wherein monomer nano silver accounts for the 10ppm～20000ppm of total solution weight;
2. prepare suppository, being about to the above-mentioned monomer nano silver aqueous solution for preparing joins in the water-soluble base, be stirred to and be uniformly dispersed, described monomer nano silver accounts for the 1ppm～2000ppm of suppository gross weight, and described water-soluble base adopts gelatin, glycerol, Polyethylene Glycol and/or water;
3. described suppository is poured into molding rear demoulding in the bolt film, obtained monomer nano silver sanitary tampon.
Embodiment one: get gelatin 35g and add distilled water 35g immersion 1 hour, heating in water bath also is stirred to whole dissolvings, add glycerol 35g, continue heating and stirring, make loss of weight add the monomer nano silver aqueous solution 10g of 3500ppm to 90g, continue to be stirred to and be uniformly dispersed, pour into while hot in the bolt mould that scribbles lubricant, the cooling back demoulding promptly.
Prescription:
Gelatin 35g
Glycerol 35g
Distilled water 35g
3500ppm monomer nano silver aqueous solution 10g
Embodiment two: get the 75g polyethylene glycol 6000 and mix with the 15g PEG400, the heating in water bath fusing stirs, the monomer nano silver aqueous solution 10g that adds 3500ppm again, continue to be stirred to and be uniformly dispersed, pour into while hot in the bolt mould that scribbles lubricant, the cooling back demoulding promptly.
Prescription:
Polyethylene glycol 6000 75g
PEG400 15g
3500ppm monomer nano silver aqueous solution 10g
Embodiment three: get the 60g Macrogol 4000 and mix with the 30g cetomacrogol 1000, the heating in water bath fusing stirs, the monomer nano silver aqueous solution 10g that adds 5000ppm again, continue to be stirred to and be uniformly dispersed, pour into while hot in the bolt mould that scribbles lubricant, the cooling back demoulding promptly.
Prescription:
Macrogol 4000 60g
Cetomacrogol 1000 30g
5000ppm monomer nano silver aqueous solution 10g
Embodiment four: get the 80g Macrogol 4000 and mix with the 10g PEG400, the heating in water bath fusing stirs, the monomer nano silver aqueous solution 10g that adds 20000ppm again, continue to be stirred to and be uniformly dispersed, pour into while hot in the bolt mould that scribbles lubricant, cooling and demolding promptly.
Prescription:
Macrogol 4000 80g
PEG400 10g
20000ppm monomer nano silver aqueous solution 10g
The effective ingredient of monomer nano silver sanitary tampon of the present invention is a monomer nano silver, and other composition all belongs to auxiliary material.This tampon has the nanometer silver broad spectrum antibacterial performance, need not add any medicine and just can promptly kill antibacterials such as colibacillus, staphylococcus aureus and have 100% killing action.The applicant has done the test of aspects such as effectiveness, nonirritant, no sensitization and cytotoxicity at main component monomer nano silver aqueous solution in this tampon.The monomer nano silver aqueous solution is 100% to the average bacteriostasis rate of escherichia coli and staphylococcus aureus, result such as table 1, table 2:
Table 1: to the colibacillus fungistatic effect
Annotate: average clump count of positive controls and scope are 4.33 * 104cfu/mL (3.60～4.90 * 104cfu/mL)
Negative control group: pbs, culture medium does not have bacterial growth
Table 2: to the staphylococcus aureus fungistatic effect
Annotate: average clump count of positive controls and scope are 5.22 * 104cfu/mL (4.60～6.00 * 104cfu/mL)
Negative control group: pbs, culture medium does not have bacterial growth
Nontoxic, non-stimulated, no sensitization aspect is detected testing result such as table 3 to the nano-silver water solution of 350ppm:
Table 3
| Sequence number | Inspection item and unit | Specification requirement | Assay | Individual event is judged |
| 1 | Chmice acute per os toxicity test LD50mg/kg | ≥5000 | ＞5000 | Actual nontoxic |
| Sequence number | Inspection item and unit | Specification requirement | Assay | Individual event is judged |
| 2 | Rabbit vagina mucomembranous irritant test stimulation index | 0～0.4 | 0 | Nonirritant |
| 3 | Guinea pig skin allergy test sensitization rate % | 0～8 | 0 | Extremely light |
Monomer nano silver aqueous solution to 400ppm carries out the cytotoxicity detection, result such as table 4 simultaneously:
Table 4
| Sequence number | Inspection item and unit | Specification requirement | Assay | Conclusion |
| 1 | The cell toxicity test cellular morphology is degree of propagation level relatively | The form normal growth well≤1 | The form normal growth well≤1 | Meet |
| Following blank | ||||
As seen from the above table, tampon of the present invention has possessed nontoxic, non-stimulated, no sensitization and outstanding effect effect, compares with ordinary suppository, has remarkable advantages.
Claims (9)
1. a monomer nano silver sanitary tampon comprises nanometer silver composition and substrate, it is characterized in that: described nanometer silver composition is a monomer nano silver, i.e. the fine silver monomer of nano-scale, and substrate is water-soluble base; Described monomer nano silver accounts for the 1ppm～2000ppm of suppository gross weight, and described monomer nano silver is to be dispersed in the described substrate with aqueous solution.
2. monomer nano silver sanitary tampon according to claim 1 is characterized in that: the concentration of described monomer nano silver aqueous solution is 3500ppm or 5000ppm.
3. monomer nano silver sanitary tampon according to claim 1 is characterized in that: described substrate comprises gelatin, glycerol, Polyethylene Glycol and/or water.
4. monomer nano silver sanitary tampon according to claim 3 is characterized in that: described substrate comprises gelatin, glycerol and distilled water.
5. monomer nano silver sanitary tampon according to claim 3 is characterized in that: described substrate comprises polyethylene glycol 6000 and PEG400.
6. monomer nano silver sanitary tampon according to claim 3 is characterized in that: described substrate comprises Macrogol 4000 and cetomacrogol 1000.
7. monomer nano silver sanitary tampon according to claim 3 is characterized in that: described substrate comprises Macrogol 4000 and PEG400.
8. the manufacture method of a monomer nano silver sanitary tampon is characterized in that: may further comprise the steps successively,
1. prepare the monomer nano silver aqueous solution, wherein monomer nano silver accounts for the 10ppm～20000ppm of total solution weight;
2. prepare suppository, be about to the above-mentioned monomer nano silver aqueous solution for preparing and join in the water-soluble base, be stirred to and be uniformly dispersed, described monomer nano silver accounts for the 1ppm～2000ppm of suppository gross weight;
3. described suppository is poured into molding rear demoulding in the bolt film, obtained monomer nano silver sanitary tampon.
9. the manufacture method of monomer nano silver sanitary tampon according to claim 8 is characterized in that: described water-soluble base employing gelatin, glycerol, Polyethylene Glycol and/or water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200610157172A CN101190181B (en) | 2006-11-28 | 2006-11-28 | Monomer nano silver sanitary tampon and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200610157172A CN101190181B (en) | 2006-11-28 | 2006-11-28 | Monomer nano silver sanitary tampon and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101190181A CN101190181A (en) | 2008-06-04 |
| CN101190181B true CN101190181B (en) | 2010-05-19 |
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| CN200610157172A Expired - Fee Related CN101190181B (en) | 2006-11-28 | 2006-11-28 | Monomer nano silver sanitary tampon and preparation method thereof |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110089523A (en) * | 2018-01-30 | 2019-08-06 | 艾铭南 | Monomer silver atoms are that anti-biotic material production prepares the application in antibacterial functions product |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1395970A (en) * | 2002-08-30 | 2003-02-12 | 林艳 | Bacterial medical nano suppository for woman and its preparing process |
| CN1480584A (en) * | 2002-09-06 | 2004-03-10 | 刘维春 | Method for preparing antibacterial material by combining nano silver and activated carbon |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1395970A (en) * | 2002-08-30 | 2003-02-12 | 林艳 | Bacterial medical nano suppository for woman and its preparing process |
| CN1480584A (en) * | 2002-09-06 | 2004-03-10 | 刘维春 | Method for preparing antibacterial material by combining nano silver and activated carbon |
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