CN101185657B - Production process and device for donkey-hide gelatin plasma substitutes - Google Patents
Production process and device for donkey-hide gelatin plasma substitutes Download PDFInfo
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- CN101185657B CN101185657B CN2007101393402A CN200710139340A CN101185657B CN 101185657 B CN101185657 B CN 101185657B CN 2007101393402 A CN2007101393402 A CN 2007101393402A CN 200710139340 A CN200710139340 A CN 200710139340A CN 101185657 B CN101185657 B CN 101185657B
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Abstract
The invention provides manufacturing techniques of donkey-hide glue plasma substitute and the apparatus thereof, relating to preparation techniques of artificial plasma and animal gum. The invention mainly adopts vacuum seal glue cooking method, refined filtration method, vacuum seal sterilization and constant temperature drying method, three-grade pressure filtration, etc. The invention is provided with four production lines, namely, a pre-processing line for raw materials, an original gum production line, an original gum refined production line, and a plasma substitute preparation productionline. The invention has the advantages that the invention has scientific and reasonable production technique, and the products prepared by the technique have few impurities, high purity and quality, more safe and reliable therapeutic effects; the products produced by the apparatus have few impurities, high purity, high quality; the invention has high production efficiency, low work intensity of workers, little environment pollution and low cost, and can further improve the production quality and clinical therapeutic effects and safety of drugs, providing higher economic and social benefits.
Description
Technical field
The present invention relates to the preparing technical field of artificial plasm and animal glue.
Background technology
Workshop-based traditional handicraft and simple and crude equipment production are adopted in the preparation of existing ass-hide glue plasma substitute, adopt the opened type cauldron to endure adhesive process, not as good as serious environment pollution, but also cause the secondary pollution of glue product, and the virgin rubber purity of enduring out is low, of poor quality; And the drying of purified gelatin, sterilization, the cool solarization are all carried out under the environment that exposes, and the glue product causes repeatedly secondary pollution; The glue filtered through gauze is separated with milk separator, filters its poor effect with Amur filtering tank and filter bulb.The mode of production that this kind is simple and crude, its complicated operation, its main single link can not continued operations, so its production cycle is long, the labor strength height, yield poorly, efficient is low, and the product impurity of being produced is many, purity is low, of poor quality, environmental pollution is serious, the cost height, deficiency in economic performance is not easy to further improve the clinical treatment effect and the safety of its quality of production and medicine; Owing to do not establish purifying area by aseptic mark, the production area is mixed in together, also is unfavorable for the civilization safety in production.Above-mentioned backward technology and production loading amount thereof and above-mentioned a series of problems of being brought thereof the people that always puzzling, everybody wants to solve always, but fails for a long time to be well solved always.
Summary of the invention
The purpose of this invention is to provide a kind of ass-hide glue plasma substitute production technology and device, be characterized in: its production technology is scientific and reasonable, and the product impurity of producing with this technology is few, purity is high, quality is high, and the product curative effect is more safe and reliable; The product impurity of producing with this device is few, purity is high, quality is high, the production efficiency height, and labor strength is low, and is low in the pollution of the environment, and cost is low, and high economic benefit and social benefit are arranged.
One of the present invention's main technical schemes is: a kind of ass-hide glue plasma substitute production technology comprises raw material roughing pre-treatment: donkey skin degrease, cutting, soaking in sodium carbonate solution; Virgin rubber is produced: endure glue, filter, separate drying; Virgin rubber is refining: virgin rubber dilution, cation exchange decontamination, and adjust pH filters drying; The plasma substitute preparation: batching and heating, adjust pH filters packing; It is characterized in that virgin rubber production endures glue and adopt vacuum seal to endure the glue method, the filtration behind the glue is endured in virgin rubber production, is that essence is filtered, and separating after drying is sealed vacuum sterilization freeze-day with constant temperature; Filtering after drying when virgin rubber is refining is sealed vacuum sterilization freeze-day with constant temperature; Plasma substitute when preparation be filtered into the pressurization three-stage filtration.
The present invention's two main technical schemes is: ass-hide glue plasma substitute process units, comprise centrifugal separator, and it is characterized in that having following device fabrication line and equipment connecting relation thereof:
A, the virgin rubber production line: enduring glue continuously is that the discharging opening of machine and the charging aperture of jacketed pan link to each other by pipeline, the discharging opening of jacketed pan links to each other by pipeline with the charging aperture of malleation filter, the discharging opening of malleation filter links to each other by pipeline with the charging aperture of colloid pressure filtration pump, the discharging opening of colloid pressure filtration pump links to each other by pipeline with the charging aperture that separates the degrease fluid reservoir, separating the discharging opening of degrease fluid reservoir and the charging aperture of colloid compression pump links to each other by pipeline, the discharging opening of colloid compression pump links to each other by pipeline with the charging aperture of centrifugal separator, the discharging opening of centrifugal separator links to each other by pipeline with the charging aperture of vacuum interlayer heating kettle, the discharging opening of vacuum interlayer heating kettle links to each other by pipeline with the charging aperture of enrichment facility, and the back of enrichment facility is provided with vacuum constant temperature dry sterilization case;
B, virgin rubber is made with extra care production line: the discharging opening of virgin rubber constant temperature dissolving material-compound tank and the charging aperture of colloidal solution press pump link to each other by pipeline, the discharging opening of colloidal solution press pump and ion exchange, the charging aperture of segregation apparatus links to each other by pipeline, ion exchange, the discharging opening of segregation apparatus links to each other by pipeline with the charging aperture of activated carbon treatment jar, the discharging opening of active carbonyl process tank and the charging aperture of hydraulic pressure asbestos sheet frame filter pump link to each other by pipeline, the discharging opening of hydraulic pressure asbestos sheet frame filter pump links to each other by pipeline with the charging aperture that leaves standstill fluid reservoir, and the back of leaving standstill fluid reservoir is provided with vacuum constant temperature dry sterilization case;
C, plasma substitute preparation production line: the discharging opening of rustless steel interlayer material-compound tank (or claiming mixing system) (being produced by Zhejiang pharmaceutical equipment factory of enterprise of Nintaus) links to each other by pipeline with the charging aperture that activated carbon removes heat source system, activated carbon removes the discharging opening of heat source system and the charging aperture of malleation filter links to each other by pipeline, the discharging opening of malleation filter links to each other by pipeline with the charging aperture of monolayer heated type filter, the discharging opening of monolayer heated type filter links to each other by pipeline with the charging aperture of collapsible micro-pore-film filtration device, and the discharging opening of collapsible micro-pore-film filtration device links to each other by pipeline with the charging aperture of automatic filling and sealing machine.
The described glue machine of enduring continuously is that to endure the glue machine continuously be good to vacuum pressure.
Described centrifugal separator is that automatic separator is good.
Described enrichment facility is that the energy-conservation enrichment facility of triple effect is good.
Described filling and sealing machine is that automatic filling and sealing machine is good.
In the described ass-hide glue plasma substitute process units, preferably be provided with following raw material roughing pre-treatment production line and equipment connecting relation thereof before the virgin rubber production line: the discharging opening of defatting machine and the charging aperture of automatic gas cutting machine link to each other by pipeline automatically, and the discharging opening of automatic gas cutting machine links to each other with douche can.
Described ass-hide glue plasma substitute process units, it is good being provided with computer operation and control device.
Technique effect of the present invention and advantage are significant: its production technology is scientific and reasonable, and the product impurity of producing with technology of the present invention is few, purity is high, quality is high, and the product curative effect is more safe and reliable; The product impurity of producing with process units of the present invention is few, purity is high, quality is high, the production efficiency height, simple to operate, main single link can realize continued operation, labor strength is low, low in the pollution of the environment, cost is low, helps further improving the clinical treatment effect and the safety of its quality of production and medicine.Solve for a long time people and wanted to solve and unsolved always problem always, had high economic benefit and social benefit.
Be described further below in conjunction with embodiment and accompanying drawing, but not as a limitation of the invention.
Description of drawings
Fig. 1 is the structural representation of process units of the present invention.
The specific embodiment
Production technology is: get fresh donkey skin 100kg, with 2% thermokalite water logging bubble 5 minutes, with automatic defatting machine degrease → cut into 50mm * 50mm blockage → usefulness tap water alembic 20% soaking through sodium carbonate with automatic gas cutting machine; With endure plastic clip layer vacuum pressure pot endure glue add sterilization (115 ℃, 3h) → 100 ℃ of pressure cookers with cover dissolve fully → with the colloid filter pump squeeze into the rustless steel fluid reservoir separate degrease → with the colloid pump squeeze into concentrated at the beginning of the automatic separator separations → vacuum interlayer pot → finish sealed vacuum constant temperature (100 ℃) drying → plastic emitting of sterilizing with thermostatic drying chamber; Go into constant temperature material-compound tank batching dissolving → colloidal solution press pump and squeeze into ion exchange, segregation apparatus and carry out cation exchange, separation, decontamination → go in the activated carbon treatment jar 100～120 ℃, hot-pressing processing in 30 branches → leave standstill 72H transfers pH value 7～8 → hydraulic pump asbestos board membrane filtration → stainless cylinder of steel to leave standstill plastic emitting in 60 fens → finish in constant temperature (100～120 ℃) sealed vacuum drying → rustless steel interlayer material-compound tank 70～80 ℃ of batching dissolving heating → transfer pH value 7～8 activated carbon except that thermal source → pressurization three-stage filtration → coating-dividing sealing → 115 pressure sterilizings with thermostatic drying chamber.
Referring to Fig. 1, this ass-hide glue plasma substitute process units has following device fabrication line and equipment connecting relation thereof, wherein:
A: be the structural representation of raw material roughing pre-treatment production line.Automatically the discharging opening of defatting machine and the charging aperture of automatic gas cutting machine link to each other by pipeline, and the discharging opening of automatic gas cutting machine and douche can link to each other by pipeline etc.
B: be the structural representation of virgin rubber production line.Enduring glue continuously is that the discharging opening of machine (or title system) (Wuhan Pharmaceutical Machinery Factory's production) and the charging aperture of jacketed pan link to each other by pipeline, the discharging opening of jacketed pan links to each other by pipeline with the charging aperture of malleation filter (Zhejiang Nintaus filter material instrument factory is produced), the discharging opening of malleation filter links to each other by pipeline with the charging aperture of colloid pressure filtration pump (Zhejiang Nintaus filter material instrument factory is produced), the discharging opening of colloid pressure filtration pump links to each other by pipeline with the charging aperture that separates degrease fluid reservoir (production of medical equipment factory of Zhejiang Nintaus), separating the discharging opening of degrease fluid reservoir and the charging aperture of colloid compression pump (production of pharmaceutical equipment factory of Zhejiang Nintaus) links to each other by pipeline, the discharging opening of colloid compression pump links to each other by pipeline with the charging aperture of centrifugal separator, the discharging opening of centrifugal separator links to each other by pipeline with the charging aperture of vacuum interlayer heating kettle (production of pharmaceutical equipment factory of Zhejiang Nintaus), the discharging opening of vacuum interlayer heating kettle links to each other by pipeline with the charging aperture of enrichment facility, and the back of enrichment facility is provided with vacuum constant temperature dry sterilization case (production of Jiangyin City's drying equipment Manufacturing Co., Ltd); The described glue machine of enduring continuously is that vacuum pressure is endured the glue machine continuously, and described centrifugal separator is automatic separator (production of pharmaceutical equipment factory of Zhejiang Nintaus), and described enrichment facility is the energy-conservation enrichment facility of triple effect (production of Wenzhou pharmaceutical machine instrument factory).
C: be the structural representation of the refining production line of virgin rubber.The discharging opening of virgin rubber constant temperature dissolving material-compound tank (production of pharmaceutical equipment factory of Zhejiang Nintaus) links to each other by pipeline with the charging aperture of colloidal solution press pump (filter material science and technology medical equipment factory of Zhejiang Nintaus produces), the discharging opening of colloidal solution press pump and ion exchange, the charging aperture of segregation apparatus (production of business equipment factory of Zhejiang Nintaus) links to each other by pipeline, ion exchange, the discharging opening of segregation apparatus links to each other by pipeline with the charging aperture of activated carbon treatment jar (production of pharmaceutical equipment factory of Zhejiang Nintaus), the discharging opening of activated carbon treatment jar links to each other by pipeline with the charging aperture of hydraulic pressure asbestos sheet frame filter pump (filter material science and technology medical equipment factory of Zhejiang Nintaus produces), the discharging opening of hydraulic pressure asbestos sheet frame filter pump links to each other by pipeline with the charging aperture that leaves standstill fluid reservoir, and the back of leaving standstill fluid reservoir is provided with vacuum constant temperature dry sterilization case (production of Jiangyin City's drying equipment Manufacturing Co., Ltd).
D: be the structural representation of plasma substitute preparation production line.The discharging opening of rustless steel interlayer material-compound tank links to each other by pipeline with the charging aperture that activated carbon removes heat source system (filter material science and technology medical equipment factory of Zhejiang Nintaus produces), activated carbon removes the discharging opening of heat source system and the charging aperture of malleation filter (filter material science and technology medical equipment factory of Zhejiang Nintaus produces) links to each other by pipeline, the discharging opening of malleation filter links to each other by pipeline with the charging aperture of monolayer heated type filter (filter material science and technology medical equipment factory of Zhejiang Nintaus produces), the discharging opening of monolayer heated type filter links to each other by pipeline with the charging aperture of collapsible micro-pore-film filtration device (filter material science and technology medical equipment factory of Zhejiang Nintaus produces), and the discharging opening of collapsible micro-pore-film filtration device links to each other by pipeline with the charging aperture of automatic filling and sealing machine.Described filling and sealing machine is an automatic filling and sealing machine.Each production line or integral body are provided with computer operation and control device is good; Also can be semi-automation, equipment is workman's difference operating structure.
Claims (7)
1. ass-hide glue plasma substitute production technology comprises raw material roughing pre-treatment: donkey skin degrease, cutting, soaking in sodium carbonate solution; Virgin rubber is produced: endure glue, filter, separate drying; Virgin rubber is refining: virgin rubber dilution, cation exchange decontamination, and adjust pH filters drying; The plasma substitute preparation: batching and heating, adjust pH filters packing; It is characterized in that virgin rubber production endures glue and adopt vacuum seal to endure the glue method, the filtration behind the glue is endured in virgin rubber production, is that essence is filtered, and separating after drying is sealed vacuum sterilization freeze-day with constant temperature; Filtering after drying when virgin rubber is refining is sealed vacuum sterilization freeze-day with constant temperature; Plasma substitute when preparation be filtered into the pressurization three-stage filtration.
2. ass-hide glue plasma substitute process units comprises centrifugal separator, it is characterized in that having following device fabrication line and equipment connecting relation thereof:
A, virgin rubber production line: endure the discharging opening of glue machine and the charging aperture of jacketed pan continuously and link to each other by pipeline, the discharging opening of jacketed pan links to each other by pipeline with the charging aperture of malleation filter, the discharging opening of malleation filter links to each other by pipeline with the charging aperture of colloid pressure filtration pump, the discharging opening of colloid pressure filtration pump links to each other by pipeline with the charging aperture that separates the degrease fluid reservoir, separating the discharging opening of degrease fluid reservoir and the charging aperture of colloid compression pump links to each other by pipeline, the discharging opening of colloid compression pump links to each other by pipeline with the charging aperture of centrifugal separator, the discharging opening of centrifugal separator links to each other by pipeline with the charging aperture of vacuum interlayer heating kettle, the discharging opening of vacuum interlayer heating kettle links to each other by pipeline with the charging aperture of enrichment facility, and the back of enrichment facility is provided with vacuum constant temperature dry sterilization case;
B, virgin rubber is made with extra care production line: the discharging opening of virgin rubber constant temperature dissolving material-compound tank and the charging aperture of colloidal solution press pump link to each other by pipeline, the discharging opening of colloidal solution press pump and ion exchange, the charging aperture of segregation apparatus links to each other by pipeline, ion exchange, the discharging opening of segregation apparatus links to each other by pipeline with the charging aperture of activated carbon treatment jar, the discharging opening of activated carbon treatment jar links to each other by pipeline with the charging aperture of hydraulic pressure asbestos sheet frame filter pump, the discharging opening of hydraulic pressure asbestos sheet frame filter pump links to each other by pipeline with the charging aperture that leaves standstill fluid reservoir, and the back of leaving standstill fluid reservoir is provided with vacuum constant temperature dry sterilization case;
C, plasma substitute preparation production line: the discharging opening of rustless steel interlayer material-compound tank links to each other by pipeline with the charging aperture that activated carbon removes heat source system, activated carbon removes the discharging opening of heat source system and the charging aperture of malleation filter links to each other by pipeline, the discharging opening of malleation filter links to each other by pipeline with the charging aperture of monolayer heated type filter, the discharging opening of monolayer heated type filter links to each other by pipeline with the charging aperture of collapsible micro-pore-film filtration device, and the discharging opening of collapsible micro-pore-film filtration device links to each other by pipeline with the charging aperture of automatic filling and sealing machine.
3. ass-hide glue plasma substitute process units according to claim 2 is characterized in that the described glue machine of enduring continuously is that vacuum pressure is endured the glue machine continuously.
4. ass-hide glue plasma substitute process units according to claim 2 is characterized in that described centrifugal separator is an automatic separator.
5. ass-hide glue plasma substitute process units according to claim 2 is characterized in that described enrichment facility is the energy-conservation enrichment facility of triple effect.
6. ass-hide glue plasma substitute process units according to claim 2 is characterized in that described filling and sealing machine is an automatic filling and sealing machine.
7. according to claim 2,3,4,5 or 6 described ass-hide glue plasma substitute process units, it is characterized in that having following raw material roughing pre-treatment production line and equipment connecting relation thereof before the virgin rubber production line: the discharging opening of defatting machine and the charging aperture of automatic gas cutting machine link to each other by pipeline automatically, and the discharging opening of automatic gas cutting machine links to each other with douche can.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101393402A CN101185657B (en) | 2007-09-05 | 2007-09-05 | Production process and device for donkey-hide gelatin plasma substitutes |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101393402A CN101185657B (en) | 2007-09-05 | 2007-09-05 | Production process and device for donkey-hide gelatin plasma substitutes |
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| Publication Number | Publication Date |
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| CN101185657A CN101185657A (en) | 2008-05-28 |
| CN101185657B true CN101185657B (en) | 2010-06-16 |
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| CN2007101393402A Expired - Fee Related CN101185657B (en) | 2007-09-05 | 2007-09-05 | Production process and device for donkey-hide gelatin plasma substitutes |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102210705B (en) * | 2011-06-03 | 2012-07-04 | 江苏建中投资有限公司 | Production process of polypeptide donkey-hide gelatin substitutive blood plasma |
| CN102210704A (en) * | 2011-06-03 | 2011-10-12 | 江苏建中投资有限公司 | Process for removing pyrogen from polypeptide donkey-hide gelatin dextran |
| CN102988989B (en) * | 2012-12-20 | 2014-04-23 | 江苏久吾高科技股份有限公司 | Refining and extracting method of dextran by membrane separation |
| CN106901356A (en) * | 2017-05-03 | 2017-06-30 | 山东东阿东盛阿胶产品科技开发有限公司 | A kind of donkey-hide gelatin production line |
| CN107927746A (en) * | 2017-11-15 | 2018-04-20 | 苏州红冠庄国药股份有限公司 | The industrialized preparing process of deerskin glue |
| CN113209137A (en) * | 2021-02-19 | 2021-08-06 | 林岳云 | Donkey-hide gelatin plasma substitute and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1055111A (en) * | 1990-03-24 | 1991-10-09 | 中国人民解放军空军石家庄医院 | Ass-hide glue plasma substitute and preparation method thereof |
| CN1071838A (en) * | 1992-07-06 | 1993-05-12 | 山东东阿阿胶厂 | A kind of preparation method of liquid donkey-hide gelatin |
| CN201101718Y (en) * | 2007-09-05 | 2008-08-20 | 中国人民解放军北京军区白求恩国际和平医院256临床部 | Ass-hide glue dextran producing device |
-
2007
- 2007-09-05 CN CN2007101393402A patent/CN101185657B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1055111A (en) * | 1990-03-24 | 1991-10-09 | 中国人民解放军空军石家庄医院 | Ass-hide glue plasma substitute and preparation method thereof |
| CN1071838A (en) * | 1992-07-06 | 1993-05-12 | 山东东阿阿胶厂 | A kind of preparation method of liquid donkey-hide gelatin |
| CN201101718Y (en) * | 2007-09-05 | 2008-08-20 | 中国人民解放军北京军区白求恩国际和平医院256临床部 | Ass-hide glue dextran producing device |
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