CN101185613A - Gargle tablet and preparation method thereof - Google Patents
Gargle tablet and preparation method thereof Download PDFInfo
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- CN101185613A CN101185613A CNA2007100326576A CN200710032657A CN101185613A CN 101185613 A CN101185613 A CN 101185613A CN A2007100326576 A CNA2007100326576 A CN A2007100326576A CN 200710032657 A CN200710032657 A CN 200710032657A CN 101185613 A CN101185613 A CN 101185613A
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Abstract
The invention provides a gargle tablet which takes the shape of a solid plate and pertains to oral cavity caring products which disperses when in mouth. The gargle tablet comprises membrane-forming agent, fresher, emulsifier, foaming cleanser and abradant, with function of killing bacterium, cleaning oral cavity, removing smell and preventing decayed tooth and being convenient for carrying and easy for use. The invention also provides a preparation method of the gargle tablet.
Description
Technical field
The present invention relates to a kind of oral care implement, particularly a kind of sheet and preparation method thereof of gargling.
Background technology
Oral disease is perplexing image, the social communication and healthy that people, particularly dental caries have had a strong impact on the people always.Many oral health products are arranged on the market, common have toothpaste, chewing gum, collutory and a flavorants etc., it mainly plays cleaning teeth, tooth-whitening, removal dental plaque, kills oral cavity noxious bacteria, caries prevention, effects such as fresh breath are also played certain positive role to the treatment as some oral diseases such as various focusing depths represented simultaneously.
Toothpaste mixes the pasty masses of forming by abrasive, thickening agent, foaming agent, wetting agent, spice, water, medicine and other additives, is the daily necessities with mode cleaning teeths such as friction protection oral hygiene.It is the present the most general oral care product of using in the world, and the ability of cleaning oral cavity is strong, and is remarkable to the prophylaxis of teeth disease effects, but must cooperate toothbrush and clear water to use, and use is inconvenient, and volume is bigger, and weight is also heavier.
Chewing gum, or claim chewing gum, generally contain glue group composition, it has fresh breath, cleaning teeth dirt simultaneously, discharges the antieurodontic ability of preventing decayed tooth composition, but owing to can not eat, therefore bring certain cleaning problems and problem of environmental pollution, people's mistake is gulped down;
Collutory is dissolved the liquid of forming by ethanol, water, wetting agent, spice, solubilizing agent and other additives.The general toothpaste of its sterilizing ability is strong, and can carry out auxiliary therapy to the oral cavity commonly encountered diseases, though need not cooperate toothbrush to use, convenient relatively, if but it adds the good foaming agent of cleaning capacity, just be easy in the packing bottle, produce a large amount of foams, therefore limited the interpolation of foaming agent, cause cleaning capacity to descend, only depend on antipathogenic compositions such as ethanol to kill oral cavity bacterium, and volume is big, and Heavy Weight carries inconvenience.
Flavorants, it forms with collutory more approaching, but effect more biases toward removing or hides halitosis, though the composition of its use is safer,, pack small and exquisite can eat, easy to carry, but do not have bacteria resistance function substantially, the oral cavity dirt there is not cleaning capacity yet.
Breath freshening tablet, can eat, with certain essence and the ice-cold implication that becomes to assign to remove, only has pure and fresh oral cavity function, based on edible reason, can't add effective foam cleaners which do and antipathogenic composition, cause it not have cleaning oral cavity ability and inhibition oral cavity bacterium ability substantially, and wherein may contain the nutritional labeling of easily being utilized by antibacterial.
Solid tooth sheet, this is the solid medicine particulate matter, mainly contains solid friction composition, essence, needs during use to bite into pieces and chew with tooth, moves in the oral cavity by the friction composition and cleans dirt.
Therefore, provide a kind of and can have antibacterial, cleaning oral cavity, removal implication simultaneously, effects such as caries prevention, and easy to carry, use and be easy to solid and gargle that sheet is real to be necessity.
Summary of the invention
Based on the deficiencies in the prior art, the object of the present invention is to provide a kind of inlet decentralized solid that contains abrasivus, foaming cleansing composition and antipathogenic composition sheet of gargling, this solid sheet of gargling can not only have antibacterial, cleaning oral cavity, removal implication simultaneously, effects such as caries prevention, and easy to carry, use easily.
A kind of sheet of gargling is solid, shaped, is inlet decentralized oral care implement, and it contains film former, freshener, emulsifying agent, foam cleaners which do and abrasivus, and the percentage by weight of each component following (calculating) with the finished product butt:
Film former 40-75%
Freshener 4-15%
Foam cleaners which do 2-10%
Abrasivus 10-25%
Emulsifying agent 5-10%.
Described film former is selected from following one or more materials: carboxymethyl cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxypropyl emthylcellulose, chitosan, trehalose, sodium alginate, modified starch, arabic gum, HANSHENGJIAO, tracasol, Konjac glucomannan, konjaku powder, pectin, gelatin, POLY-karaya, guar gum, locust bean gum, Algin, carrageenan, Pullulan, maltodextrin;
Described freshener comprises edible essence;
Described foam cleaners which do is selected from following one or more materials: sodium lauryl sulphate, sodium lauroyl sarcosine, sodium lauroyl glutamate;
Described abrasivus is selected from following one or more materials: silicon dioxide, calcium carbonate, calcium hydrogen phosphate, aluminium hydroxide;
Described antibacterial is selected from following one or more materials: 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether (triclosan), metronidazole, chlorhexidine acetate, cetylpyridinium chloride, benzalkonium bromide;
Described emulsifying agent is selected from following one or more materials: lecithin, stearic acid monoglycerides, tween 80, Tween-60 and tween 20;
Described sweeting agent is selected from following one or more materials: aspartame, sucralose, acesulfame potassium, steviol glycosides;
Described plasticizer is selected from polyhydric alcohol, and wherein, polyhydric alcohol is selected from following one or more materials: glycerol, sorbitol, ethylene glycol, propylene glycol and mannitol;
Described mothproof composition is xylitol, sodium fluoride or sodium monofluorophosphate;
Described food antiseptics is sodium benzoate or potassium sorbate.
The present invention simultaneously also provides a kind of preparation method of the sheet of gargling, and the described sheet of gargling includes film former, freshener, emulsifying agent, foam cleaners which do and abrasivus, said method comprising the steps of:
(1) film former added carry out swelling in an amount of ionized water, this solution is warming up to 70 ℃ after insulation 20 minutes, be cooled to 45 ℃ then;
(2) add described freshener, emulsifying agent, foam cleaners which do and abrasivus successively in the colloid with gained after the above-mentioned swelling, stir, form rubber cement;
(3) rubber cement with gained in the step (2) forms thin film;
(4) in the presence of steam, the thin film of gained in the step (3) is dried, obtain the finished product sheet of gargling after the cooling, its section is stand-by.
In step (2), also can add sweeting agent, antibacterial, plasticizer, mothproof composition, food antiseptics and pigment.
Compared with prior art, the sheet structure in the form of sheets of gargling of the present invention with respect to traditional collutory, has reduced volume greatly, has made things convenient for carrying and using of people's daily life.For traditional toothpaste, the use of the sheet of gargling need be by toothbrush, and its sterilizing ability is stronger than toothpaste.With respect to other oral care products, as flavorants, breath freshening tablet and chewing gum etc., the effect that fresh breath is not only arranged, and can also effectively remove intraoral antibacterial, the cleaning teeth dirt, in addition, this character that the sheet inlet promptly looses of gargling, make it neither can disorderly tell contaminated environment, also can not eat and cause the injury of health because of mistake because of the throwing out without care of colloid thing that can not eat.
The specific embodiment
A kind of sheet of gargling provided by the invention is solid, shaped, is inlet decentralized oral care implement, and it contains film former, freshener, emulsifying agent, foam cleaners which do and abrasivus, fill a prescription following (calculating with the finished product butt):
Film former 40-75%
Freshener 4-15%
Foam cleaners which do 2-10%
Abrasivus 10-25%
Emulsifying agent 5-10%.
Wherein, the effect of described film former is the carrier as each component, is plates with the product final molding, and in use, make gargle flake products can be dissolved and be dispersed in the oral cavity.It can be selected from following one or more materials: carboxymethyl cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxypropyl emthylcellulose, chitosan, trehalose, sodium alginate, modified starch, arabic gum, HANSHENGJIAO, tracasol, Konjac glucomannan, konjaku powder, pectin, gelatin, POLY-karaya, guar gum, locust bean gum, Algin, carrageenan, Pullulan, maltodextrin.
The effect of described freshener is can obtain good oral sensation in order to make after gargling, and it can select edible essence for use.
The time spent of doing of described foam cleaners which do forms an amount of foam when gargling, simultaneously can emulsifying and the oral cavity, place to go in spot, it can be selected from following one or more materials: sodium lauryl sulphate, sodium lauroyl sarcosine, sodium lauroyl glutamate.
The effect of described abrasive is auxiliary cleaning, and it can be selected from following one or more materials: silicon dioxide, calcium carbonate, calcium hydrogen phosphate, aluminium hydroxide.
Described emulsifying agent plays the effect of the stable sheet of gargling, and also is convenient to formed thin film simultaneously and plays plate, and it can be selected from following one or more materials: lecithin, stearic acid monoglycerides, tween 80, Tween-60 and tween 20.
In a preferred embodiment of the invention, the described sheet of gargling also further contains antibacterial, sweeting agent, plasticizer, mothproof composition, food antiseptics and pigment, fill a prescription following (calculating with the finished product butt):
Film former 40-75%
Freshener 4-15%
Foam cleaners which do 2-10%
Abrasivus 10-25%
Emulsifying agent 5-10%
Antibacterial 0.5-2.5%
Sweeting agent 0.3-3%
Plasticizer 0.3-8%
Mothproof composition 0.1-5%
Food antiseptics 0.1-1.5%
Pigment 0.001-0.5%.
Wherein, described antibacterial is used for suppressing and killing the noxious bacteria in oral cavity, it can be selected from following one or more materials: 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether (triclosan), metronidazole, chlorhexidine acetate, cetylpyridinium chloride, benzalkonium bromide.
The effect and the freshener of described sweeting agent are basic identical, are can obtain good oral sensation in order to make after gargling, and it can be selected from following one or more materials: aspartame, sucralose, acesulfame potassium, steviol glycosides.
The effect of described plasticizer is that it can be selected from polyhydric alcohol for the ease of the formation thin film, and wherein, polyhydric alcohol is selected from following one or more materials: glycerol, sorbitol, ethylene glycol, propylene glycol and mannitol, preferred polyhydric alcohol are glycerol.
Described mothproof composition is xylitol, sodium fluoride or sodium monofluorophosphate.
Described food antiseptics is sodium benzoate or potassium sorbate.
The present invention also provides a kind of preparation method of the sheet of gargling, and it may further comprise the steps:
(1) film former added carry out swelling in an amount of ionized water, on electric furnace, heat, turn on agitator, mixing speed is made as 500r/min, this solution is warming up to 70 ℃ after insulation 20 minutes, be cooled to 45 ℃ then;
(2) add remaining composition such as described emulsifying agent, foam cleaners which do and abrasivus, freshener etc. successively in the colloid with gained after the above-mentioned swelling, restir 1 hour, stir, form rubber cement, wherein the part solid material need add with appropriate amount of deionized water dissolving back;
(3) rubber cement with gained in the step (2) forms thin film: above-mentioned rubber cement is poured on 50 * 30 * 0.3 (on the metallic plate of cm * cm * cm), evenly paves, guarantee that rubber cement has certain thickness;
(4) in the presence of steam, with the thin film evaporate to dryness film forming of gained in the step (3), obtain the finished product sheet of gargling after the cooling, its section is stand-by.
In a preferred embodiment of the invention, also can add sweeting agent, antibacterial, plasticizer, mothproof composition, food antiseptics and pigment in the step (2).
Because rubber cement contains a large amount of moisture, certain thickness rubber cement could guarantee the one-tenth film-strength of solid film behind the evaporate to dryness, thereby is not easy cracked; Heating-up temperature and time change along with the variation of rubber cement thickness and formula system, are that the needed heating-up temperature of rubber cement of difficult more evaporate to dryness is high more on the whole, and heat time heating time is relatively just long more.
In the present invention, the film forming procedure of film former mainly divided for three steps carried out: the diffusion of moisture content volatilization, particle deformation and macromolecular chain.If the film former aqueous solutions of polymers is cast on the substrate, and under a certain temperature with the moisture content evaporate to dryness, what obtain is opaque thin film; If being higher than evaporate to dryness under a certain temperature, will obtain homogeneous phase and clear films, this critical temperature is exactly minimum film formation temperature (MFFT).In the above two kinds of cases, moisture content is evaporation fully all, so the existence of MFFT shows, except water evaporates, in film forming procedure, relate to other effect, thereby impel the film former polymer beads to become dodecahedron, disappear until the border by sphere, this effect be by interface energy reduce caused.In essence, film former polymer film forming process is a kind of strand coacervation.This is one and is in contact with one another, is deformed to the process that strand runs through mutually from granule that the initial conformation of this process and macromolecular chain, transport property of molecules, membrance casting condition and kinetics of diffusion process are closely related, and the performance of telolemma is had significant effects.
By above-mentioned experimental technique and following each formulation the present invention who implements to provide sheet of gargling
Embodiment 1
In the present embodiment, the sheet of gargling contains following components in weight percentage:
Sodium alginate 15.6%
Maltodextrin 35.8%
Carrageenan 1.6%
Glycerol 5.0%
Lecithin 10%
Silica 1 7%
Sodium lauryl sulphate 3%
2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether 0.5%
Essence 5.0%
Sodium benzoate 0.5%
Food coloring indigo plant 0.005%
Aspartame 0.5%
Xylitol 5%
Acesulfame-K 0.495%.
In the present invention, the described sheet finished product of gargling is even, glossy from seeing in appearance, generally is blue or white; On taste, sugariness is moderate, and is not bitter, ice-cold; Content of beary metal: arsenic≤0.5m9/k9; Copper≤10m9/k9; Lead≤1m9/k9; Total number of bacteria:<1000/9; Escherichia coli:<30/1009; Pathogenic bacterium: must not detect.
Embodiment 2
In the present embodiment, the sheet of gargling contains following components in weight percentage:
Hydroxyethyl-cellulose 10.4%
Hydroxypropyl cellulose 10%
Maltodextrin 35%
Sorbitol 5%
Lecithin 7%
Benzalkonium bromide 0.8%
Sodium lauroyl sarcosine 10%
Calcium carbonate 15%
Essence 3%
Mentholum 2.1%
Food coloring indigo plant 0.005%
Aspartame 0.6%
Potassium sorbate 0.5%
Acesulfame-K 0.595%.
Embodiment 3
In the present embodiment, the sheet of gargling contains following components in weight percentage:
Carboxymethyl cellulose 5%
HANSHENGJIAO 5%
Modified starch 38%
Glycerol 6%
Tween-60 7%
Essence 4.8%
Silicon dioxide 20%
Sodium lauroyl glutamate 10%
Cetylpyridinium chloride 1%
Sodium benzoate 1.5%
Food coloring indigo plant 0.005%
Aspartame 0.8%
Sodium fluoride 0.1%
Acesulfame-K 0.795%.
When this gargled sheet during use, the sheet that only needs to gargle contained in the inlet, contains a bite clear water then, gargled according to the normal method of gargling, and finished liquid to be spued after gargling.The sheet structure in the form of sheets of gargling of the present invention with respect to traditional collutory, has reduced volume greatly, has made things convenient for carrying and using of people's daily life.For traditional toothpaste, the use of the sheet of gargling need be by toothbrush, and its sterilizing ability is stronger than toothpaste.With respect to other oral care products, as flavorants, breath freshening tablet and chewing gum etc., the effect that fresh breath is not only arranged, and can also effectively remove intraoral antibacterial, the cleaning teeth dirt, in addition, this character that the sheet inlet promptly looses of gargling, make it neither can disorderly tell contaminated environment, also can not eat and cause the injury of health because of mistake because of the throwing out without care of colloid thing that can not eat.
Claims (9)
1. the sheet of gargling is the solid lamellar, is inlet decentralized oral care implement, and it contains film former, freshener and emulsifying agent, it is characterized in that: also further include foam cleaners which do and abrasivus.
2. the sheet of gargling as claimed in claim 1 is characterized in that: contain following components in weight percentage (calculating with the finished product butt):
Film former 40-75%
Freshener 4-15%
Foam cleaners which do 2-10%
Abrasivus 10-25%
Emulsifying agent 5-10%.
3. the sheet of gargling as claimed in claim 1 is characterized in that: the described sheet of gargling further contains antibacterial, sweeting agent, plasticizer, mothproof composition, food antiseptics and pigment, the percentage by weight of each component following (calculating with the finished product butt):
Film former 40-75%
Freshener 4-15%
Foam cleaners which do 2-10%
Abrasivus 10-25%
Emulsifying agent 5-10%
Antibacterial 0.5-2.5%
Sweeting agent 0.3-3%
Plasticizer 0.3-8%
Mothproof composition 0.1-5%
Food antiseptics 0.1-1.5%
Pigment 0.001-0.5%.
4. the sheet of gargling as claimed in claim 3 is characterized in that:
Described film former is selected from following one or more materials: carboxymethyl cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxypropyl emthylcellulose, chitosan, trehalose, sodium alginate, modified starch, arabic gum, HANSHENGJIAO, tracasol, Konjac glucomannan, konjaku powder, pectin, gelatin, POLY-karaya, guar gum, locust bean gum, Algin, carrageenan, Pullulan, maltodextrin;
Described freshener comprises edible essence;
Described foam cleaners which do is selected from following one or more materials: sodium lauryl sulphate, sodium lauroyl sarcosine, sodium lauroyl glutamate;
Described abrasivus is selected from following one or more materials: silicon dioxide, calcium carbonate, calcium hydrogen phosphate, aluminium hydroxide;
Described antibacterial is selected from following one or more materials: 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether (triclosan), metronidazole, chlorhexidine acetate, cetylpyridinium chloride, benzalkonium bromide;
Described emulsifying agent is selected from following one or more materials: lecithin, stearic acid monoglycerides, tween 80, Tween-60 and tween 20;
Described sweeting agent is selected from following one or more materials: aspartame, sucralose, acesulfame potassium, steviol glycosides;
Described plasticizer is selected from polyhydric alcohol, and wherein, polyhydric alcohol is selected from following one or more materials: glycerol, sorbitol, ethylene glycol, propylene glycol and mannitol;
Described mothproof composition is xylitol, sodium fluoride or sodium monofluorophosphate;
Described food antiseptics is sodium benzoate or potassium sorbate.
5. the sheet of gargling as claimed in claim 3 is characterized in that: contain following components in weight percentage:
Sodium alginate 15.6%
Maltodextrin 35.8%
Carrageenan 1.6%
Glycerol 5.0%
Lecithin 10%
Silica 1 7%
Sodium lauryl sulphate 3%
2,4,4 '-three chloro-2 '-hydroxyl hexichol 0.5%
Essence 5.0%
Sodium benzoate 0.5%
Food coloring indigo plant 0.005%
Aspartame 0.5%
Xylitol 5%
Acesulfame-K 0.495%.
6. the sheet of gargling as claimed in claim 5 is characterized in that: contain following components in weight percentage:
Hydroxyethyl-cellulose 10.4%
Hydroxypropyl cellulose 10%
Maltodextrin 35%
Sorbitol 5%
Lecithin 7%
Benzalkonium bromide 0.8%
Sodium lauroyl sarcosine 10%
Calcium carbonate 15%
Essence 3%
Mentholum 2.1%
Food coloring indigo plant 0.005%
Aspartame 0.6%
Potassium sorbate 0.5%
Acesulfame-K 0.595%.
7. the sheet of gargling as claimed in claim 3 is characterized in that: contain following components in weight percentage:
Carboxymethyl cellulose 5%
HANSHENGJIAO 5%
Modified starch 38%
Glycerol 6%
Tween-60 7%
Essence 4.8%
Silicon dioxide 20%
Sodium lauroyl glutamate 10%
Cetylpyridinium chloride 1%
Sodium benzoate 1.5%
Food coloring indigo plant 0.005%
Aspartame 0.8%
Sodium fluoride 0.1%
Acesulfame-K 0.795%.
8. the preparation method of the sheet of gargling, the described sheet of gargling includes film former, freshener, emulsifying agent, foam cleaners which do and abrasivus, it is characterized in that: said method comprising the steps of:
(1) film former added carry out swelling in an amount of ionized water, this solution is warming up to 70 ℃ after insulation 20 minutes, be cooled to 45 ℃ then;
(2) add described freshener, emulsifying agent, foam cleaners which do and abrasivus successively in the colloid with gained after the above-mentioned swelling, stir, form rubber cement;
(3) rubber cement with gained in the step (2) forms thin film;
(4) in the presence of steam, the thin film of gained in the step (3) is dried, obtain the finished product sheet of gargling after the cooling, its section is stand-by.
9. the preparation method of the sheet of gargling as claimed in claim 1 is characterized in that, also can add sweeting agent, antibacterial, plasticizer, mothproof composition, food antiseptics and pigment in the step (2).
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CN2007100326576A CN101185613B (en) | 2007-12-18 | 2007-12-18 | Oral cleaning tablet and preparation method thereof |
Applications Claiming Priority (1)
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CN2007100326576A CN101185613B (en) | 2007-12-18 | 2007-12-18 | Oral cleaning tablet and preparation method thereof |
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CN101185613A true CN101185613A (en) | 2008-05-28 |
CN101185613B CN101185613B (en) | 2011-06-29 |
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CN2007100326576A Expired - Fee Related CN101185613B (en) | 2007-12-18 | 2007-12-18 | Oral cleaning tablet and preparation method thereof |
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CN101971908A (en) * | 2010-11-18 | 2011-02-16 | 林国军 | Chewing gum capable of cleaning teeth |
CN102793885A (en) * | 2012-09-06 | 2012-11-28 | 苏州谷力生物科技有限公司 | Plant extract with effect of refreshing oral cavity |
CN103876846A (en) * | 2012-12-23 | 2014-06-25 | 崔允太 | Tooth sheath |
CN104473822A (en) * | 2014-12-02 | 2015-04-01 | 东莞市荷花食品有限公司 | Mouthwash tablet containing plant extract and preparation method of mouthwash tablet |
CN105342877A (en) * | 2015-11-24 | 2016-02-24 | 梁修剑 | Preparation formula and preparation method for amino acid face-cleansing paper |
CN106309148A (en) * | 2016-09-28 | 2017-01-11 | 北京瑞济善健康科技有限公司 | Quickly released oral cavity nursing mouthwash refreshing tablet and preparation method and application thereof |
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CN107007539A (en) * | 2017-04-17 | 2017-08-04 | 江苏恩为众心生物医药有限公司 | Probiotics gargle production technology |
CN108290061A (en) * | 2015-12-09 | 2018-07-17 | 高露洁-棕榄公司 | Oral care composition and method |
CN108853023A (en) * | 2018-07-05 | 2018-11-23 | 广州立白企业集团有限公司 | Oral cavity bacteriostatic composition and the preparation method and application thereof |
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CN101971908A (en) * | 2010-11-18 | 2011-02-16 | 林国军 | Chewing gum capable of cleaning teeth |
CN102793885A (en) * | 2012-09-06 | 2012-11-28 | 苏州谷力生物科技有限公司 | Plant extract with effect of refreshing oral cavity |
CN103876846A (en) * | 2012-12-23 | 2014-06-25 | 崔允太 | Tooth sheath |
CN104473822A (en) * | 2014-12-02 | 2015-04-01 | 东莞市荷花食品有限公司 | Mouthwash tablet containing plant extract and preparation method of mouthwash tablet |
CN105342877A (en) * | 2015-11-24 | 2016-02-24 | 梁修剑 | Preparation formula and preparation method for amino acid face-cleansing paper |
CN105342877B (en) * | 2015-11-24 | 2017-09-05 | 广州市轩琳生物科技有限公司 | A kind of amino acid cleansing paper and preparation method thereof |
CN108290061A (en) * | 2015-12-09 | 2018-07-17 | 高露洁-棕榄公司 | Oral care composition and method |
CN106344428A (en) * | 2016-07-27 | 2017-01-25 | 青岛琛蓝海洋生物工程有限公司 | Marine polysaccharide-based dry mouth symptom relieving mouthwash and preparation method thereof |
CN106309148B (en) * | 2016-09-28 | 2019-04-26 | 北京瑞济善健康科技有限公司 | Quick-release oral care is gargled freshening tablet and its preparation method and application |
CN106309148A (en) * | 2016-09-28 | 2017-01-11 | 北京瑞济善健康科技有限公司 | Quickly released oral cavity nursing mouthwash refreshing tablet and preparation method and application thereof |
CN107007539A (en) * | 2017-04-17 | 2017-08-04 | 江苏恩为众心生物医药有限公司 | Probiotics gargle production technology |
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